The linear transmission impairments,such as the timing offset(TO),frequency offset(FO),and chromatic dispersion(CD),are major factors of signal degradations in coherent optical fiber communication systems.The estimati...The linear transmission impairments,such as the timing offset(TO),frequency offset(FO),and chromatic dispersion(CD),are major factors of signal degradations in coherent optical fiber communication systems.The estimation and compensation of such impairments play significant roles in the receiver side digital signal processing(DSP)unit.In this paper,we propose to combat the linear impairments systematically(including TO,FO and CD)with a joint timefrequency signal processing by taking the advantage of fractional Fourier transform(FrFT).In view of geometrical analysis,TO/FO induces a shift in time/frequency coordinate and the CD leads to the rotation in the fractional domain.Both mathematical derivations and geometrical interpretations have been established to unveil the relationships between impairments and linear frequency modulated(LFM)training symbols(TSs).By considering a typical coherent optical orthogonal frequency-division multiplexing(COOFDM)transmission system,three kinds of linear impairments have been jointly estimated by simple geometric calculations using appropriately designed TS based on FrFTs.Simulation and experimental results confirmed the feasibility of time-frequency techniques with better accuracy,less complexity,and improved spectral efficiency.展开更多
We demonstrate optical-carrier transfer over a 112-km single-span urban fiber link, By actively compensating the phase noise induced along the fiber link, a noise suppression of 55 dB at 1 Hz is obtained. A fractional...We demonstrate optical-carrier transfer over a 112-km single-span urban fiber link, By actively compensating the phase noise induced along the fiber link, a noise suppression of 55 dB at 1 Hz is obtained. A fractional frequency instability of 2.5× 10^-16 at i s is achieved, and reaching 7.5× 10^-20 at 10000 s. The system is stable and able to run for a long time. This work will contribute to optical frequency distribution and remote comparison among atomic clocks.展开更多
An improved zero-interpolation method with signal clipping to improve fiber nonlinearity tolerance in the long-haul coherent optical orthogonal frequency division multiplexing system （CO-OFDM） is presented. The new ...An improved zero-interpolation method with signal clipping to improve fiber nonlinearity tolerance in the long-haul coherent optical orthogonal frequency division multiplexing system （CO-OFDM） is presented. The new technique is implemented by interpolating zero subcarriers and selecting the odd subcarriers to carry data and clipping conventional CO-OFDM signal at zero. With such a scheme,the effect of fiber nonlinearity can be miti-gated,and the wanted signal carried on odd subcarriers is or-thogonal to clipping noise,which falls on even frequencies. Simu-lation shows that the system Q value is improved by more than 2 dB at the length of 960 km展开更多
Two-photon microscopy normally suffers from the scattering of the tissue in biological imaging.Multidither coberent optical adaptive technique(COAT)can correct the scattered wavefront in parallel.However,the determina...Two-photon microscopy normally suffers from the scattering of the tissue in biological imaging.Multidither coberent optical adaptive technique(COAT)can correct the scattered wavefront in parallel.However,the determination of the corrective phases may not be completely accurate using conventional method,which undermines the performance of this technique.In this paper,we theoretically demonstrate a method that can obtain more accurate corrective phases by determining the phase values from the square root of the fuorescence signal.A numnerical simulation model is established to study the performance of adaptive optics in two-photon micros-copy by combining scalar diffraction theory with vector diffraction theory.The results show that the distortion of the wavefront can be corrected more thoroughly with our method in two-photon imaging.In our simulation,with the scattering from a 450-mn-thick mouse brain tissue,excitation focal spots with higher peak-to background ratio(PBR)and images with higher contrast can be obtained.Hence,further enhancement of the multidither COAT correction performance in two-photon imaging can be expected.展开更多
We demonstrate a triple-pass scheme for coherent transfer of optical frequency and the delay effect on the fiber phase noise compensation. It is theoretically proved that the delay effect consists of both fiber delay ...We demonstrate a triple-pass scheme for coherent transfer of optical frequency and the delay effect on the fiber phase noise compensation. It is theoretically proved that the delay effect consists of both fiber delay and servo delay. The delay effect confines the servo bandwidth within 1/8 and induces a residual fiber phase noise after noise compensation. For a 25-km-long fiber, the servo bandwidth is found to be around 1 k Hz, and the fiber phase noise is suppressed approaching to the theoretical limitation. The triple-pass scheme enables the simultaneous transfer of optical frequency to multiple remote users. The performance of noise compensator in the triple-pass scheme can achieve a similar level result compared with that in the double-pass scheme.展开更多
A pocket coherent population trapping（CPT） atomic magnetometer scheme that uses a vertical cavity surface emitting laser as a light source is proposed and experimentally investigated.Using the differential detecting...A pocket coherent population trapping（CPT） atomic magnetometer scheme that uses a vertical cavity surface emitting laser as a light source is proposed and experimentally investigated.Using the differential detecting magneto–optic rotation effect,a CPT spectrum with the background canceled and a high signal-to-noise ratio is obtained.The experimental results reveal that the sensitivity of the proposed scheme can be improved by half an order,and the ability to detect weak magnetic fields is extended one-fold.Therefore,the proposed scheme is suited to realize a pocket-size CPT magnetometer.展开更多
This paper introduces a joint nonlinearity and chromatic dispersion pre-compensation method for coherent optical orthogonal frequency-division multiplexing systems. The research results show that this method can reduc...This paper introduces a joint nonlinearity and chromatic dispersion pre-compensation method for coherent optical orthogonal frequency-division multiplexing systems. The research results show that this method can reduce the walk- off effect and can therefore equalize the nonlinear impairments effectively. Compared with the only other existing nonlinearity pre-compensation method, the joint nonlinearity and chromatic dispersion pre-compensation method is not only suitable for low-dispersion optical orthogonal frequency-division multiplexing system, but also effective for high- dispersion optical orthogonal frequency-division multiplexing transmission system with higher input power but without optical dispersion compensation. The suggested solution does not increase computation complexity compared with only nonlinearity pre-compensation method. For 40 Gbit/s coherent optical orthogonal frequency-division multiplexing 20 × 80 km standard single-mode fibre system, the suggested method can improve the nonlinear threshold （for Q 〉 10 dB） about 2.7, 1.2 and 1.0 dB, and the maximum Q factor about 1.2, 0.4 and 0.3 dB, for 2, 8 and 16 ps/（nm.km） dispersion coefficients.展开更多
Using the mutually coherent function, the self-trapping of the circle partially coherent optical beam in the total internal reflective photonic crystal fiber(TIRPCF) under Compton scattering is studied. The study show...Using the mutually coherent function, the self-trapping of the circle partially coherent optical beam in the total internal reflective photonic crystal fiber(TIRPCF) under Compton scattering is studied. The study shows that the composition of the non-coherent optical beam in the optical spectrum and the diffraction effect are decreased by Compton scattering, and the probability of forming the soliton is greatly increased. The vibration peak value in the propagation, compressed degree, changed cycle, and radius of the soliton are all smaller than those before the scattering, but its coherent radius is larger than that before the scattering. In this propagation, the self-focusing plays a key role.展开更多
The coherent exciton plays an important role in the photosynthetic primary process, and its functions are deeply dependent on the orientation arrangements of local transition dipole moments （TDMs）. We theoretically ...The coherent exciton plays an important role in the photosynthetic primary process, and its functions are deeply dependent on the orientation arrangements of local transition dipole moments （TDMs）. We theoretically and systematically study the physical property of the coherent exciton at different orientation arrangements of the local TDMs in circular light-harvesting （LH） complexes. Especially, if the orientation arrangements are different, the delocalized TDMs of the coherent excitons and the energy locations of the optically active coherent excitons （OACEs） can be obviously different, and then there are more manners to capture, store and transfer light energy in and between LH complexes. Similarly, if the orientation arrangements are altered, light absorption and radiative intensities can be converted fully between the OACEs in the upper and lower coherent exciton bands, and then the blue and red shifts of the absorption and radiative bands of the pigment molecules can occur simultaneously at some orientation arrangements. If the systems are in the vicinities of the critical orientation arrangements, the weak static disorder or small thermal excitation can destroy the coherent electronic excitations, and then the coherent exciton cannot exist any more.展开更多
Fiber nonlinearity is one of the most important limiters of capacity in coherent optical communications. In this paper, we review two nonlinear compensation methods： digital backward propagation （BP） and nonlinear ...Fiber nonlinearity is one of the most important limiters of capacity in coherent optical communications. In this paper, we review two nonlinear compensation methods： digital backward propagation （BP） and nonlinear electrical equalizer （NLEE） based on the timedomain Volterra series. These compensation algorithms are implemented in a singlechannel 50 Gb/s coherent optical singlecarrier frequency division multiplexed （CO-SCFDM） system transmitting over 10 × 80 km of standard singlemode fiber （SSMF）.展开更多
Future high-speed mobile communication systems require low latency and high capacity networks.Coherent wavelength division multiplexing(WDM)passive optical network(PON)scheme is expected to play a vital role in these ...Future high-speed mobile communication systems require low latency and high capacity networks.Coherent wavelength division multiplexing(WDM)passive optical network(PON)scheme is expected to play a vital role in these systems.In this paper,coherent WDM-PON scheme based on dual-polarization 16-quadrature amplitude modulation(DP-16 QAM)transceiver has been investigated.The aim of this scheme is to build a 2 Tbit/s(125 Gbit/s/λ×16 wavelengths)network that will be used in the construction of the transport architecture of fifth generation(5 G)and beyond 5 G(B5 G)cellular networks either in mobile front haul(MFH)or mobile back haul(MBH).The results indicate that the proposed scheme is very adequate for both 5 G and B5 G cellular networks requirements.展开更多
AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA scree...AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA screening indicators to detect concurrent DR at an early stage.METHODS:A total of 200 patients who treated in the ophthalmology department of the Seventh Affiliated Hospital,Sun Yat-sen University from 2022 to 2023 were included,including 95 first-diagnosed DR patients and 105 patients without DR,and all patients underwent OCTA examination and a collection of demographics and renal function parameters.After a quality check,automated measurements of the foveal avascular zone area,vessel density(VD),and perfusion density(PD)of both 3 mm×3 mm and 6 mm×6 mm windows were obtained.RESULTS:Using random forest and multivariate Logistic regression methods,we developed a diagnostic model for DR based on 12 variables(age,FBG,SBP,DBP,HbA1c,ALT,ALP,urea/Scr,DM duration,HUA,DN,and CMT).Adding specific OCTA parameters enhanced the efficacy of the existing diagnostic model for DR(outer vessel density in 6 mm×6 mm window,AUC=0.837 vs 0.819,P=0.03).In the study of DN patients,the parameters in the 6 mm×6 mm window improved the diagnostic efficacy of DR(inner VD;outer VD;full VD;outer PD;full PD).CONCLUSION:The outer VD in the 6 mm×6 mm window can enhance the efficacy of the traditional DR diagnostic model.Meanwhile,compared with the 3 mm×3 mm window,the microvascular parameters in the 6 mm×6 mm window focusing on DN patients can be more sensitive to diagnosing the occurrence of DR.展开更多
BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic im...BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management strategies.Vascular and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated damage.With the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural changes.AIM To study the macular microvascular and structural changes on OCTA in atypical optic neuritis.METHODS This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy controls.Macular vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using OCTA.RESULTS There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy controls.NMOSD and MOGAD affected eyes had significant GCIPL thinning compared with healthy controls.NMOSD unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected eyes.On comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected eyes.CONCLUSION Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.展开更多
AIM:To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab(IVR)in treating macular edema(ME)secondary to retinal vein occlusion(RVO).METHODS:This...AIM:To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab(IVR)in treating macular edema(ME)secondary to retinal vein occlusion(RVO).METHODS:This retrospective study involved 65 RVO patients(65 eyes)who received IVR and were followedup for more than 3mo.ME was categorized into cystoid macular edema(CME),diffuse retinal thickening(DRT),and serous retinal detachment(SRD)according to optical coherence tomography(OCT)images.The comparison of best corrected visual acuity(BCVA;logMAR)and central macular thickness(CMT)among different follow-up points and those among 3 groups were performed by Kruskal-Wallis test.The correlation between BCVA and baseline parameters during treatment was analyzed using Spearman correlation analysis.RESULTS:BCVA tended to improve in all groups,with marked improvement in CME and DRT groups.CMT showed the greatest reduction after 1wk,and remained stable over the following 3mo.DRT patients had the worst BCVA and the highest CMT at baseline,but the differences became smaller after IVR treatment.CMT in SRD group was significantly better than in CME and DRT groups 3mo after IVR.Most patients of CME and SRD groups transitioned to a normal pattern at 3mo follow-up.DRT patients were most likely to transform into the other morphological groups,while SRD patients showed minimal transitions.BCVA at baseline was identified as the most important prognostic indicator in all 3 groups.Additionally,DRT patients with a longer clinical course,higher CMT and central retinal vein occlusion(CRVO)tend to exhibit worse BCVA after treatment.In addition,CRVO patients are more likely to have worse BCVA at 2 and 3mo follow-up compared with branch retinal vein occlusion(BRVO)patients in CME group.SRD patients with higher baseline CMT were prone to experiencing worse BCVA after treatment.CONCLUSION:The effectiveness of IVR is strongly correlated with baseline BCVA in all 3 groups.Baseline parameters including clinical course,CMT,and RVO position are also useful in predicting the BCVA at different time points after treatment.展开更多
To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these me...To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly age-related.In this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed laser.We observed the molding process in mice of different ages and presented age-dependent vascular embolism differentiation.Moreover,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a stroke.Our imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.展开更多
The morphological description of wear particles in lubricating oil is crucial for wear state monitoring and fault diagnosis in aero-engines.Accurately and comprehensively acquiring three-dimensional(3D)morphological d...The morphological description of wear particles in lubricating oil is crucial for wear state monitoring and fault diagnosis in aero-engines.Accurately and comprehensively acquiring three-dimensional(3D)morphological data of these particles has became a key focus in wear debris analysis.Herein,we develop a novel multi-view polarization-sensitive optical coherence tomography(PS-OCT)method to achieve accurate 3D morphology detection and reconstruction of aero-engine lubricant wear particles,effectively resolving occlusion-induced information loss while enabling material-specific characterization.The particle morphology is captured by multi-view imaging,followed by filtering,sharpening,and contour recognition.The method integrates advanced registration algorithms with Poisson reconstruction to generate high-precision 3D models.This approach not only provides accurate 3D morphological reconstruction but also mitigates information loss caused by particle occlusion,ensuring model completeness.Furthermore,by collecting polarization characteristics of typical metals and their oxides in aero-engine lubricants,this work comprehensively characterizes and comparatively analyzes particle polarization properties using Stokes vectors,polarization uniformity,and cumulative phase retardation,and obtains a three-dimensional model containing polarization information.Ultimately,the proposed method enables multidimensional information acquisition for the reliable identification of abrasive particle types.展开更多
BACKGROUND Central retinal artery occlusion(CRAO)is a potentially blinding disease,and hyperbaric oxygen therapy(HBOT)is becoming increasingly popular with the support of scientific evidence.Despite the presence of va...BACKGROUND Central retinal artery occlusion(CRAO)is a potentially blinding disease,and hyperbaric oxygen therapy(HBOT)is becoming increasingly popular with the support of scientific evidence.Despite the presence of various acute management measures,there is no clear evidence on the gold standard treatment for CRAO.AIM To identify factors and imaging parameters associated with good visual outcome,which guide ophthalmologists in the triage of CRAO patients for HBOT.METHODS Patients who suffered from CRAO and had a symptom onset≤6 h were recruited for a course of HBOT in a tertiary hospital after failing bedside treatment.Patient demographics,onset time,CRAO eye parameters,and past medical history were prospectively collected.Visual outcomes after HBOT were also analyzed.RESULTS A total of 26 patients were included;the female-to-male ratio was 1:1.6,and the mean age was 67.5 years±13.3 years(range 44–89 years).The mean duration of follow-up and mean visual acuity(VA)improvement were 10.0 mo±5.3 mo and 0.48 logarithm of minimal angle of resolution(logMAR)±0.57 logMAR(approx-imately 9 letters in ETDRS)(P=0.0001,Z=-3.67),respectively.The 1 mm zone of central macular thickness(CMT)on optical coherence tomography was not associated with VA changes(P=0.119);however,the 1-to-3 mm circular rim of CMT was fairly associated(P=0.02,Spearman's coefficient=0.45).Complete retinal perfusion time during fundus fluorescein angiography(FFA)was mode-rately associated(P=0.01,Spearman's coefficient=0.58)with visual outcome.展开更多
A novel suppression method of the phase noise is proposed to reduce the negative impacts of phase noise in coherent optical orthogonal frequency division multiplexing(CO-OFDM)systems.The method integrates the sub-symb...A novel suppression method of the phase noise is proposed to reduce the negative impacts of phase noise in coherent optical orthogonal frequency division multiplexing(CO-OFDM)systems.The method integrates the sub-symbol second-order polynomial interpolation(SSPI)with cubature Kalman filter(CKF)to improve the precision and effectiveness of the data processing through using a three-stage processing approach of phase noise.First of all,the phase noise values in OFDM symbols are calculated by using pilot symbols.Then,second-order Newton interpolation(SNI)is used in second-order interpolation to acquire precise noise estimation.Afterwards,every OFDM symbol is partitioned into several sub-symbols,and second-order polynomial interpolation(SPI)is utilized in the time domain to enhance suppression accuracy and time resolution.Ultimately,CKF is employed to suppress the residual phase noise.The simulation results show that this method significantly suppresses the impact of the phase noise on the system,and the error floors can be decreased at the condition of 16 quadrature amplitude modulation(16QAM)and 32QAM.The proposed method can greatly improve the CO-OFDM system's ability to tolerate the wider laser linewidth.This method,compared to the linear interpolation sub-symbol common phase error compensation(LI-SCPEC)and Lagrange interpolation and extended Kalman filter(LRI-EKF)algorithms,has superior suppression effect.展开更多
Diabetes mellitus ranks among the most prevalent non-communicable diseases worldwide,affecting a vast number of individuals.It can impact almost every organ in the body,leading to serious complications such as diabeti...Diabetes mellitus ranks among the most prevalent non-communicable diseases worldwide,affecting a vast number of individuals.It can impact almost every organ in the body,leading to serious complications such as diabetic retinopathy(DR),diabetic nephropathy,and diabetic neuropathy.Scientific literature indi-cates that patients with severely compromised kidney function may develop non-responsive DR.Moreover,anaemia in individuals with diabetic kidney disease(DKD)complicates DR and can contribute to significant health issues.Optical coherence tomography(OCT)is a widely used non-invasive imaging tool for diagnosing,managing,and predicting DR.OCT findings in patients with DR and DKD include cystoid macular oedema,diffuse retinal thickening,disruptions in the ellipsoid layer,hyperreflective dots,and damage to the external limiting membrane.The review examines OCT patterns of diabetic macular oedema in DKD,correlating these patterns with declines in kidney function and visual acuity.Additionally,we review various biomarkers linked to DR in DKD patients and the growing importance of novel imaging biomarkers in predicting and connecting the severity of DR with DKD.展开更多
AIM:To evaluate the choroidopathy in patients with systemic lupus erythematosus(SLE)using enhanced depth imaging spectral domain optical coherence tomography(EDI SD-OCT)and optical coherence tomography angiography(OCT...AIM:To evaluate the choroidopathy in patients with systemic lupus erythematosus(SLE)using enhanced depth imaging spectral domain optical coherence tomography(EDI SD-OCT)and optical coherence tomography angiography(OCTA).METHODS:A total of 74 patients with SLE and 40 healthy volunteers were included in this cross-sectional study.SLE patients were further divided into three subgroups based on clinical and blood biochemistry findings.Ocular parameters obtained on ophthalmologic examination and optical imaging(EDI SD-OCT and OCTA)included the best corrected distance visual acuity(logMAR CDVA),subfoveal choroidal thickness(SCT),choroidal vascularity index(CVI)and vessel density(VD)of superficial capillary plexus(SCP)and deep capillary plexus(DCP).RESULTS:SLE patients had significantly lower values for CVI and VD of DCP(DVD)than control subjects.Amongst SLE patients,gender and chloroquine dose were found to be independent determinants of CVI while age predicted SCT.Steroid dose was a significant predictor for foveal VD of SCP(SVD),chloroquine dose for parafoveal SVD,gender for total DVD,and gender and steroid dose for perifoveal DVD.No correlation of logMAR CDVA and SCT was noted between SLE patients and control subjects.No correlation of SCT was noted with disease duration,Systemic Lupus Erythematosus Disease Activity Index(SLEDAI)score,hydroxychloroquine(HCQ)dose or steroid dose.No correlation of CVI was noted with patient age,disease duration,SLEDAI score,HCQ dose or steroid dose.No significant difference was noted between SLE subgroups in terms of any of the ocular parameters studied.CONCLUSION:The findings reveal the presence of ocular findings suggestive of early onset choroidopathy on EDI SD-OCT and OCTA in SLE patients,in the absence of ocular manifestations or active disease.展开更多
文摘The linear transmission impairments,such as the timing offset(TO),frequency offset(FO),and chromatic dispersion(CD),are major factors of signal degradations in coherent optical fiber communication systems.The estimation and compensation of such impairments play significant roles in the receiver side digital signal processing(DSP)unit.In this paper,we propose to combat the linear impairments systematically(including TO,FO and CD)with a joint timefrequency signal processing by taking the advantage of fractional Fourier transform(FrFT).In view of geometrical analysis,TO/FO induces a shift in time/frequency coordinate and the CD leads to the rotation in the fractional domain.Both mathematical derivations and geometrical interpretations have been established to unveil the relationships between impairments and linear frequency modulated(LFM)training symbols(TSs).By considering a typical coherent optical orthogonal frequency-division multiplexing(COOFDM)transmission system,three kinds of linear impairments have been jointly estimated by simple geometric calculations using appropriately designed TS based on FrFTs.Simulation and experimental results confirmed the feasibility of time-frequency techniques with better accuracy,less complexity,and improved spectral efficiency.
基金Supported by the Special Fund for Major Scientific Equipment and Instrument Development of the National Natural Science Foundation of China under Grant No 61127901the National Natural Science Foundation of China under Grant Nos 10225417,11273024,61025023 and 91636101+3 种基金the Young Scientists Fund of the National Natural Science Foundation of China under Grant No 11403031the Key Deployment Project of the Chinese Academy of Sciences under Grant No KJZD-EW-W02the Strategic Priority Research Program of the Chinese Academy of Sciences under Grant No XDB21030800the National Key Research and Development Program of China under Grant Nos 2016YFF0200200 and 2016YFF0200205
文摘We demonstrate optical-carrier transfer over a 112-km single-span urban fiber link, By actively compensating the phase noise induced along the fiber link, a noise suppression of 55 dB at 1 Hz is obtained. A fractional frequency instability of 2.5× 10^-16 at i s is achieved, and reaching 7.5× 10^-20 at 10000 s. The system is stable and able to run for a long time. This work will contribute to optical frequency distribution and remote comparison among atomic clocks.
基金Supported by the National Natural Science Foundation of China (60871075)
文摘An improved zero-interpolation method with signal clipping to improve fiber nonlinearity tolerance in the long-haul coherent optical orthogonal frequency division multiplexing system （CO-OFDM） is presented. The new technique is implemented by interpolating zero subcarriers and selecting the odd subcarriers to carry data and clipping conventional CO-OFDM signal at zero. With such a scheme,the effect of fiber nonlinearity can be miti-gated,and the wanted signal carried on odd subcarriers is or-thogonal to clipping noise,which falls on even frequencies. Simu-lation shows that the system Q value is improved by more than 2 dB at the length of 960 km
基金supported by National Natural Science Foundation of China(Nos.31571110 and 81771877)Natural Science Foundation of Zhejiang Province of China(LZ17F050001)the Fundamental Research Funds for the Central Universities.
文摘Two-photon microscopy normally suffers from the scattering of the tissue in biological imaging.Multidither coberent optical adaptive technique(COAT)can correct the scattered wavefront in parallel.However,the determination of the corrective phases may not be completely accurate using conventional method,which undermines the performance of this technique.In this paper,we theoretically demonstrate a method that can obtain more accurate corrective phases by determining the phase values from the square root of the fuorescence signal.A numnerical simulation model is established to study the performance of adaptive optics in two-photon micros-copy by combining scalar diffraction theory with vector diffraction theory.The results show that the distortion of the wavefront can be corrected more thoroughly with our method in two-photon imaging.In our simulation,with the scattering from a 450-mn-thick mouse brain tissue,excitation focal spots with higher peak-to background ratio(PBR)and images with higher contrast can be obtained.Hence,further enhancement of the multidither COAT correction performance in two-photon imaging can be expected.
基金Supported by the National Natural Science Foundation of China under Grant No 61378037the Fundamental Research Funds for the Central Universities under Grant No JUSRP51628B
文摘We demonstrate a triple-pass scheme for coherent transfer of optical frequency and the delay effect on the fiber phase noise compensation. It is theoretically proved that the delay effect consists of both fiber delay and servo delay. The delay effect confines the servo bandwidth within 1/8 and induces a residual fiber phase noise after noise compensation. For a 25-km-long fiber, the servo bandwidth is found to be around 1 k Hz, and the fiber phase noise is suppressed approaching to the theoretical limitation. The triple-pass scheme enables the simultaneous transfer of optical frequency to multiple remote users. The performance of noise compensator in the triple-pass scheme can achieve a similar level result compared with that in the double-pass scheme.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11304362 and 61434005)
文摘A pocket coherent population trapping（CPT） atomic magnetometer scheme that uses a vertical cavity surface emitting laser as a light source is proposed and experimentally investigated.Using the differential detecting magneto–optic rotation effect,a CPT spectrum with the background canceled and a high signal-to-noise ratio is obtained.The experimental results reveal that the sensitivity of the proposed scheme can be improved by half an order,and the ability to detect weak magnetic fields is extended one-fold.Therefore,the proposed scheme is suited to realize a pocket-size CPT magnetometer.
基金supported by the National High Technology Research and Development Program of China(Grant No.2009AA01A345)the National Basic Research Program of China(Grant No.2011CB302702)the National Natural Science Foundation of China(Grant No.60932004)
文摘This paper introduces a joint nonlinearity and chromatic dispersion pre-compensation method for coherent optical orthogonal frequency-division multiplexing systems. The research results show that this method can reduce the walk- off effect and can therefore equalize the nonlinear impairments effectively. Compared with the only other existing nonlinearity pre-compensation method, the joint nonlinearity and chromatic dispersion pre-compensation method is not only suitable for low-dispersion optical orthogonal frequency-division multiplexing system, but also effective for high- dispersion optical orthogonal frequency-division multiplexing transmission system with higher input power but without optical dispersion compensation. The suggested solution does not increase computation complexity compared with only nonlinearity pre-compensation method. For 40 Gbit/s coherent optical orthogonal frequency-division multiplexing 20 × 80 km standard single-mode fibre system, the suggested method can improve the nonlinear threshold （for Q 〉 10 dB） about 2.7, 1.2 and 1.0 dB, and the maximum Q factor about 1.2, 0.4 and 0.3 dB, for 2, 8 and 16 ps/（nm.km） dispersion coefficients.
基金Natural Science Basic Research Project for Education Depart ment of Henan Province Natural ScienceFoundation of Zhumadian City(058001)
文摘Using the mutually coherent function, the self-trapping of the circle partially coherent optical beam in the total internal reflective photonic crystal fiber(TIRPCF) under Compton scattering is studied. The study shows that the composition of the non-coherent optical beam in the optical spectrum and the diffraction effect are decreased by Compton scattering, and the probability of forming the soliton is greatly increased. The vibration peak value in the propagation, compressed degree, changed cycle, and radius of the soliton are all smaller than those before the scattering, but its coherent radius is larger than that before the scattering. In this propagation, the self-focusing plays a key role.
基金project supported by the National Natural Science Foundation of China （Grant Nos 60438020 and 60321003）, and the Knowledge innovation program of the Chinese Academy of Sciences （Grant No KJCX2-SW-W14）.
文摘The coherent exciton plays an important role in the photosynthetic primary process, and its functions are deeply dependent on the orientation arrangements of local transition dipole moments （TDMs）. We theoretically and systematically study the physical property of the coherent exciton at different orientation arrangements of the local TDMs in circular light-harvesting （LH） complexes. Especially, if the orientation arrangements are different, the delocalized TDMs of the coherent excitons and the energy locations of the optically active coherent excitons （OACEs） can be obviously different, and then there are more manners to capture, store and transfer light energy in and between LH complexes. Similarly, if the orientation arrangements are altered, light absorption and radiative intensities can be converted fully between the OACEs in the upper and lower coherent exciton bands, and then the blue and red shifts of the absorption and radiative bands of the pigment molecules can occur simultaneously at some orientation arrangements. If the systems are in the vicinities of the critical orientation arrangements, the weak static disorder or small thermal excitation can destroy the coherent electronic excitations, and then the coherent exciton cannot exist any more.
基金supported by National Natural Science Foundation of China (No. 61077053, 60932004, and60877045)National Basic Research Program of China(No. 2010CB328201)
文摘Fiber nonlinearity is one of the most important limiters of capacity in coherent optical communications. In this paper, we review two nonlinear compensation methods： digital backward propagation （BP） and nonlinear electrical equalizer （NLEE） based on the timedomain Volterra series. These compensation algorithms are implemented in a singlechannel 50 Gb/s coherent optical singlecarrier frequency division multiplexed （CO-SCFDM） system transmitting over 10 × 80 km of standard singlemode fiber （SSMF）.
基金the Alexander von Humboldt Foundation for their support。
文摘Future high-speed mobile communication systems require low latency and high capacity networks.Coherent wavelength division multiplexing(WDM)passive optical network(PON)scheme is expected to play a vital role in these systems.In this paper,coherent WDM-PON scheme based on dual-polarization 16-quadrature amplitude modulation(DP-16 QAM)transceiver has been investigated.The aim of this scheme is to build a 2 Tbit/s(125 Gbit/s/λ×16 wavelengths)network that will be used in the construction of the transport architecture of fifth generation(5 G)and beyond 5 G(B5 G)cellular networks either in mobile front haul(MFH)or mobile back haul(MBH).The results indicate that the proposed scheme is very adequate for both 5 G and B5 G cellular networks requirements.
文摘AIM:To investigate the value of optical coherence tomography angiography(OCTA)indicators in the diagnosis of diabetic retinopathy(DR),and to provide patients with diabetic nephropathy(DN)with more sensitive OCTA screening indicators to detect concurrent DR at an early stage.METHODS:A total of 200 patients who treated in the ophthalmology department of the Seventh Affiliated Hospital,Sun Yat-sen University from 2022 to 2023 were included,including 95 first-diagnosed DR patients and 105 patients without DR,and all patients underwent OCTA examination and a collection of demographics and renal function parameters.After a quality check,automated measurements of the foveal avascular zone area,vessel density(VD),and perfusion density(PD)of both 3 mm×3 mm and 6 mm×6 mm windows were obtained.RESULTS:Using random forest and multivariate Logistic regression methods,we developed a diagnostic model for DR based on 12 variables(age,FBG,SBP,DBP,HbA1c,ALT,ALP,urea/Scr,DM duration,HUA,DN,and CMT).Adding specific OCTA parameters enhanced the efficacy of the existing diagnostic model for DR(outer vessel density in 6 mm×6 mm window,AUC=0.837 vs 0.819,P=0.03).In the study of DN patients,the parameters in the 6 mm×6 mm window improved the diagnostic efficacy of DR(inner VD;outer VD;full VD;outer PD;full PD).CONCLUSION:The outer VD in the 6 mm×6 mm window can enhance the efficacy of the traditional DR diagnostic model.Meanwhile,compared with the 3 mm×3 mm window,the microvascular parameters in the 6 mm×6 mm window focusing on DN patients can be more sensitive to diagnosing the occurrence of DR.
文摘BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management strategies.Vascular and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated damage.With the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural changes.AIM To study the macular microvascular and structural changes on OCTA in atypical optic neuritis.METHODS This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy controls.Macular vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using OCTA.RESULTS There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy controls.NMOSD and MOGAD affected eyes had significant GCIPL thinning compared with healthy controls.NMOSD unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected eyes.On comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected eyes.CONCLUSION Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.
基金Supported by the Suzhou Medical Innovation Application Research Project(SZM2023027).
文摘AIM:To explore the morphological and functional parameters to evaluate the effectiveness of intravitreal injections of ranibizumab(IVR)in treating macular edema(ME)secondary to retinal vein occlusion(RVO).METHODS:This retrospective study involved 65 RVO patients(65 eyes)who received IVR and were followedup for more than 3mo.ME was categorized into cystoid macular edema(CME),diffuse retinal thickening(DRT),and serous retinal detachment(SRD)according to optical coherence tomography(OCT)images.The comparison of best corrected visual acuity(BCVA;logMAR)and central macular thickness(CMT)among different follow-up points and those among 3 groups were performed by Kruskal-Wallis test.The correlation between BCVA and baseline parameters during treatment was analyzed using Spearman correlation analysis.RESULTS:BCVA tended to improve in all groups,with marked improvement in CME and DRT groups.CMT showed the greatest reduction after 1wk,and remained stable over the following 3mo.DRT patients had the worst BCVA and the highest CMT at baseline,but the differences became smaller after IVR treatment.CMT in SRD group was significantly better than in CME and DRT groups 3mo after IVR.Most patients of CME and SRD groups transitioned to a normal pattern at 3mo follow-up.DRT patients were most likely to transform into the other morphological groups,while SRD patients showed minimal transitions.BCVA at baseline was identified as the most important prognostic indicator in all 3 groups.Additionally,DRT patients with a longer clinical course,higher CMT and central retinal vein occlusion(CRVO)tend to exhibit worse BCVA after treatment.In addition,CRVO patients are more likely to have worse BCVA at 2 and 3mo follow-up compared with branch retinal vein occlusion(BRVO)patients in CME group.SRD patients with higher baseline CMT were prone to experiencing worse BCVA after treatment.CONCLUSION:The effectiveness of IVR is strongly correlated with baseline BCVA in all 3 groups.Baseline parameters including clinical course,CMT,and RVO position are also useful in predicting the BCVA at different time points after treatment.
基金supported by University of Macao,China,Nos.MYRG2022-00054-FHS and MYRG-GRG2023-00038-FHS-UMDF(to ZY)the Macao Science and Technology Development Fund,China,Nos.FDCT0048/2021/AGJ and FDCT0020/2019/AMJ and FDCT 0011/2018/A1(to ZY)Natural Science Foundation of Guangdong Province of China,No.EF017/FHS-YZ/2021/GDSTC(to ZY)。
文摘To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly age-related.In this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed laser.We observed the molding process in mice of different ages and presented age-dependent vascular embolism differentiation.Moreover,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a stroke.Our imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.
文摘The morphological description of wear particles in lubricating oil is crucial for wear state monitoring and fault diagnosis in aero-engines.Accurately and comprehensively acquiring three-dimensional(3D)morphological data of these particles has became a key focus in wear debris analysis.Herein,we develop a novel multi-view polarization-sensitive optical coherence tomography(PS-OCT)method to achieve accurate 3D morphology detection and reconstruction of aero-engine lubricant wear particles,effectively resolving occlusion-induced information loss while enabling material-specific characterization.The particle morphology is captured by multi-view imaging,followed by filtering,sharpening,and contour recognition.The method integrates advanced registration algorithms with Poisson reconstruction to generate high-precision 3D models.This approach not only provides accurate 3D morphological reconstruction but also mitigates information loss caused by particle occlusion,ensuring model completeness.Furthermore,by collecting polarization characteristics of typical metals and their oxides in aero-engine lubricants,this work comprehensively characterizes and comparatively analyzes particle polarization properties using Stokes vectors,polarization uniformity,and cumulative phase retardation,and obtains a three-dimensional model containing polarization information.Ultimately,the proposed method enables multidimensional information acquisition for the reliable identification of abrasive particle types.
文摘BACKGROUND Central retinal artery occlusion(CRAO)is a potentially blinding disease,and hyperbaric oxygen therapy(HBOT)is becoming increasingly popular with the support of scientific evidence.Despite the presence of various acute management measures,there is no clear evidence on the gold standard treatment for CRAO.AIM To identify factors and imaging parameters associated with good visual outcome,which guide ophthalmologists in the triage of CRAO patients for HBOT.METHODS Patients who suffered from CRAO and had a symptom onset≤6 h were recruited for a course of HBOT in a tertiary hospital after failing bedside treatment.Patient demographics,onset time,CRAO eye parameters,and past medical history were prospectively collected.Visual outcomes after HBOT were also analyzed.RESULTS A total of 26 patients were included;the female-to-male ratio was 1:1.6,and the mean age was 67.5 years±13.3 years(range 44–89 years).The mean duration of follow-up and mean visual acuity(VA)improvement were 10.0 mo±5.3 mo and 0.48 logarithm of minimal angle of resolution(logMAR)±0.57 logMAR(approx-imately 9 letters in ETDRS)(P=0.0001,Z=-3.67),respectively.The 1 mm zone of central macular thickness(CMT)on optical coherence tomography was not associated with VA changes(P=0.119);however,the 1-to-3 mm circular rim of CMT was fairly associated(P=0.02,Spearman's coefficient=0.45).Complete retinal perfusion time during fundus fluorescein angiography(FFA)was mode-rately associated(P=0.01,Spearman's coefficient=0.58)with visual outcome.
基金supported by the National Natural Science Foundation of China(Nos.U21A20447 and 61971079)。
文摘A novel suppression method of the phase noise is proposed to reduce the negative impacts of phase noise in coherent optical orthogonal frequency division multiplexing(CO-OFDM)systems.The method integrates the sub-symbol second-order polynomial interpolation(SSPI)with cubature Kalman filter(CKF)to improve the precision and effectiveness of the data processing through using a three-stage processing approach of phase noise.First of all,the phase noise values in OFDM symbols are calculated by using pilot symbols.Then,second-order Newton interpolation(SNI)is used in second-order interpolation to acquire precise noise estimation.Afterwards,every OFDM symbol is partitioned into several sub-symbols,and second-order polynomial interpolation(SPI)is utilized in the time domain to enhance suppression accuracy and time resolution.Ultimately,CKF is employed to suppress the residual phase noise.The simulation results show that this method significantly suppresses the impact of the phase noise on the system,and the error floors can be decreased at the condition of 16 quadrature amplitude modulation(16QAM)and 32QAM.The proposed method can greatly improve the CO-OFDM system's ability to tolerate the wider laser linewidth.This method,compared to the linear interpolation sub-symbol common phase error compensation(LI-SCPEC)and Lagrange interpolation and extended Kalman filter(LRI-EKF)algorithms,has superior suppression effect.
文摘Diabetes mellitus ranks among the most prevalent non-communicable diseases worldwide,affecting a vast number of individuals.It can impact almost every organ in the body,leading to serious complications such as diabetic retinopathy(DR),diabetic nephropathy,and diabetic neuropathy.Scientific literature indi-cates that patients with severely compromised kidney function may develop non-responsive DR.Moreover,anaemia in individuals with diabetic kidney disease(DKD)complicates DR and can contribute to significant health issues.Optical coherence tomography(OCT)is a widely used non-invasive imaging tool for diagnosing,managing,and predicting DR.OCT findings in patients with DR and DKD include cystoid macular oedema,diffuse retinal thickening,disruptions in the ellipsoid layer,hyperreflective dots,and damage to the external limiting membrane.The review examines OCT patterns of diabetic macular oedema in DKD,correlating these patterns with declines in kidney function and visual acuity.Additionally,we review various biomarkers linked to DR in DKD patients and the growing importance of novel imaging biomarkers in predicting and connecting the severity of DR with DKD.
文摘AIM:To evaluate the choroidopathy in patients with systemic lupus erythematosus(SLE)using enhanced depth imaging spectral domain optical coherence tomography(EDI SD-OCT)and optical coherence tomography angiography(OCTA).METHODS:A total of 74 patients with SLE and 40 healthy volunteers were included in this cross-sectional study.SLE patients were further divided into three subgroups based on clinical and blood biochemistry findings.Ocular parameters obtained on ophthalmologic examination and optical imaging(EDI SD-OCT and OCTA)included the best corrected distance visual acuity(logMAR CDVA),subfoveal choroidal thickness(SCT),choroidal vascularity index(CVI)and vessel density(VD)of superficial capillary plexus(SCP)and deep capillary plexus(DCP).RESULTS:SLE patients had significantly lower values for CVI and VD of DCP(DVD)than control subjects.Amongst SLE patients,gender and chloroquine dose were found to be independent determinants of CVI while age predicted SCT.Steroid dose was a significant predictor for foveal VD of SCP(SVD),chloroquine dose for parafoveal SVD,gender for total DVD,and gender and steroid dose for perifoveal DVD.No correlation of logMAR CDVA and SCT was noted between SLE patients and control subjects.No correlation of SCT was noted with disease duration,Systemic Lupus Erythematosus Disease Activity Index(SLEDAI)score,hydroxychloroquine(HCQ)dose or steroid dose.No correlation of CVI was noted with patient age,disease duration,SLEDAI score,HCQ dose or steroid dose.No significant difference was noted between SLE subgroups in terms of any of the ocular parameters studied.CONCLUSION:The findings reveal the presence of ocular findings suggestive of early onset choroidopathy on EDI SD-OCT and OCTA in SLE patients,in the absence of ocular manifestations or active disease.
