[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold...[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold-dampness obstruction syndrome.[Methods]A total of 162 KOA patients admitted to Huadong Hospital Affiliated to Fudan University from January 2021 to May 2023 were enrolled and randomly divided into an electroacupuncture group and a control group,with 81 patients in each group.The control group received routine rehabilitation training,while the electroacupuncture group received electroacupuncture treatment in addition to the same rehabilitation training,both for 4 weeks.The efficacy,syndrome scores,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),Lysholm Knee Score(LKS),3D gait parameters,and levels of inflammatory markers were compared between the two groups.[Results]Following treatment,the total effective rate in the electroacupuncture group was 92.59%,which was significantly higher than 77.78%observed in the control group(P<0.05).Additionally,the electroacupuncture group exhibited lower TCM syndrome scores(P<0.05),reduced WOMAC scores,and elevated LKS scores compared to the control group(P<0.05).Gait parameters,including step frequency,step speed,stride length,initial ground contact flexion angle,maximum swing phase extension angle,and support phase extension angle,were all higher in the electroacupuncture group.Additionally,the sagittal plane maximum abduction moment was lower in the electroacupuncture group.Inflammatory markers showed that interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were lower in the electroacupuncture group,while transforming growth factor-β1(TGF-β1)was higher(P<0.05).[Conclusions]Electroacupuncture combined with rehabilitation training effectively enhances clinical efficacy,alleviates symptoms,improves knee joint mobility and walking ability,enhances knee function scores,and reduces inflammatory levels,contributing to the rapid recovery of knee joints in KOA patients.展开更多
Xishui National Forest Park in Heilongjiang Province hosts China's most pristine temperate forests and serves as a key site for ecotourism and forest therapy.However,the emission patterns of phytoncides(key bio ac...Xishui National Forest Park in Heilongjiang Province hosts China's most pristine temperate forests and serves as a key site for ecotourism and forest therapy.However,the emission patterns of phytoncides(key bio active compounds) remain poorly understood,limiting their therapeutic application.This study provides the first comprehensive characterization of spatiotemporal dynamics in airborne phytoncides and their synergistic interactions with environmental factors throughout the autumn-early spring seasonal transition in a temperate forest ecosystem.We analyzed the compositional dynamics of phytoncides and terpenoid content variations using thermal desorption-gas chromatography-mass spectrometry(TD-GC-MS) from September 2024 to March 2025.This period encompassed seasonal transitions from autumn to early spring,including diurnal variations in September and snowfall events in November.The method demonstrated detection limits(LODs) ranging from 1.35 to 5.33 ng m-3 and quantification limits(LOQs) from 4.09 to 16.15 ng m-3.Our results revealed pronounced seasonal fluctuations in phytoncide composition.In September,terpenoids,esters,alcohols,and alkanes displayed a diurnal "decrease-increase" trend,whereas aldehydes and ketones peaked at midday.Notably,esters and alcohols were undetectable in November and January.By January,terpenoids reached their lowest proportion(0.17±0.02%) at noon.Five terpenoids(α-pinene,myrcene,D-limonene,camphene,p-cymene) were detected in September,four(α-pinene,D-limonene,camphene,p-cymene) in November,two(D-limonene,p-cymene) in January,and only p-cymene in March.The total concentration and emission rate of the five terpenoids peaked in September afternoons at 1961.58±106.67 ng m^(-3) and653.86±35.56 ng m^(-3) h^(-1),respectively.Nocturnal emissions(32131.95±2522.21 ng m^(-3)) significantly surpassed daytime levels(14473.04±958.49 ng m^(-3)),with emission rates escalating from 1447.30±95.85 ng m^(-3) h^(-1)(day) to 5355.33±420.37 ng m^(-3) h^(-1)(night),marking a3.7-fold increase.Snowfall dramatically elevated terpenoid concentrations(pre-snowfall:158.58±14.12 ng m^(-3);post-snowfall:1080.57±57.76 ng m^(-3)) and emission rates(pre-snowfall:52.86±4.71 ng m^(-3) h^(-1);post-snowfall:360.19±19.25 ng m^(-3) h^(-1)),reflecting a 6.8-fold surge.This study underscores the profound influence of light intensity,seasonal shifts,and climatic conditions on airborne phytoncide levels,offering a scientific foundation for optimizing forest therapy and ecotourism strategies.展开更多
Urban forests are essential components of green infrastructure,however,rapid urbanization-induced changes in landscape patterns may affect their ecosystem services through complex ecological processes.A total of 184 s...Urban forests are essential components of green infrastructure,however,rapid urbanization-induced changes in landscape patterns may affect their ecosystem services through complex ecological processes.A total of 184 sample plots in the built-up areas of Nanchang,China,were used as research sites.Urbanization intensities were categorized by the rate of impervious surface area,and forest types were classified into landscape and relaxation forest,attached forest(AF),road forest(RF),and ecological public welfare forest.This study aimed to explore the spatial variations in vegetation characteristics and landscape pattern indices of different forest types under rapid urbanization.The results indicated that the largest patch index(LPI),aggregation index(AI),and percentage of landscape(PLAND)in RF and AF were lower than those in the other forest types(p<0.05).With increasing urbanization intensity,the mean perimeter-area ratio increased by 130.84%,whereas the PLAND,LPI,and AI decreased by 22−86%(p<0.05).Redundancy analysis and variation partitioning suggested that the interpretation rate of landscape pattern indices for variations in vegetation characteristics increased from low to heavy urbanization areas.Especially,the landscape shape index,patch connection index,PLAND,and mean patch size were significantly correlated with vegetation characteristics(e.g.,tree richness,herb coverage,and tree height).In the future,appropriate landscape layout superiority cases should be considered in different urbanization areas and forest types;for instance,increasing the patch connection index will beneficially improve the diversity of trees and herbs in heavy urbanization areas and the RF.This study serves as a reference for maximizing the ecosystem services of urban forests.展开更多
The performance of data restore is one of the key indicators of user experience for backup storage systems.Compared to the traditional offline restore process,online restore reduces downtime during backup restoration,...The performance of data restore is one of the key indicators of user experience for backup storage systems.Compared to the traditional offline restore process,online restore reduces downtime during backup restoration,allowing users to operate on already restored files while other files are still being restored.This approach improves availability during restoration tasks but suffers from a critical limitation:inconsistencies between the access sequence and the restore sequence.In many cases,the file a user needs to access at a given moment may not yet be restored,resulting in significant delays and poor user experience.To this end,we present Histore,which builds on the user’s historical access sequence to schedule the restore sequence,in order to reduce users’access delayed time.Histore includes three restore approaches:(i)the frequency-based approach,which restores files based on historical file access frequencies and prioritizes ensuring the availability of frequently accessed files;(ii)the graph-based approach,which preferentially restores the frequently accessed files as well as their correlated files based on historical access patterns,and(iii)the trie-based approach,which restores particular files based on both users’real-time and historical access patterns to deduce and restore the files to be accessed in the near future.We implement a prototype of Histore and evaluate its performance from multiple perspectives.Trace-driven experiments on two datasets show that Histore significantly reduces users’delay time by 4-700×with only 1.0%-14.5%additional performance overhead.展开更多
Tajikistan represents a core region of the biodiversity hotspot in Central Asian mountains and has exceptional vascular plant diversity.However,the species diversity of the country faces urgent conservation challenges...Tajikistan represents a core region of the biodiversity hotspot in Central Asian mountains and has exceptional vascular plant diversity.However,the species diversity of the country faces urgent conservation challenges.There has been a lack of a comprehensive and multidimensional assessment to inform strategic conservation planning.Therefore,this study integrated 4 key biodiversity indices including species richness(SR),phylogenetic diversity(PD),threatened species richness(TSR),and endemic species richness(ESR)to map species diversity distribution patterns,identify conservation gaps,and elucidate their effects of climatic factors.This study revealed that species diversity shows a clear trend of decreasing from the western region to the eastern region of Tajikistan.The central–western mountains(specifically the Gissar-Darvasian and Zeravshanian regions)emerge as irreplaceable biodiversity hotspots.However,we found a severe spatial mismatch between these priority areas and the existing protected areas(PAs).Protection coverage for all hotspots was alarmingly low,ranging from 31.00%to 38.00%.Consequently,a critical 64.80%of integrated priority areas fall outside of the current PAs,representing a major conservation gap.This study identified precipitation seasonality and isothermality as the principal drivers,collectively explaining over 50.00%of the diversity variation and suggesting high vulnerability to hydrological shifts.Furthermore,we detected significant geographic sampling bias in the public biodiversity databases,with the most critical hotspot being systematically under-sampled.This study provides a robust scientific basis for conservation action,highlighting the urgent need to strategically expand PAs in the under-protected southwestern region and to mitigate critical sampling gaps through targeted data digitization and field surveys.These measures are indispensable for securing Tajikistan’s unique biodiversity and achieving the Kunming-Montreal Global Biodiversity Framework Target 3(“30×30 Protection”).展开更多
Wide-field mesoscopy provides the capabilities of cortex-wide field of view(FOV),cellular resolution and high frame rate for neuronal imaging in the mouse brain.However,inherent background fluorescence degrades the im...Wide-field mesoscopy provides the capabilities of cortex-wide field of view(FOV),cellular resolution and high frame rate for neuronal imaging in the mouse brain.However,inherent background fluorescence degrades the image quality and hinders neuronal signal extraction.To address this problem,we first introduce a cortex-wide,high-resolution lineillumination mesoscope with a moving slit designed for in vivo mouse brain imaging.This system achieves a 6.6×6.6 mm FOV,microscale cellular resolution,a high frame rate of 10 Hz,as well as the background rejection ability.Furthermore,we integrated patterned illumination into the system to enhance the background suppression.Experimental results show that the proposed system successfully captures neurodynamics in the living mouse brain.Compared with conventional wide-field mesoscopes,the cortex-wide patterned line-illumination mesoscope(PLIM)achieves a threefold increase in the signal-to-background ratio(SBR).With patterned illumination integrated,the SBR enhancement further reaches four-anda-half-fold.展开更多
BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Resear...BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.展开更多
Understanding spatial patterns of plant species diversity and the factors(e.g.,climate and human)that drive these patterns is essential for biodiversity conservation.We used data from 1700.1-ha forest plots in the She...Understanding spatial patterns of plant species diversity and the factors(e.g.,climate and human)that drive these patterns is essential for biodiversity conservation.We used data from 1700.1-ha forest plots in the Shettihalli tropical forest landscape of the Western Ghats biodiversity hotspot,India,to analyse tree community composition and the drivers ofα-diversity(Shannon)andβ-diversity(LCBD).Compositional patterns were visualized using Non-Metric Multidimensional Scaling(NMDS),and hybrid feature selection with structural equation modeling(SEM)was employed to evaluate the direct and indirect effects of environmental variables on diversity.NMDS identified four distinct forest types in the Shettihalli landscape:semi-evergreen,dry deciduous,moist deciduous,and plantation forests,each with distinct plant composition.Shannon diversity and ecological uniqueness was significantly higher in semi-evergreen forest than in deciduous forest plots.The SEMs explained about 79%and 39–45%of the variation inα-diversity andβ-diversity.Our analysis indicated that current diversity patterns result from multiple processes,with structure,disturbance,and edaphic parameters exerting the strongest direct and indirect effects onα-diversity.β-diversity,in contrast,was largely influenced by climate,topography,stand structure,and edaphic factors.Overall,our findings indicate that various factors(e.g.,climate,topography,and human disturbance)interact to shape tree diversity patterns in tropical forests.These findings will help develop unique conservation and management strategies for distinct forest types in tropical forest ecosystems.展开更多
Mineral resources in Asia continent and its mining industry play a significant role in the economic growth and industrialization of both Asia and the world.Asia continent boasts the most comprehensive kinds of mineral...Mineral resources in Asia continent and its mining industry play a significant role in the economic growth and industrialization of both Asia and the world.Asia continent boasts the most comprehensive kinds of minerals,with reserves of at least 38 of over 80 widely used minerals worldwide accounting for more than30%of the global total reserves.Asia continent experienced three main tectonic evolution and mineralization stages:The Precambrian,the Paleozoic,and the Mesozoic to Cenozoic.The abundant mineral resources in this continent can be divided into seven first-order metallogenic belts(metallogenic domains),18 second-order metallogenic belts(metallogenic provinces),61 third-order metallogenic belts(metallogenic zones),and nine main minerogenetic series.Asia continent exhibits the most significant metallogenic specialization among all continents.Specifically,granite belts of Asia continent manifest pronounced metallogenic specialization of tin,rare metals,and porphyry Cu-Au-Mo deposits.Its maficultramafic rock belts and ophiolite belts display notable metallogenic specialization of lateritic nickel deposits and magmatic type chromite deposits,while its Mesozoic to Cenozoic basalt belts show remarkable metallogenic specialization of lateritic bauxite deposits.Consequently,many giant metallogenic belts were formed,including the Southeast Asian tin belt,the Qinghai-Xizang Plateau rare metal metallogenic belt,the Tethyan porphyry Cu-Au-Mo metallogenic belt,the circum-Pacific porphyry Cu-Au-Mo metallogenic belt,the Southeast Asian lateritic bauxite metallogenic belt,the Deccan Plateau lateritic bauxite metallogenic belt in India,the Southeast Asian lateritic nickel metallogenic belt,and the Tethyan magmatic type chromite metallogenic belt—all of which are significant metallogenic belts in Asia continent.Future mineral exploration in Asia should focus primarily on the Precambrian mineralization of ancient cratons,the Paleozoic mineralization of the Central Asian-Mongolian orogenic belt,and the Mesozoic to Cenozoic mineralization of the Tethyan and circum-Pacific mobile belts.Asia's mining industry not only underpins its own economic growth but also propels global economic development and industrialization,contributing significantly to the world economy.Asia boasts the highest production value of minerals,the largest annual production of minerals,and the greatest trade value of mineral products among all the continents,having emerged as the trade center of global mineral products and the center of the mining industry economy.China is identified as one of the few countries that possess the most comprehensive kinds of minerals,and its mining industry has supported and driven the economic development and industrialization of Asia and even the world.Standing as the largest mineral producer worldwide,China ranked first in the production of 28 mineral commodities in the world in 2022.Besides,China exhibits the highest annual production value of minerals and the largest trade value of mineral products among all countries.Therefore,China's demand for global mineral products influences the global supply and demand patterns of minerals and the world economic situation.展开更多
Objectives:To observe and compare the clinical efficacy difference among long snake moxibustion,acupuncture and western medication for treating lumbar disc herniation with cold-dampness syndrome,and to provide a prefe...Objectives:To observe and compare the clinical efficacy difference among long snake moxibustion,acupuncture and western medication for treating lumbar disc herniation with cold-dampness syndrome,and to provide a preferred treatment for cold-dampness lumbar disc herniation.Methods:A total of 90 patients with cold-dampness lumbar disc herniation were randomized into three groups according to the random number table,including the long snake moxibustion group(31 cases),the acupuncture group(28 cases)and the western medication group(31 cases).Treated with long snake moxibustion,patients in the long snake moxibustion group.The acupuncture group was treated with conventional acupuncture therapy,by adopting acupoints of Shènshū(肾俞 BL23),Dàchángshū(大肠俞BL25),Yāoyángguān(腰阳关GV3),Wěizhōng(委中 BL40)and local Ashi points.Patients in the western medication group were given oral diclofenac sodium.Visual analogous scale(VAS),Oswestry Dysfunction Index(ODI)score,yang deficiency scale score and clinical efficacy were observed before and after treatment.Results:(1)The VAS scores of the patients after treatment in each group decreased compared with those before the treatment.The long snake moxibustion group decreased from 7.22±1.14 to 1.10±0.75(P<0.05);the acupuncture group,from 6.75±1.18 to 1.46±0.88(P<0.05);and the western medication group,from 7.38±1.02 to 1.51 ±0.81(P<0.05).After treatment,the VAS score of the long snake moxibustion group was lower than that of the acupuncture and western medication groups,the differences were statistically significant(both P<0.05).(2)ODI scores of all the groups were lower than those before the treatment.The long snake moxibustion group decreased from 33.35±10.85 to 7.84±3.59(P<0.05);the acupuncture group,from 31.65±8.23 to 9.00±6.10(P<0.05);and the western medication group from 27.77±7.30 to 23.87±10.81(P<0.05).The score of ODI in the long snake moxibustion group was lower than those in the acupuncture and western medication groups,the differences were statistically significant(both P<0.05).(3)The scores of yang deficiency scale score in each group were lower than those before treatment.The long snake moxibustion group decreased from 61.81±15.49 to 32.26±6.08(P<0.05);the acupuncture group,from 67.64±12.47 to 62.00±17.77(P<0.05);and the western medication group from 64.68 ± 12.73 to 59.77±14.02(P<0.05).The score of yang deficiency scale of the long snake moxibustion group was lower than those of the acupuncture and western medication groups after treatment,the differences were statistically significant(both P<0.05).(4)The effective rates of the long snake moxibustion group,acupuncture group and western medication group were 93.55%,85.71% and74.19% respectively,and the differences among three groups were statistically significant(all P<0.05).Conclusion:The long snake moxibustion therapy has a significant clinical effect for lumbar disc herniation with cold-damp syndrome,which is better than those of acupuncture and western medication groups,the therapy can effectively improve the patients’ physical constitution as a preferred solution for cold-damp lumbar disc herniation by acupuncture therapy.展开更多
Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific ...Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.展开更多
Objective:To explore the molecular mechanism of the prescription for the syndrome of cold-damp-ness obstructing the lung in the treatment of corona virus disease 2019(COVID-19).Methods:The medicinals for the treatment...Objective:To explore the molecular mechanism of the prescription for the syndrome of cold-damp-ness obstructing the lung in the treatment of corona virus disease 2019(COVID-19).Methods:The medicinals for the treatment of the syndrome of cold-dampness obstructing the lung,such as Cangzhu(Rhizoma Atractylo-dis),Chenpi(Pericarpium Gitri Reticulatae),Houpo(Cortex Magnoliae Officinalis),Huoxiang(Herba Agastachis),Caoguo(Fructus Tsaoko),Mahuang(Herba Ephedrae),Qianghuo(Rhizoma et Radix Notoptery-gi),Shengjiang(Rhizoma Zingiberis Recens),Binlang(Semen Arecae)in the Diagnosis and Treatment Pro-gram of COVID-19(Trial Version 6)were taken as research subjects,and the combination of these nine me-dicinals can be called Hanshi Zufei Fang(寒湿阻肺方,HSZFF).The active components and targets of each single Chinese materia medica was screened and obtained through the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database.The target information related to COVID-19 was retrieved through the Gene-Cards disease-related target database.The medicinal prediction targets were mapped to the disease target to ob-tain the intersection targets.The DAVID database was applied to perform gene ontology(GO)enrichment anal-ysis and kyoto encyclopedia of genes and genomes(KEGG)pathway analysis on the targets;GraphPad Prism 5.0 software was applied to plot the biological process(BP)of GO enrichment analysis,cellular component(CC),molecular function(MF)histograms;OmicShare online software was applied to make KEGG advanced bubble chart;Cytoscape software was applied to visualize the interaction with the targets and Chinese materia medica-components-targets results.Results:Totally 56 key active components of 9 Chinese materia medica for cold-dampness obstructing lung syndrome were screened,and 55 targets were obtained.The results of GO and KEGG enrichment analysis showed that the compound prescription mainly regulated the body's immune re-sponse and reduced inflammation by regulating such signaling pathways of inflammatory response and immune regulation as TNF signaling pathway,HIF-1 signaling pathway,Toll-like receptor signaling pathway,infuenza A signaling pathway,T cell receptor signaling pathway.Conclusion:HSZFF can eliminate infl ammation and inhibit virus by regulating immune inflammatory factors closely related to the occurrence and development of diseases through multi-component and multi-target.展开更多
The preparation of red,green,and blue quantum dot(QD)pixelated arrays with high precision,resolution,and brightness poses a significant challenge on the development of advanced micro-displays for virtual,augmented,and...The preparation of red,green,and blue quantum dot(QD)pixelated arrays with high precision,resolution,and brightness poses a significant challenge on the development of advanced micro-displays for virtual,augmented,and mixed reality applications.Alongside the controlled synthesis of high-performance QDs,a reliable QD patterning technology is crucial in overcoming this challenge.Among the various methods available,photolithography-based patterning technologies show great potentials in producing ultra-fine QD patterns at micron scale.This review article presents the recent advancements in the field of QD patterning using photolithography techniques and explores their applications in micro-display technology.Firstly,we discuss QD patterning through photolithography techniques employing photoresist(PR),which falls into two categories:PRassisted photolithography and photolithography of QDPR.Subsequently,direct photolithography techniques based on photo-induced crosslinking of photosensitive groups and photo-induced ligand cleavage mechanisms are thoroughly reviewed.Meanwhile,we assess the performance of QD arrays fabricated using these photolithography techniques and their integration into QD light emitting diode display devices as well as color conversionbased micro light emitting diode display devices.Lastly,we summarize the most recent developments in this field and outline future prospects.展开更多
Tumor is defined as a kind of chronic diseases by the World Health Organization.The integrative traditional Chinese and western medicine works well on the treatment of tumors,even in advanced patients or patients with...Tumor is defined as a kind of chronic diseases by the World Health Organization.The integrative traditional Chinese and western medicine works well on the treatment of tumors,even in advanced patients or patients with recurring and metastatic tumor.However,the pathogenic mechanism of tumors is still unclear.Therefore,based on the 19 th pathogenesis in Yellow Emperor's Internal Class that"Diseases producing the liquid that is clear and chill all result from coldness",the paper explore s the etiology pathogenesis of malignant tumors,and the correlation between which and tumor recurrence and metastasis,and also discusses the rules for the treatment of tumors at various stages with great method of warming yang for dispelling cold.展开更多
Ecological security provides the basis of maintaining both a sustainable regional ecosystem and economic development.However,few studies have focused on how the features such as topography and geomorphology,lithologic...Ecological security provides the basis of maintaining both a sustainable regional ecosystem and economic development.However,few studies have focused on how the features such as topography and geomorphology,lithologic stratigraphic assemblages,and geohazard distribution affect the construction of ecological security patterns and the layout of optimization measures.In order to comprehensively reveal the key areas and key objects of ecological restoration in karst basins,this study takes the Beipan River Basin(BRB)as an example,constructs an ecological security pattern(ESP)based on the methods of morphological spatial pattern analysis(MSPA),landscape connectivity analysis and circuit theory,and lays out the optimization measures in combination with the spatial distribution characteristics of topographic and geomorphological differences and lithological stratigraphic combinations.The results show that 151 ecological sources,343 ecological corridors,121 pinch points and 178 barriers constitute the ESP of the BRB.Lithology is closely related to the spatial distribution characteristics of ecological source sites.Level 1 and 2 ecological sources(The ecological sources were categorized into level 1,level 2,and level 3 source from high to low importance.)are concentrated in the Emeishan basalt region of the upstream and the clastic and impure carbonate rock region of the downstream part of the BRB;level 3ecological sources are concentrated in the carbonate rock region of the midstream.Taking into account the outstanding ecological problems in the basin,and based on the characteristics of lithology and geohazard distribution,we propose the optimization scheme of“three axes,three zones and multiple points”for the ESP and the layout of specific measures of the BRB.The results can provide scientific references for maintaining ecological security maintenance in karst ecologically fragile areas.展开更多
AIM:To report the demographic and systemic characteristics of patients,clinical progression of endophthalmitis,and the efficacy of various treatment strategies,with a focus on identifying key factors for preserving vi...AIM:To report the demographic and systemic characteristics of patients,clinical progression of endophthalmitis,and the efficacy of various treatment strategies,with a focus on identifying key factors for preserving vision in eyes with endogenous endophthalmitis due to Klebsiella pneumoniae(K.pneumoniae)liver abscess.METHODS:In this single-center,retrospective case series of 18 patients with endogenous endophthalmitis due to K.pneumoniae liver abscess were analyzed.Ophthalmologic features of endophthalmitis at early,intermediate and advanced stages were obtained from eyes with endophthalmitis of different severities.Prompt vitrectomy was considered primarily for all eyes except for very early endophthalmitis.Intravitreal injections of antibiotics were performed in eyes with endophthalmitis in the very early stages and in eyes where vitrectomy was not available,and additional control of infection was needed after vitrectomy.Evisceration was performed in eyes with corneoscleral perforation,advanced endophthalmitis,perforation with preseptal or orbital cellulitis,uncontrolled infection,or severe pain with no vision.RESULTS:Mean(±standard deviation)age of the 18 patients with endophthalmitis was 64.5±12.2(range:32-84)y,and 14 patients(77.8%)were males.Endophthalmitis tended to involve the retinal parenchyma first and then progressed into the vitreous cavity and anterior segments.However,it presented a tendency to cause massive subretinal abscesses even after vitrectomy with silicone oil tamponade.Very high intraocular pressure with new vessels on the iris(41.7%)were also commonly observed.Although all but three patients had systemic disease such as diabetes or hypertension,visual prognosis after treatment did not appear to depend significantly on underlying comorbidities.A final best-corrected visual acuity better than 20/60 was achieved only when lesions were detected very early,with relatively good initial visual acuity,likely reflecting lower bacterial inoculation in the eye.CONCLUSION:Detection of early endophthalmitis lesions appears to be the only way to preserve good vision in patients with K.pneumoniae liver abscesses.Therefore,proper guidelines for ophthalmologic screening remain to be established for subjects at a high risk of endophthalmitis.展开更多
The Hengduan Mountains,situated on the southeastern edge of the Qinghai-Tibet Plateau,are the longest and widest north-south-oriented mountain range in China,exerting a significant influence on the ecological and geog...The Hengduan Mountains,situated on the southeastern edge of the Qinghai-Tibet Plateau,are the longest and widest north-south-oriented mountain range in China,exerting a significant influence on the ecological and geographical pattern.Understanding the topographic and geomorphological characteristics of the Hengduan Mountains is fundamental and crucial for research in related fields such as ecology,geography,and sustainability.In this study,Digital Elevation Model(DEM)data were utilized to extract and analyze the topography and geomorphology(TG)pattern.TG maps have been developed to quantitatively classify the TG types in the Hengduan Mountains by combining the five factors of elevation,slope,aspect,relief and landform.The spatial distribution and quantitative characteristics of these factors were mapped and investigated using geographic information systems.The results revealed that:(1)The Hengduan Mountains exhibit an elongated north-south distribution,with an average elevation of approximately 3746 m,an average slope of around 25°,and an average relief of about 266 m.(2)The Hengduan Mountains display significant elevation differences,with an overall high elevation,characterized by a trend of lower elevation in the east and higher elevation in the west,as well as irregular orientations of various aspects.(3)The 19 landform types were identified,the landform types of the Hengduan Mountains are primarily composed of low-relief high-mountains(42.0618%),low-relief mid-mountains(22.4624%),and high-elevation hills(20.5839%).The results of the study can provide data and information support for the ecology,environmental protection and sustainable development of the Hengduan Mountains.展开更多
Clarifying the mechanisms that control the evolution of territorial space patterns is essential for regulating and optimizing the geographical structure and processes related to sustainable development.Using the Guang...Clarifying the mechanisms that control the evolution of territorial space patterns is essential for regulating and optimizing the geographical structure and processes related to sustainable development.Using the Guangdong and Guangxi sections of the Pearl River Basin as examples,the transfer-matrix method and standard deviation ellipse model were applied to characterize the evolution of territorial space patterns from 1990 to 2020.A trend surface analysis and the Theil index were used to analyze regional differences in the evolution process,and geodetectors were used to identify the underlying mechanisms of the changes.There were three key results.(1)In these critical areas of the Pearl River Basin,agricultural and ecological spaces have rapidly declined due to urban expansion,with transfers between these spaces dominating the evolution of territorial space patterns.Spatial pattern changes in the Guangdong section were more intense than in the Guangxi section.(2)Regional differences in urban space have decreased,whereas differences in agricultural and ecological spaces have intensified.Driven by socio-economic growth,the cross-regional transfers of territorial space have created a“high in the east,while low in the west”inter-regional difference,and a“high in the south,while low in the north”intra-regional difference shaped by natural conditions.The regional differences in space patterns were greater in Guangdong than in Guangxi.(3)The evolution of watershed territorial space patterns resulted from scale changes,locational shifts,structural reorganizations,and directional changes driven by multiple factors.Natural environment,social life,economic development,and policy factors played foundational,leading,key driving,and guiding roles,respectively.Additionally,the regional differences in the evolution of watershed territorial space patterns originated from the differential transmission of the influence of various factors affecting spatial evolution.Enhancing urban space efficiency,restructuring agricultural space,and optimizing ecological space are key strategies for building a complementary and synergistic territorial space pattern in the basin.展开更多
Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examine...Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examined.In this study,we apply two widely-used objective methods,the self-organizing map(SOM)and K-means clustering analysis,to derive ozone-favorable SWPs at four Chinese megacities in 2015-2022.We find that the two algorithms are largely consistent in recognizing dominant ozone-favorable SWPs for four Chinese megacities.In the case of classifying six SWPs,the derived circulation fields are highly similar with a spatial correlation of 0.99 between the two methods,and the difference in themean frequency of each SWP is less than 7%.The six dominant ozone-favorable SWPs in Guangzhou are all characterized by anomaly higher radiation and temperature,lower cloud cover,relative humidity,and wind speed,and stronger subsidence compared to climatology mean.We find that during 2015-2022,the occurrence of ozone-favorable SWPs days increases significantly at a rate of 3.2 days/year,faster than the increases in the ozone exceedance days(3.0 days/year).The interannual variability between the occurrence of ozone-favorable SWPs and ozone exceedance days are generally consistent with a temporal correlation coefficient of 0.6.In particular,the significant increase in ozone-favorable SWPs in 2022,especially the Subtropical High type which typically occurs in September,is consistent with a long-lasting ozone pollution episode in Guangzhou during September 2022.Our results thus reveal that enhanced frequency of ozone-favorable SWPs plays an important role in the observed 2015-2022 ozone increase in Guangzhou.展开更多
基金Supported by General Program of the National Natural Science Foundation of China(81973883)Three-Year Action Plan Project for Enhancing Clinical Skills and Clinical Innovation Capabilities of Municipal Hospitals(SHDC2020CR1010A).
文摘[Objectives]To explore the effects of electroacupuncture combined with rehabilitation training on knee joint function,three-dimensional(3D)gait,and inflammatory markers in patients with knee osteoarthritis(KOA)of cold-dampness obstruction syndrome.[Methods]A total of 162 KOA patients admitted to Huadong Hospital Affiliated to Fudan University from January 2021 to May 2023 were enrolled and randomly divided into an electroacupuncture group and a control group,with 81 patients in each group.The control group received routine rehabilitation training,while the electroacupuncture group received electroacupuncture treatment in addition to the same rehabilitation training,both for 4 weeks.The efficacy,syndrome scores,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),Lysholm Knee Score(LKS),3D gait parameters,and levels of inflammatory markers were compared between the two groups.[Results]Following treatment,the total effective rate in the electroacupuncture group was 92.59%,which was significantly higher than 77.78%observed in the control group(P<0.05).Additionally,the electroacupuncture group exhibited lower TCM syndrome scores(P<0.05),reduced WOMAC scores,and elevated LKS scores compared to the control group(P<0.05).Gait parameters,including step frequency,step speed,stride length,initial ground contact flexion angle,maximum swing phase extension angle,and support phase extension angle,were all higher in the electroacupuncture group.Additionally,the sagittal plane maximum abduction moment was lower in the electroacupuncture group.Inflammatory markers showed that interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were lower in the electroacupuncture group,while transforming growth factor-β1(TGF-β1)was higher(P<0.05).[Conclusions]Electroacupuncture combined with rehabilitation training effectively enhances clinical efficacy,alleviates symptoms,improves knee joint mobility and walking ability,enhances knee function scores,and reduces inflammatory levels,contributing to the rapid recovery of knee joints in KOA patients.
基金supported by the Key Research and Development Plan Project of Heilongjiang Province (2022ZX02C13)。
文摘Xishui National Forest Park in Heilongjiang Province hosts China's most pristine temperate forests and serves as a key site for ecotourism and forest therapy.However,the emission patterns of phytoncides(key bio active compounds) remain poorly understood,limiting their therapeutic application.This study provides the first comprehensive characterization of spatiotemporal dynamics in airborne phytoncides and their synergistic interactions with environmental factors throughout the autumn-early spring seasonal transition in a temperate forest ecosystem.We analyzed the compositional dynamics of phytoncides and terpenoid content variations using thermal desorption-gas chromatography-mass spectrometry(TD-GC-MS) from September 2024 to March 2025.This period encompassed seasonal transitions from autumn to early spring,including diurnal variations in September and snowfall events in November.The method demonstrated detection limits(LODs) ranging from 1.35 to 5.33 ng m-3 and quantification limits(LOQs) from 4.09 to 16.15 ng m-3.Our results revealed pronounced seasonal fluctuations in phytoncide composition.In September,terpenoids,esters,alcohols,and alkanes displayed a diurnal "decrease-increase" trend,whereas aldehydes and ketones peaked at midday.Notably,esters and alcohols were undetectable in November and January.By January,terpenoids reached their lowest proportion(0.17±0.02%) at noon.Five terpenoids(α-pinene,myrcene,D-limonene,camphene,p-cymene) were detected in September,four(α-pinene,D-limonene,camphene,p-cymene) in November,two(D-limonene,p-cymene) in January,and only p-cymene in March.The total concentration and emission rate of the five terpenoids peaked in September afternoons at 1961.58±106.67 ng m^(-3) and653.86±35.56 ng m^(-3) h^(-1),respectively.Nocturnal emissions(32131.95±2522.21 ng m^(-3)) significantly surpassed daytime levels(14473.04±958.49 ng m^(-3)),with emission rates escalating from 1447.30±95.85 ng m^(-3) h^(-1)(day) to 5355.33±420.37 ng m^(-3) h^(-1)(night),marking a3.7-fold increase.Snowfall dramatically elevated terpenoid concentrations(pre-snowfall:158.58±14.12 ng m^(-3);post-snowfall:1080.57±57.76 ng m^(-3)) and emission rates(pre-snowfall:52.86±4.71 ng m^(-3) h^(-1);post-snowfall:360.19±19.25 ng m^(-3) h^(-1)),reflecting a 6.8-fold surge.This study underscores the profound influence of light intensity,seasonal shifts,and climatic conditions on airborne phytoncide levels,offering a scientific foundation for optimizing forest therapy and ecotourism strategies.
基金supported by the National Natural Science Foundation of China(32460380,42007042)State Key Laboratory of Subtropical Silviculture(SKLSSKF2023-06)+2 种基金Natural Science Foundation of Jiangxi Province(20242BAB25389)National Undergraduate Innovation and Entrepreneurship Training Program(202410410029X)Jiangxi Province Graduate Student Innovation Special Fund Project(YC2024-S330).
文摘Urban forests are essential components of green infrastructure,however,rapid urbanization-induced changes in landscape patterns may affect their ecosystem services through complex ecological processes.A total of 184 sample plots in the built-up areas of Nanchang,China,were used as research sites.Urbanization intensities were categorized by the rate of impervious surface area,and forest types were classified into landscape and relaxation forest,attached forest(AF),road forest(RF),and ecological public welfare forest.This study aimed to explore the spatial variations in vegetation characteristics and landscape pattern indices of different forest types under rapid urbanization.The results indicated that the largest patch index(LPI),aggregation index(AI),and percentage of landscape(PLAND)in RF and AF were lower than those in the other forest types(p<0.05).With increasing urbanization intensity,the mean perimeter-area ratio increased by 130.84%,whereas the PLAND,LPI,and AI decreased by 22−86%(p<0.05).Redundancy analysis and variation partitioning suggested that the interpretation rate of landscape pattern indices for variations in vegetation characteristics increased from low to heavy urbanization areas.Especially,the landscape shape index,patch connection index,PLAND,and mean patch size were significantly correlated with vegetation characteristics(e.g.,tree richness,herb coverage,and tree height).In the future,appropriate landscape layout superiority cases should be considered in different urbanization areas and forest types;for instance,increasing the patch connection index will beneficially improve the diversity of trees and herbs in heavy urbanization areas and the RF.This study serves as a reference for maximizing the ecosystem services of urban forests.
基金supported in part by National Key R&D Program of China(2022YFB4501200),National Natural Science Foundation of China(62332018)Science and Technology Program(2024NSFTD0031,2024YFHZ0339 and 2025ZNSFSC0497).
文摘The performance of data restore is one of the key indicators of user experience for backup storage systems.Compared to the traditional offline restore process,online restore reduces downtime during backup restoration,allowing users to operate on already restored files while other files are still being restored.This approach improves availability during restoration tasks but suffers from a critical limitation:inconsistencies between the access sequence and the restore sequence.In many cases,the file a user needs to access at a given moment may not yet be restored,resulting in significant delays and poor user experience.To this end,we present Histore,which builds on the user’s historical access sequence to schedule the restore sequence,in order to reduce users’access delayed time.Histore includes three restore approaches:(i)the frequency-based approach,which restores files based on historical file access frequencies and prioritizes ensuring the availability of frequently accessed files;(ii)the graph-based approach,which preferentially restores the frequently accessed files as well as their correlated files based on historical access patterns,and(iii)the trie-based approach,which restores particular files based on both users’real-time and historical access patterns to deduce and restore the files to be accessed in the near future.We implement a prototype of Histore and evaluate its performance from multiple perspectives.Trace-driven experiments on two datasets show that Histore significantly reduces users’delay time by 4-700×with only 1.0%-14.5%additional performance overhead.
基金the Chinese Academy of Sciences Research Center for Ecology and Environment of Central Asia(RCEECA),the construction and joint research for the China-Tajikistan“Belt and Road”Joint Laboratory on Biodiversity Conservation and Sustainable Use(2024YFE0214200)the Shanghai Cooperation Organization Partnership and International Technology Cooperation Plan of Science and Technology Projects(2023E01018,2025E01056)the Chinese Academy of Sciences President’s International Fellowship Initiative(PIFI)(2024VBC0006).
文摘Tajikistan represents a core region of the biodiversity hotspot in Central Asian mountains and has exceptional vascular plant diversity.However,the species diversity of the country faces urgent conservation challenges.There has been a lack of a comprehensive and multidimensional assessment to inform strategic conservation planning.Therefore,this study integrated 4 key biodiversity indices including species richness(SR),phylogenetic diversity(PD),threatened species richness(TSR),and endemic species richness(ESR)to map species diversity distribution patterns,identify conservation gaps,and elucidate their effects of climatic factors.This study revealed that species diversity shows a clear trend of decreasing from the western region to the eastern region of Tajikistan.The central–western mountains(specifically the Gissar-Darvasian and Zeravshanian regions)emerge as irreplaceable biodiversity hotspots.However,we found a severe spatial mismatch between these priority areas and the existing protected areas(PAs).Protection coverage for all hotspots was alarmingly low,ranging from 31.00%to 38.00%.Consequently,a critical 64.80%of integrated priority areas fall outside of the current PAs,representing a major conservation gap.This study identified precipitation seasonality and isothermality as the principal drivers,collectively explaining over 50.00%of the diversity variation and suggesting high vulnerability to hydrological shifts.Furthermore,we detected significant geographic sampling bias in the public biodiversity databases,with the most critical hotspot being systematically under-sampled.This study provides a robust scientific basis for conservation action,highlighting the urgent need to strategically expand PAs in the under-protected southwestern region and to mitigate critical sampling gaps through targeted data digitization and field surveys.These measures are indispensable for securing Tajikistan’s unique biodiversity and achieving the Kunming-Montreal Global Biodiversity Framework Target 3(“30×30 Protection”).
基金support from the National Natural Science Foundation of China(Grant No.61971256)。
文摘Wide-field mesoscopy provides the capabilities of cortex-wide field of view(FOV),cellular resolution and high frame rate for neuronal imaging in the mouse brain.However,inherent background fluorescence degrades the image quality and hinders neuronal signal extraction.To address this problem,we first introduce a cortex-wide,high-resolution lineillumination mesoscope with a moving slit designed for in vivo mouse brain imaging.This system achieves a 6.6×6.6 mm FOV,microscale cellular resolution,a high frame rate of 10 Hz,as well as the background rejection ability.Furthermore,we integrated patterned illumination into the system to enhance the background suppression.Experimental results show that the proposed system successfully captures neurodynamics in the living mouse brain.Compared with conventional wide-field mesoscopes,the cortex-wide patterned line-illumination mesoscope(PLIM)achieves a threefold increase in the signal-to-background ratio(SBR).With patterned illumination integrated,the SBR enhancement further reaches four-anda-half-fold.
文摘BACKGROUND Drug utilization research has an important role in assisting the healthcare administration to know,compute,and refine the prescription whose principal objective is to enable the rational use of drugs.Research in developing nations relating to the cost of treatment is scarce when compared with developed countries.Thus,the drug utilization research studies from developing nations are most needed,and their number has been growing.AIM To evaluate patterns of utilization of antipsychotic drugs and direct medical cost analysis in patients newly diagnosed with schizophrenia.METHODS The present study was observational in type and based on a retrospective cohort to evaluate patterns of utilization of antipsychotic drugs using World Health Organization(WHO)core prescribing indicators and anatomical therapeutic chemical/defined daily dose indicators.We also calculated direct medical costs for a period of 6 months.RESULTS This study has found that atypical antipsychotics are the mainstay of treatment for schizophrenia in every age group and subcategories of schizophrenia.The evaluation based on WHO prescribing indicators showed a low average number of drugs per prescription and low prescribing frequency of antipsychotics from the National List of Essential Medicines 2015 and the WHO Essential Medicines List 2019.The total mean drug cost of our study was 1396 Indian rupees.The total mean cost due to the investigation in our study was 1017.34 Indian rupees.Therefore,the total mean direct medical cost incurred on patients in our study was 4337.28 Indian rupees.CONCLUSION The information from the present study can be used for reviewing and updating treatment policy at the institutional level.
基金supported by the Department of Biotechnology,Ministry of Science and Technology,Govt.India,under grant No.BT/Coord.II/10/02/2016/22.03.2018the Indian Council of Social Science Research,New Delhi,India,for providing a short-term doctoral fellowship(RFD/Short-Term/2022-23/ENV/ST/66).
文摘Understanding spatial patterns of plant species diversity and the factors(e.g.,climate and human)that drive these patterns is essential for biodiversity conservation.We used data from 1700.1-ha forest plots in the Shettihalli tropical forest landscape of the Western Ghats biodiversity hotspot,India,to analyse tree community composition and the drivers ofα-diversity(Shannon)andβ-diversity(LCBD).Compositional patterns were visualized using Non-Metric Multidimensional Scaling(NMDS),and hybrid feature selection with structural equation modeling(SEM)was employed to evaluate the direct and indirect effects of environmental variables on diversity.NMDS identified four distinct forest types in the Shettihalli landscape:semi-evergreen,dry deciduous,moist deciduous,and plantation forests,each with distinct plant composition.Shannon diversity and ecological uniqueness was significantly higher in semi-evergreen forest than in deciduous forest plots.The SEMs explained about 79%and 39–45%of the variation inα-diversity andβ-diversity.Our analysis indicated that current diversity patterns result from multiple processes,with structure,disturbance,and edaphic parameters exerting the strongest direct and indirect effects onα-diversity.β-diversity,in contrast,was largely influenced by climate,topography,stand structure,and edaphic factors.Overall,our findings indicate that various factors(e.g.,climate,topography,and human disturbance)interact to shape tree diversity patterns in tropical forests.These findings will help develop unique conservation and management strategies for distinct forest types in tropical forest ecosystems.
基金funded by geological survey project of China Geological Survey(DD20211404)。
文摘Mineral resources in Asia continent and its mining industry play a significant role in the economic growth and industrialization of both Asia and the world.Asia continent boasts the most comprehensive kinds of minerals,with reserves of at least 38 of over 80 widely used minerals worldwide accounting for more than30%of the global total reserves.Asia continent experienced three main tectonic evolution and mineralization stages:The Precambrian,the Paleozoic,and the Mesozoic to Cenozoic.The abundant mineral resources in this continent can be divided into seven first-order metallogenic belts(metallogenic domains),18 second-order metallogenic belts(metallogenic provinces),61 third-order metallogenic belts(metallogenic zones),and nine main minerogenetic series.Asia continent exhibits the most significant metallogenic specialization among all continents.Specifically,granite belts of Asia continent manifest pronounced metallogenic specialization of tin,rare metals,and porphyry Cu-Au-Mo deposits.Its maficultramafic rock belts and ophiolite belts display notable metallogenic specialization of lateritic nickel deposits and magmatic type chromite deposits,while its Mesozoic to Cenozoic basalt belts show remarkable metallogenic specialization of lateritic bauxite deposits.Consequently,many giant metallogenic belts were formed,including the Southeast Asian tin belt,the Qinghai-Xizang Plateau rare metal metallogenic belt,the Tethyan porphyry Cu-Au-Mo metallogenic belt,the circum-Pacific porphyry Cu-Au-Mo metallogenic belt,the Southeast Asian lateritic bauxite metallogenic belt,the Deccan Plateau lateritic bauxite metallogenic belt in India,the Southeast Asian lateritic nickel metallogenic belt,and the Tethyan magmatic type chromite metallogenic belt—all of which are significant metallogenic belts in Asia continent.Future mineral exploration in Asia should focus primarily on the Precambrian mineralization of ancient cratons,the Paleozoic mineralization of the Central Asian-Mongolian orogenic belt,and the Mesozoic to Cenozoic mineralization of the Tethyan and circum-Pacific mobile belts.Asia's mining industry not only underpins its own economic growth but also propels global economic development and industrialization,contributing significantly to the world economy.Asia boasts the highest production value of minerals,the largest annual production of minerals,and the greatest trade value of mineral products among all the continents,having emerged as the trade center of global mineral products and the center of the mining industry economy.China is identified as one of the few countries that possess the most comprehensive kinds of minerals,and its mining industry has supported and driven the economic development and industrialization of Asia and even the world.Standing as the largest mineral producer worldwide,China ranked first in the production of 28 mineral commodities in the world in 2022.Besides,China exhibits the highest annual production value of minerals and the largest trade value of mineral products among all countries.Therefore,China's demand for global mineral products influences the global supply and demand patterns of minerals and the world economic situation.
基金Supported by Science and Technology Program of Jiangxi Provincial Health and Family Planning Commission:20187065
文摘Objectives:To observe and compare the clinical efficacy difference among long snake moxibustion,acupuncture and western medication for treating lumbar disc herniation with cold-dampness syndrome,and to provide a preferred treatment for cold-dampness lumbar disc herniation.Methods:A total of 90 patients with cold-dampness lumbar disc herniation were randomized into three groups according to the random number table,including the long snake moxibustion group(31 cases),the acupuncture group(28 cases)and the western medication group(31 cases).Treated with long snake moxibustion,patients in the long snake moxibustion group.The acupuncture group was treated with conventional acupuncture therapy,by adopting acupoints of Shènshū(肾俞 BL23),Dàchángshū(大肠俞BL25),Yāoyángguān(腰阳关GV3),Wěizhōng(委中 BL40)and local Ashi points.Patients in the western medication group were given oral diclofenac sodium.Visual analogous scale(VAS),Oswestry Dysfunction Index(ODI)score,yang deficiency scale score and clinical efficacy were observed before and after treatment.Results:(1)The VAS scores of the patients after treatment in each group decreased compared with those before the treatment.The long snake moxibustion group decreased from 7.22±1.14 to 1.10±0.75(P<0.05);the acupuncture group,from 6.75±1.18 to 1.46±0.88(P<0.05);and the western medication group,from 7.38±1.02 to 1.51 ±0.81(P<0.05).After treatment,the VAS score of the long snake moxibustion group was lower than that of the acupuncture and western medication groups,the differences were statistically significant(both P<0.05).(2)ODI scores of all the groups were lower than those before the treatment.The long snake moxibustion group decreased from 33.35±10.85 to 7.84±3.59(P<0.05);the acupuncture group,from 31.65±8.23 to 9.00±6.10(P<0.05);and the western medication group from 27.77±7.30 to 23.87±10.81(P<0.05).The score of ODI in the long snake moxibustion group was lower than those in the acupuncture and western medication groups,the differences were statistically significant(both P<0.05).(3)The scores of yang deficiency scale score in each group were lower than those before treatment.The long snake moxibustion group decreased from 61.81±15.49 to 32.26±6.08(P<0.05);the acupuncture group,from 67.64±12.47 to 62.00±17.77(P<0.05);and the western medication group from 64.68 ± 12.73 to 59.77±14.02(P<0.05).The score of yang deficiency scale of the long snake moxibustion group was lower than those of the acupuncture and western medication groups after treatment,the differences were statistically significant(both P<0.05).(4)The effective rates of the long snake moxibustion group,acupuncture group and western medication group were 93.55%,85.71% and74.19% respectively,and the differences among three groups were statistically significant(all P<0.05).Conclusion:The long snake moxibustion therapy has a significant clinical effect for lumbar disc herniation with cold-damp syndrome,which is better than those of acupuncture and western medication groups,the therapy can effectively improve the patients’ physical constitution as a preferred solution for cold-damp lumbar disc herniation by acupuncture therapy.
基金The National Key Research and Development Plan"Public Safety Risk Prevention and Control and Emergency Technical Equipment"Key Project"Clinical Evaluation Research on Chinese Medicine Intervention in COVID-19 Recovery Period"(2020YFC0845000)。
文摘Objective:To evaluate the curative effect of"Cold-Dampness Epidemic Prescription(寒湿疫方)"on the main symptoms of quarantined people in community based on real-world research data,and to provide scientific basis for Chinese medicine to fight Coronavirus disease 2019 under the"Wuchang Model".Methods:From February 4,2020 to March 5,2020,the data of community quarantined people who only took"Cold-Dampness Epidemic Prescription(寒湿疫方)"under the management of"Wuchang Model"were collected,and the demographic characteristics,basic diseases,distribution of sick people,treatment process,disappearance time of eight clinical symptoms,adverse reactions and clinical outcomes of patients were statistically analyzed.Results:A total of 951 quarantined people in COVID-19 community were included,including 440 males(46.27%)and 511 females(53.73%),the oldest was 89 years old,the youngest was 2 years old,and the average age was 43.34 years old;Among the quarantined population in the community,there were 141 cases diagnosed by CDC(14.83%),CDC excluded 810 cases(85.17%);106 cases of CDC were diagnosed as COVID-19,accounting for 47.96%of the self-reported cases,and 311 cases(32.70%)had previous medical history;696(73.19%)had no obvious symptoms,and 255(26.81%)developed fever,fatigue,cough,sputum,shortness of breath,loss of appetite,diarrhea and mood,of which 187(19.66%)had cough symptoms,followed by sputum coughing(14.30%)and fever(13.56%).Conclusion:"Cold-Dampness Epidemic Prescription(寒湿疫方)"is effective in treating the clinical symptoms of COVID-19 without obvious adverse reactions.
基金We thank for the funding support from the National Natural Science Foundation of China(81873285)。
文摘Objective:To explore the molecular mechanism of the prescription for the syndrome of cold-damp-ness obstructing the lung in the treatment of corona virus disease 2019(COVID-19).Methods:The medicinals for the treatment of the syndrome of cold-dampness obstructing the lung,such as Cangzhu(Rhizoma Atractylo-dis),Chenpi(Pericarpium Gitri Reticulatae),Houpo(Cortex Magnoliae Officinalis),Huoxiang(Herba Agastachis),Caoguo(Fructus Tsaoko),Mahuang(Herba Ephedrae),Qianghuo(Rhizoma et Radix Notoptery-gi),Shengjiang(Rhizoma Zingiberis Recens),Binlang(Semen Arecae)in the Diagnosis and Treatment Pro-gram of COVID-19(Trial Version 6)were taken as research subjects,and the combination of these nine me-dicinals can be called Hanshi Zufei Fang(寒湿阻肺方,HSZFF).The active components and targets of each single Chinese materia medica was screened and obtained through the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database.The target information related to COVID-19 was retrieved through the Gene-Cards disease-related target database.The medicinal prediction targets were mapped to the disease target to ob-tain the intersection targets.The DAVID database was applied to perform gene ontology(GO)enrichment anal-ysis and kyoto encyclopedia of genes and genomes(KEGG)pathway analysis on the targets;GraphPad Prism 5.0 software was applied to plot the biological process(BP)of GO enrichment analysis,cellular component(CC),molecular function(MF)histograms;OmicShare online software was applied to make KEGG advanced bubble chart;Cytoscape software was applied to visualize the interaction with the targets and Chinese materia medica-components-targets results.Results:Totally 56 key active components of 9 Chinese materia medica for cold-dampness obstructing lung syndrome were screened,and 55 targets were obtained.The results of GO and KEGG enrichment analysis showed that the compound prescription mainly regulated the body's immune re-sponse and reduced inflammation by regulating such signaling pathways of inflammatory response and immune regulation as TNF signaling pathway,HIF-1 signaling pathway,Toll-like receptor signaling pathway,infuenza A signaling pathway,T cell receptor signaling pathway.Conclusion:HSZFF can eliminate infl ammation and inhibit virus by regulating immune inflammatory factors closely related to the occurrence and development of diseases through multi-component and multi-target.
基金supported by the National Natural Science Foundation of China(62374142,12175189 and 11904302)External Cooperation Program of Fujian(2022I0004)+1 种基金Fundamental Research Funds for the Central Universities(20720190005 and 20720220085)Major Science and Technology Project of Xiamen in China(3502Z20191015).
文摘The preparation of red,green,and blue quantum dot(QD)pixelated arrays with high precision,resolution,and brightness poses a significant challenge on the development of advanced micro-displays for virtual,augmented,and mixed reality applications.Alongside the controlled synthesis of high-performance QDs,a reliable QD patterning technology is crucial in overcoming this challenge.Among the various methods available,photolithography-based patterning technologies show great potentials in producing ultra-fine QD patterns at micron scale.This review article presents the recent advancements in the field of QD patterning using photolithography techniques and explores their applications in micro-display technology.Firstly,we discuss QD patterning through photolithography techniques employing photoresist(PR),which falls into two categories:PRassisted photolithography and photolithography of QDPR.Subsequently,direct photolithography techniques based on photo-induced crosslinking of photosensitive groups and photo-induced ligand cleavage mechanisms are thoroughly reviewed.Meanwhile,we assess the performance of QD arrays fabricated using these photolithography techniques and their integration into QD light emitting diode display devices as well as color conversionbased micro light emitting diode display devices.Lastly,we summarize the most recent developments in this field and outline future prospects.
文摘Tumor is defined as a kind of chronic diseases by the World Health Organization.The integrative traditional Chinese and western medicine works well on the treatment of tumors,even in advanced patients or patients with recurring and metastatic tumor.However,the pathogenic mechanism of tumors is still unclear.Therefore,based on the 19 th pathogenesis in Yellow Emperor's Internal Class that"Diseases producing the liquid that is clear and chill all result from coldness",the paper explore s the etiology pathogenesis of malignant tumors,and the correlation between which and tumor recurrence and metastasis,and also discusses the rules for the treatment of tumors at various stages with great method of warming yang for dispelling cold.
基金jointly supported by the Key Project of the Natural Science Foundation of Guizhou Province(No.Qiankehe Jichu-ZK[2023]Zhongdian027)the Project of the Science and Technology Innovation Base Construction of Guizhou Province(No.Qiankehe Zhongyindi[2023]005)Philosophy and Social Science Planning Subjects in Guizhou Province in 2022(No.22GZYB53)。
文摘Ecological security provides the basis of maintaining both a sustainable regional ecosystem and economic development.However,few studies have focused on how the features such as topography and geomorphology,lithologic stratigraphic assemblages,and geohazard distribution affect the construction of ecological security patterns and the layout of optimization measures.In order to comprehensively reveal the key areas and key objects of ecological restoration in karst basins,this study takes the Beipan River Basin(BRB)as an example,constructs an ecological security pattern(ESP)based on the methods of morphological spatial pattern analysis(MSPA),landscape connectivity analysis and circuit theory,and lays out the optimization measures in combination with the spatial distribution characteristics of topographic and geomorphological differences and lithological stratigraphic combinations.The results show that 151 ecological sources,343 ecological corridors,121 pinch points and 178 barriers constitute the ESP of the BRB.Lithology is closely related to the spatial distribution characteristics of ecological source sites.Level 1 and 2 ecological sources(The ecological sources were categorized into level 1,level 2,and level 3 source from high to low importance.)are concentrated in the Emeishan basalt region of the upstream and the clastic and impure carbonate rock region of the downstream part of the BRB;level 3ecological sources are concentrated in the carbonate rock region of the midstream.Taking into account the outstanding ecological problems in the basin,and based on the characteristics of lithology and geohazard distribution,we propose the optimization scheme of“three axes,three zones and multiple points”for the ESP and the layout of specific measures of the BRB.The results can provide scientific references for maintaining ecological security maintenance in karst ecologically fragile areas.
文摘AIM:To report the demographic and systemic characteristics of patients,clinical progression of endophthalmitis,and the efficacy of various treatment strategies,with a focus on identifying key factors for preserving vision in eyes with endogenous endophthalmitis due to Klebsiella pneumoniae(K.pneumoniae)liver abscess.METHODS:In this single-center,retrospective case series of 18 patients with endogenous endophthalmitis due to K.pneumoniae liver abscess were analyzed.Ophthalmologic features of endophthalmitis at early,intermediate and advanced stages were obtained from eyes with endophthalmitis of different severities.Prompt vitrectomy was considered primarily for all eyes except for very early endophthalmitis.Intravitreal injections of antibiotics were performed in eyes with endophthalmitis in the very early stages and in eyes where vitrectomy was not available,and additional control of infection was needed after vitrectomy.Evisceration was performed in eyes with corneoscleral perforation,advanced endophthalmitis,perforation with preseptal or orbital cellulitis,uncontrolled infection,or severe pain with no vision.RESULTS:Mean(±standard deviation)age of the 18 patients with endophthalmitis was 64.5±12.2(range:32-84)y,and 14 patients(77.8%)were males.Endophthalmitis tended to involve the retinal parenchyma first and then progressed into the vitreous cavity and anterior segments.However,it presented a tendency to cause massive subretinal abscesses even after vitrectomy with silicone oil tamponade.Very high intraocular pressure with new vessels on the iris(41.7%)were also commonly observed.Although all but three patients had systemic disease such as diabetes or hypertension,visual prognosis after treatment did not appear to depend significantly on underlying comorbidities.A final best-corrected visual acuity better than 20/60 was achieved only when lesions were detected very early,with relatively good initial visual acuity,likely reflecting lower bacterial inoculation in the eye.CONCLUSION:Detection of early endophthalmitis lesions appears to be the only way to preserve good vision in patients with K.pneumoniae liver abscesses.Therefore,proper guidelines for ophthalmologic screening remain to be established for subjects at a high risk of endophthalmitis.
基金funded by the Yunnan Provincial Basic Research Joint Special Fund Project(2019FH001(-052))Cangshan Mountain Synthetic Scientific Expeditions Fund.
文摘The Hengduan Mountains,situated on the southeastern edge of the Qinghai-Tibet Plateau,are the longest and widest north-south-oriented mountain range in China,exerting a significant influence on the ecological and geographical pattern.Understanding the topographic and geomorphological characteristics of the Hengduan Mountains is fundamental and crucial for research in related fields such as ecology,geography,and sustainability.In this study,Digital Elevation Model(DEM)data were utilized to extract and analyze the topography and geomorphology(TG)pattern.TG maps have been developed to quantitatively classify the TG types in the Hengduan Mountains by combining the five factors of elevation,slope,aspect,relief and landform.The spatial distribution and quantitative characteristics of these factors were mapped and investigated using geographic information systems.The results revealed that:(1)The Hengduan Mountains exhibit an elongated north-south distribution,with an average elevation of approximately 3746 m,an average slope of around 25°,and an average relief of about 266 m.(2)The Hengduan Mountains display significant elevation differences,with an overall high elevation,characterized by a trend of lower elevation in the east and higher elevation in the west,as well as irregular orientations of various aspects.(3)The 19 landform types were identified,the landform types of the Hengduan Mountains are primarily composed of low-relief high-mountains(42.0618%),low-relief mid-mountains(22.4624%),and high-elevation hills(20.5839%).The results of the study can provide data and information support for the ecology,environmental protection and sustainable development of the Hengduan Mountains.
基金National Social Science Foundation Program,No.22VRC163National Natural Science Foundation of China,No.42061043+1 种基金Postgraduate Research&Practice Innovation Program of Jiangsu Province,No.KYCX24_1008Innovation Project of Guangxi Graduate Education,No.YCSW2024473。
文摘Clarifying the mechanisms that control the evolution of territorial space patterns is essential for regulating and optimizing the geographical structure and processes related to sustainable development.Using the Guangdong and Guangxi sections of the Pearl River Basin as examples,the transfer-matrix method and standard deviation ellipse model were applied to characterize the evolution of territorial space patterns from 1990 to 2020.A trend surface analysis and the Theil index were used to analyze regional differences in the evolution process,and geodetectors were used to identify the underlying mechanisms of the changes.There were three key results.(1)In these critical areas of the Pearl River Basin,agricultural and ecological spaces have rapidly declined due to urban expansion,with transfers between these spaces dominating the evolution of territorial space patterns.Spatial pattern changes in the Guangdong section were more intense than in the Guangxi section.(2)Regional differences in urban space have decreased,whereas differences in agricultural and ecological spaces have intensified.Driven by socio-economic growth,the cross-regional transfers of territorial space have created a“high in the east,while low in the west”inter-regional difference,and a“high in the south,while low in the north”intra-regional difference shaped by natural conditions.The regional differences in space patterns were greater in Guangdong than in Guangxi.(3)The evolution of watershed territorial space patterns resulted from scale changes,locational shifts,structural reorganizations,and directional changes driven by multiple factors.Natural environment,social life,economic development,and policy factors played foundational,leading,key driving,and guiding roles,respectively.Additionally,the regional differences in the evolution of watershed territorial space patterns originated from the differential transmission of the influence of various factors affecting spatial evolution.Enhancing urban space efficiency,restructuring agricultural space,and optimizing ecological space are key strategies for building a complementary and synergistic territorial space pattern in the basin.
基金supported by the Guangdong Basic and Applied Basic Research project (No.2020B0301030004)the Key-Area Research and Development Program of Guangdong Province (No.2020B1111360003)+1 种基金the National Natural Science Foundation of China (No.42105103)the Guangdong Basic and Applied Basic Research Foundation (No.2022A1515011554).
文摘Objective weather classification methods have been extensively applied to identify dominant ozone-favorable synoptic weather patterns(SWPs),however,the consistency of different classification methods is rarely examined.In this study,we apply two widely-used objective methods,the self-organizing map(SOM)and K-means clustering analysis,to derive ozone-favorable SWPs at four Chinese megacities in 2015-2022.We find that the two algorithms are largely consistent in recognizing dominant ozone-favorable SWPs for four Chinese megacities.In the case of classifying six SWPs,the derived circulation fields are highly similar with a spatial correlation of 0.99 between the two methods,and the difference in themean frequency of each SWP is less than 7%.The six dominant ozone-favorable SWPs in Guangzhou are all characterized by anomaly higher radiation and temperature,lower cloud cover,relative humidity,and wind speed,and stronger subsidence compared to climatology mean.We find that during 2015-2022,the occurrence of ozone-favorable SWPs days increases significantly at a rate of 3.2 days/year,faster than the increases in the ozone exceedance days(3.0 days/year).The interannual variability between the occurrence of ozone-favorable SWPs and ozone exceedance days are generally consistent with a temporal correlation coefficient of 0.6.In particular,the significant increase in ozone-favorable SWPs in 2022,especially the Subtropical High type which typically occurs in September,is consistent with a long-lasting ozone pollution episode in Guangzhou during September 2022.Our results thus reveal that enhanced frequency of ozone-favorable SWPs plays an important role in the observed 2015-2022 ozone increase in Guangzhou.
