Objective： To evaluate the clinical efficacy and safety of Yinchen Zhufu Decoction（茵陈术附汤, YCZFD） in the treatment of acute-on-chronic liver failure caused by hepatitis B virus（HBV-ACLF） with cold pattern in ...Objective： To evaluate the clinical efficacy and safety of Yinchen Zhufu Decoction（茵陈术附汤, YCZFD） in the treatment of acute-on-chronic liver failure caused by hepatitis B virus（HBV-ACLF） with cold pattern in Chinese medicine（CM）. Methods： This is a multi-center randomized controlled trial of integrative treatment of CM and Western medicine（WM） for the management of HBV-ACLF patients. A total of 200 HBV-ACLF patients with cold pattern were equally randomly assigned to receive YCZFD and WM（integrative treatment） or WM conventional therapy alone respectively for 4 weeks. The primary end point was the mortality for HBV-ACLF patients. Secondary outcome measures included Model for End-Stage Liver disease（MELD） score, liver biochemical function, coagulation function and complications. Adverse events during treatment were reported. Results： The mortality was decreased 14.28% in the integrative treatment group compared with WM group（χ^2=6.156, P=0.013）. The integrative treatment was found to significantly improve the MELD score（t=2.353, P=0.020）. There were statistically significant differences in aspartate transaminase, total bilirubin, indirect bilirubin, direct bilirubin and prothrombin time between the two groups（P〈0.05 or P〈0.01）. The complications of ascites（χ^2=9.033, P=0.003） and spontaneous bacteria peritonitis（χ^2=4.194, P=0.041） were improved significantly in the integrative treatment group. No serious adverse event was reported. Conclusions： The integrative treatment of CM and WM was effective and safe for HBV-ACLF patients with cold pattern in CM. The Chinese therapeutic principle ＂treating cold pattern with hot herbs＂ remains valuable to the clinical therapy.（Trial registration No. Chi CTR-TRC-10000766）展开更多
This paper presents new high-resolution proxies and paleoclimatic reconstructions for studying climate changes in China for the past 2000 years. Multi-proxy synthesized reconstructions show that temperature variation ...This paper presents new high-resolution proxies and paleoclimatic reconstructions for studying climate changes in China for the past 2000 years. Multi-proxy synthesized reconstructions show that temperature variation in China has exhibited significant 50–70-yr, 100–120-yr, and 200–250-yr cycles. Results also show that the amplitudes of decadal and centennial temperature variation were 1.3℃ and 0.7℃, respectively, with the latter significantly correlated with long-term changes in solar radiation, especially cold periods, which correspond approximately to sunspot minima. The most rapid warming in China occurred over AD 1870–2000, at a rate of 0.56°± 0.42℃（100 yr）^（-1）; however, temperatures recorded in the 20 th century may not be unprecedented for the last 2000 years, as data show records for the periods AD 981–1100 and AD1201–70 are comparable to the present. The ensemble means of dryness/wetness spatial patterns in eastern China across all centennial warm periods illustrate a tripole pattern： dry south of 25°N, wet from 25°–30°N, and dry to the north of 30°N. However, for all centennial cold periods, this spatial pattern also exhibits a meridional distribution. The increase in precipitation over the monsoonal regions of China associated with the 20 th century warming can primarily be attributed to a mega El Nino–Southern Oscillation and the Atlantic Multidecadal Oscillation. In addition, a significant association between increasing numbers of locusts and dry/cold conditions is found in eastern China. Plague intensity also generally increases in concert with wetness in northern China, while more precipitation is likely to have a negative effect in southern China.展开更多
Fog has recently become a frequent high-impact weather phenomenon along the coastal regions of North China. Accurate fog forecasting remains challenging due to limited understanding of the predictability and mechanism...Fog has recently become a frequent high-impact weather phenomenon along the coastal regions of North China. Accurate fog forecasting remains challenging due to limited understanding of the predictability and mechanism of fog formation associated with synoptic-scale circulation. One frequent synoptic pattern of fog formation in this area is associated with cold front passage(cold-front synoptic pattern, CFSP). This paper explored the predictability of a typical CFSP fog event from the perspective of analyzing key characteristics of synoptic-scale circulation determining fog forecasting performance and the possible mechanism. The event was ensemble forecasted with the Weather Research and Forecasting model. Two groups of ensemble members with good and bad forecasting performance were selected and composited. Results showed that the predictability of this case was largely determined by the simulated strengths of the cold-front circulation(i.e., trough and ridge and the associated surface high). The bad-performing members tended to have a weaker ridge behind a stronger trough, and associated higher pressure over land and a weaker surface high over the sea, leading to an adverse impact on strength and direction of steering flows that inhibit warm moist advection and enhance cold dry advection transported to the focus region. Associated with this cold dry advection, adverse synoptic conditions of stratification and moisture for fog formation were produced, consequently causing failure of fog forecasting in the focus region. This study highlights the importance of accurate synoptic-scale information for improved CFSP fog forecasting, and enhances understanding of fog predictability from perspective of synoptic-scale circulation.展开更多
基金Supported by the Ministry of Science and Technology of China,through its National Key Projects for Basic Research(No.2007CB512607)National Eleventh Five-year Great Science and Technology Project(No.2008ZX10005-007)
文摘Objective： To evaluate the clinical efficacy and safety of Yinchen Zhufu Decoction（茵陈术附汤, YCZFD） in the treatment of acute-on-chronic liver failure caused by hepatitis B virus（HBV-ACLF） with cold pattern in Chinese medicine（CM）. Methods： This is a multi-center randomized controlled trial of integrative treatment of CM and Western medicine（WM） for the management of HBV-ACLF patients. A total of 200 HBV-ACLF patients with cold pattern were equally randomly assigned to receive YCZFD and WM（integrative treatment） or WM conventional therapy alone respectively for 4 weeks. The primary end point was the mortality for HBV-ACLF patients. Secondary outcome measures included Model for End-Stage Liver disease（MELD） score, liver biochemical function, coagulation function and complications. Adverse events during treatment were reported. Results： The mortality was decreased 14.28% in the integrative treatment group compared with WM group（χ^2=6.156, P=0.013）. The integrative treatment was found to significantly improve the MELD score（t=2.353, P=0.020）. There were statistically significant differences in aspartate transaminase, total bilirubin, indirect bilirubin, direct bilirubin and prothrombin time between the two groups（P〈0.05 or P〈0.01）. The complications of ascites（χ^2=9.033, P=0.003） and spontaneous bacteria peritonitis（χ^2=4.194, P=0.041） were improved significantly in the integrative treatment group. No serious adverse event was reported. Conclusions： The integrative treatment of CM and WM was effective and safe for HBV-ACLF patients with cold pattern in CM. The Chinese therapeutic principle ＂treating cold pattern with hot herbs＂ remains valuable to the clinical therapy.（Trial registration No. Chi CTR-TRC-10000766）
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA050800)the Key Program of the Chinese Academy of Sciences (Grant No. KJZD-EW-TZ-G10)the National Natural Science Foundation of China (Grant No.41671201 and 91525101)
文摘This paper presents new high-resolution proxies and paleoclimatic reconstructions for studying climate changes in China for the past 2000 years. Multi-proxy synthesized reconstructions show that temperature variation in China has exhibited significant 50–70-yr, 100–120-yr, and 200–250-yr cycles. Results also show that the amplitudes of decadal and centennial temperature variation were 1.3℃ and 0.7℃, respectively, with the latter significantly correlated with long-term changes in solar radiation, especially cold periods, which correspond approximately to sunspot minima. The most rapid warming in China occurred over AD 1870–2000, at a rate of 0.56°± 0.42℃（100 yr）^（-1）; however, temperatures recorded in the 20 th century may not be unprecedented for the last 2000 years, as data show records for the periods AD 981–1100 and AD1201–70 are comparable to the present. The ensemble means of dryness/wetness spatial patterns in eastern China across all centennial warm periods illustrate a tripole pattern： dry south of 25°N, wet from 25°–30°N, and dry to the north of 30°N. However, for all centennial cold periods, this spatial pattern also exhibits a meridional distribution. The increase in precipitation over the monsoonal regions of China associated with the 20 th century warming can primarily be attributed to a mega El Nino–Southern Oscillation and the Atlantic Multidecadal Oscillation. In addition, a significant association between increasing numbers of locusts and dry/cold conditions is found in eastern China. Plague intensity also generally increases in concert with wetness in northern China, while more precipitation is likely to have a negative effect in southern China.
基金supported by the National Key R&D Program of China (Nos. 2017YFC1404100 and 2017YFC1404104)the National Natural Science Foundation of China (Nos. 41705081 and 41575067)the Global Change Research Program of China (No. 2015CB953904)
文摘Fog has recently become a frequent high-impact weather phenomenon along the coastal regions of North China. Accurate fog forecasting remains challenging due to limited understanding of the predictability and mechanism of fog formation associated with synoptic-scale circulation. One frequent synoptic pattern of fog formation in this area is associated with cold front passage(cold-front synoptic pattern, CFSP). This paper explored the predictability of a typical CFSP fog event from the perspective of analyzing key characteristics of synoptic-scale circulation determining fog forecasting performance and the possible mechanism. The event was ensemble forecasted with the Weather Research and Forecasting model. Two groups of ensemble members with good and bad forecasting performance were selected and composited. Results showed that the predictability of this case was largely determined by the simulated strengths of the cold-front circulation(i.e., trough and ridge and the associated surface high). The bad-performing members tended to have a weaker ridge behind a stronger trough, and associated higher pressure over land and a weaker surface high over the sea, leading to an adverse impact on strength and direction of steering flows that inhibit warm moist advection and enhance cold dry advection transported to the focus region. Associated with this cold dry advection, adverse synoptic conditions of stratification and moisture for fog formation were produced, consequently causing failure of fog forecasting in the focus region. This study highlights the importance of accurate synoptic-scale information for improved CFSP fog forecasting, and enhances understanding of fog predictability from perspective of synoptic-scale circulation.
