Background:Biliary stent placement during endoscopic retrograde cholangiopancreatography(ERCP)is important for drainage in common bile duct(CBD)strictures,while the stent length is associated with many stent-related c...Background:Biliary stent placement during endoscopic retrograde cholangiopancreatography(ERCP)is important for drainage in common bile duct(CBD)strictures,while the stent length is associated with many stent-related complications.We aimed to develop an artificial intelligence(AI)model for stent length selection during ERCP.Methods:Images of the patients who underwent ERCP and were diagnosed with CBD strictures were collected.Training involved identifying and delineating the duodenoscope,CBD and guidewire,calculating the pixel distance of the target guidewire and determining the required biliary stent length based on the diameter of the duodenoscope.The performance of the model,accuracy for length calculation and the assistance for endoscopists were validated using the testing set.Results:A total of 794 images from 431 patients were included and data augmentation was conducted.The mean intersection over union(mIoU)for duodenoscope,CBD and guidewire were 90.46%,84.79%and 84.64%,respectively.The accuracy in identifying the strictures was 97.58%(121/124).The accuracy for stent length calculation achieved 85.95%(104/121)with an error margin of±1 cm.The mean absolute error(MAE)and mean relative error(MRE)of the AI model was 0.81 cm and 0.13,respectively.The AI model could reduce approximately 202 mGycm^(2)of the radiation exposure for each patient.It significantly improved both MAE and MRE for less experienced endoscopists(P=0.01 and P=0.02,respectively).Conclusions:The AI model could accurately identify duodenoscope,CBD and guidewire,enabling accurate strictures identification and stent length selection.展开更多
To characterize the spatial patterns of vertical crustal movement of Chinese mainland,GNSS imaging technology was applied to map the tectonic deformation of the region.In this study,the vertical crustal velocities inf...To characterize the spatial patterns of vertical crustal movement of Chinese mainland,GNSS imaging technology was applied to map the tectonic deformation of the region.In this study,the vertical crustal velocities inferred from GNSS data for Chinese mainland over two decades were rigorously estimated.First,by analyzing the vertical displacement time series from continuous GNSS stations and environmental load data,we found that the annual and semi-annual vertical displacements are highly correlated.This indicates that the vertical seasonal variations on the ground surface are mainly caused by environmental loading.After removing the seasonal variations caused by environmental loads from the GNSS time series,we applied an improved PCA technique to filter out common mode errors.Next,we estimated the optimal noise models for the filtered time series and derived the vertical velocity field of Chinese mainland.Finally,we employed an empirical Spatial Structure Function(SSF)to image the tectonic deformation of Chinese mainland.This method effectively mitigates issues with abrupt circular arc-shaped boundaries in GNSS imaging caused by sparse station networks.The imaging results show that vertical crustal deformation in Chinese mainland generally ranges from-3 to 3 mm/yr,with significant spatial variability.The central and northern parts of Qinghai-Xizang Plateau are identified as primary subsidence zones,indicating that plate boundaries and tectonic compression continue to shape the crustal movement in these regions.The major uplift zones are located in northern and central China,likely linked to regional tectonic activity and plate compression.Subsidence deformation in parts of eastern China appears to be influenced by human activities.展开更多
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You...Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.展开更多
Glutamate receptors and schizophrenia:Schizophrenia is a chronic mental disorder affecting approximately 1%of the global population,with 70%-80%heritability.It has a multifactorial etiology involving both environmenta...Glutamate receptors and schizophrenia:Schizophrenia is a chronic mental disorder affecting approximately 1%of the global population,with 70%-80%heritability.It has a multifactorial etiology involving both environmental factors and a complex polygenic genetic architecture.Over the last two decades,large-scale genome-wide approaches revealed contributions of common variants with individually small effect sizes and of rare copy number variants with a large effect size.N-methy l-D-a spar tat e receptor(NMDAR)hypofunction has been implicated as a central mechanism in the pathophysiology of schizophrenia(Coyle et al.,2020).展开更多
Self-supported nanoarrays have emerged as a promising alternative electrocatalyst for alkaline H_(2)O splitting,owing to their accessible active sites and strongly coupled interfaces with current collectors for improv...Self-supported nanoarrays have emerged as a promising alternative electrocatalyst for alkaline H_(2)O splitting,owing to their accessible active sites and strongly coupled interfaces with current collectors for improved mass transfer and stability.Herein,self-supported crystalline/amorphous NiO/Ni(OH)_(2)nanosheet arrays on nickel foam(NF)are fabricated via an in-situ dissolution-deposition hydrothermal growing of Ni(OH)_(2)nanosheets without additional metal sources assisted by a common Lewis base,EDTA,followed by a rapid calcination at 300℃in air.The as-prepared EDTA-NF-12 h exhibits high OER and HER performance under alkaline conditions,requiring 235 mV and 158 mV,respectively,to reach 10 mA cm^(-2),and the decent performance can be maintained for 24 h without obvious degradation.The dual interfaces,i.e.,the dense crystalline/amorphous interfaces within the NiO/Ni(OH)_(2)nanosheet arrays,as well as the intimate interfaces between nanoarrays and NF,both serve as reaction active sites,facilitate electron transfer,and endow the catalyst with high activity and stability.Furthermore,by applying EDTA-Ni^(2+)and other Lewis bases with varying basicities instead of EDTA,the interfaces with the NF substrate are found to promote the formation of crystalline/amorphous interfaces within the nanosheets.This study offers appealing opportunities for tailoring the electrocatalytic performance of self-supported electrodes via dual interface engineering.展开更多
To address the challenges of complexity,power consumption,and cost constraints in traditional display driver integrated circuits(DDICs)caused by external NOR Flash and SRAM,this work proposes an embedded resistive ran...To address the challenges of complexity,power consumption,and cost constraints in traditional display driver integrated circuits(DDICs)caused by external NOR Flash and SRAM,this work proposes an embedded resistive random-access memory(RRAM)integration solution based on a 40 nm high-voltage CMOS logic platform.Targeting the yield fluctuations and stability challenges during RRAM mass production,systematic process optimizations are implemented to achieve synergistic improvements in RRAM performance and yield.Through modifications to the film sputtering and pre-deposition treatment,the withinwafer resistance uniformity(RSU)of the oxygen-deficient layer(ODL)thin film is improved from 11%to 8%,while inter-wafer process stability variation reduces from 23%to below 6%.Consequently,the yield of 8 Mb RRAM embedded mass production products increases from 87%to 98.5%.In terms of device performance,the RRAM demonstrates a fast 4.8 ns read speed,exceptional read disturb immunity of 3×10^(8) cycles at 95℃,10^(3) write/erase endurance cycles for the 1 Mb cells,and data retention of 12.5 years at 125℃.Post high-temperature operating life(HTOL)testing exhibits stable high/low resistance window.This study provides process optimization strategies and a reliability assurance framework for the mass production of highly integrated,low-power embedded RRAM display driver IC.展开更多
IC10 alloy is a promising material for the applications of engine turbine blades.Fabricating and repairing of the turbine blades urgently need a sound joining technique for the IC10 alloy.The traditional transient liq...IC10 alloy is a promising material for the applications of engine turbine blades.Fabricating and repairing of the turbine blades urgently need a sound joining technique for the IC10 alloy.The traditional transient liquid phase(TLP)bonding method is difficult to achieve isothermal solidification,which tends to form brittle eutectic phases.In this study,a novel Al/BNi2 composite filler was designed.This new type of composite filler facilitates the diffusion of elements to completely dissolve or disperse the brittle eutectic structure of continuous large blocks in the TLP joint,thereby improving the room-temperature mechanical properties of the joint and increasing its average shear strength by 20%to 550 MPa.Effect of Al content and bonding temperature on microstructure and mechanical strength of the IC10/Al/BNi2/IC10 joint was investigated.Microstructure evolution mechanisms of the traditional TLP bonding method(with a pure BNi2 filler)and the novel TLP bonding method(with the Al/BNi2 composite filler)were put into comparison.The TLP joint of the new filler achieved a maximum room temperature shear strength of 570 MPa(3 wt.%Al,1100℃,2 h).展开更多
Debate over the benefits and harms of icing acute muscle injuries remains unresolved.Some contend that ice is ineffective or even harmful,while others promote cryotherapy as a universal remedy.Centrists,often academic...Debate over the benefits and harms of icing acute muscle injuries remains unresolved.Some contend that ice is ineffective or even harmful,while others promote cryotherapy as a universal remedy.Centrists,often academics,call for more high-quality randomized controlled trials(RCTs)to resolve the issue.This viewpoint reframes the debate around 3 key points:first,although ice produces analgesia,evidence for sustained pain relief,beyond the immediate post-treatment period.展开更多
基金supported by grants from the Taishan Scholars Program of Shandong Province(tsqn202312333)the National Natural Science Foundation of China(82470695).
文摘Background:Biliary stent placement during endoscopic retrograde cholangiopancreatography(ERCP)is important for drainage in common bile duct(CBD)strictures,while the stent length is associated with many stent-related complications.We aimed to develop an artificial intelligence(AI)model for stent length selection during ERCP.Methods:Images of the patients who underwent ERCP and were diagnosed with CBD strictures were collected.Training involved identifying and delineating the duodenoscope,CBD and guidewire,calculating the pixel distance of the target guidewire and determining the required biliary stent length based on the diameter of the duodenoscope.The performance of the model,accuracy for length calculation and the assistance for endoscopists were validated using the testing set.Results:A total of 794 images from 431 patients were included and data augmentation was conducted.The mean intersection over union(mIoU)for duodenoscope,CBD and guidewire were 90.46%,84.79%and 84.64%,respectively.The accuracy in identifying the strictures was 97.58%(121/124).The accuracy for stent length calculation achieved 85.95%(104/121)with an error margin of±1 cm.The mean absolute error(MAE)and mean relative error(MRE)of the AI model was 0.81 cm and 0.13,respectively.The AI model could reduce approximately 202 mGycm^(2)of the radiation exposure for each patient.It significantly improved both MAE and MRE for less experienced endoscopists(P=0.01 and P=0.02,respectively).Conclusions:The AI model could accurately identify duodenoscope,CBD and guidewire,enabling accurate strictures identification and stent length selection.
基金National Natural Science Foundation of China(42274012,42004001)the Science and Technology Innovation Project of Anhui Surveying and Mapping Bureau(2025-KJ-08)+1 种基金the Open Fund of Wuhan Gravitation and Solid Earth Tides,National Observation and Research Station(WHYWZ202107)the Fundamental Research Funds for the Central Universities(JZ2022HGTB0268)。
文摘To characterize the spatial patterns of vertical crustal movement of Chinese mainland,GNSS imaging technology was applied to map the tectonic deformation of the region.In this study,the vertical crustal velocities inferred from GNSS data for Chinese mainland over two decades were rigorously estimated.First,by analyzing the vertical displacement time series from continuous GNSS stations and environmental load data,we found that the annual and semi-annual vertical displacements are highly correlated.This indicates that the vertical seasonal variations on the ground surface are mainly caused by environmental loading.After removing the seasonal variations caused by environmental loads from the GNSS time series,we applied an improved PCA technique to filter out common mode errors.Next,we estimated the optimal noise models for the filtered time series and derived the vertical velocity field of Chinese mainland.Finally,we employed an empirical Spatial Structure Function(SSF)to image the tectonic deformation of Chinese mainland.This method effectively mitigates issues with abrupt circular arc-shaped boundaries in GNSS imaging caused by sparse station networks.The imaging results show that vertical crustal deformation in Chinese mainland generally ranges from-3 to 3 mm/yr,with significant spatial variability.The central and northern parts of Qinghai-Xizang Plateau are identified as primary subsidence zones,indicating that plate boundaries and tectonic compression continue to shape the crustal movement in these regions.The major uplift zones are located in northern and central China,likely linked to regional tectonic activity and plate compression.Subsidence deformation in parts of eastern China appears to be influenced by human activities.
文摘Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization.
文摘Glutamate receptors and schizophrenia:Schizophrenia is a chronic mental disorder affecting approximately 1%of the global population,with 70%-80%heritability.It has a multifactorial etiology involving both environmental factors and a complex polygenic genetic architecture.Over the last two decades,large-scale genome-wide approaches revealed contributions of common variants with individually small effect sizes and of rare copy number variants with a large effect size.N-methy l-D-a spar tat e receptor(NMDAR)hypofunction has been implicated as a central mechanism in the pathophysiology of schizophrenia(Coyle et al.,2020).
基金the foundation of Guangdong Engineering Technology Research Center for Hydrogen Energy and Fuel Cells,the Guangdong Provincial Department of Education Innovation Project(No.2022KQNCX056)the Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515110354 and 2021A1515110582)。
文摘Self-supported nanoarrays have emerged as a promising alternative electrocatalyst for alkaline H_(2)O splitting,owing to their accessible active sites and strongly coupled interfaces with current collectors for improved mass transfer and stability.Herein,self-supported crystalline/amorphous NiO/Ni(OH)_(2)nanosheet arrays on nickel foam(NF)are fabricated via an in-situ dissolution-deposition hydrothermal growing of Ni(OH)_(2)nanosheets without additional metal sources assisted by a common Lewis base,EDTA,followed by a rapid calcination at 300℃in air.The as-prepared EDTA-NF-12 h exhibits high OER and HER performance under alkaline conditions,requiring 235 mV and 158 mV,respectively,to reach 10 mA cm^(-2),and the decent performance can be maintained for 24 h without obvious degradation.The dual interfaces,i.e.,the dense crystalline/amorphous interfaces within the NiO/Ni(OH)_(2)nanosheet arrays,as well as the intimate interfaces between nanoarrays and NF,both serve as reaction active sites,facilitate electron transfer,and endow the catalyst with high activity and stability.Furthermore,by applying EDTA-Ni^(2+)and other Lewis bases with varying basicities instead of EDTA,the interfaces with the NF substrate are found to promote the formation of crystalline/amorphous interfaces within the nanosheets.This study offers appealing opportunities for tailoring the electrocatalytic performance of self-supported electrodes via dual interface engineering.
文摘To address the challenges of complexity,power consumption,and cost constraints in traditional display driver integrated circuits(DDICs)caused by external NOR Flash and SRAM,this work proposes an embedded resistive random-access memory(RRAM)integration solution based on a 40 nm high-voltage CMOS logic platform.Targeting the yield fluctuations and stability challenges during RRAM mass production,systematic process optimizations are implemented to achieve synergistic improvements in RRAM performance and yield.Through modifications to the film sputtering and pre-deposition treatment,the withinwafer resistance uniformity(RSU)of the oxygen-deficient layer(ODL)thin film is improved from 11%to 8%,while inter-wafer process stability variation reduces from 23%to below 6%.Consequently,the yield of 8 Mb RRAM embedded mass production products increases from 87%to 98.5%.In terms of device performance,the RRAM demonstrates a fast 4.8 ns read speed,exceptional read disturb immunity of 3×10^(8) cycles at 95℃,10^(3) write/erase endurance cycles for the 1 Mb cells,and data retention of 12.5 years at 125℃.Post high-temperature operating life(HTOL)testing exhibits stable high/low resistance window.This study provides process optimization strategies and a reliability assurance framework for the mass production of highly integrated,low-power embedded RRAM display driver IC.
基金funded by the National Natural Science Foundation of China(Grant No.U2167216,52504408,52475335)China Postdoctoral Science Foundation Funded Project(Grant No.2024M754181).
文摘IC10 alloy is a promising material for the applications of engine turbine blades.Fabricating and repairing of the turbine blades urgently need a sound joining technique for the IC10 alloy.The traditional transient liquid phase(TLP)bonding method is difficult to achieve isothermal solidification,which tends to form brittle eutectic phases.In this study,a novel Al/BNi2 composite filler was designed.This new type of composite filler facilitates the diffusion of elements to completely dissolve or disperse the brittle eutectic structure of continuous large blocks in the TLP joint,thereby improving the room-temperature mechanical properties of the joint and increasing its average shear strength by 20%to 550 MPa.Effect of Al content and bonding temperature on microstructure and mechanical strength of the IC10/Al/BNi2/IC10 joint was investigated.Microstructure evolution mechanisms of the traditional TLP bonding method(with a pure BNi2 filler)and the novel TLP bonding method(with the Al/BNi2 composite filler)were put into comparison.The TLP joint of the new filler achieved a maximum room temperature shear strength of 570 MPa(3 wt.%Al,1100℃,2 h).
文摘Debate over the benefits and harms of icing acute muscle injuries remains unresolved.Some contend that ice is ineffective or even harmful,while others promote cryotherapy as a universal remedy.Centrists,often academics,call for more high-quality randomized controlled trials(RCTs)to resolve the issue.This viewpoint reframes the debate around 3 key points:first,although ice produces analgesia,evidence for sustained pain relief,beyond the immediate post-treatment period.
