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Dual-strategy approach for fungicide discovery: Machine learning-based activity prediction and fragment co-occurrence network construction
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作者 Binyan Jin Jialin Cui +4 位作者 Qi He Huan Xu Xinpeng Sun Ziyao Chai Li Zhang 《Advanced Agrochem》 2025年第4期373-381,共9页
The development of fungicides is time-consuming and costly.Introducing a fungicide-likeness assessment strategy at the early screening stage can help reduce development risks and improve the success rate.However,exist... The development of fungicides is time-consuming and costly.Introducing a fungicide-likeness assessment strategy at the early screening stage can help reduce development risks and improve the success rate.However,existing assessment methods are often plagued by low accuracy and poor generalization,while fragment-based design strategies commonly fail to account for synergistic effects between structural units.Therefore,based on a small-scale sample set,this study developed a more efficient global predictive model for fungicidal activity—-named APPf—by integrating multi-scale feature screening methods and machine learning algorithms,which also accounts for synergistic effects among different structural fragments.We utilized three independent external test sets for model validation:External Test Set 1 for general validation,External Test Set 2 for comparison with existing models,and External Test Set 3 for disease-specific fungicide evaluation.On External Test Set 1,the APPf model achieved a precision of 0.6454,a recall of 0.8535,and an F1 score of 0.7350,demonstrating its robust predictive performance.It also exhibited strong enrichment capability for positive samples in External Test Set 2.For External Test Set 3,APPf achieved a prediction accuracy exceeding 80%for each disease,suggesting its promising potential in practical fungicide development.Furthermore,we quantified the contribution of molecular descriptors to the model predictions using SHAP value analysis and identified nHdNH and NssssNp as strong indicative features for predicting fungicidal activity,thereby enhancing the interpretability of the model.APPf has been deployed on a public web server(http://pesticides.cau.edu.cn/APPf),providing a user-friendly online prediction service to support the discovery of novel fungicides.Meanwhile,we employed a molecular fragmentation strategy to analyze the co-occurrence relationships between fragments in fungicides and constructed a network map of fragment co-occurrence associated with fungicidal activity.This study provides both an active fragment library and a global fungicide-likeness assessment tool for AI-based de novo molecular generation aimed at discovering novel fungicidal leads,which is expected to enhance the efficiency of developing new fungicides. 展开更多
关键词 Machine learning Activity prediction Fragment co-occurrence Interpretability Online website
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Effect of land use on soil nematode community composition and co-occurrence network relationship
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作者 Xiaotong Liu Siwei Liang +3 位作者 Yijia Tian Xiao Wang Wenju Liang Xiaoke Zhang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第8期2807-2819,共13页
Land use influences soil biota community composition and diversity,and then belowground ecosystem processes and functions.To characterize the effect of land use on soil biota,soil nematode communities in crop land,for... Land use influences soil biota community composition and diversity,and then belowground ecosystem processes and functions.To characterize the effect of land use on soil biota,soil nematode communities in crop land,forest land and fallow land were investigated in six regions of northern China.Generic richness,diversity,abundance and biomass of soil nematodes was the lowest in crop land.The richness and diversity of soil nematodes were 28.8and 15.1%higher in fallow land than in crop land,respectively.No significant differences in soil nematode indices were found between forest land and fallow land,but their network keystone genera composition was different.Among the keystone genera,50%of forest land genera were omnivores-predators and 36%of fallow land genera were bacterivores.The proportion of fungivores in forest land was 20.8%lower than in fallow land.The network complexity and the stability were lower in crop land than forest land and fallow land.Soil pH,NH_(4)^(+)-N and NO_(3)^(–)-N were the major factors influencing the soil nematode community in crop land while soil organic carbon and moisture were the major factors in forest land.Soil nematode communities in crop land influenced by artificial management practices were more dependent on the soil environment than communities in forest land and fallow land.Land use induced soil environment variation and altered network relationships by influencing trophic group proportions among keystone nematode genera. 展开更多
关键词 soil nematode trophic groups community composition co-occurrence network land use
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Phytochemical interventions for post-traumatic stress disorder:A cluster co-occurrence network analysis using CiteSpace
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作者 Biao Gao Yi-cui Qu +5 位作者 Meng-yu Cai Yin-yin Zhang Hong-tao Lu Hong-xia Li Yu-xiao Tang Hui Shen 《Journal of Integrative Medicine》 SCIE CAS CSCD 2023年第4期385-396,共12页
Objective:This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder(PTSD).Methods:The Web of Science database(2007-2022)was searched using the search terms“phytochemical... Objective:This study investigated trends in the study of phytochemical treatment of post-traumatic stress disorder(PTSD).Methods:The Web of Science database(2007-2022)was searched using the search terms“phytochemicals”and“PTSD,”and relevant literature was compiled.Network clustering co-occurrence analysis and qualitative narrative review were conducted.Results:Three hundred and one articles were included in the analysis of published research,which has surged since 2015 with nearly half of all relevant articles coming from North America.The category is dominated by neuroscience and neurology,with two journals,Addictive Behaviors and Drug and Alcohol Dependence,publishing the greatest number of papers on these topics.Most studies focused on psychedelic intervention for PTSD.Three timelines show an“ebb and flow”phenomenon between“substance use/marijuana abuse”and“psychedelic medicine/medicinal cannabis.”Other phytochemicals account for a small proportion of the research and focus on topics like neurosteroid turnover,serotonin levels,and brain-derived neurotrophic factor expression.Conclusion:Research on phytochemicals and PTSD is unevenly distributed across countries/regions,disciplines,and journals.Since 2015,the research paradigm shifted to constitute the mainstream of psychedelic research thus far,leading to the exploration of botanical active ingredients and molecular mechanisms.Other studies focus on anti-oxidative stress and anti-inflammation. 展开更多
关键词 PHYTOCHEMICAL Post-traumatic stress disorder Text analysis Clustering co-occurrence network PSYCHEDELIC
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Spatial environmental heterogeneity of ocean currents affects pelagic ciliate community structure,assembly,and co-occurrence network complexity in the Scotia Sea,Antarctic
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作者 Tianjing Shi Furong Cao +5 位作者 Wangxinze Shu Yurou Jiang Eun Jin Yang Qian Liu Mingjian Liu Yong Jiang 《Marine Life Science & Technology》 2025年第4期757-778,共22页
The complex current systems of the Southern Ocean play a critical role in shaping the heterogeneity and distinctiveness of Antarctic habitats.Nonetheless,how Antarctic water masses influence ciliates,one of the most c... The complex current systems of the Southern Ocean play a critical role in shaping the heterogeneity and distinctiveness of Antarctic habitats.Nonetheless,how Antarctic water masses influence ciliates,one of the most common groups of protozoa in polar regions,remains largely unknown.The present study investigated how the ciliate communities are affected by com-plex Southern Ocean currents by analyzing the diversity distributions,community assembly mechanisms,and co-occurrence networks of ciliates across three distinct water masses in the Scotia Sea.The findings reveal that the hydrography of the Scotia Sea significantly affects the spatial patterns of planktonic ciliates,primarily through the combination of temperature,salinity,and depth.In contract to surface waters(Antarctic Surface Water and Antarctic Circumpolar Current),ciliates inhab-iting deep waters(Circumpolar Deep Water)exhibit stronger and more direct correlations with the environment parameters,alongside greater network stability.Community assembly in surface and deep-water masses is governed by stochastic and deterministic processes,respectively.Compared to other Antarctic regions documented in previous studies,the Scotia Sea demonstrated the lowest alpha diversity indices for ciliates while harboring the highest number of endemic species.A detailed re-evaluation of Antarctic ciliate community structure in the Antarctic from prior research offers valuable insights into how dynamic ocean currents shape the ecological dynamics of ciliate communities,thus providing a broader understanding of the environmental changes impacting polar marine ecosystems. 展开更多
关键词 Ciliated protists co-occurrence network Microbial community assembly Polar water masses Southern Ocean
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Increasing Elevation Reduces Complexity of Soil Microbial Co-occurring Network in Changbai Mountains,China
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作者 LIU Xue WU Haitao +4 位作者 GUAN Qiang LU Kangle LIU Dandan KANG Yujuan ZHANG Shixiu 《Chinese Geographical Science》 2026年第2期306-319,I0004-I0006,共17页
Elevation patterns and assembly processes of soil microbial community structures are essential for understanding biogeo-chemical processes in mountain systems.Differences in soil properties caused by elevation gradien... Elevation patterns and assembly processes of soil microbial community structures are essential for understanding biogeo-chemical processes in mountain systems.Differences in soil properties caused by elevation gradients can regulate the spatial distribu-tion and network complexity of the community structure.To explore the variations in soil microbial community structures and their as-sembly mechanisms across different elevations of the Changbai Mountains,as well as their responses to environmental factors,we col-lected microbial samples along an elevational gradient(seven elevations containing four vegetation zones)on the western slope of the Changbai Mountains using the method of metagenomic sequencing.The results showed a significant difference(P<0.05)for the Chao1 index across different elevations,but no significant difference was observed for the Shannon and Simpson indices.With increasing elev-ation,the number of nodes and links in the microbial network gradually decreased.Acidobacteria were highly connected to many nodes.The microbial communities indicated a significant distance-decay relationship(P<0.001)and were affected more by stochastic pro-cesses along the elevation gradient.The results of the Structural Equation Model(SEM)showed that elevation had direct significant ef-fect on carbon(C,P<0.01),nitrogen(N,P<0.01),and phosphorus(P,P<0.05)and weak negative effect on their ecological stoi-chiometry.Elevation was one of the major variables contributing to microbial network topology.The contribution of C and N to micro-bial network complexity was higher than that of P.Our study provides valuable insights into the responses of soil microbial communit-ies to elevation variations. 展开更多
关键词 assembly processes co-occurring network elevation gradient microbial community soil nutrient Changbai Mountains China
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Strong partitioning of soil bacterial community composition and co-occurrence networks along a small-scale elevational gradient on Zijin Mountain 被引量:3
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作者 Xu Liu Teng Yang +5 位作者 Yu Shi Yichen Zhu Mulin He Yunke Zhao Jonathan MAdams Haiyan Chu 《Soil Ecology Letters》 CAS 2021年第4期290-302,共13页
The elevational distributions of bacterial communities in natural mountain forests,especially along large elevational gradients,have been studied for many years.However,the distributional patterns that underlie variat... The elevational distributions of bacterial communities in natural mountain forests,especially along large elevational gradients,have been studied for many years.However,the distributional patterns that underlie variations in soil bacterial communities along small-scale elevational gradients in urban ecosystems are not yet well understood.Using Illumina MiSeq DNA sequencing,we surveyed soil bacterial communities at three elevations on Zijin Mountain in Nanjing City:the hilltop(300 m a.s.l.),the hillside(150 m a.s.l.),and the foot of the hill(0 m a.s.l.).The results showed that edaphic properties differed significantly with elevation.Bacterial community composition,rather than alpha diversity,strongly differed among the three elevations(Adonis:R2=0.12,P<0.01).Adonis and DistLM analyses demonstrated that bacterial community composition was highly correlated with soil pH,elevation,total nitrogen(TN),and dissolved organic carbon(DOC).The degree scores,betweenness centralities,and composition of keystone species were distinct among the elevations.These results demonstrate strong elevational partitioning in the distributions of soil bacterial communities along the gradient on Zijin Mountain.Soil pH and elevation together drove the smallscale elevational distribution of soil bacterial communities.This study broadens our understanding of distribution patterns and biotic co-occurrence associations of soil bacterial communities from large elevational gradients to short elevational gradients. 展开更多
关键词 Elevational distribution Soil pH Bacterial community composition co-occurrence network
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Sporocarp-associated fungal co-occurrence networks in a corn field revealed by long-read high-throughput sequencing
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作者 Teng Yang Luyao Song +5 位作者 Xu Liu Xia Luo Qiuyan Tan Cunzhi Zhang Jonathan MAdams Haiyan Chu 《Soil Ecology Letters》 CSCD 2024年第4期99-111,共13页
We identified a sporocarp as Agrocybe dura growing next to a living corn using PacBio sequencing.The mycoparasitism of Trichoderma spp.on A.dura were revealed by the co-occurrence network analysis.For long-read HTS da... We identified a sporocarp as Agrocybe dura growing next to a living corn using PacBio sequencing.The mycoparasitism of Trichoderma spp.on A.dura were revealed by the co-occurrence network analysis.For long-read HTS data,we updated a bioinformatic pipeline to enhance fungal taxonomic resolution.In forests,fungal sporocarps house the diverse fungicolous fungi;however,the relationships of sporocarps and associated fungal communities are rarely explored in agroecosystems.In a corn field near Gongzhuling City,Jilin Province,China,we found an epigeous sporocarp with agaricoid morphology that could grow next to the living corn plants.Using PacBio metabarcoding combined with an updated bioinformatic pipeline,we surveyed the fungal community profile along its cap,rhizomorph and hyphosphere soil at a much-improved taxonomic resolution.We identified the sporocarp,at a high probability,as Agrocybe dura,and this mushroom was significantly negatively correlated with Trichoderma hamatum and T.harzianum in the co-occurrence network.Fungal diversity in hyphosphere habitat was significantly higher than that in cap and rhizomorph habitats.Consistent with the pattern in fungal diversity,the node number,edge number,network diameter and average degree were significantly higher in hyphosphere habitat than other habitats.However,both the negative and positive cohesion were significantly higher in rhizomorph habitat than other habitats.Moreover,the z-c plot identified A.dura as the only network hub,linking multiple fungal species.The results give us a glimpse of the ecological relevance of saprobic mushrooms across the extensive northeastern black soil region of China.Our findings will aid in the assessment and forecasting of fungal diversity hotspots and their relationships with soil fertility in the‘Golden Corn Belt’of northeast China. 展开更多
关键词 PacBio metabarcoding saprobic mushroom species identification co-occurrence network corn field northeast China
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Birds'co-occurrence is mediated by diet,habitat type,and anthropogenic disturbances in Ghana's Central Region
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作者 Collins Ayine Nsor Michael Perry-Amissah +4 位作者 John Nkrumah Mensah Samuel Boadi Micheal Asigbase Louis Addae-Wireko Rockson Acolats 《Avian Research》 2025年第3期412-422,共11页
Understanding the fundamental drivers of large-scale species co-occurrence is a critical issue in ecology and conservation research. Here, we assessed foraging guilds, habitat type and disturbances as drivers of bird ... Understanding the fundamental drivers of large-scale species co-occurrence is a critical issue in ecology and conservation research. Here, we assessed foraging guilds, habitat type and disturbances as drivers of bird species co-occurrence in Ghana's Central Region over six months. Birds were sampled in 120 points across six different habitat types (farmland, forest reserve, urban area, coastal savannah, wetland, and mangrove), using the point-centred count technique. In total, 4060 individuals belonging to 216 species were recorded across all six habitat types. We found that co-occurring species were more similar in their foraging behaviour and habitat association. About 60% of the birds were found to co-occur randomly, 15% co-occurred negatively, and 25% co-occurred positively. Carnivores like the Black Heron (Egretta ardesiaca) and Spur-winged Lapwing (Vanellus spinosus) randomly co-occurred with other guild groups and were dominant in the mangroves and wetlands. Frugivores from forest reserves had only a 25% chance of randomly co-occurring with other birds and about a 60% chance of positively co-occurring with other birds. Our findings suggest that foraging guilds and habitat type are major factors driving bird co-occurrence and community assemblages in this West African suburban region. 展开更多
关键词 Community assembly Competition Foraging guilds Habitat.preference NMDS Species co-occurrence
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AGGREGATE IMAGE BASED TEXTURE IDENTIFICATION USING GRAY LEVEL CO-OCCURRENCE PROBABILITY AND BP NEURAL NETWORK
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作者 Chen Ken Wang Yicong +2 位作者 Zhao Pan Larry E. Banta Zhao Xuemei 《Journal of Electronics(China)》 2009年第3期428-432,共5页
Classifying the texture of granules in 2D images has aroused manifold research atten-tion for its technical challenges in image processing areas.This letter presents an aggregate texture identification approach by joi... Classifying the texture of granules in 2D images has aroused manifold research atten-tion for its technical challenges in image processing areas.This letter presents an aggregate texture identification approach by jointly using Gray Level Co-occurrence Probability(GLCP) and BP neural network techniques.First, up to 8 GLCP-associated texture feature parameters are defined and computed, and these consequent parameters next serve as the inputs feeding to the BP neural network to calculate the similarity to any of given aggregate texture type.A finite number of aggregate images of 3 kinds, with each containing specific type of mineral particles, are put to the identification test, experimentally proving the feasibility and robustness of the proposed method. 展开更多
关键词 Aggregate image Texture identification Gray Level co-occurrence Probability(GLCP) BP neural network
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Biogeographic shifts in the microbial co-occurrence network features of three domains across complex environmental gradients in subtropical coastal waters
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作者 Dandi Hou Huizhen Yan +3 位作者 Huaying Lin Huajun Zhang Demin Zhang Kai Wang 《Ecological Processes》 CSCD 2024年第4期184-199,共16页
Background Bacteria,Archaea,and Microeukaryotes comprise taxonomic domains that interact in mediating biogeochemical cycles in coastal waters.Many studies have revealed contrasting biogeographic patterns of community ... Background Bacteria,Archaea,and Microeukaryotes comprise taxonomic domains that interact in mediating biogeochemical cycles in coastal waters.Many studies have revealed contrasting biogeographic patterns of community structure and assembly mechanisms in microbial communities from diferent domains in coastal ecosystems;however,knowledge of specifc biogeographic patterns on microbial co-occurrence relationships across complex coastal environmental gradients remains limited.Using a dense sampling scheme at the regional scale,SSU rRNA gene amplicon sequencing,and network analysis,we investigated intra-and inter-domain co-occurrence relationships and network topology-based biogeographic patterns from three microbial domains in coastal waters that show environmental gradients across the inshore-nearshore-ofshore continuum in the East China Sea.Results Overall,we found the highest complexity and connectivity in the bacterial network,the highest modularity in the archaeal network,and the lowest complexity,connectivity,and modularity in the microeukaryotic network.Although microbial co-occurrence networks from the three domains showed distinct topological features,they exhibited a consistent biogeographic pattern across the inshore-nearshore-ofshore continuum.Specifcally,the nearshore zones with intermediate levels of terrestrial impacts refected by multiple environmental factors(including water temperature,salinity,pH,dissolved oxygen,and nutrient-related parameters)had a higher intensity of microbial co-occurrence for all three domains.In contrast,the intensity of microbial co-occurrence was weaker in both the inshore and the ofshore zones at the two ends of the environmental gradients.Archaea occupied a central position in the microbial inter-domain co-occurrence network.In particular,members of the Thaumarchaeota Marine Group I(MGI,now placed within the Family Nitrosopumilaceae of the Phylum Thermoproteota)appeared to be the hubs in the biogeographic shift between inter-domain network modules across environmental gradients.Conclusions Our work ofers new insights into microbial biogeography by integrating network features into biogeographic patterns,towards a better understanding of the potential of microbial interactions in shaping biogeographic patterns of coastal marine microbiota. 展开更多
关键词 co-occurrence BIOGEOGRAPHY Bacteria ARCHAEA Microeukaryote Environmental gradient
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Spatial scaling of soil microbial co-occurrence networks in a fragmented landscape
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作者 Pandeng Wang Shao-Peng Li +4 位作者 Xian Yang Xingfeng Si Wen-Jun Li Wensheng Shu Lin Jiang 《mLife》 CSCD 2023年第2期209-215,共7页
Impact statement Habitat loss has been a primary threat to biodiversity.However,species do not function in isolation but often associate with each other and form complex networks.Thus,revealing how the network complex... Impact statement Habitat loss has been a primary threat to biodiversity.However,species do not function in isolation but often associate with each other and form complex networks.Thus,revealing how the network complexity and stability scale with habitat area will give us more insights into the effects of habitat loss on ecosystems.In this study,we explored the relationships between the island area and the network complexity and stability of soil microbes.We found that the complexity and stability of soil microbial co‐occurrence networks scale positively with island area,indicating that habitat loss will potentially simplify and destabilize soil microbial networks. 展开更多
关键词 SOIL HABITAT networkS
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Joint Optimization of Routing and Resource Allocation in Decentralized UAV Networks Based on DDQN and GNN
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作者 Nawaf Q.H.Othman YANG Qinghai JIANG Xinpei 《电讯技术》 北大核心 2026年第1期1-10,共10页
Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combinin... Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks. 展开更多
关键词 decentralized UAV network resource allocation routing algorithm GNN DDQN DRL
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Exploring the material basis and mechanisms of the action of Hibiscus mutabilis L. for its anti-inflammatory effects based on network pharmacology and cell experiments
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作者 Wenyuan Chen Xiaolan Chen +2 位作者 Jing Wan Qin Deng Yong Gao 《日用化学工业(中英文)》 北大核心 2026年第1期55-64,共10页
To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review a... To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review and SwissADME platform.Genes related to the inflammation were collected using Genecards and OMIM databases,and the intersection genes were submitted on STRING and DAVID websites.Then,the protein interaction network(PPI),gene ontology(GO)and pathway(KEGG)were analyzed.Cytoscape 3.7.2 software was used to construct the“Hibiscus mutabilis L.-active ingredient-target-inflammation”network diagram,and AutoDockTools-1.5.6 software was used for the molecular docking verification.The antiinflammatory effect of Hibiscus mutabilis L.active ingredient was verified by the RAW264.7 inflammatory cell model.The results showed that 11 active components and 94 potential targets,1029 inflammatory targets and 24 intersection targets were obtained from Hibiscus mutabilis L..The key anti-inflammatory active ingredients of Hibiscus mutabilis L.are quercetin,apigenin and luteolin.Its action pathway is mainly related to NF-κB,cancer pathway and TNF signaling pathway.Cell experiments showed that total flavonoids of Hibiscus mutabilis L.could effectively inhibit the expression of tumor necrosis factor(TNF-α),interleukin 8(IL-8)and epidermal growth factor receptor(EGFR)in LPS-induced RAW 264.7 inflammatory cells.It also downregulates the phosphorylation of human nuclear factor ĸB inhibitory protein α(IĸBα)and NF-κB p65 subunit protein(p65).Overall,the anti-inflammatory effect of Hibiscus mutabilis L.is related to many active components,many signal pathways and targets,which provides a theoretical basis for its further development and application. 展开更多
关键词 Hibiscus mutabilis L. INFLAMMATION network pharmacology molecular docking cell validation
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Deciphering microeukaryotic–bacterial co-occurrence networks in coastal aquaculture ponds
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作者 Xiafei Zheng Kui Xu +4 位作者 Jonathan Naoum Yingli Lian Bo Wu Zhili He Qingyun Yan 《Marine Life Science & Technology》 SCIE CAS CSCD 2023年第1期44-55,共12页
Microeukaryotes and bacteria are key drivers of primary productivity and nutrient cycling in aquaculture ecosystems.Although their diversity and composition have been widely investigated in aquaculture systems,the co-... Microeukaryotes and bacteria are key drivers of primary productivity and nutrient cycling in aquaculture ecosystems.Although their diversity and composition have been widely investigated in aquaculture systems,the co-occurrence bipartite network between microeukaryotes and bacteria remains poorly understood.This study used the bipartite network analysis of high-throughput sequencing datasets to detect the co-occurrence relationships between microeukaryotes and bacteria in water and sediment from coastal aquaculture ponds.Chlorophyta and fungi were dominant phyla in the microeukaryotic–bacterial bipartite networks in water and sediment,respectively.Chlorophyta also had overrepresented links with bacteria in water.Most microeukaryotes and bacteria were classified as generalists,and tended to have symmetric positive and negative links with bacteria in both water and sediment.However,some microeukaryotes with high density of links showed asymmetric links with bacteria in water.Modularity detection in the bipartite network indicated that four microeukaryotes and twelve uncultured bacteria might be potential keystone taxa among the module connections.Moreover,the microeukaryotic–bacterial bipartite network in sediment harbored significantly more nestedness than that in water.The loss of microeukaryotes and generalists will more likely lead to the collapse of positive co-occurrence relationships between microeukaryotes and bacteria in both water and sediment.This study unveils the topology,dominant taxa,keystone species,and robustness in the microeukaryotic–bacterial bipartite networks in coastal aquaculture ecosystems.These species herein can be applied for further management of ecological services,and such knowledge may also be very useful for the regulation of other eutrophic ecosystems. 展开更多
关键词 Microeukaryote Bipartite network Interactions Keystone taxa NESTEDNESS
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A Multi-Scale Graph Neural Networks Ensemble Approach for Enhanced DDoS Detection
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作者 Noor Mueen Mohammed Ali Hayder Seyed Amin Hosseini Seno +2 位作者 Hamid Noori Davood Zabihzadeh Mehdi Ebady Manaa 《Computers, Materials & Continua》 2026年第4期1216-1242,共27页
Distributed Denial of Service(DDoS)attacks are one of the severe threats to network infrastructure,sometimes bypassing traditional diagnosis algorithms because of their evolving complexity.PresentMachine Learning(ML)t... Distributed Denial of Service(DDoS)attacks are one of the severe threats to network infrastructure,sometimes bypassing traditional diagnosis algorithms because of their evolving complexity.PresentMachine Learning(ML)techniques for DDoS attack diagnosis normally apply network traffic statistical features such as packet sizes and inter-arrival times.However,such techniques sometimes fail to capture complicated relations among various traffic flows.In this paper,we present a new multi-scale ensemble strategy given the Graph Neural Networks(GNNs)for improving DDoS detection.Our technique divides traffic into macro-and micro-level elements,letting various GNN models to get the two corase-scale anomalies and subtle,stealthy attack models.Through modeling network traffic as graph-structured data,GNNs efficiently learn intricate relations among network entities.The proposed ensemble learning algorithm combines the results of several GNNs to improve generalization,robustness,and scalability.Extensive experiments on three benchmark datasets—UNSW-NB15,CICIDS2017,and CICDDoS2019—show that our approach outperforms traditional machine learning and deep learning models in detecting both high-rate and low-rate(stealthy)DDoS attacks,with significant improvements in accuracy and recall.These findings demonstrate the suggested method’s applicability and robustness for real-world implementation in contexts where several DDoS patterns coexist. 展开更多
关键词 DDoS detection graph neural networks multi-scale learning ensemble learning network security stealth attacks network graphs
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Multi-Criteria Discovery of Communities in Social Networks Based on Services
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作者 Karim Boudjebbour Abdelkader Belkhir Hamza Kheddar 《Computers, Materials & Continua》 2026年第3期984-1005,共22页
Identifying the community structure of complex networks is crucial to extracting insights and understanding network properties.Although several community detection methods have been proposed,many are unsuitable for so... Identifying the community structure of complex networks is crucial to extracting insights and understanding network properties.Although several community detection methods have been proposed,many are unsuitable for social networks due to significant limitations.Specifically,most approaches depend mainly on user-user structural links while overlooking service-centric,semantic,and multi-attribute drivers of community formation,and they also lack flexible filtering mechanisms for large-scale,service-oriented settings.Our proposed approach,called community discovery-based service(CDBS),leverages user profiles and their interactions with consulted web services.The method introduces a novel similarity measure,global similarity interaction profile(GSIP),which goes beyond typical similarity measures by unifying user and service profiles for all attributes types into a coherent representation,thereby clarifying its novelty and contribution.It applies multiple filtering criteria related to user attributes,accessed services,and interaction patterns.Experimental comparisons against Louvain,Hierarchical Agglomerative Clustering,Label Propagation and Infomap show that CDBS reveals the higher performance as it achieves 0.74 modularity,0.13 conductance,0.77 coverage,and significantly fast response time of 9.8 s,even with 10,000 users and 400 services.Moreover,community discoverybased service consistently detects a larger number of communities with distinct topics of interest,underscoring its capacity to generate detailed and efficient structures in complex networks.These results confirm both the efficiency and effectiveness of the proposed method.Beyond controlled evaluation,communities discovery based service is applicable to targeted recommendations,group-oriented marketing,access control,and service personalization,where communities are shaped not only by user links but also by service engagement. 展开更多
关键词 Social network communities discovery complex network CLUSTERING web services similarity measure
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A Comprehensive Evaluation of Distributed Learning Frameworks in AI-Driven Network Intrusion Detection
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作者 Sooyong Jeong Cheolhee Park +1 位作者 Dowon Hong Changho Seo 《Computers, Materials & Continua》 2026年第4期310-332,共23页
With the growing complexity and decentralization of network systems,the attack surface has expanded,which has led to greater concerns over network threats.In this context,artificial intelligence(AI)-based network intr... With the growing complexity and decentralization of network systems,the attack surface has expanded,which has led to greater concerns over network threats.In this context,artificial intelligence(AI)-based network intrusion detection systems(NIDS)have been extensively studied,and recent efforts have shifted toward integrating distributed learning to enable intelligent and scalable detection mechanisms.However,most existing works focus on individual distributed learning frameworks,and there is a lack of systematic evaluations that compare different algorithms under consistent conditions.In this paper,we present a comprehensive evaluation of representative distributed learning frameworks—Federated Learning(FL),Split Learning(SL),hybrid collaborative learning(SFL),and fully distributed learning—in the context of AI-driven NIDS.Using recent benchmark intrusion detection datasets,a unified model backbone,and controlled distributed scenarios,we assess these frameworks across multiple criteria,including detection performance,communication cost,computational efficiency,and convergence behavior.Our findings highlight distinct trade-offs among the distributed learning frameworks,demonstrating that the optimal choice depends strongly on systemconstraints such as bandwidth availability,node resources,and data distribution.This work provides the first holistic analysis of distributed learning approaches for AI-driven NIDS and offers practical guidelines for designing secure and efficient intrusion detection systems in decentralized environments. 展开更多
关键词 network intrusion detection network security distributed learning
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HGS-ATD:A Hybrid Graph Convolutional Network-GraphSAGE Model for Anomaly Traffic Detection
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作者 Zhian Cui Hailong Li Xieyang Shen 《Journal of Harbin Institute of Technology(New Series)》 2026年第1期33-50,共18页
With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a ... With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a promising Deep Learning(DL)approach,has proven to be highly effective in identifying intricate patterns in graph⁃structured data and has already found wide applications in the field of network security.In this paper,we propose a hybrid Graph Convolutional Network(GCN)⁃GraphSAGE model for Anomaly Traffic Detection,namely HGS⁃ATD,which aims to improve the accuracy of anomaly traffic detection by leveraging edge feature learning to better capture the relationships between network entities.We validate the HGS⁃ATD model on four publicly available datasets,including NF⁃UNSW⁃NB15⁃v2.The experimental results show that the enhanced hybrid model is 5.71%to 10.25%higher than the baseline model in terms of accuracy,and the F1⁃score is 5.53%to 11.63%higher than the baseline model,proving that the model can effectively distinguish normal traffic from attack traffic and accurately classify various types of attacks. 展开更多
关键词 anomaly traffic detection graph neural network deep learning graph convolutional network
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Information Diffusion Models and Fuzzing Algorithms for a Privacy-Aware Data Transmission Scheduling in 6G Heterogeneous ad hoc Networks
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作者 Borja Bordel Sánchez Ramón Alcarria Tomás Robles 《Computer Modeling in Engineering & Sciences》 2026年第2期1214-1234,共21页
In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic h... In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic heterogeneous infrastructures,unstable links and non-uniform hardware capabilities create critical issues regarding security and privacy.Traditional protocols are often too computationally heavy to allow 6G services to achieve their expected Quality-of-Service(QoS).As the transport network is built of ad hoc nodes,there is no guarantee about their trustworthiness or behavior,and transversal functionalities are delegated to the extreme nodes.However,while security can be guaranteed in extreme-to-extreme solutions,privacy cannot,as all intermediate nodes still have to handle the data packets they are transporting.Besides,traditional schemes for private anonymous ad hoc communications are vulnerable against modern intelligent attacks based on learning models.The proposed scheme fulfills this gap.Findings show the probability of a successful intelligent attack reduces by up to 65%compared to ad hoc networks with no privacy protection strategy when used the proposed technology.While congestion probability can remain below 0.001%,as required in 6G services. 展开更多
关键词 6G networks ad hoc networks PRIVACY scheduling algorithms diffusion models fuzzing algorithms
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Multi-Label Classification Model Using Graph Convolutional Neural Network for Social Network Nodes
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作者 Junmin Lyu Guangyu Xu +4 位作者 Feng Bao Yu Zhou Yuxin Liu Siyu Lu Wenfeng Zheng 《Computer Modeling in Engineering & Sciences》 2026年第2期1235-1256,共22页
Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relati... Graph neural networks(GNN)have shown strong performance in node classification tasks,yet most existing models rely on uniform or shared weight aggregation,lacking flexibility in modeling the varying strength of relationships among nodes.This paper proposes a novel graph coupling convolutional model that introduces an adaptive weighting mechanism to assign distinct importance to neighboring nodes based on their similarity to the central node.Unlike traditional methods,the proposed coupling strategy enhances the interpretability of node interactions while maintaining competitive classification performance.The model operates in the spatial domain,utilizing adjacency list structures for efficient convolution and addressing the limitations of weight sharing through a coupling-based similarity computation.Extensive experiments are conducted on five graph-structured datasets,including Cora,Citeseer,PubMed,Reddit,and BlogCatalog,as well as a custom topology dataset constructed from the Open University Learning Analytics Dataset(OULAD)educational platform.Results demonstrate that the proposed model achieves good classification accuracy,while significantly reducing training time through direct second-order neighbor fusion and data preprocessing.Moreover,analysis of neighborhood order reveals that considering third-order neighbors offers limited accuracy gains but introduces considerable computational overhead,confirming the efficiency of first-and second-order convolution in practical applications.Overall,the proposed graph coupling model offers a lightweight,interpretable,and effective framework for multi-label node classification in complex networks. 展开更多
关键词 GNN social networks nodes multi-label classification model graphic convolution neural network coupling principle
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