This study investigated the relationship between parental cognitive ability and child logical reasoning ability,and the role of academic expectation and family environment in that relationship.Based on the 2020 China ...This study investigated the relationship between parental cognitive ability and child logical reasoning ability,and the role of academic expectation and family environment in that relationship.Based on the 2020 China Family Panel Studies(CFPS)data,1491 children(girls ratio=53.78%;average grade=6.023 years,school grade standard deviation=1.825 years).Results following multiple regression model(OLS)show that the higher the parental cognitive ability,the higher the children’s logical reasoning ability.Secondly,parental academic expectation serves as a mediator between their cognitive ability and children’s logical reasoning ability for higher logical reasoning by children.Third,a possible family environment acts as a mediator in the relationship between parents’cognitive ability and children’s logical reasoning ability to be higher.We conclude from thesefindings that parents with high cognitive abilities can enhance their children’s logical reasoning skills not only by setting higher academic expectations,but also by cultivating a supportive family environment.Thesefindings imply a need for intervention to improve family quality of life to enhance children’s thinking abilities to optimize their academic learning.展开更多
BACKGROUND The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.AIM To explore the intervention value of a drug-p...BACKGROUND The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.AIM To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.METHODS Overall,98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study(50 patients)and control groups(48 patients).For 3 months,the control group was treated with conventional drugs,and the research group with a comprehensive intervention model of drug-psychology-society-skills.Data were obtained for the mini mental assessment scale(MMSE),Montreal cognitive assessment scale(MoCA),positive and negative symptom scale,insight and treatment attitude scale,cognitive ability scale and social skills[personal and social function scale(PSP)].The adverse reactions were observed.RESULTS After the intervention,the MMSE and MoCA scores improved in both groups.MoCA scores in the study group(26.58±3.21)were significantly(P<0.05)higher than those in the control group(24.68±3.02),MMSE scores were not significantly higher.Post-intervention,positive and negative symptom scores improved in both groups,and the positive and negative symptom scores in the study group[(12.01±2.58)and(32.51±2.11)]were significantly(P<0.05)different than those in the control group[(14.54±2.33)and(33.74±2.55)].Post-intervention,insight and treatment attitudes questionnaire scores of both groups were improved and compared with the control group(7.97±3.02),the study group(13.56±6.35)had significantly(P<0.05)higher scores.Post-intervention,the MATRICS consensus cognitive battery score of both groups was improved and compared with the control group(38.44±6.23),the score of the study group was significantly(P<0.05)increased(43.51±6.01).Post-intervention,the PSP score of the study group(78.38±6.63)was significantly(P<0.05)higher than that of the control group(74.52±7.01).During the intervention period,the incidence of adverse reactions in the study group was 6.25%,not significantly different from that in the control group(8.33%).During the intervention,both groups experienced adverse reactions,with no significant difference between groups(P>0.05).CONCLUSION The comprehensive intervention model based on drug-psychology-society-skills has obvious intervention effects on patients with chronic schizophrenia,which improves their cognitive ability and reduces their positive and negative symptoms.Simultaneously,it improves the self-knowledge of patients,improves their attitude toward treatment,effectively promotes the recovery of patients'social functions,and is safe.Therefore,it is worthy of being vigorously promoted and widely used in clinics.展开更多
Objectives:This study aimed to investigate the protective effects and underlying mechanisms of aerobic intermittent exercise on cognitive impairment by PM_(2.5)exposure.Methods:Thirty-two rats were randomly divided in...Objectives:This study aimed to investigate the protective effects and underlying mechanisms of aerobic intermittent exercise on cognitive impairment by PM_(2.5)exposure.Methods:Thirty-two rats were randomly divided into four groups:sedentary,exercise,sedentary+PM_(2.5)exposure,and exercise+PM_(2.5)exposure.The exercise groups underwent 8 weeks of exercise training(5 days of exercise per week).Subsequently,PM_(2.5)exposure groups were subjected to PM_(2.5)for three weeks.Post-exposure,we assessed cognitive abilities(shuttle box test),hippocampal tissue structure,related inflammatory factors(TNF-α,IL-6,IL-1β),the protein of inflammatory responses mechanism(P65,IκκB)and cognitiverelated protein levels(BDNF,Aβ-42).Results:PM_(2.5)exposure caused cognitive impairment,abnormal histopathological changes,reduced cognitive related protein and increased pro-inflammatory cytokine levels.Analysis of shuttle box test data revealed significant main effects on the passive avoidance latency times measured in rats(p<0.05).Aerobic intermittent exercise improves spatial learning decline in rats induced by PM_(2.5).Conversely,the Exercise+PM_(2.5)group demonstrated a significant reduction in latency of 24.9%compared to the Sedentary+PM_(2.5)group(p<0.05,ES=1.41).Conclustion:Aerobic intermittent exercise may help in protecting against the decrease of cognitive ability induced by PM_(2.5)exposure.展开更多
The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concen...The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concentrated oxygen administration. This study investigated changes in cognitive ability, blood oxygen saturation （%）, and heart rate （beats/min） in normal elderly subjects at three different levels of oxygen [21% （1 L/min）, 93% （1 L/min）, and 93% （5 L/min）] administered during a 1-back task. Eight elderly male （75.3 ＋ 4.3 years old） and 10 female （71.1 ＋ 3.9 years old） subjects, who were normal in cognitive ability as shown by a score of more than 24 points in the Mini-Mental State Examination-Korea, participated in the experiment. The experiment consisted of an adaptation phase after the start of oxygen administration （3 minutes）, a control phase to obtain stable baseline measurements of heart rate and blood oxygen saturation before the task （2 minutes） and a task phase during which the 1-back task was performed （2 minutes）. Three levels of oxygen were administered throughout the three phases （7 minutes）. Blood oxygen saturation and heart rate were measured during each phase. Our results show that blood oxygen saturation increased, heart rate decreased, and response time in the 1-back task decreased as the concentration and amount of administered oxygen increased. This shows that administration of sufficient oxygen for optimal cognitive functioning increases blood oxygen saturation and decreases heart rate.展开更多
Cognitive ability is important component of competitive ability of athletes,an important content of winning elements in sports,and an important topic of modern sports training and scientific research.These problems wi...Cognitive ability is important component of competitive ability of athletes,an important content of winning elements in sports,and an important topic of modern sports training and scientific research.These problems will restrict the improvement of athletes’cognitive ability and mental level.Based on the theory of psychology,use multiple hierarchical thinking,research cognitive theory of sports and the characteristics of cognitive ability of elite athletes,research the structure element system of cognitive ability,construct a two-level structure model of the cognitive ability of excellent athletes,summarize specific characteristics of the first level elements,and apply psychological cognitive theory to the training of modern Olympic Games mobilization,so as to provide valuable cognitive training,psychological training,and intelligence training for athletes theoretical guidance.展开更多
Using a sample of~3,100 U.S.counties,we tested geoclimatic explanations for why cognitive ability varies across geography.These models posit that geoclimatic factors will strongly predict cognitive ability across geog...Using a sample of~3,100 U.S.counties,we tested geoclimatic explanations for why cognitive ability varies across geography.These models posit that geoclimatic factors will strongly predict cognitive ability across geography,even when a variety of common controls appear in the regression equations.Our results generally do not support UV radiation(UVR)based or other geoclimatic models.Specifically,although UVR alone predicted cognitive ability at the U.S.county-level(β=-.33),its validity was markedly reduced in the presence of climatic and demographic covariates(β=-.16),and was reduced even further with a spatial lag(β=-.10).For climate models,average temperature remained a significant predictor in the regression equation containing a spatial lag(β=.35).However,the effect was in the wrong direction relative to typical cold weather hypotheses.Moreover,when we ran the analyses separately by race/ethnicity,no consistent pattern appeared in the models containing the spatial lag.Analyses of gap sizes across counties were also generally inconsistent with predictions from the UVR model.Instead,results seemed to provide support for compositional models.展开更多
Human cognition ability comes from sensory experience or gift concept.This is the difference between empiricism and rationalism in the two major factions of Western European philosophy in the 16th and 18th centuries.T...Human cognition ability comes from sensory experience or gift concept.This is the difference between empiricism and rationalism in the two major factions of Western European philosophy in the 16th and 18th centuries.The weakness of empiricism is that it is impossible to obtain knowledge with universal necessity from complicated experience,and the inability to obtain new knowledge is the weakness of theory.How to reconcile the contradiction between the two has become a new theme.This paper will cut into the three aspects of philosophy,geometry,and modern business economy,and explore the innate nature of cognitive ability and the characteristics of human self-renewal that are manifested in the process of self-development of cognitive ability.Its significance is not only to explore the essence of human beings,but also to give hope to the multiple possibilities of human beings.展开更多
Areca nut is the basic ingredient of betel quid,which is chewed by hundreds of millions of people in South-Eastern Asia.Chewing of areca nut has been associated with oral cancers potentially due to its specific alkalo...Areca nut is the basic ingredient of betel quid,which is chewed by hundreds of millions of people in South-Eastern Asia.Chewing of areca nut has been associated with oral cancers potentially due to its specific alkaloids,among which arecoline constitutes about 90%of total fraction.Being the world’s fourth most commonly used psychoactive substance,arecoline evokes stimulation,addiction,and other direct neurological effects,while its misuse correlates to neurotoxic effects.However,what might underlie its neurotoxic mechanisms has been poorly documented.The brain is encoded by a complex network of neuronal and glial cell types,and neurotoxicity of hazardous compounds present transcriptional heterogeneity.Recently,the eusocial bumblebee has been used as a model for studying brain effects,with sophisticated cognitive capability and precisely measured brain architecture.Here,we decipher cell-type-specific mental risks to arecoline using bumblebees.Arecoline induced locomotor hyperactivity and cognitive impairment.Single nucleus RNA sequencing(snRNA-seq)unearthed arecoline-induced cell-specific responses,primarily targeted on Kenyon cells(KC).Moreover,high-dose arecoline induced distinctive cell responses among KC subtypes,particularly class I large Kenyon cell(lKC),leading to DNA damage,excitatory/inhibitory(E/I)imbalance,and calcium dyshomeostasis,which potentially resulted in cognitive impairment.Given arecoline’s popularity and growing exposure risks to humans,neurological health risks of areca nut warrant serious consideration.展开更多
The study aims to determine the validity and reliability of the Wechsler Preschool and Primary Scale of Intelligence–Third Edition(WPPSI-III)scores in a sample of kindergarten and lower primary pupils from Khartoum S...The study aims to determine the validity and reliability of the Wechsler Preschool and Primary Scale of Intelligence–Third Edition(WPPSI-III)scores in a sample of kindergarten and lower primary pupils from Khartoum State,Sudan.It also aims to examine whether test’s factor structure in this sample replicated that of the original WPPSI-III.The study sample consisted of 384 kindergarten and primary school children in Khartoum State(females=50%mean age=4.14,SD=1.37),selected using stratified random sampling across its seven localities:Khartoum,Jebel Awliya,Khartoum Bahri,East Nile,Omdurman,Ombada,Karari.For concurrent validation,the children additionally completed the Goodenough Draw-a-Man Test,and the Colored Progressive Matrices.WPPSI-III scores demonstrated high internal consistency across the subtest items.Confirmatory factor analysis indicators for total,verbal,and performance intelligence were all excellent.The scale also showed weak to strong score stability ranging from 0.25(weak)to 0.88(strong)based on the Spearman-Brown equation,0.25 to 0.75 based on the Guttman split-half method.The Cronbach’s alpha coefficient scores ranged from 0.54 to 0.93.The WPPSI-III and Goodenough Draw-a-Man Test scores concurrent validity scores were poor(0.05)to modest(0.31),and while those with the Colored Progressive Matrices test were poor(r=0.04–0.18).Thesefindings provide evidence to suggest that the WPPSI-III is appropriate for research use with kindergarten and lower primary school students in Khartoum State,Sudan.展开更多
This is a replication of Tyler and Bro's study (1992) on the effect of discourse level phenomena on audience perception of comprehensibility. 53 Chinese students of English and 10 native English speakers were take...This is a replication of Tyler and Bro's study (1992) on the effect of discourse level phenomena on audience perception of comprehensibility. 53 Chinese students of English and 10 native English speakers were taken as informants to a questionnaire, in which orders of ideas, discourse miscues and other types of errors (e.g. cohesion and redundant ideas, etc.) were used as variables to see whether they could affect the comprehensibility of texts. Strong resemblances were found between the two groups. Order of ideas (i.e. deductive or inductive) seems not to have affected text comprehensibility much, but the interactive cumulating miscues at the discourse level played an important role in discourse comprehension. As disparities are found between what nonnative speakers do and how they react to what they have done, the paper discusses whether people think the way they write, and if linguistic competence correlates with cognitive ability. The paper suggests that knowing and doing are two aspects of learning; teachers of English, therefore, have to understand the perplexities second language learners face and try to help them write as effectively as possible in the target language.展开更多
Progressive memory loss and cognitive impairment are the main clinical manifestations of Alzheimer’s disease(AD).Currently,there is no effective drug available for the treatment of AD.Previous studies have demonstrat...Progressive memory loss and cognitive impairment are the main clinical manifestations of Alzheimer’s disease(AD).Currently,there is no effective drug available for the treatment of AD.Previous studies have demonstrated that the cognitive impairment of AD is associated with oxidative stress and the inhibition of AKT and ERK phosphorylation.Grape seed proanthocyanidin extract(GSPE)has been shown to have strong antioxidant effect and can protect the nervous system from oxidative stress damage.This study aimed to investigate the protective effect of GSPE on the cognitive and synaptic impairments of AD using a sporadic AD rat model induced by intracerebroventricular(ICV)injection of streptozotocin(STZ)(ICV-STZ).Rats were treated with GSPE(50,100,or 200 mg/kg every day)by intragastrical(ig.)administration for continuous 7 weeks,and ICV-STZ(3 mg/kg)was performed on the first day and third day of week 5.Learning and memory abilities were assessed by the Morris water maze(MWM)test at week 8.After behavioral test,hippocampal long-term potentiation(LTP)was recorded,and the levels of malondialdehyde(MDA),superoxide dismutases(SOD),glutathione(GSH)and the protein expression of AKT and ERK were measured in the hippocampus and cerebral cortex of rats.Our study revealed that ICV-STZ significantly impaired the working learning ability and hippocampal LTP of rats,significantly increased the levels of MDA,and decreased the activity of SOD and GSH in the hippocampus and cerebral cortex.In contrast,GSPE treatment prevented the impairment of cognitive function and hippocampal LTP induced by ICV-STZ,decreased the level of MDA,and increased the level of SOD and GSH.Furthermore,Western blot results showed that GSPE treatment could prevent the loss of AKT and ERK activities in the hippocampus and cerebral cortex induced by ICV-STZ.Our findings demonstrate that GSPE treatment could ameliorate the impairment of cognitive ability and hippocampal synaptic plasticity in a rat model of sporadic AD by inhibiting oxidative stress and preserving AKT and ERK activities.Therefore,GSPE may be an effective agent for the treatment of cognitive deficits associated with sporadic AD.展开更多
Standardized Ginkgo biloba leaf extract has been used in clinical trials for its beneficial effects on brain func- tions, particularly in dementia. Substantial experimental evidences indicated that Ginkgo biloba leaf ...Standardized Ginkgo biloba leaf extract has been used in clinical trials for its beneficial effects on brain func- tions, particularly in dementia. Substantial experimental evidences indicated that Ginkgo biloba leaf extract （EGB） protected neuronal cells from a variety of insults. We investigated the effect of EGB on cognitive ability and protein kinase B （PKB） activity in hippocampal neuronal cells of dementia model rats. Rats received an intra- peritoneal injection of D-galactose to induce dementia. Forty-eight Spraque-Dawley rats were randomly divided into six groups, including the control group, D-galactose group （Gal）, low-dose EGB group （EGB-L）, mid-dose EGB group （EGB-M）, high-dose EGB group （EGB-H） and treatment group. The EGB-L, EGB-M and EGB-H groups were administered with EGB and D-galactose simultaneously. Y-maze, cresyl violet staining, TUNEL assays and immunohistochemistry staining were performed to detect learning and memory abilities, morpho- logical changes in the hippocampus, neuronal apoptosis and the expressing level of phospho-PKB, respectively. Rats in the Gal group showed decreased abilities of learning and memory, and hippocampal pyramidal cell layer was damaged, while EGB administration improved learning and memory abilities. The Gal group exhibited many stained, condensed nuclei and micronuclei, either isolated or within the cytoplasm of cells （39.5 ± 1.4）. Apoptotic cells decreased in the groups of EGB-L （35.9±0.9）, EGB-M （16.8± 1.0） and EGB-H （10.1±0.8）, and there were statistical significances compared with the Gal group. Immunoreactivity of phospho-PKB was localized diffusely throughout the cytosol of cells in all groups, while the immunoreactivity of the Gal group was weak. EGB signifi- cantly attenuated learning and memory impairment in a dose-dependent manner, while it could decrease the nmber of TUNEL-positive cells, and increase the activity of PKB. Our results demonstrated that EGB attenuated memory impairment and cell apoptosis in galactose-induced dementia model rats by activating PKB.展开更多
1 A study shows that music lessons obviously enhance children's cognitive abilities,including short⁃term memory and planning,which lead to improving academic performance.The research is the first large⁃scale and l...1 A study shows that music lessons obviously enhance children's cognitive abilities,including short⁃term memory and planning,which lead to improving academic performance.The research is the first large⁃scale and long⁃term study to be adapted into the regular school curriculum.Visual arts lessons were also found to significantly improve children's visual memory.展开更多
Animal behavioral studies are often combined with research concerning cognitive abilities.Larger brains usually mean more complex neural networks and advanced cognitive functions.By measuring the brain size of differe...Animal behavioral studies are often combined with research concerning cognitive abilities.Larger brains usually mean more complex neural networks and advanced cognitive functions.By measuring the brain size of different individual animals,we can explore differences in behavioral complexity between populations or species.However,obtaining accurate measurements of brain size is challenging both in field and laboratory environments,especially for rare and endangered species.Therefore,there is an urgent need to develop reliable methods for performing cranial brain mass.This study tests which external structures of the avian head can most accurately predict brain size.We selected five bird species from four orders,categorized external head measures into three types of parameters(direct,calculated and composite measurements),and analyzed these in relation to brain mass.The results showed that while head size can partially explain brain mass,the parameters of head height x head width were the most accurate predictors of brain mass in birds(90.4%).In addition,the positive correlation between endocranial volume and brain mass once again confirmed that avian endocranial volume can,to a certain extent,serve as a valid proxy for brain mass.Our study demonstrates that in the future we can more conveniently perform non-invasive measurements to better understand the relationship between bird brain size and behavior,ecology,and evolution.展开更多
Purpose:This study compared the relative effectiveness of Chinese calligraphy handwriting(CCH)and acupuncture in the treatment of patients with senile dementia.Materials and Methods:A randomized controlled trial(RCT)w...Purpose:This study compared the relative effectiveness of Chinese calligraphy handwriting(CCH)and acupuncture in the treatment of patients with senile dementia.Materials and Methods:A randomized controlled trial(RCT)with 17 mild-to-moderate dementia patients with an average age of 77.29 years were randomly assigned with 9 to the calligraphy handwriting group and 8 to the acupuncture treatment group for a month of consecutive treatment.The participants'cognitive abilities,as well as symptoms of senile dementia,were measured by the Chinese version of the Mini-mental State Examination(CMMSE)and the Chinese Medicine Quantitative Diagnostic Survey for Senile Dementia Symptoms,respectively,before and after the treatment.Results:The calligraphy group showed a significant increase in calculation and memory as well as a decline in the symptoms of senile dementia.Patients in the acupuncture group experienced a significant growth in total CMMSE scores and the subscales in orientation to time and place,behavioral operations,as well as reduced clinical symptoms.However,no significant changes were found in their memory and calculation abilities.Conclusion:Both CCH and acupuncture treatments were found significantly effective for,respectively,enhancing the patients'cognitive abilities and reducing their clinical symptoms.Further,calligraphy handwriting also improved the level of their attention and concentration,physical relaxation,and emotional stability.展开更多
In English business news discourses, there are numerous financial words or terms which are quite difficult for readers to under-stand, especially those ones built on the basis of metaphorical mechanism. Conceptual Met...In English business news discourses, there are numerous financial words or terms which are quite difficult for readers to under-stand, especially those ones built on the basis of metaphorical mechanism. Conceptual Metaphor has a strong power to explain the cor-rect meaning of these words with their specific types of metaphors. Through the explanation of the meaning construction of the metaphori-cal words, it can be a great help for the news readers to master the accurate and deep-seated messages in the discourse. Simultaneously,it gives the reader an insight into the English culture in order to grasp the international economic trends and makes them accomplishcross-cultural communication task with ease.展开更多
As Internet slang and memes increasingly make their way into school-age children's daily conversations and even formal writing,educators are concerned that its excessive use could lead to a decline in their lingui...As Internet slang and memes increasingly make their way into school-age children's daily conversations and even formal writing,educators are concerned that its excessive use could lead to a decline in their linguistic and cognitive abilities."BBQ le,we're all done for!" shouted a boy in Yu Gu’s class,prompting her fourth graders to burst out laughing.Pronounced ba hi cue le,the phrase is a homonym for“barbecue”often used in Chinese internet slang to express that“someone messed up.”展开更多
Alzheimer's disease(AD)is a prevalent neurodegenerative disorder among the elderly population,and timely intervention has been shown to effectively slow down the progression of dementia stage.(1)Although drugs suc...Alzheimer's disease(AD)is a prevalent neurodegenerative disorder among the elderly population,and timely intervention has been shown to effectively slow down the progression of dementia stage.(1)Although drugs such as memantine,donepezil,and quetiapine are commonly used in treatment of AD,they do not significantly enhance cognitive abilities or ameliorate memory loss in AD patients.Acupuncture,a non-pharmacological therapy rooted in Chinese medicine,has demonstrated certain efficacy in improving cerebral blood circulation through acupoint stimulation,thereby potentially slowing down the progression of AD.(2)Stellate ganglion block can augment cerebral blood flow(CBF)by inhibiting sympathetic nerve activity,however,there is currently no clinical evidence regarding its application for treating AD.Therefore,integrated Chinese and Western medicine holds promise for enhancing memory function and improving quality of life in AD patients.Arterial spin labeling-magnetic resonance imaging(ASL-MRI)perfusion imaging can be employed to identify reduced CBF specifically within the hippocampus and limbic system of individuals with AD;this technique serves as a sensitive indicator for evaluating therapeutic outcomes.(3)Herein we present a case study involving an individual with AD who underwent integrative treatment focusing on CBF alterations within brain regions associated with the disease along with neurocognitive assessment.展开更多
Extra-pair paternity(EPP)benefits to improve the reproductive success via extra-pair fertilizations without the costs of parental care in males and through improved offspring quality with additional food and parental c...Extra-pair paternity(EPP)benefits to improve the reproductive success via extra-pair fertilizations without the costs of parental care in males and through improved offspring quality with additional food and parental care in females among species of birds.Variations in the EPP appear to link to behavioral and ecological factors and sexual selection.According to the“relationship intelligence hypothesis”,the cognitive abilities of the birds play an important role in maintaining long-term relationships.Here,we undertook thefirst comparative test of the relationships between extra-pair paternity and brain size,testis size,and life histories among 315 species of birds using phylogenetically controlled comparative analyses and path analysis.After controlling for the effects of shared ancestry and body mass,the frequency of EPP was negatively correlated with relative brain size,but positively with testis size across species of birds.However,the frequency of EPP was not linked to life-history traits(e.g.incubation period,fledging period,clutch size,egg mass,and longevity).Ourfindings suggest that large-brained birds associated with enhanced cognitive abilities are more inclined to maintain long-term stable relationships with their mates and to mutualism with them than to increase the frequency of EPP.展开更多
Alzheimer’s disease(AD)is a multifactorial neurodegenerative disorder associated with aging.Due to its insidious onset,protracted progression,and unclear pathogenesis,it is considered one of the most obscure and intr...Alzheimer’s disease(AD)is a multifactorial neurodegenerative disorder associated with aging.Due to its insidious onset,protracted progression,and unclear pathogenesis,it is considered one of the most obscure and intractable brain disorders,and currently,there are no effective therapies for it.Convincing evidence indicates that the irreversible decline of cognitive abilities in patients coincides with the deterioration and degeneration of neurons and synapses in the AD brain.Human neural stem cells(NSCs)hold the potential to functionally replace lost neurons,reinforce impaired synaptic networks,and repair the damaged AD brain.They have therefore received extensive attention as a possible source of donor cells for cellular replacement therapies for AD.Here,we review the progress in NSC-based transplantation studies in animal models of AD and assess the therapeutic advantages and challenges of human NSCs as donor cells.We then formulate a promising transplantation approach for the treatment of human AD,which would help to explore the disease-modifying cellular therapeutic strategy for the treatment of human AD.展开更多
基金supported by scientific research fund of Jiangxi Provincial Social Sciences“14th Five-Year Plan”(No.23SH05).
文摘This study investigated the relationship between parental cognitive ability and child logical reasoning ability,and the role of academic expectation and family environment in that relationship.Based on the 2020 China Family Panel Studies(CFPS)data,1491 children(girls ratio=53.78%;average grade=6.023 years,school grade standard deviation=1.825 years).Results following multiple regression model(OLS)show that the higher the parental cognitive ability,the higher the children’s logical reasoning ability.Secondly,parental academic expectation serves as a mediator between their cognitive ability and children’s logical reasoning ability for higher logical reasoning by children.Third,a possible family environment acts as a mediator in the relationship between parents’cognitive ability and children’s logical reasoning ability to be higher.We conclude from thesefindings that parents with high cognitive abilities can enhance their children’s logical reasoning skills not only by setting higher academic expectations,but also by cultivating a supportive family environment.Thesefindings imply a need for intervention to improve family quality of life to enhance children’s thinking abilities to optimize their academic learning.
文摘BACKGROUND The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.AIM To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.METHODS Overall,98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study(50 patients)and control groups(48 patients).For 3 months,the control group was treated with conventional drugs,and the research group with a comprehensive intervention model of drug-psychology-society-skills.Data were obtained for the mini mental assessment scale(MMSE),Montreal cognitive assessment scale(MoCA),positive and negative symptom scale,insight and treatment attitude scale,cognitive ability scale and social skills[personal and social function scale(PSP)].The adverse reactions were observed.RESULTS After the intervention,the MMSE and MoCA scores improved in both groups.MoCA scores in the study group(26.58±3.21)were significantly(P<0.05)higher than those in the control group(24.68±3.02),MMSE scores were not significantly higher.Post-intervention,positive and negative symptom scores improved in both groups,and the positive and negative symptom scores in the study group[(12.01±2.58)and(32.51±2.11)]were significantly(P<0.05)different than those in the control group[(14.54±2.33)and(33.74±2.55)].Post-intervention,insight and treatment attitudes questionnaire scores of both groups were improved and compared with the control group(7.97±3.02),the study group(13.56±6.35)had significantly(P<0.05)higher scores.Post-intervention,the MATRICS consensus cognitive battery score of both groups was improved and compared with the control group(38.44±6.23),the score of the study group was significantly(P<0.05)increased(43.51±6.01).Post-intervention,the PSP score of the study group(78.38±6.63)was significantly(P<0.05)higher than that of the control group(74.52±7.01).During the intervention period,the incidence of adverse reactions in the study group was 6.25%,not significantly different from that in the control group(8.33%).During the intervention,both groups experienced adverse reactions,with no significant difference between groups(P>0.05).CONCLUSION The comprehensive intervention model based on drug-psychology-society-skills has obvious intervention effects on patients with chronic schizophrenia,which improves their cognitive ability and reduces their positive and negative symptoms.Simultaneously,it improves the self-knowledge of patients,improves their attitude toward treatment,effectively promotes the recovery of patients'social functions,and is safe.Therefore,it is worthy of being vigorously promoted and widely used in clinics.
文摘Objectives:This study aimed to investigate the protective effects and underlying mechanisms of aerobic intermittent exercise on cognitive impairment by PM_(2.5)exposure.Methods:Thirty-two rats were randomly divided into four groups:sedentary,exercise,sedentary+PM_(2.5)exposure,and exercise+PM_(2.5)exposure.The exercise groups underwent 8 weeks of exercise training(5 days of exercise per week).Subsequently,PM_(2.5)exposure groups were subjected to PM_(2.5)for three weeks.Post-exposure,we assessed cognitive abilities(shuttle box test),hippocampal tissue structure,related inflammatory factors(TNF-α,IL-6,IL-1β),the protein of inflammatory responses mechanism(P65,IκκB)and cognitiverelated protein levels(BDNF,Aβ-42).Results:PM_(2.5)exposure caused cognitive impairment,abnormal histopathological changes,reduced cognitive related protein and increased pro-inflammatory cytokine levels.Analysis of shuttle box test data revealed significant main effects on the passive avoidance latency times measured in rats(p<0.05).Aerobic intermittent exercise improves spatial learning decline in rats induced by PM_(2.5).Conversely,the Exercise+PM_(2.5)group demonstrated a significant reduction in latency of 24.9%compared to the Sedentary+PM_(2.5)group(p<0.05,ES=1.41).Conclustion:Aerobic intermittent exercise may help in protecting against the decrease of cognitive ability induced by PM_(2.5)exposure.
文摘The supply of highly concentrated oxygen positively affects cognitive processing in normal young adults. However, there have been few reports on changes in cognitive ability in elderly subjects following highly concentrated oxygen administration. This study investigated changes in cognitive ability, blood oxygen saturation （%）, and heart rate （beats/min） in normal elderly subjects at three different levels of oxygen [21% （1 L/min）, 93% （1 L/min）, and 93% （5 L/min）] administered during a 1-back task. Eight elderly male （75.3 ＋ 4.3 years old） and 10 female （71.1 ＋ 3.9 years old） subjects, who were normal in cognitive ability as shown by a score of more than 24 points in the Mini-Mental State Examination-Korea, participated in the experiment. The experiment consisted of an adaptation phase after the start of oxygen administration （3 minutes）, a control phase to obtain stable baseline measurements of heart rate and blood oxygen saturation before the task （2 minutes） and a task phase during which the 1-back task was performed （2 minutes）. Three levels of oxygen were administered throughout the three phases （7 minutes）. Blood oxygen saturation and heart rate were measured during each phase. Our results show that blood oxygen saturation increased, heart rate decreased, and response time in the 1-back task decreased as the concentration and amount of administered oxygen increased. This shows that administration of sufficient oxygen for optimal cognitive functioning increases blood oxygen saturation and decreases heart rate.
基金Thanks to Professor Korobeynikov Georgiy of National University of Physical Education and Sports of Ukraine.Thanks to Professor Chen Jinsong of Jiangsu Ocean University of Chinathanks for your support and help.
文摘Cognitive ability is important component of competitive ability of athletes,an important content of winning elements in sports,and an important topic of modern sports training and scientific research.These problems will restrict the improvement of athletes’cognitive ability and mental level.Based on the theory of psychology,use multiple hierarchical thinking,research cognitive theory of sports and the characteristics of cognitive ability of elite athletes,research the structure element system of cognitive ability,construct a two-level structure model of the cognitive ability of excellent athletes,summarize specific characteristics of the first level elements,and apply psychological cognitive theory to the training of modern Olympic Games mobilization,so as to provide valuable cognitive training,psychological training,and intelligence training for athletes theoretical guidance.
文摘Using a sample of~3,100 U.S.counties,we tested geoclimatic explanations for why cognitive ability varies across geography.These models posit that geoclimatic factors will strongly predict cognitive ability across geography,even when a variety of common controls appear in the regression equations.Our results generally do not support UV radiation(UVR)based or other geoclimatic models.Specifically,although UVR alone predicted cognitive ability at the U.S.county-level(β=-.33),its validity was markedly reduced in the presence of climatic and demographic covariates(β=-.16),and was reduced even further with a spatial lag(β=-.10).For climate models,average temperature remained a significant predictor in the regression equation containing a spatial lag(β=.35).However,the effect was in the wrong direction relative to typical cold weather hypotheses.Moreover,when we ran the analyses separately by race/ethnicity,no consistent pattern appeared in the models containing the spatial lag.Analyses of gap sizes across counties were also generally inconsistent with predictions from the UVR model.Instead,results seemed to provide support for compositional models.
文摘Human cognition ability comes from sensory experience or gift concept.This is the difference between empiricism and rationalism in the two major factions of Western European philosophy in the 16th and 18th centuries.The weakness of empiricism is that it is impossible to obtain knowledge with universal necessity from complicated experience,and the inability to obtain new knowledge is the weakness of theory.How to reconcile the contradiction between the two has become a new theme.This paper will cut into the three aspects of philosophy,geometry,and modern business economy,and explore the innate nature of cognitive ability and the characteristics of human self-renewal that are manifested in the process of self-development of cognitive ability.Its significance is not only to explore the essence of human beings,but also to give hope to the multiple possibilities of human beings.
基金supported by the National Natural Science Foundation of China Project(32200387)the Emergency Project for Risk Assessment of Areca Nut(Key Project of the Department of Agriculture and Rural Affairs of Hainan Province&Wanning Municipal People’s Government).
文摘Areca nut is the basic ingredient of betel quid,which is chewed by hundreds of millions of people in South-Eastern Asia.Chewing of areca nut has been associated with oral cancers potentially due to its specific alkaloids,among which arecoline constitutes about 90%of total fraction.Being the world’s fourth most commonly used psychoactive substance,arecoline evokes stimulation,addiction,and other direct neurological effects,while its misuse correlates to neurotoxic effects.However,what might underlie its neurotoxic mechanisms has been poorly documented.The brain is encoded by a complex network of neuronal and glial cell types,and neurotoxicity of hazardous compounds present transcriptional heterogeneity.Recently,the eusocial bumblebee has been used as a model for studying brain effects,with sophisticated cognitive capability and precisely measured brain architecture.Here,we decipher cell-type-specific mental risks to arecoline using bumblebees.Arecoline induced locomotor hyperactivity and cognitive impairment.Single nucleus RNA sequencing(snRNA-seq)unearthed arecoline-induced cell-specific responses,primarily targeted on Kenyon cells(KC).Moreover,high-dose arecoline induced distinctive cell responses among KC subtypes,particularly class I large Kenyon cell(lKC),leading to DNA damage,excitatory/inhibitory(E/I)imbalance,and calcium dyshomeostasis,which potentially resulted in cognitive impairment.Given arecoline’s popularity and growing exposure risks to humans,neurological health risks of areca nut warrant serious consideration.
基金The authors extend their appreciation to the Ongoing Research Funding Program,number(ORF2025R705),King Saud University,Riyadh,Saudi Arabia,for funding this work.
文摘The study aims to determine the validity and reliability of the Wechsler Preschool and Primary Scale of Intelligence–Third Edition(WPPSI-III)scores in a sample of kindergarten and lower primary pupils from Khartoum State,Sudan.It also aims to examine whether test’s factor structure in this sample replicated that of the original WPPSI-III.The study sample consisted of 384 kindergarten and primary school children in Khartoum State(females=50%mean age=4.14,SD=1.37),selected using stratified random sampling across its seven localities:Khartoum,Jebel Awliya,Khartoum Bahri,East Nile,Omdurman,Ombada,Karari.For concurrent validation,the children additionally completed the Goodenough Draw-a-Man Test,and the Colored Progressive Matrices.WPPSI-III scores demonstrated high internal consistency across the subtest items.Confirmatory factor analysis indicators for total,verbal,and performance intelligence were all excellent.The scale also showed weak to strong score stability ranging from 0.25(weak)to 0.88(strong)based on the Spearman-Brown equation,0.25 to 0.75 based on the Guttman split-half method.The Cronbach’s alpha coefficient scores ranged from 0.54 to 0.93.The WPPSI-III and Goodenough Draw-a-Man Test scores concurrent validity scores were poor(0.05)to modest(0.31),and while those with the Colored Progressive Matrices test were poor(r=0.04–0.18).Thesefindings provide evidence to suggest that the WPPSI-III is appropriate for research use with kindergarten and lower primary school students in Khartoum State,Sudan.
文摘This is a replication of Tyler and Bro's study (1992) on the effect of discourse level phenomena on audience perception of comprehensibility. 53 Chinese students of English and 10 native English speakers were taken as informants to a questionnaire, in which orders of ideas, discourse miscues and other types of errors (e.g. cohesion and redundant ideas, etc.) were used as variables to see whether they could affect the comprehensibility of texts. Strong resemblances were found between the two groups. Order of ideas (i.e. deductive or inductive) seems not to have affected text comprehensibility much, but the interactive cumulating miscues at the discourse level played an important role in discourse comprehension. As disparities are found between what nonnative speakers do and how they react to what they have done, the paper discusses whether people think the way they write, and if linguistic competence correlates with cognitive ability. The paper suggests that knowing and doing are two aspects of learning; teachers of English, therefore, have to understand the perplexities second language learners face and try to help them write as effectively as possible in the target language.
基金This work was supported by grants from the Scientific Research Projects of the Education Department of Hubei of China(No.D20162801)Open Fund Project of Hubei Key Laboratory of Cardiovascular,Cerebrovascularand Metabolic Disorders(No.2019-20XZ06).
文摘Progressive memory loss and cognitive impairment are the main clinical manifestations of Alzheimer’s disease(AD).Currently,there is no effective drug available for the treatment of AD.Previous studies have demonstrated that the cognitive impairment of AD is associated with oxidative stress and the inhibition of AKT and ERK phosphorylation.Grape seed proanthocyanidin extract(GSPE)has been shown to have strong antioxidant effect and can protect the nervous system from oxidative stress damage.This study aimed to investigate the protective effect of GSPE on the cognitive and synaptic impairments of AD using a sporadic AD rat model induced by intracerebroventricular(ICV)injection of streptozotocin(STZ)(ICV-STZ).Rats were treated with GSPE(50,100,or 200 mg/kg every day)by intragastrical(ig.)administration for continuous 7 weeks,and ICV-STZ(3 mg/kg)was performed on the first day and third day of week 5.Learning and memory abilities were assessed by the Morris water maze(MWM)test at week 8.After behavioral test,hippocampal long-term potentiation(LTP)was recorded,and the levels of malondialdehyde(MDA),superoxide dismutases(SOD),glutathione(GSH)and the protein expression of AKT and ERK were measured in the hippocampus and cerebral cortex of rats.Our study revealed that ICV-STZ significantly impaired the working learning ability and hippocampal LTP of rats,significantly increased the levels of MDA,and decreased the activity of SOD and GSH in the hippocampus and cerebral cortex.In contrast,GSPE treatment prevented the impairment of cognitive function and hippocampal LTP induced by ICV-STZ,decreased the level of MDA,and increased the level of SOD and GSH.Furthermore,Western blot results showed that GSPE treatment could prevent the loss of AKT and ERK activities in the hippocampus and cerebral cortex induced by ICV-STZ.Our findings demonstrate that GSPE treatment could ameliorate the impairment of cognitive ability and hippocampal synaptic plasticity in a rat model of sporadic AD by inhibiting oxidative stress and preserving AKT and ERK activities.Therefore,GSPE may be an effective agent for the treatment of cognitive deficits associated with sporadic AD.
文摘Standardized Ginkgo biloba leaf extract has been used in clinical trials for its beneficial effects on brain func- tions, particularly in dementia. Substantial experimental evidences indicated that Ginkgo biloba leaf extract （EGB） protected neuronal cells from a variety of insults. We investigated the effect of EGB on cognitive ability and protein kinase B （PKB） activity in hippocampal neuronal cells of dementia model rats. Rats received an intra- peritoneal injection of D-galactose to induce dementia. Forty-eight Spraque-Dawley rats were randomly divided into six groups, including the control group, D-galactose group （Gal）, low-dose EGB group （EGB-L）, mid-dose EGB group （EGB-M）, high-dose EGB group （EGB-H） and treatment group. The EGB-L, EGB-M and EGB-H groups were administered with EGB and D-galactose simultaneously. Y-maze, cresyl violet staining, TUNEL assays and immunohistochemistry staining were performed to detect learning and memory abilities, morpho- logical changes in the hippocampus, neuronal apoptosis and the expressing level of phospho-PKB, respectively. Rats in the Gal group showed decreased abilities of learning and memory, and hippocampal pyramidal cell layer was damaged, while EGB administration improved learning and memory abilities. The Gal group exhibited many stained, condensed nuclei and micronuclei, either isolated or within the cytoplasm of cells （39.5 ± 1.4）. Apoptotic cells decreased in the groups of EGB-L （35.9±0.9）, EGB-M （16.8± 1.0） and EGB-H （10.1±0.8）, and there were statistical significances compared with the Gal group. Immunoreactivity of phospho-PKB was localized diffusely throughout the cytosol of cells in all groups, while the immunoreactivity of the Gal group was weak. EGB signifi- cantly attenuated learning and memory impairment in a dose-dependent manner, while it could decrease the nmber of TUNEL-positive cells, and increase the activity of PKB. Our results demonstrated that EGB attenuated memory impairment and cell apoptosis in galactose-induced dementia model rats by activating PKB.
文摘1 A study shows that music lessons obviously enhance children's cognitive abilities,including short⁃term memory and planning,which lead to improving academic performance.The research is the first large⁃scale and long⁃term study to be adapted into the regular school curriculum.Visual arts lessons were also found to significantly improve children's visual memory.
基金supported by the National Key R&D Program of China(2023YFF1304600)。
文摘Animal behavioral studies are often combined with research concerning cognitive abilities.Larger brains usually mean more complex neural networks and advanced cognitive functions.By measuring the brain size of different individual animals,we can explore differences in behavioral complexity between populations or species.However,obtaining accurate measurements of brain size is challenging both in field and laboratory environments,especially for rare and endangered species.Therefore,there is an urgent need to develop reliable methods for performing cranial brain mass.This study tests which external structures of the avian head can most accurately predict brain size.We selected five bird species from four orders,categorized external head measures into three types of parameters(direct,calculated and composite measurements),and analyzed these in relation to brain mass.The results showed that while head size can partially explain brain mass,the parameters of head height x head width were the most accurate predictors of brain mass in birds(90.4%).In addition,the positive correlation between endocranial volume and brain mass once again confirmed that avian endocranial volume can,to a certain extent,serve as a valid proxy for brain mass.Our study demonstrates that in the future we can more conveniently perform non-invasive measurements to better understand the relationship between bird brain size and behavior,ecology,and evolution.
文摘Purpose:This study compared the relative effectiveness of Chinese calligraphy handwriting(CCH)and acupuncture in the treatment of patients with senile dementia.Materials and Methods:A randomized controlled trial(RCT)with 17 mild-to-moderate dementia patients with an average age of 77.29 years were randomly assigned with 9 to the calligraphy handwriting group and 8 to the acupuncture treatment group for a month of consecutive treatment.The participants'cognitive abilities,as well as symptoms of senile dementia,were measured by the Chinese version of the Mini-mental State Examination(CMMSE)and the Chinese Medicine Quantitative Diagnostic Survey for Senile Dementia Symptoms,respectively,before and after the treatment.Results:The calligraphy group showed a significant increase in calculation and memory as well as a decline in the symptoms of senile dementia.Patients in the acupuncture group experienced a significant growth in total CMMSE scores and the subscales in orientation to time and place,behavioral operations,as well as reduced clinical symptoms.However,no significant changes were found in their memory and calculation abilities.Conclusion:Both CCH and acupuncture treatments were found significantly effective for,respectively,enhancing the patients'cognitive abilities and reducing their clinical symptoms.Further,calligraphy handwriting also improved the level of their attention and concentration,physical relaxation,and emotional stability.
文摘In English business news discourses, there are numerous financial words or terms which are quite difficult for readers to under-stand, especially those ones built on the basis of metaphorical mechanism. Conceptual Metaphor has a strong power to explain the cor-rect meaning of these words with their specific types of metaphors. Through the explanation of the meaning construction of the metaphori-cal words, it can be a great help for the news readers to master the accurate and deep-seated messages in the discourse. Simultaneously,it gives the reader an insight into the English culture in order to grasp the international economic trends and makes them accomplishcross-cultural communication task with ease.
文摘As Internet slang and memes increasingly make their way into school-age children's daily conversations and even formal writing,educators are concerned that its excessive use could lead to a decline in their linguistic and cognitive abilities."BBQ le,we're all done for!" shouted a boy in Yu Gu’s class,prompting her fourth graders to burst out laughing.Pronounced ba hi cue le,the phrase is a homonym for“barbecue”often used in Chinese internet slang to express that“someone messed up.”
基金Supported by Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences (No. CI2021B00)。
文摘Alzheimer's disease(AD)is a prevalent neurodegenerative disorder among the elderly population,and timely intervention has been shown to effectively slow down the progression of dementia stage.(1)Although drugs such as memantine,donepezil,and quetiapine are commonly used in treatment of AD,they do not significantly enhance cognitive abilities or ameliorate memory loss in AD patients.Acupuncture,a non-pharmacological therapy rooted in Chinese medicine,has demonstrated certain efficacy in improving cerebral blood circulation through acupoint stimulation,thereby potentially slowing down the progression of AD.(2)Stellate ganglion block can augment cerebral blood flow(CBF)by inhibiting sympathetic nerve activity,however,there is currently no clinical evidence regarding its application for treating AD.Therefore,integrated Chinese and Western medicine holds promise for enhancing memory function and improving quality of life in AD patients.Arterial spin labeling-magnetic resonance imaging(ASL-MRI)perfusion imaging can be employed to identify reduced CBF specifically within the hippocampus and limbic system of individuals with AD;this technique serves as a sensitive indicator for evaluating therapeutic outcomes.(3)Herein we present a case study involving an individual with AD who underwent integrative treatment focusing on CBF alterations within brain regions associated with the disease along with neurocognitive assessment.
基金Financial support was provided by the National Natural Sciences Foundation of China(31772451,31970393)the Science and Technology Youth Innovation Team of Sichuan Province(19DTTD0012)+1 种基金the Innovation Project of Guangxi Graduate Education(YCSW2021116)the project of Guangxi Key Laboratory of Rare and Endangered Animal Ecology,Guangxi Normal University(18-A-02-04).
文摘Extra-pair paternity(EPP)benefits to improve the reproductive success via extra-pair fertilizations without the costs of parental care in males and through improved offspring quality with additional food and parental care in females among species of birds.Variations in the EPP appear to link to behavioral and ecological factors and sexual selection.According to the“relationship intelligence hypothesis”,the cognitive abilities of the birds play an important role in maintaining long-term relationships.Here,we undertook thefirst comparative test of the relationships between extra-pair paternity and brain size,testis size,and life histories among 315 species of birds using phylogenetically controlled comparative analyses and path analysis.After controlling for the effects of shared ancestry and body mass,the frequency of EPP was negatively correlated with relative brain size,but positively with testis size across species of birds.However,the frequency of EPP was not linked to life-history traits(e.g.incubation period,fledging period,clutch size,egg mass,and longevity).Ourfindings suggest that large-brained birds associated with enhanced cognitive abilities are more inclined to maintain long-term stable relationships with their mates and to mutualism with them than to increase the frequency of EPP.
基金This work was supported in part by the"Strategic Priority Research Program"of the Chinese Academy of Sciences,Grant No.(XDA16020501,XDA16020404)National Key Basic Research and Development Program of China(2018YFA0108000,2018YFA0107200,2017YFA0102700)the research developmental fund(RDF-21-01-021,PGRS2112030)of Xi’an Jiaotong-Liverpool University.
文摘Alzheimer’s disease(AD)is a multifactorial neurodegenerative disorder associated with aging.Due to its insidious onset,protracted progression,and unclear pathogenesis,it is considered one of the most obscure and intractable brain disorders,and currently,there are no effective therapies for it.Convincing evidence indicates that the irreversible decline of cognitive abilities in patients coincides with the deterioration and degeneration of neurons and synapses in the AD brain.Human neural stem cells(NSCs)hold the potential to functionally replace lost neurons,reinforce impaired synaptic networks,and repair the damaged AD brain.They have therefore received extensive attention as a possible source of donor cells for cellular replacement therapies for AD.Here,we review the progress in NSC-based transplantation studies in animal models of AD and assess the therapeutic advantages and challenges of human NSCs as donor cells.We then formulate a promising transplantation approach for the treatment of human AD,which would help to explore the disease-modifying cellular therapeutic strategy for the treatment of human AD.
