Objectives:This study aimed to assess the reliability and validity of the abbreviated Committed Action Questionnaire(CAQ-8)in a cohort of 1635 Chinese university students.Methods:Participants completed the Chinese ver...Objectives:This study aimed to assess the reliability and validity of the abbreviated Committed Action Questionnaire(CAQ-8)in a cohort of 1635 Chinese university students.Methods:Participants completed the Chinese version of the CAQ-8 along with other standardized measures,including the Acceptance and Action Questionnaire-II(AAQ-II),the Valuing Questionnaire(VQ),the Satisfaction with Life Scale(SWLS),the Depression Anxiety Stress Scales(DASS-21),and the World Health Organization Fiveitem Well-Being Index(WHO-5).A retest was conducted one month later with 300 valid responses.Results:Exploratory factor analysis(n=818)identified a 2-factor structure,confirmed through validated factor analysis(n=817),showing good fit indices(CFI=0.990,RMSEA=0.040).Measurement equivalence across genders was established.The CAQ-8 showed significant positive correlations with life satisfaction,mental health,and values,and negative correlations with depression,anxiety,stress,and experiential avoidance.The scale demonstrated good internal consistency(Cronbach’sα=0.76)and retest reliability(ICC=0.70).Network analysis confirmed the robustness of the 2-factor model,with item 4 in CAQ-8 identified as a core item.Conclusion:The CAQ-8 is a reliable and valid tool for measuring committed action within the psychological flexibility model in Chinese populations.展开更多
The recent 2024 World Conference of the International Federation of Navigation in Beijing focused on the expansion of navigation applications.Hosted by the China Navigation Society,the event aimed to explore the integ...The recent 2024 World Conference of the International Federation of Navigation in Beijing focused on the expansion of navigation applications.Hosted by the China Navigation Society,the event aimed to explore the integration of navigation,communication,and remote sensing technologies.The head of the International Cooperation Department of the Ministry of Transport emphasized China’s commitment to promoting innovation in navigation.China has become the nation with the largest shipping infrastructure,the highest volume of goods transported by sea,and one of the largest fleets globally.展开更多
Background: Numerous studies of tissues’ regeneration have confessed the recovery of damaged liver by hematopoietic stem cells. The cells act not only by cell replacement in the target organ but also by delivering tr...Background: Numerous studies of tissues’ regeneration have confessed the recovery of damaged liver by hematopoietic stem cells. The cells act not only by cell replacement in the target organ but also by delivering trophic factors that support endogenous liver regeneration. A little is known of how organ-derived signals recruit such committed cells into circulation. Objective: We investigated the roles of noninvasive mechanical percutaneous stress of cirrhotic human liver in numbers fluctuation of trophic, liver-specific alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells in lymphocytes of patients waiting for liver transplantation. Methods: To promote in blood the number of the alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells, committed to liver’ tissue, we activated mechanically the cirrhotic liver of patient by transcutaneous micro vibration received from skin-contacted electro-magnetic vibraphones generated mechanical pulses with amplitude 10 μm and smoothly changing frequency from 0.03 kHz to 18 kHz and back forth during one cycle duration 1 minute. The number of the alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells in lymphocytes of potential recipients was controlled by flow cytometry before and during daily sonication of skin area, which corresponds to liver projection on it. The 15 minutes cyclic sonication of the liver area performed daily for three weeks. Results: The sonication increased significantly averaged number of liver-specific alpha-fetoprotein-positive CD133-positive blood lymphocytes in 2 - 3 times compared to a base lane. The second similar sonication, the same zone after three weeks break showed differences with baseline, but it was statistically insignificant. The result was specifically related to the liver as it showed the control sonication of the backbone’s projection on the skin of a separate group of patients with cirrhotic liver from the waiting list. Conclusion: The stem cells committed to the liver recruit from the bone marrow into circulation, when organ mechanically stresses and secretes specific humoral signals to provoke of lymphopoiesis on host liver repair.展开更多
An identity-based verifiably committed signature scheme (IB-VCS) was proposed, which is proved secure in the standard model (i.e., without random oracles). It enjoys the setup-free property and stand-alone property, b...An identity-based verifiably committed signature scheme (IB-VCS) was proposed, which is proved secure in the standard model (i.e., without random oracles). It enjoys the setup-free property and stand-alone property, both of which make an exchange protocol more practical. The scheme is unconditionally secure against the cheating signer, its security against the cheating verifier is reduced to the computational Diffie-Hellman (CDH) problem in the underlying group, it is secure against the cheating trusted third party if the underlying Paterson Schuldt's identity based signature (IBS) scheme is secure, which is proven true based on the CDH assumption in the standard model.展开更多
We use a nuclear technique based on the determination of the detection efficiencies of solid state nuclear track detectors CR-39 and LR-115 type II (SSNTDs) for alpha particles emitted from the series of uranium-238 a...We use a nuclear technique based on the determination of the detection efficiencies of solid state nuclear track detectors CR-39 and LR-115 type II (SSNTDs) for alpha particles emitted from the series of uranium-238 and thorium-232 in a phytotherapeutic sample and the measurement of alpha track densities registered on these detectors to assess alpha activities due to uranium-238;thorium-232;radon and thoron in samples of phytotherapeutic preparations consumed by Moroccan adult patients. For modern preparations, the alpha activities due to <sup>238</sup>U, <sup>232</sup>Th and <sup>222</sup>Rn range from 14.27 mBq/kg to 22.02 mBq/kg, from 6.27 mBq/kg to 9.64 mBq/kg and from 14.27 Bq/kg to 22.02 Bq/kg respectively. For classical preparations, the alpha activities due to <sup>238</sup>U, <sup>232</sup>Th and <sup>222</sup>Rn range from 16.73 mBq/kg to 24 mBq/kg, from 7.34 mBq/kg to 10.82 mBq/kg and from 16.73 Bq/kg to 24.72 Bq/kg respectively. A dosimetric model for ingestion has been highlighted to determine committed equivalent dose to different compartments of human gastrointestinal system due to the ingestion of phytotherapeutic preparations by Moroccan adult patients. The maximum overall effective dose due to <sup>238</sup>U, <sup>232</sup>Th, and <sup>222</sup>Rn after the ingestion of the studied phytotherapeutic preparations, was found equal to 38 × 10<sup>-8</sup> S·vy<sup>-1</sup> which is less than the dose limit given by the international commission for radiological protection in it publication 56.展开更多
In 2019,Guangxi’s Non-governmental Organizations actively engaged in the Belt and Road Initiative to promote closer people-to-people ties among countries along the Belt and Road.Guangxi NGO Network for International ...In 2019,Guangxi’s Non-governmental Organizations actively engaged in the Belt and Road Initiative to promote closer people-to-people ties among countries along the Belt and Road.Guangxi NGO Network for International Exchanges(GNIE)and its members have taken solid steps to contribute to the building of the Belt and Road Initiative,China’s neighborhood diplomacy and Guangxi’s economic and social development.展开更多
When Xi Jinping stood at the podium, placed his left hand on the newly amended Constitution, raised his right hand in a fist of solidarity and took the public oath of allegiance to the Consti- tution in the Great Hall...When Xi Jinping stood at the podium, placed his left hand on the newly amended Constitution, raised his right hand in a fist of solidarity and took the public oath of allegiance to the Consti- tution in the Great Hall of the People in Beijing on March 17, it not only signaled the beginning of his second term as the Chinese president.展开更多
BACK in 2001 China＇s admission to the World Trade Organization （WTO） was a watershed event for the organization, its members and China itselE December 11, 2016 marked the 15th anniversary of China＇s admission to t...BACK in 2001 China＇s admission to the World Trade Organization （WTO） was a watershed event for the organization, its members and China itselE December 11, 2016 marked the 15th anniversary of China＇s admission to the WTO. The country has since become better integrated with the global economy and gained a strong foothold in global trade. In addition to being the world＇s second largest economy. China is now the world＇s largest trader in goods, the second largest destination for foreign investment and the third larg- est outbound investor. China＇s forex reserves also far outstrip that of any other country.展开更多
The tradition of the Chinese minister of foreign affairs making the first New Year trip abroad to Africa has continued unabated for 28 years.From January 12 to 16 this year,Chinese Foreign Minister Wang Yi made his wa...The tradition of the Chinese minister of foreign affairs making the first New Year trip abroad to Africa has continued unabated for 28 years.From January 12 to 16 this year,Chinese Foreign Minister Wang Yi made his way to Rwanda,Angola,Gabon,and Sǎo Toméand Príncipe.展开更多
China's new-energy vehicle(NEV)industry has taken the global lead in breaking through technological barriers.It has secured the world's top position in production and sales for nine consecutive years,with a ma...China's new-energy vehicle(NEV)industry has taken the global lead in breaking through technological barriers.It has secured the world's top position in production and sales for nine consecutive years,with a market share of more than 60 percent.展开更多
Hematopoietic stem cells(HSCs)have been considered to progressively lose their self-renewal and differentiation potentials prior to the commitment to each blood lineage.However,recent studies have suggested that megak...Hematopoietic stem cells(HSCs)have been considered to progressively lose their self-renewal and differentiation potentials prior to the commitment to each blood lineage.However,recent studies have suggested that megakaryocyte progenitors(MkPs)are generated at the level of HSCs.In this study,we newly identified early megakaryocyte lineage-committed progenitors(MgPs)mainly in CD201-CD48-cells and CD48+cells separated from the CD150+CD34-Kit+Sca-1+Lin-HSC population of the bone marrow in adult mice.Single-cell colony assay and single-cell transplantation showed that MgPs,unlike platelet-biased HSCs,had little repopulating potential in vivo,but formed larger megakaryocyte colonies in vitro(on average 8 megakaryocytes per colony)than did previously reported MkPs.Single-cell RNA sequencing supported that HSCs give rise to MkPs through MgPs along a Mk differentiation pathway.Single-cell reverse transcription polymerase chain reaction(RT-PCR)analysis showed that MgPs expressed Mk-related genes,but were transcriptionally heterogenous.Clonal culture of HSCs suggested that MgPs are not direct progeny of HSCs.We propose a differentiation model in which HSCs give rise to MgPs which then give rise to MkPs,supporting a classic model in which Mk-lineage commitment takes place at a late stage of differentiation.展开更多
Dear Editor,Dendritic cells(DCs)are the most efficient professional antigen presenting cells that act as sentinels of the immune system and conduct vital functions in the initiation and regulation of innate and adapti...Dear Editor,Dendritic cells(DCs)are the most efficient professional antigen presenting cells that act as sentinels of the immune system and conduct vital functions in the initiation and regulation of innate and adaptive immunities(Wculek et al.,2020).In addition to being critical cellular components in pathogen clearance,DCs are promising targets for improved tumor immunotherapy,vaccine design,and intervention of autoimmune diseases(Nutt and Chopin,2020).DCs can be classified as plasmacytoid DCs(pDCs)and conventional DCs(cDCs)in both mouse and human(Anderson et al.,2018;Nutt and Chopin,2020).展开更多
Strategic initiative:Entering Oman for a new strategy In 2004,the International Department of CNPC’s BGP took a crucial step in the Middle East market by successfully securing a seismic exploration project for the na...Strategic initiative:Entering Oman for a new strategy In 2004,the International Department of CNPC’s BGP took a crucial step in the Middle East market by successfully securing a seismic exploration project for the national oil company of Oman,Petroleum Development Oman(PDO).展开更多
This study examined the relationships among workplace spirituality,mindfulness,mental well-being,and organizational commitment in professional female dancers.A total of 424 dancers from the United States participated ...This study examined the relationships among workplace spirituality,mindfulness,mental well-being,and organizational commitment in professional female dancers.A total of 424 dancers from the United States participated in the survey.Structural equation modeling indicated that workplace spirituality was positively associated with both mental well-being and organizational commitment,whereas mindfulness was significantly related only to organizational commitment.Mental well-being was a significant predictor of organizational commitment and mediated the relationship between workplace spirituality and organizational commitment,but not between mindfulness and commitment.These results suggest that workplace spirituality functions as a psychological resource that enhances emotional health and strengthens organizational engagement.Thesefindings are consistent with self-determination theory,highlighting the role of value congruence and intrinsic purpose in sustaining motivation in high-performance contexts.Moreover,the studyfindings underscore the importance of fostering spiritually supportive work environments to promote psychological well-being and long-term organizational commitment.展开更多
In the heart of Addis Ababa,where tradition meets modern ambition,a gleaming structure of steel and glass is quietly reshaping Africa’s future.The new Africa Centres for Disease Control and Prevention(Africa CDC)Head...In the heart of Addis Ababa,where tradition meets modern ambition,a gleaming structure of steel and glass is quietly reshaping Africa’s future.The new Africa Centres for Disease Control and Prevention(Africa CDC)Headquarters is more than just a building-it’s a bold statement of partnership,progress,and a shared commitment to advancing public health across the continent.展开更多
In this paper,a strength-constrained unit commitment(UC)model incorporating system strength constraints based on the weighted short-circuit ratio(WSCR)is proposed.This model facilitates the comprehensive assessment of...In this paper,a strength-constrained unit commitment(UC)model incorporating system strength constraints based on the weighted short-circuit ratio(WSCR)is proposed.This model facilitates the comprehensive assessment of area-wide system strength in power systems with high inverter-based resource(IBR)penetration,thereby contributing to the mitigation of weak grid issues.Unlike traditional models,this approach considers the interactions among multiple IBRs.The UC problem is initially formulated as a mixed-integer nonlinear programming(MINLP)model,reflecting WSCR and bus impedance matrix modification constraints.To enhance computational tractability,the model is transformed into a mixed-integer linear programming(MILP)form.The effectiveness of the proposed approach is validated through simulations on the IEEE 5-bus,IEEE 39-bus,and a modified Korean power system,demonstrating the ability of the proposed UC model enhancing system strength compared to the conventional methodologies.展开更多
BACKGROUND Acceptance and commitment therapy(ACT)is a third-generation therapy that appears to be a promising psychological intervention for psychotic disorders.While several systematic reviews and meta-analyses that ...BACKGROUND Acceptance and commitment therapy(ACT)is a third-generation therapy that appears to be a promising psychological intervention for psychotic disorders.While several systematic reviews and meta-analyses that address the efficacy of ACT for psychosis have been conducted,no systematic review has specifically focused on the application of ACT to the early stages of psychosis.AIM To review the state of the art regarding the feasibility and efficacy of treating early psychosis(EP)with ACT-based interventions.METHODS First,we describe the foundations of the ACT model to provide the background required to contextualize the main objective of this review.Second,we searched the PubMed and PsycINFO databases for studies published up to January 2025 and identified eight studies that met our selection criteria.The systematic review was conducted in accordance with the PRISMA guidelines and the critical appraisal checklist provided by the Joanna Briggs Institute for randomized controlled trials(RCTs).RESULTS All studies were published after 2019.Among the reviewed studies,five were RCTs with a total combined sample of 399 nonoverlapping participants.The methodological quality was moderate for RCTs.The results showed that ACTbased treatments are feasible and improve psychotic symptoms,medication adherence,and global functioning in patients with EP.Furthermore,preliminary evidence exists for the benefits of group-based and online-delivered programs and those that combine face-to-face therapy with novel real-time digital interventions,such as“ecological momentary intervention”,to apply therapeutic con cepts to real life.CONCLUSION ACT-based treatments in the early stages of psychosis are feasible and improve symptoms,treatment adherence,and self-care skills.Although promising,these results are inconclusive.Further research is required.展开更多
Background:Restrained eating,often motivated by the desire to control weight,is prevalent among young female college students and is considered a risk factor for eating disorders.Negative evaluation fear,exacerbated b...Background:Restrained eating,often motivated by the desire to control weight,is prevalent among young female college students and is considered a risk factor for eating disorders.Negative evaluation fear,exacerbated by social pressure,peer comparison,and academic stress,has been identified as a potential contributor to restrained eating behavior.However,research exploring the relationship between negative evaluation fear and restrained eating,particularly in the context of self-esteem and physical appearance perfectionism,remains limited.This study aims to investigate these relationships and design an intervention program to reduce restrained eating behaviors in female college students.Methods:Study 1 involved 617 female college students,using the Physical Appearance Perfectionism Scale,Rosenberg Self-Esteem Scale,Fear of Negative Evaluation Scale,and Dutch Eating Behavior Questionnaire to measure key variables.We examined the relationships between physical appearance perfectionism,self-esteem,fear of negative evaluation,and restrained eating.In Study 2,a 4-week group psychological intervention based on Acceptance and Commitment Therapy(ACT)was implemented with 45 students,divided into experimental,control,and placebo groups.The intervention’s effectiveness was assessed in reducing restrained eating and negative evaluation fear.Results:The study found that fear of negative evaluation significantly predicted restrained eating and physical appearance perfectionism.Physical appearance perfectionism,in turn,positively predicted restrained eating and partially mediated the relationship between negative evaluation fear and restrained eating.Self-esteem moderated this mediation effect.Additionally,the ACT-based intervention significantly reduced fear of negative evaluation and restrained eating behavior in the experimental group.Conclusion:This study identifies fear of negative evaluation and physical appearance perfectionism as key predictors of restrained eating in female college students.Fear of negative evaluation significantly predicted restrained eating,with physical appearance perfectionism partially mediating this relationship.The ACT-based intervention effectively reduced both fear of negative evaluation and restrained eating.These findings highlight the importance of addressing negative evaluation fear and appearance perfectionism in interventions for restrained eating.展开更多
文摘Objectives:This study aimed to assess the reliability and validity of the abbreviated Committed Action Questionnaire(CAQ-8)in a cohort of 1635 Chinese university students.Methods:Participants completed the Chinese version of the CAQ-8 along with other standardized measures,including the Acceptance and Action Questionnaire-II(AAQ-II),the Valuing Questionnaire(VQ),the Satisfaction with Life Scale(SWLS),the Depression Anxiety Stress Scales(DASS-21),and the World Health Organization Fiveitem Well-Being Index(WHO-5).A retest was conducted one month later with 300 valid responses.Results:Exploratory factor analysis(n=818)identified a 2-factor structure,confirmed through validated factor analysis(n=817),showing good fit indices(CFI=0.990,RMSEA=0.040).Measurement equivalence across genders was established.The CAQ-8 showed significant positive correlations with life satisfaction,mental health,and values,and negative correlations with depression,anxiety,stress,and experiential avoidance.The scale demonstrated good internal consistency(Cronbach’sα=0.76)and retest reliability(ICC=0.70).Network analysis confirmed the robustness of the 2-factor model,with item 4 in CAQ-8 identified as a core item.Conclusion:The CAQ-8 is a reliable and valid tool for measuring committed action within the psychological flexibility model in Chinese populations.
文摘The recent 2024 World Conference of the International Federation of Navigation in Beijing focused on the expansion of navigation applications.Hosted by the China Navigation Society,the event aimed to explore the integration of navigation,communication,and remote sensing technologies.The head of the International Cooperation Department of the Ministry of Transport emphasized China’s commitment to promoting innovation in navigation.China has become the nation with the largest shipping infrastructure,the highest volume of goods transported by sea,and one of the largest fleets globally.
文摘Background: Numerous studies of tissues’ regeneration have confessed the recovery of damaged liver by hematopoietic stem cells. The cells act not only by cell replacement in the target organ but also by delivering trophic factors that support endogenous liver regeneration. A little is known of how organ-derived signals recruit such committed cells into circulation. Objective: We investigated the roles of noninvasive mechanical percutaneous stress of cirrhotic human liver in numbers fluctuation of trophic, liver-specific alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells in lymphocytes of patients waiting for liver transplantation. Methods: To promote in blood the number of the alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells, committed to liver’ tissue, we activated mechanically the cirrhotic liver of patient by transcutaneous micro vibration received from skin-contacted electro-magnetic vibraphones generated mechanical pulses with amplitude 10 μm and smoothly changing frequency from 0.03 kHz to 18 kHz and back forth during one cycle duration 1 minute. The number of the alpha-fetoprotein-positive fraction of CD133-positive hematopoietic stem cells in lymphocytes of potential recipients was controlled by flow cytometry before and during daily sonication of skin area, which corresponds to liver projection on it. The 15 minutes cyclic sonication of the liver area performed daily for three weeks. Results: The sonication increased significantly averaged number of liver-specific alpha-fetoprotein-positive CD133-positive blood lymphocytes in 2 - 3 times compared to a base lane. The second similar sonication, the same zone after three weeks break showed differences with baseline, but it was statistically insignificant. The result was specifically related to the liver as it showed the control sonication of the backbone’s projection on the skin of a separate group of patients with cirrhotic liver from the waiting list. Conclusion: The stem cells committed to the liver recruit from the bone marrow into circulation, when organ mechanically stresses and secretes specific humoral signals to provoke of lymphopoiesis on host liver repair.
基金The National Hi-Tech Research and Development Program (863) of China (No. 2005AA145110)The Pudong New Area Technology Innovation Public Service Platform of China (No. PDP2005-04)
文摘An identity-based verifiably committed signature scheme (IB-VCS) was proposed, which is proved secure in the standard model (i.e., without random oracles). It enjoys the setup-free property and stand-alone property, both of which make an exchange protocol more practical. The scheme is unconditionally secure against the cheating signer, its security against the cheating verifier is reduced to the computational Diffie-Hellman (CDH) problem in the underlying group, it is secure against the cheating trusted third party if the underlying Paterson Schuldt's identity based signature (IBS) scheme is secure, which is proven true based on the CDH assumption in the standard model.
文摘We use a nuclear technique based on the determination of the detection efficiencies of solid state nuclear track detectors CR-39 and LR-115 type II (SSNTDs) for alpha particles emitted from the series of uranium-238 and thorium-232 in a phytotherapeutic sample and the measurement of alpha track densities registered on these detectors to assess alpha activities due to uranium-238;thorium-232;radon and thoron in samples of phytotherapeutic preparations consumed by Moroccan adult patients. For modern preparations, the alpha activities due to <sup>238</sup>U, <sup>232</sup>Th and <sup>222</sup>Rn range from 14.27 mBq/kg to 22.02 mBq/kg, from 6.27 mBq/kg to 9.64 mBq/kg and from 14.27 Bq/kg to 22.02 Bq/kg respectively. For classical preparations, the alpha activities due to <sup>238</sup>U, <sup>232</sup>Th and <sup>222</sup>Rn range from 16.73 mBq/kg to 24 mBq/kg, from 7.34 mBq/kg to 10.82 mBq/kg and from 16.73 Bq/kg to 24.72 Bq/kg respectively. A dosimetric model for ingestion has been highlighted to determine committed equivalent dose to different compartments of human gastrointestinal system due to the ingestion of phytotherapeutic preparations by Moroccan adult patients. The maximum overall effective dose due to <sup>238</sup>U, <sup>232</sup>Th, and <sup>222</sup>Rn after the ingestion of the studied phytotherapeutic preparations, was found equal to 38 × 10<sup>-8</sup> S·vy<sup>-1</sup> which is less than the dose limit given by the international commission for radiological protection in it publication 56.
文摘In 2019,Guangxi’s Non-governmental Organizations actively engaged in the Belt and Road Initiative to promote closer people-to-people ties among countries along the Belt and Road.Guangxi NGO Network for International Exchanges(GNIE)and its members have taken solid steps to contribute to the building of the Belt and Road Initiative,China’s neighborhood diplomacy and Guangxi’s economic and social development.
文摘When Xi Jinping stood at the podium, placed his left hand on the newly amended Constitution, raised his right hand in a fist of solidarity and took the public oath of allegiance to the Consti- tution in the Great Hall of the People in Beijing on March 17, it not only signaled the beginning of his second term as the Chinese president.
文摘BACK in 2001 China＇s admission to the World Trade Organization （WTO） was a watershed event for the organization, its members and China itselE December 11, 2016 marked the 15th anniversary of China＇s admission to the WTO. The country has since become better integrated with the global economy and gained a strong foothold in global trade. In addition to being the world＇s second largest economy. China is now the world＇s largest trader in goods, the second largest destination for foreign investment and the third larg- est outbound investor. China＇s forex reserves also far outstrip that of any other country.
文摘The tradition of the Chinese minister of foreign affairs making the first New Year trip abroad to Africa has continued unabated for 28 years.From January 12 to 16 this year,Chinese Foreign Minister Wang Yi made his way to Rwanda,Angola,Gabon,and Sǎo Toméand Príncipe.
文摘China's new-energy vehicle(NEV)industry has taken the global lead in breaking through technological barriers.It has secured the world's top position in production and sales for nine consecutive years,with a market share of more than 60 percent.
基金supported by grants from the National Key Research and Development Program of China(2022YFA1103500,2021YFA1100900)Science,Technology&Innovation Project of Xiongan New Area(2022XAGG0142)+3 种基金the National Natural Science Foundation of China(82170118,82370116,82250710178,82222004,82070112)Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00038)the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-I2M-1-073),Distinguished Young Scholars of Tianjin(23JCJQJC00220)the CAMS Fundamental Research Funds for Central Research Institutes(2022-RC180-06).
文摘Hematopoietic stem cells(HSCs)have been considered to progressively lose their self-renewal and differentiation potentials prior to the commitment to each blood lineage.However,recent studies have suggested that megakaryocyte progenitors(MkPs)are generated at the level of HSCs.In this study,we newly identified early megakaryocyte lineage-committed progenitors(MgPs)mainly in CD201-CD48-cells and CD48+cells separated from the CD150+CD34-Kit+Sca-1+Lin-HSC population of the bone marrow in adult mice.Single-cell colony assay and single-cell transplantation showed that MgPs,unlike platelet-biased HSCs,had little repopulating potential in vivo,but formed larger megakaryocyte colonies in vitro(on average 8 megakaryocytes per colony)than did previously reported MkPs.Single-cell RNA sequencing supported that HSCs give rise to MkPs through MgPs along a Mk differentiation pathway.Single-cell reverse transcription polymerase chain reaction(RT-PCR)analysis showed that MgPs expressed Mk-related genes,but were transcriptionally heterogenous.Clonal culture of HSCs suggested that MgPs are not direct progeny of HSCs.We propose a differentiation model in which HSCs give rise to MgPs which then give rise to MkPs,supporting a classic model in which Mk-lineage commitment takes place at a late stage of differentiation.
文摘Dear Editor,Dendritic cells(DCs)are the most efficient professional antigen presenting cells that act as sentinels of the immune system and conduct vital functions in the initiation and regulation of innate and adaptive immunities(Wculek et al.,2020).In addition to being critical cellular components in pathogen clearance,DCs are promising targets for improved tumor immunotherapy,vaccine design,and intervention of autoimmune diseases(Nutt and Chopin,2020).DCs can be classified as plasmacytoid DCs(pDCs)and conventional DCs(cDCs)in both mouse and human(Anderson et al.,2018;Nutt and Chopin,2020).
文摘Strategic initiative:Entering Oman for a new strategy In 2004,the International Department of CNPC’s BGP took a crucial step in the Middle East market by successfully securing a seismic exploration project for the national oil company of Oman,Petroleum Development Oman(PDO).
文摘This study examined the relationships among workplace spirituality,mindfulness,mental well-being,and organizational commitment in professional female dancers.A total of 424 dancers from the United States participated in the survey.Structural equation modeling indicated that workplace spirituality was positively associated with both mental well-being and organizational commitment,whereas mindfulness was significantly related only to organizational commitment.Mental well-being was a significant predictor of organizational commitment and mediated the relationship between workplace spirituality and organizational commitment,but not between mindfulness and commitment.These results suggest that workplace spirituality functions as a psychological resource that enhances emotional health and strengthens organizational engagement.Thesefindings are consistent with self-determination theory,highlighting the role of value congruence and intrinsic purpose in sustaining motivation in high-performance contexts.Moreover,the studyfindings underscore the importance of fostering spiritually supportive work environments to promote psychological well-being and long-term organizational commitment.
文摘In the heart of Addis Ababa,where tradition meets modern ambition,a gleaming structure of steel and glass is quietly reshaping Africa’s future.The new Africa Centres for Disease Control and Prevention(Africa CDC)Headquarters is more than just a building-it’s a bold statement of partnership,progress,and a shared commitment to advancing public health across the continent.
基金partially supported by Korea Electrotechnology Research Institute(KERI)Primary research program through the National Research Council of Science&Technology(NST)funded by the Ministry of Science and ICT(MSIT)(No.25A01038)partially supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2024-00218377).
文摘In this paper,a strength-constrained unit commitment(UC)model incorporating system strength constraints based on the weighted short-circuit ratio(WSCR)is proposed.This model facilitates the comprehensive assessment of area-wide system strength in power systems with high inverter-based resource(IBR)penetration,thereby contributing to the mitigation of weak grid issues.Unlike traditional models,this approach considers the interactions among multiple IBRs.The UC problem is initially formulated as a mixed-integer nonlinear programming(MINLP)model,reflecting WSCR and bus impedance matrix modification constraints.To enhance computational tractability,the model is transformed into a mixed-integer linear programming(MILP)form.The effectiveness of the proposed approach is validated through simulations on the IEEE 5-bus,IEEE 39-bus,and a modified Korean power system,demonstrating the ability of the proposed UC model enhancing system strength compared to the conventional methodologies.
文摘BACKGROUND Acceptance and commitment therapy(ACT)is a third-generation therapy that appears to be a promising psychological intervention for psychotic disorders.While several systematic reviews and meta-analyses that address the efficacy of ACT for psychosis have been conducted,no systematic review has specifically focused on the application of ACT to the early stages of psychosis.AIM To review the state of the art regarding the feasibility and efficacy of treating early psychosis(EP)with ACT-based interventions.METHODS First,we describe the foundations of the ACT model to provide the background required to contextualize the main objective of this review.Second,we searched the PubMed and PsycINFO databases for studies published up to January 2025 and identified eight studies that met our selection criteria.The systematic review was conducted in accordance with the PRISMA guidelines and the critical appraisal checklist provided by the Joanna Briggs Institute for randomized controlled trials(RCTs).RESULTS All studies were published after 2019.Among the reviewed studies,five were RCTs with a total combined sample of 399 nonoverlapping participants.The methodological quality was moderate for RCTs.The results showed that ACTbased treatments are feasible and improve psychotic symptoms,medication adherence,and global functioning in patients with EP.Furthermore,preliminary evidence exists for the benefits of group-based and online-delivered programs and those that combine face-to-face therapy with novel real-time digital interventions,such as“ecological momentary intervention”,to apply therapeutic con cepts to real life.CONCLUSION ACT-based treatments in the early stages of psychosis are feasible and improve symptoms,treatment adherence,and self-care skills.Although promising,these results are inconclusive.Further research is required.
文摘Background:Restrained eating,often motivated by the desire to control weight,is prevalent among young female college students and is considered a risk factor for eating disorders.Negative evaluation fear,exacerbated by social pressure,peer comparison,and academic stress,has been identified as a potential contributor to restrained eating behavior.However,research exploring the relationship between negative evaluation fear and restrained eating,particularly in the context of self-esteem and physical appearance perfectionism,remains limited.This study aims to investigate these relationships and design an intervention program to reduce restrained eating behaviors in female college students.Methods:Study 1 involved 617 female college students,using the Physical Appearance Perfectionism Scale,Rosenberg Self-Esteem Scale,Fear of Negative Evaluation Scale,and Dutch Eating Behavior Questionnaire to measure key variables.We examined the relationships between physical appearance perfectionism,self-esteem,fear of negative evaluation,and restrained eating.In Study 2,a 4-week group psychological intervention based on Acceptance and Commitment Therapy(ACT)was implemented with 45 students,divided into experimental,control,and placebo groups.The intervention’s effectiveness was assessed in reducing restrained eating and negative evaluation fear.Results:The study found that fear of negative evaluation significantly predicted restrained eating and physical appearance perfectionism.Physical appearance perfectionism,in turn,positively predicted restrained eating and partially mediated the relationship between negative evaluation fear and restrained eating.Self-esteem moderated this mediation effect.Additionally,the ACT-based intervention significantly reduced fear of negative evaluation and restrained eating behavior in the experimental group.Conclusion:This study identifies fear of negative evaluation and physical appearance perfectionism as key predictors of restrained eating in female college students.Fear of negative evaluation significantly predicted restrained eating,with physical appearance perfectionism partially mediating this relationship.The ACT-based intervention effectively reduced both fear of negative evaluation and restrained eating.These findings highlight the importance of addressing negative evaluation fear and appearance perfectionism in interventions for restrained eating.
