W Comae has significant variability in multi-wavelengthes, from radio to gamma-ray bands. A bright outburst in optical and X-ray bands was observed in 1998, and most recently, a strong TeV flare was detected by VERITA...W Comae has significant variability in multi-wavelengthes, from radio to gamma-ray bands. A bright outburst in optical and X-ray bands was observed in 1998, and most recently, a strong TeV flare was detected by VERITAS in 2008. It is the first TeV intermediate-frequency-peaked BL Lacertae source. I find that both the broadband spectral energy distributions （SEDs） which were quasi-simultaneously obtained during the TeV flare and during the optical/X-ray outburst are well fit by using a single-zone synchrotron ＋ synchrotron-self-Compton model. The satisfactory fitting requires a large beaming factor, i.e., δ- 25 and δ- 20 for the TeV flare and the optical/X-ray outburst, respectively, suggesting that both the optical/X-ray outburst and the TeV flare are from a relativistic jet. The size of the emission region of the TeV flare is three times larger than that of the optical/X-ray outburst, and the strength of the magnetic field for the TeV flare is - 14 times smaller than that of the X-ray/optical outburst, likely indicating that the region of the TeV flare is more distant from the core than that of the X-ray/optical outburst. The inverse Compton component of the TeV flare peaks around 1.3 GeV, but it is around 20 MeV for the X-ray/optical outburst, lower than that for the TeV flare by two orders of magnitude. The model predicts that the optical/X-ray outburst might be accompanied by a strong MeV/GeV emission, but the TeV flare may be not associated with the X-ray/optical outburst. The GeV emission is critical for characterizing the SEDs of the optical/X-ray outburst and the TeV flare. The predicted GeV flux is above the sensitivity of Fermi/LAT, and it could be verified with the observations by Fermi/LAT in the near future.展开更多
Objective To explore the relationship between serum chloride levels and prognosis in patients with hepatic coma in the intensive care unit(ICU).Methods We analyzed 545 patients with hepatic coma in the ICU from the Me...Objective To explore the relationship between serum chloride levels and prognosis in patients with hepatic coma in the intensive care unit(ICU).Methods We analyzed 545 patients with hepatic coma in the ICU from the Medical Information Mart for Intensive Care IV(MIMIC-IV)database.Associations between serum chloride levels and 28-day and 1-year mortality rates were assessed using restricted cubic splines(RCSs),Kaplan-Meier(KM)curves,and Cox regression.Subgroup analyses,external validation,and mechanistic studies were also performed.Results A total of 545 patients were included in the study.RCS analysis revealed a U-shaped association between serum chloride levels and mortality in patients with hepatic coma.The KM curves indicated lower survival rates among patients with low chloride levels(<103 mmol/L).Low chloride levels were independently linked to increased 28-day and 1-year all-cause mortality rates.In the multivariate models,the hazard ratio(HR)for 28-day mortality in the low-chloride group was 1.424(95%confidence interval[CI]:1.041–1.949),while the adjusted hazard ratio for 1-year mortality was 1.313(95%CI:1.026–1.679).Subgroup analyses and external validation supported these findings.Cytological experiments suggested that low chloride levels may activate the phosphorylation of the NF-κB signaling pathway,promote the expression of pro-inflammatory cytokines,and reduce neuronal cell viability.Conclusion Low serum chloride levels are independently associated with increased mortality in patients with hepatic coma.展开更多
Rationale:Salmonella is a common etiological agent behind the tropical fever syndrome in the Indian subcontinent.Its prevalence in India remains high due to a lack of proper sanitation services in large parts of the c...Rationale:Salmonella is a common etiological agent behind the tropical fever syndrome in the Indian subcontinent.Its prevalence in India remains high due to a lack of proper sanitation services in large parts of the country.Its neuropsychiatric manifestations is rare and the understanding on their pathophysiology is still poor.Patient concerns:A 19-year-old male,presented with a 10-day history of altered mental status,high-grade fever and violent behaviour.2 Days prior to admission,he developed decreased responsiveness and a muttering delirium with self-talking.Diagnosis:Coma vigil secondary to salmonellosis.Interventions:Intravenous ceftriaxone and dexamethasone.Outcomes:The resolution of the coma vigil and the associated Salmonella infection were observed;however,the patient developed residual mutism.Lessons:The atypical presentation of a globally obtunded state followed by mutism in typhoid coma in this case should be brought to the attention of clinicians worldwide.Additionally,the enduring speech limitations and potential psychiatric consequences may be linked to the prolonged duration of the infection.展开更多
西方的科学研究成果大多来源于英语的语言文化环境,把西方的科学研究成果介绍到中国,必须重视英语的语言文化环境和汉语的语言文化环境的不同,这样才能使国人准确、方便地应用西方的科学研究成果,西学东渐。格拉斯哥昏迷评分(Glasgow co...西方的科学研究成果大多来源于英语的语言文化环境,把西方的科学研究成果介绍到中国,必须重视英语的语言文化环境和汉语的语言文化环境的不同,这样才能使国人准确、方便地应用西方的科学研究成果,西学东渐。格拉斯哥昏迷评分(Glasgow coma scale)被翻译、介绍到国内已有数十年,但汉语版的"Glasgow coma scale"多种多样,容易造成初学者和使用者的迷惑。本文复习有关"Glasgow coma scale"的原始英式英文文献、美式英语英文文献和以往的几个主要的汉语翻译版。结合英式英语、美式英语和汉语的语言文化特点,新译了"Glasgow coma scale",以方便医护人员使用。展开更多
基于Gaia Data Release 2 (Gaia-DR2)星表,采用数据挖掘技术中的DBSCAN(Density-Based Spatial Clustering of Applications with Noise)算法进行邻近疏散星团成员检测.从Gaia-DR2中选取了594284颗恒星(距离太阳<100 pc)作为样本,使...基于Gaia Data Release 2 (Gaia-DR2)星表,采用数据挖掘技术中的DBSCAN(Density-Based Spatial Clustering of Applications with Noise)算法进行邻近疏散星团成员检测.从Gaia-DR2中选取了594284颗恒星(距离太阳<100 pc)作为样本,使用恒星的五维数据(三维空间位置和两维自行)进行聚类分析.在数据预处理阶段,将每一维数据标准化到[0, 1]区间内,避免了单位不一致对聚类效果的影响.然后,利用k-dist图确定了DBSCAN算法的输入参数(Eps, MinPts).最终,使用DBSCAN算法获取了133颗成员星,它们在五维相空间中可以被分成两组,分别对应于疏散星团Hyades和Coma.分析结果表明得到的成员星是可靠的.根据两个星团的成员星, Hyades和Coma的距离分别确定为(46.5±0.3) pc和(84.9±0.4) pc.展开更多
In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical st...In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R in the rat prefrontal cortex. Orexin-A expression gradually in-creased with increasing stimulation, while OX1R expression reached a peak at 12 hours and then decreased. In addition, after the OX1R antagonist, SB334867, was injected into the brain of rats after traumatic brain injury, fewer rats were restored to consciousness, and orexin-A and OXIR expression in the prefrontal cortex was downregulated. Our ifndings indicate that median nerve electrical stimulation induced an up-regulation of orexin-A and OX1R expression in the pre-frontal cortex of traumatic brain injury-induced coma rats, which may be a potential mechanism involved in the wake-promoting effects of median nerve electrical stimulation.展开更多
基金supported by the National Natural Science Foundation of China under grants 10533050the National Basic Research Program ("973" Program) of China under Grant 2009CB824800
文摘W Comae has significant variability in multi-wavelengthes, from radio to gamma-ray bands. A bright outburst in optical and X-ray bands was observed in 1998, and most recently, a strong TeV flare was detected by VERITAS in 2008. It is the first TeV intermediate-frequency-peaked BL Lacertae source. I find that both the broadband spectral energy distributions （SEDs） which were quasi-simultaneously obtained during the TeV flare and during the optical/X-ray outburst are well fit by using a single-zone synchrotron ＋ synchrotron-self-Compton model. The satisfactory fitting requires a large beaming factor, i.e., δ- 25 and δ- 20 for the TeV flare and the optical/X-ray outburst, respectively, suggesting that both the optical/X-ray outburst and the TeV flare are from a relativistic jet. The size of the emission region of the TeV flare is three times larger than that of the optical/X-ray outburst, and the strength of the magnetic field for the TeV flare is - 14 times smaller than that of the X-ray/optical outburst, likely indicating that the region of the TeV flare is more distant from the core than that of the X-ray/optical outburst. The inverse Compton component of the TeV flare peaks around 1.3 GeV, but it is around 20 MeV for the X-ray/optical outburst, lower than that for the TeV flare by two orders of magnitude. The model predicts that the optical/X-ray outburst might be accompanied by a strong MeV/GeV emission, but the TeV flare may be not associated with the X-ray/optical outburst. The GeV emission is critical for characterizing the SEDs of the optical/X-ray outburst and the TeV flare. The predicted GeV flux is above the sensitivity of Fermi/LAT, and it could be verified with the observations by Fermi/LAT in the near future.
文摘Objective To explore the relationship between serum chloride levels and prognosis in patients with hepatic coma in the intensive care unit(ICU).Methods We analyzed 545 patients with hepatic coma in the ICU from the Medical Information Mart for Intensive Care IV(MIMIC-IV)database.Associations between serum chloride levels and 28-day and 1-year mortality rates were assessed using restricted cubic splines(RCSs),Kaplan-Meier(KM)curves,and Cox regression.Subgroup analyses,external validation,and mechanistic studies were also performed.Results A total of 545 patients were included in the study.RCS analysis revealed a U-shaped association between serum chloride levels and mortality in patients with hepatic coma.The KM curves indicated lower survival rates among patients with low chloride levels(<103 mmol/L).Low chloride levels were independently linked to increased 28-day and 1-year all-cause mortality rates.In the multivariate models,the hazard ratio(HR)for 28-day mortality in the low-chloride group was 1.424(95%confidence interval[CI]:1.041–1.949),while the adjusted hazard ratio for 1-year mortality was 1.313(95%CI:1.026–1.679).Subgroup analyses and external validation supported these findings.Cytological experiments suggested that low chloride levels may activate the phosphorylation of the NF-κB signaling pathway,promote the expression of pro-inflammatory cytokines,and reduce neuronal cell viability.Conclusion Low serum chloride levels are independently associated with increased mortality in patients with hepatic coma.
文摘Rationale:Salmonella is a common etiological agent behind the tropical fever syndrome in the Indian subcontinent.Its prevalence in India remains high due to a lack of proper sanitation services in large parts of the country.Its neuropsychiatric manifestations is rare and the understanding on their pathophysiology is still poor.Patient concerns:A 19-year-old male,presented with a 10-day history of altered mental status,high-grade fever and violent behaviour.2 Days prior to admission,he developed decreased responsiveness and a muttering delirium with self-talking.Diagnosis:Coma vigil secondary to salmonellosis.Interventions:Intravenous ceftriaxone and dexamethasone.Outcomes:The resolution of the coma vigil and the associated Salmonella infection were observed;however,the patient developed residual mutism.Lessons:The atypical presentation of a globally obtunded state followed by mutism in typhoid coma in this case should be brought to the attention of clinicians worldwide.Additionally,the enduring speech limitations and potential psychiatric consequences may be linked to the prolonged duration of the infection.
文摘西方的科学研究成果大多来源于英语的语言文化环境,把西方的科学研究成果介绍到中国,必须重视英语的语言文化环境和汉语的语言文化环境的不同,这样才能使国人准确、方便地应用西方的科学研究成果,西学东渐。格拉斯哥昏迷评分(Glasgow coma scale)被翻译、介绍到国内已有数十年,但汉语版的"Glasgow coma scale"多种多样,容易造成初学者和使用者的迷惑。本文复习有关"Glasgow coma scale"的原始英式英文文献、美式英语英文文献和以往的几个主要的汉语翻译版。结合英式英语、美式英语和汉语的语言文化特点,新译了"Glasgow coma scale",以方便医护人员使用。
基金funded by grants from the National Natural Science Foundation of China,No.81260295the Natural Science Foundation of Jiangxi Province of China,No.20132BAB205063
文摘In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1R in the rat prefrontal cortex. Orexin-A expression gradually in-creased with increasing stimulation, while OX1R expression reached a peak at 12 hours and then decreased. In addition, after the OX1R antagonist, SB334867, was injected into the brain of rats after traumatic brain injury, fewer rats were restored to consciousness, and orexin-A and OXIR expression in the prefrontal cortex was downregulated. Our ifndings indicate that median nerve electrical stimulation induced an up-regulation of orexin-A and OX1R expression in the pre-frontal cortex of traumatic brain injury-induced coma rats, which may be a potential mechanism involved in the wake-promoting effects of median nerve electrical stimulation.
