Cold therapy has been used regularly as an immediate treatment to induce analgesia following acute soft-tissue injuries,however,a prolonged ice application has proved to delay the start of the healing and lengthen the...Cold therapy has been used regularly as an immediate treatment to induce analgesia following acute soft-tissue injuries,however,a prolonged ice application has proved to delay the start of the healing and lengthen the recovery process.Hyperbaric gaseous cryotherapy,also known as neurocryostimulation,has shown the ability to overcome most of the limitations of traditional cold therapy,and meanwhile promotes the analgesic and anti-inflammatory effects well,but the current existing studies have shown conflicting results on its effects.Traditional cold therapy still has beneficial effect especially when injuries are severe and swelling is the limiting factor for recovery after soft-tissue injuries,and therefore no need to be entirely put out to pasture in the rehabilitation practice.Strong randomized controlled trials with good methodological quality are still needed in the future to evaluate the effects of different cryotherapy modalities.展开更多
Major depressive disorder(MDD),a widespread psychiatric disease with significant impacts on neurological functioning and quality of life,affects 4.4%of the global population.Despite the availability of various treatme...Major depressive disorder(MDD),a widespread psychiatric disease with significant impacts on neurological functioning and quality of life,affects 4.4%of the global population.Despite the availability of various treatments,including antidepressants and cognitive behavioral therapy,approximately 50%of patients with MDD exhibit inadequate responses,leading to treatment-resistant depression(TRD).This review evaluates novel physical treatments for depression,focusing on music therapy,light therapy,cold therapy,and brain stimulation techniques such as repetitive transcranial magnetic stimulation(rTMS),transcranial direct current stimulation(tDCS),and deep-brain stimulation(DBS).Music therapy leverages the emotional and social benefits of music to improve mood and cognitive function.Light therapy influences circadian rhythms and neurotransmitter modulation to reduce depressive symptoms.Cold therapy,by regulating the hypothalamic-pituitary-adrenal(HPA)axis and neurotransmitter systems,offers a promising approach for depression management.Brain stimulation techniques,including rTMS,tDCS,and DBS,provide non-pharmacological alternatives by modulating brain activity and connectivity.Although these novel treatments show potential,significant variabilities in clinical outcomes highlight the need for personalized treatment strategies.Future research should prioritize elucidating the mechanisms of these therapies,optimizing treatment protocols,and conducting larger randomized controlled trials to evaluate their efficacy and safety.The integration of advanced technologies and comprehensive mechanistic analyses will be crucial for advancing the field and improving treatment outcomes for MDD.展开更多
文摘Cold therapy has been used regularly as an immediate treatment to induce analgesia following acute soft-tissue injuries,however,a prolonged ice application has proved to delay the start of the healing and lengthen the recovery process.Hyperbaric gaseous cryotherapy,also known as neurocryostimulation,has shown the ability to overcome most of the limitations of traditional cold therapy,and meanwhile promotes the analgesic and anti-inflammatory effects well,but the current existing studies have shown conflicting results on its effects.Traditional cold therapy still has beneficial effect especially when injuries are severe and swelling is the limiting factor for recovery after soft-tissue injuries,and therefore no need to be entirely put out to pasture in the rehabilitation practice.Strong randomized controlled trials with good methodological quality are still needed in the future to evaluate the effects of different cryotherapy modalities.
基金the Science and Technology innovation 2030-Major Project of the Ministry of Science and Technology of China(2021ZD0202904/2021ZD0202900)the National Natural Science Foundation of Distinguished Young Scholars(82025033)+3 种基金the National Natural Science Foundation of China(82230115,82304471)the Open Project Program of the Key Laboratory of Developmental Genes and Human Diseases,Ministry of Education,China(LDGHD202304)the Fundamental Research Funds for the Central Universities(RF1028623253)the Jiangsu Provincial Doctors of Entrepreneurship and Innovation(JSSCBS20230037).
文摘Major depressive disorder(MDD),a widespread psychiatric disease with significant impacts on neurological functioning and quality of life,affects 4.4%of the global population.Despite the availability of various treatments,including antidepressants and cognitive behavioral therapy,approximately 50%of patients with MDD exhibit inadequate responses,leading to treatment-resistant depression(TRD).This review evaluates novel physical treatments for depression,focusing on music therapy,light therapy,cold therapy,and brain stimulation techniques such as repetitive transcranial magnetic stimulation(rTMS),transcranial direct current stimulation(tDCS),and deep-brain stimulation(DBS).Music therapy leverages the emotional and social benefits of music to improve mood and cognitive function.Light therapy influences circadian rhythms and neurotransmitter modulation to reduce depressive symptoms.Cold therapy,by regulating the hypothalamic-pituitary-adrenal(HPA)axis and neurotransmitter systems,offers a promising approach for depression management.Brain stimulation techniques,including rTMS,tDCS,and DBS,provide non-pharmacological alternatives by modulating brain activity and connectivity.Although these novel treatments show potential,significant variabilities in clinical outcomes highlight the need for personalized treatment strategies.Future research should prioritize elucidating the mechanisms of these therapies,optimizing treatment protocols,and conducting larger randomized controlled trials to evaluate their efficacy and safety.The integration of advanced technologies and comprehensive mechanistic analyses will be crucial for advancing the field and improving treatment outcomes for MDD.
