Objective:To systematically review the effects of administering metformin and glutathione alone and in coformulation with other compounds on the fertility and reproductive health of diabetic male rodents.Methods:The g...Objective:To systematically review the effects of administering metformin and glutathione alone and in coformulation with other compounds on the fertility and reproductive health of diabetic male rodents.Methods:The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA)were followed to conduct this systematic review.Studies published until August 2024 in PubMed,Web of Science,and Scopus databases were searched,identified,screened,and selected for a detailed review.The keywords included metformin,diabetes,reproduction,glutathione,and rodent models.Results:A total of 166 studies were identified,of which 11 met the inclusion criteria and were included in the qualitative synthesis.One additional study was identified through snowballing and citation tracking,bringing the total to 12 studies.The findings indicate that metformin and glutathione,administered alone or in combination with other compounds,improved sperm count,motility,and morphology;restored reproductive hormone levels;reduced oxidative stress markers;and improved testicular histopathology in diabetic male rodents.Conclusions:Coformulation of metformin and glutathione with other compounds was found to be more effective in improving fertility and reproductive parameters in diabetic male rodents compared to mono-administration.However,further studies on the coformulation of metformin and glutathione are needed to confirm their efficacy and elucidate the underlying mechanisms.Study registration:The study protocol was registered in the International Prospective Register of Systematic Reviews(PROSPERO)with registration number CRD42024561820.展开更多
BACKGROUND Highly active antiretroviral therapy (HAART) is provided free of charge to all human immunodeficiency virus (HIV) positive residents in Italy. As fixed dose coformulations (FDCs) are often more expensive in...BACKGROUND Highly active antiretroviral therapy (HAART) is provided free of charge to all human immunodeficiency virus (HIV) positive residents in Italy. As fixed dose coformulations (FDCs) are often more expensive in comparison to the same drugs administered separately in a multi-tablet regimen (MTR), we considered a costeffective strategy involving patients in the switch from their FDCs to corresponding MTRs including generic antiretrovirals. AIM To verify if this would affect the virological and immunological response in comparison to maintaining the FDC regimens. METHODS From January 2012 to December 2013, we assessed the eligibility of all the HIV-1 positive adults on stable HAART being treated at our hospital-based outpatient clinic in Treviso, Italy. Participants who accepted to switch from their FDC regimen to the corresponding MTR joined the MTR group, while those who maintained a FDC regimen joined the FDC group. Clinical data, including changes in HAART regimens, respective reasons why and adverse effects, were recorded at baseline and at follow-up visits occurring at weeks 24, 48 and 96. All participants were assessed for virological and immunological responses at baseline and at weeks 24, 48 and 96. RESULTS Two hundred and forty-three eligible HIV-1 adults on HAART were enrolled: 163 (67%) accepted to switch to a MTR, joining the MTR group, while 80 (33%) maintained their FDCs, joining the FDC group. In a parallel analysis, there were no significant differences in linear trend of distribution of HIV-RNA levels between the two groups and there were no significant odds in favour of a higher level of HIV-RNA in either group at any follow-up and on the overall three strata analysis. In a before-after analysis, both FDC and MTR groups presented no significant differences in distribution of HIV-RNA levels at either weeks 48 vs 24 and weeks 96 vs 24 cross tabulations. A steady increase of mean CD4 count was observed in the MTR group only, while in the FDC group we observed a slight decrease (-23 cells per mmc) between weeks 24 and 48. CONCLUSION Involving patients in the switch from their FDC regimens to the corresponding MTRs for economic reasons did not affect the effectiveness of antiretroviral therapy in terms of virological response and immunological recovery.展开更多
基金supported by University Technology Mara(UiTM)under grant number 600-IRMI/FRGS 5/3(273/2019).
文摘Objective:To systematically review the effects of administering metformin and glutathione alone and in coformulation with other compounds on the fertility and reproductive health of diabetic male rodents.Methods:The guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses(PRISMA)were followed to conduct this systematic review.Studies published until August 2024 in PubMed,Web of Science,and Scopus databases were searched,identified,screened,and selected for a detailed review.The keywords included metformin,diabetes,reproduction,glutathione,and rodent models.Results:A total of 166 studies were identified,of which 11 met the inclusion criteria and were included in the qualitative synthesis.One additional study was identified through snowballing and citation tracking,bringing the total to 12 studies.The findings indicate that metformin and glutathione,administered alone or in combination with other compounds,improved sperm count,motility,and morphology;restored reproductive hormone levels;reduced oxidative stress markers;and improved testicular histopathology in diabetic male rodents.Conclusions:Coformulation of metformin and glutathione with other compounds was found to be more effective in improving fertility and reproductive parameters in diabetic male rodents compared to mono-administration.However,further studies on the coformulation of metformin and glutathione are needed to confirm their efficacy and elucidate the underlying mechanisms.Study registration:The study protocol was registered in the International Prospective Register of Systematic Reviews(PROSPERO)with registration number CRD42024561820.
文摘BACKGROUND Highly active antiretroviral therapy (HAART) is provided free of charge to all human immunodeficiency virus (HIV) positive residents in Italy. As fixed dose coformulations (FDCs) are often more expensive in comparison to the same drugs administered separately in a multi-tablet regimen (MTR), we considered a costeffective strategy involving patients in the switch from their FDCs to corresponding MTRs including generic antiretrovirals. AIM To verify if this would affect the virological and immunological response in comparison to maintaining the FDC regimens. METHODS From January 2012 to December 2013, we assessed the eligibility of all the HIV-1 positive adults on stable HAART being treated at our hospital-based outpatient clinic in Treviso, Italy. Participants who accepted to switch from their FDC regimen to the corresponding MTR joined the MTR group, while those who maintained a FDC regimen joined the FDC group. Clinical data, including changes in HAART regimens, respective reasons why and adverse effects, were recorded at baseline and at follow-up visits occurring at weeks 24, 48 and 96. All participants were assessed for virological and immunological responses at baseline and at weeks 24, 48 and 96. RESULTS Two hundred and forty-three eligible HIV-1 adults on HAART were enrolled: 163 (67%) accepted to switch to a MTR, joining the MTR group, while 80 (33%) maintained their FDCs, joining the FDC group. In a parallel analysis, there were no significant differences in linear trend of distribution of HIV-RNA levels between the two groups and there were no significant odds in favour of a higher level of HIV-RNA in either group at any follow-up and on the overall three strata analysis. In a before-after analysis, both FDC and MTR groups presented no significant differences in distribution of HIV-RNA levels at either weeks 48 vs 24 and weeks 96 vs 24 cross tabulations. A steady increase of mean CD4 count was observed in the MTR group only, while in the FDC group we observed a slight decrease (-23 cells per mmc) between weeks 24 and 48. CONCLUSION Involving patients in the switch from their FDC regimens to the corresponding MTRs for economic reasons did not affect the effectiveness of antiretroviral therapy in terms of virological response and immunological recovery.
