Because neurons are susceptible to oxidative damage and thioredoxin reductase 1 is extensively distributed in the central nervous system and has antioxidant properties, we speculated that the enzyme may be involved in...Because neurons are susceptible to oxidative damage and thioredoxin reductase 1 is extensively distributed in the central nervous system and has antioxidant properties, we speculated that the enzyme may be involved in the pathogenesis of Parkinson＇s disease. A Parkinson＇s disease model was produced by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into C57BL/6 mice. Real-time reverse transcription-PCR, western blot analysis and colorimetric assay showed that the levels of thioredoxin reductase 1 mRNA and protein were decreased, along with a significant reduction in thioredoxin reductase activity, in the midbrain of Parkinson＇s disease mice compared with normal mice. Immunohistochemical staining revealed that the number of thioredoxin reductase 1-positive neurons in the substantia nigra pars compacta of Parkinson＇s disease mice was significantly decreased compared with normal mice. These experimental findings suggest that the expression of thioredoxin reductase 1 in the substantia nigra pars compacta of Parkinson＇s disease mice is significantly decreased, and that the enzyme may be associated with disease onset.展开更多
The ontogenesis of the form Biota orientalis compacta (Cupressaceae) was first studied in the conditions of introduction of the Tashkent Botanical Garden. The passage of periods and stages of ontogenesis, full ripenin...The ontogenesis of the form Biota orientalis compacta (Cupressaceae) was first studied in the conditions of introduction of the Tashkent Botanical Garden. The passage of periods and stages of ontogenesis, full ripening of the cones, a high rate of growth and development, as well as high seed productivity are the main indicators of the success and prospects of the introduction of the form Biota orientalis compacta. The data obtained will serve as a theoretical basis for the agrotechnical development in landscaping.展开更多
位于0ttersweier的德国印刷企业B＆KOffsetdruck公司雄心勃勃,希望扩大其市场份额,它已经订购了一套高宝(K BA)C om pacta217高性能16页式的商业印刷机.自35年前创建以来,B&K公司在专门从事产品定制和提供一站武服务方面,从设计开...位于0ttersweier的德国印刷企业B＆KOffsetdruck公司雄心勃勃,希望扩大其市场份额,它已经订购了一套高宝(K BA)C om pacta217高性能16页式的商业印刷机.自35年前创建以来,B&K公司在专门从事产品定制和提供一站武服务方面,从设计开发到印刷产品的转化,一直在稳步壮大,这个家族企业共有250名员工,他们在操纵先进设备时展示出非凡的技能和丰富的经验.展开更多
We prove that a topological space is uniform Eberlein compact iff it is homeomorphic to a super weakly compact subset C of a Banach space such that the closed convex hull coC of C is super weakly compact. We also show...We prove that a topological space is uniform Eberlein compact iff it is homeomorphic to a super weakly compact subset C of a Banach space such that the closed convex hull coC of C is super weakly compact. We also show that a Banach space X is super weakly compactly generated iff the dual unit ball B;of X;in its weak star topology is affinely homeomorphic to a super weakly compactly convex subset of a Banach space.展开更多
观察运动疲劳大鼠黑质致密区(substantia nigra zonacompacta,SNc)多巴胺(dopamine,DA)神经元自发放电特征,探讨运动疲劳产生的中枢机制。方法:采用胞外玻璃微电极技术,在体观察运动疲劳后大鼠SNc区DA神经元自发电活动的变化。结果:运...观察运动疲劳大鼠黑质致密区(substantia nigra zonacompacta,SNc)多巴胺(dopamine,DA)神经元自发放电特征,探讨运动疲劳产生的中枢机制。方法:采用胞外玻璃微电极技术,在体观察运动疲劳后大鼠SNc区DA神经元自发电活动的变化。结果:运动疲劳大鼠SNc区DA能神经元自发单放电频率较对照组显著降低,神经元出现了不规则放电,且爆发式放电比例明显增多,放电间隔直方图成正偏态或随机分布(AI<1),ISI和CV值均显著大于对照组。结论:运动疲劳大鼠SNc区DA能神经元电活动出现明显改变,主要特征为兴奋性和活动规律性降低。SNc和纹状体的腹外侧和背外侧区构成的黑质—纹状体DA能神经通路参与了基底神经节对运动的调节,也是运动疲劳调控的重要中枢脑区之一。展开更多
基金supported by the Fundamental Research Funds for the Central Universities, No. lzujbky-2011-83Project of the International Cooperation and Communion Department of Chinese Education Ministry (46th batch)the Science Foundation of Key Laboratory of Preclinical Study for New Drugs of Gansu Province, No. GSKFKT-0804
文摘Because neurons are susceptible to oxidative damage and thioredoxin reductase 1 is extensively distributed in the central nervous system and has antioxidant properties, we speculated that the enzyme may be involved in the pathogenesis of Parkinson＇s disease. A Parkinson＇s disease model was produced by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into C57BL/6 mice. Real-time reverse transcription-PCR, western blot analysis and colorimetric assay showed that the levels of thioredoxin reductase 1 mRNA and protein were decreased, along with a significant reduction in thioredoxin reductase activity, in the midbrain of Parkinson＇s disease mice compared with normal mice. Immunohistochemical staining revealed that the number of thioredoxin reductase 1-positive neurons in the substantia nigra pars compacta of Parkinson＇s disease mice was significantly decreased compared with normal mice. These experimental findings suggest that the expression of thioredoxin reductase 1 in the substantia nigra pars compacta of Parkinson＇s disease mice is significantly decreased, and that the enzyme may be associated with disease onset.
文摘The ontogenesis of the form Biota orientalis compacta (Cupressaceae) was first studied in the conditions of introduction of the Tashkent Botanical Garden. The passage of periods and stages of ontogenesis, full ripening of the cones, a high rate of growth and development, as well as high seed productivity are the main indicators of the success and prospects of the introduction of the form Biota orientalis compacta. The data obtained will serve as a theoretical basis for the agrotechnical development in landscaping.
文摘位于0ttersweier的德国印刷企业B＆KOffsetdruck公司雄心勃勃,希望扩大其市场份额,它已经订购了一套高宝(K BA)C om pacta217高性能16页式的商业印刷机.自35年前创建以来,B&K公司在专门从事产品定制和提供一站武服务方面,从设计开发到印刷产品的转化,一直在稳步壮大,这个家族企业共有250名员工,他们在操纵先进设备时展示出非凡的技能和丰富的经验.
基金The first author is supported by Natural Science Foundation of Guangxi Education Department(Grant No.KY2015LX518)the second author is supported by National Natural Science Foundation of China(Grant No.11671065)the third author is supported by National Natural Science Foundation of China(Grant No.11471271)
文摘We prove that a topological space is uniform Eberlein compact iff it is homeomorphic to a super weakly compact subset C of a Banach space such that the closed convex hull coC of C is super weakly compact. We also show that a Banach space X is super weakly compactly generated iff the dual unit ball B;of X;in its weak star topology is affinely homeomorphic to a super weakly compactly convex subset of a Banach space.
文摘观察运动疲劳大鼠黑质致密区(substantia nigra zonacompacta,SNc)多巴胺(dopamine,DA)神经元自发放电特征,探讨运动疲劳产生的中枢机制。方法:采用胞外玻璃微电极技术,在体观察运动疲劳后大鼠SNc区DA神经元自发电活动的变化。结果:运动疲劳大鼠SNc区DA能神经元自发单放电频率较对照组显著降低,神经元出现了不规则放电,且爆发式放电比例明显增多,放电间隔直方图成正偏态或随机分布(AI<1),ISI和CV值均显著大于对照组。结论:运动疲劳大鼠SNc区DA能神经元电活动出现明显改变,主要特征为兴奋性和活动规律性降低。SNc和纹状体的腹外侧和背外侧区构成的黑质—纹状体DA能神经通路参与了基底神经节对运动的调节,也是运动疲劳调控的重要中枢脑区之一。
