Based on the previous findings that the presence of hydroxyl groups on the outer surface is crucial for maintaining skeletal stability,we propose a strategy modified Cu/SAPO-34 using Pr ions in this study.Therefore,we...Based on the previous findings that the presence of hydroxyl groups on the outer surface is crucial for maintaining skeletal stability,we propose a strategy modified Cu/SAPO-34 using Pr ions in this study.Therefore,we conducted several measurements to investigate the effect of Pr ions on the lowtemperature hydrothermal stability of Cu/SAPO-34.We find that Pr exists only on the surface of Cu/SAPO-34 as ions and oxides,with Pr^(3+)ions playing a protective role in occupying surface acidic sites.The addition of small amounts of Pr leads to the re-dispersion of Cu,resulting in improved lowtemperature selective catalytic reduction(SCR)activity in the as-synthesized samples.Furthermore,it enhances the resistance to decomposition of the Si-(OH)-Al framework during low-temperature hydrothermal aging,thereby preserving the framework structure and allowing detached active Cu species to return to exchangeable positions,ultimately restoring SCR activity.However,as the Pr content increases,the enhanced acidity causes some structural damage,gradually weakening the protective effect.Our work demonstrates that Pr modification is a simple and effective solution to the issue of poor lowtemperature hydrothermal stability in Cu/SAPO-34,providing a promising way for the application of light rare earth elements.展开更多
目的:探讨IL-34对ApoE-/-小鼠动脉粥样硬化(AS)和炎症反应的影响。方法:给予高脂饲料喂养的雄性ApoE-/-小鼠20只分为两组,每组10只。实验组隔天1次腹腔注射200 ng重组IL-34(rIL-34),对照组隔天1次腹腔注射0.3 mL PBS,干预12周。检测小...目的:探讨IL-34对ApoE-/-小鼠动脉粥样硬化(AS)和炎症反应的影响。方法:给予高脂饲料喂养的雄性ApoE-/-小鼠20只分为两组,每组10只。实验组隔天1次腹腔注射200 ng重组IL-34(rIL-34),对照组隔天1次腹腔注射0.3 mL PBS,干预12周。检测小鼠血清总胆固醇(TC),甘油三酯(TG)及高密度脂蛋白胆固醇(HDL-C);油红O染色评估小鼠主动脉AS形成情况;免疫组化法检测主动脉根部斑块炎症细胞(CD3+T细胞和Mac-3+巨噬细胞)浸润情况;流式细胞术检测脾脏T细胞亚群;ELISA法和Bio-Plex系统检测小鼠血清细胞炎性因子IL-1β、TNF-α、IFN-γ、IL-6、IL-4、IL-10、TGF-β1和IL-17A水平;qRT-PCR法检测小鼠主动脉弓上述细胞因子mRNA的表达水平。结果:两组小鼠血脂水平差异无统计学意义(P>0.05))。与对照组比较,实验组小鼠血清IL-34水平增加,主动脉和主动脉根部斑块面积增加,斑块内CD3+T细胞和Mac-3+巨噬细胞浸润增多,脾脏Th17细胞亚群比例升高,血清IL-1β、TNF-α、IFN-γ、IL-6和IL-17A水平升高,主动脉弓IL-1β、TNF-α、IFN-γ、IL-6和IL-17A mRNA表达水平升高(P均<0.05)。结论:IL-34可升高脾脏Th17细胞亚群比例,促进炎症因子表达,有助于小鼠AS形成。展开更多
目的观察重症肺结核患者治疗前血清白蛋白(albumin,ALB)、白介素-34(interleukin-34,IL-34)表达水平,并分析血清ALB、IL-34水平与重症肺结核患者预后之间可能的相关性。方法回顾性分析,收集郑州市第六人民医院2021年1月—2023年8月收治...目的观察重症肺结核患者治疗前血清白蛋白(albumin,ALB)、白介素-34(interleukin-34,IL-34)表达水平,并分析血清ALB、IL-34水平与重症肺结核患者预后之间可能的相关性。方法回顾性分析,收集郑州市第六人民医院2021年1月—2023年8月收治的112例重症肺结核患者资料,根据患者预后情况(入院开始接受治疗持续6个月内生存情况)分组,将25例死亡患者纳入预后不良组,87例生存患者纳入预后良好组,比较不同预后情况患者基线资料和治疗前血清ALB、IL-34水平,采用Cox风险模型和限制性立方样条法分析血清ALB、IL-34与重症肺结核患者预后的关系,并使用相对超危险度比(relative excess risk due to interaction,RERI)、归因比(attributable proportion,AP)以及交互作用指数(synergy index,SI)分析血清ALB、IL-34水平对重症肺结核患者预后的交互作用。结果不同预后患者基线资料比较,差异无统计学意义(P>0.05);预后不良组治疗前血清γ-干扰素(interferon-γ,IFN-γ)、ALB水平低于预后良好组,血清C-反应蛋白(C-reactive protein,CRP)、IL-34高于预后良好组,差异有统计学意义(P<0.05)。IFN-γ、CRP、ALB、IL-34的偏残差和时间秩次的Pearson相关性分析结果表明均满足PH假设(r=-0.068、-0.066、-0.210、0.186,P>0.05),经Cox生存回归分析结果显示,重症肺结核患者预后与入院时血清IFN-γ、ALB表达下调,血清CRP、IL-34表达上调有关(P<0.05)。经剂量反应分析结果显示,重症肺结核患者治疗前血清ALB、IL-34水平与预后不良的关联强度呈线性剂量反应关系(P<0.05)。血清ALB、IL-34对重症肺结核患者不良预后的发生存在负向交互作用,血清ALB低表达且IL-34高表达时不良预后风险是血清ALB高表达且IL-34低表达时的26.523倍。结论重症肺结核患者预后不良风险较高,入院时血清ALB呈低表达、IL-34呈高表达,这种异常的ALB低表达、IL-34高表达与患者不良预后有关,且二者对患者预后的影响呈交互作用。展开更多
基金supported by the National Key R&D Program of China(2021YFB3503200)the Innovative Research Groups of the National Natural Science Foundation of China(51921004)+1 种基金Young Elite Scientists Sponsorship Program by CAST(2021QNRC001)the Key R&D project of Shandong Province(2021CXGC010703,2022CXGC020311)。
文摘Based on the previous findings that the presence of hydroxyl groups on the outer surface is crucial for maintaining skeletal stability,we propose a strategy modified Cu/SAPO-34 using Pr ions in this study.Therefore,we conducted several measurements to investigate the effect of Pr ions on the lowtemperature hydrothermal stability of Cu/SAPO-34.We find that Pr exists only on the surface of Cu/SAPO-34 as ions and oxides,with Pr^(3+)ions playing a protective role in occupying surface acidic sites.The addition of small amounts of Pr leads to the re-dispersion of Cu,resulting in improved lowtemperature selective catalytic reduction(SCR)activity in the as-synthesized samples.Furthermore,it enhances the resistance to decomposition of the Si-(OH)-Al framework during low-temperature hydrothermal aging,thereby preserving the framework structure and allowing detached active Cu species to return to exchangeable positions,ultimately restoring SCR activity.However,as the Pr content increases,the enhanced acidity causes some structural damage,gradually weakening the protective effect.Our work demonstrates that Pr modification is a simple and effective solution to the issue of poor lowtemperature hydrothermal stability in Cu/SAPO-34,providing a promising way for the application of light rare earth elements.
文摘目的:探讨IL-34对ApoE-/-小鼠动脉粥样硬化(AS)和炎症反应的影响。方法:给予高脂饲料喂养的雄性ApoE-/-小鼠20只分为两组,每组10只。实验组隔天1次腹腔注射200 ng重组IL-34(rIL-34),对照组隔天1次腹腔注射0.3 mL PBS,干预12周。检测小鼠血清总胆固醇(TC),甘油三酯(TG)及高密度脂蛋白胆固醇(HDL-C);油红O染色评估小鼠主动脉AS形成情况;免疫组化法检测主动脉根部斑块炎症细胞(CD3+T细胞和Mac-3+巨噬细胞)浸润情况;流式细胞术检测脾脏T细胞亚群;ELISA法和Bio-Plex系统检测小鼠血清细胞炎性因子IL-1β、TNF-α、IFN-γ、IL-6、IL-4、IL-10、TGF-β1和IL-17A水平;qRT-PCR法检测小鼠主动脉弓上述细胞因子mRNA的表达水平。结果:两组小鼠血脂水平差异无统计学意义(P>0.05))。与对照组比较,实验组小鼠血清IL-34水平增加,主动脉和主动脉根部斑块面积增加,斑块内CD3+T细胞和Mac-3+巨噬细胞浸润增多,脾脏Th17细胞亚群比例升高,血清IL-1β、TNF-α、IFN-γ、IL-6和IL-17A水平升高,主动脉弓IL-1β、TNF-α、IFN-γ、IL-6和IL-17A mRNA表达水平升高(P均<0.05)。结论:IL-34可升高脾脏Th17细胞亚群比例,促进炎症因子表达,有助于小鼠AS形成。
文摘目的观察重症肺结核患者治疗前血清白蛋白(albumin,ALB)、白介素-34(interleukin-34,IL-34)表达水平,并分析血清ALB、IL-34水平与重症肺结核患者预后之间可能的相关性。方法回顾性分析,收集郑州市第六人民医院2021年1月—2023年8月收治的112例重症肺结核患者资料,根据患者预后情况(入院开始接受治疗持续6个月内生存情况)分组,将25例死亡患者纳入预后不良组,87例生存患者纳入预后良好组,比较不同预后情况患者基线资料和治疗前血清ALB、IL-34水平,采用Cox风险模型和限制性立方样条法分析血清ALB、IL-34与重症肺结核患者预后的关系,并使用相对超危险度比(relative excess risk due to interaction,RERI)、归因比(attributable proportion,AP)以及交互作用指数(synergy index,SI)分析血清ALB、IL-34水平对重症肺结核患者预后的交互作用。结果不同预后患者基线资料比较,差异无统计学意义(P>0.05);预后不良组治疗前血清γ-干扰素(interferon-γ,IFN-γ)、ALB水平低于预后良好组,血清C-反应蛋白(C-reactive protein,CRP)、IL-34高于预后良好组,差异有统计学意义(P<0.05)。IFN-γ、CRP、ALB、IL-34的偏残差和时间秩次的Pearson相关性分析结果表明均满足PH假设(r=-0.068、-0.066、-0.210、0.186,P>0.05),经Cox生存回归分析结果显示,重症肺结核患者预后与入院时血清IFN-γ、ALB表达下调,血清CRP、IL-34表达上调有关(P<0.05)。经剂量反应分析结果显示,重症肺结核患者治疗前血清ALB、IL-34水平与预后不良的关联强度呈线性剂量反应关系(P<0.05)。血清ALB、IL-34对重症肺结核患者不良预后的发生存在负向交互作用,血清ALB低表达且IL-34高表达时不良预后风险是血清ALB高表达且IL-34低表达时的26.523倍。结论重症肺结核患者预后不良风险较高,入院时血清ALB呈低表达、IL-34呈高表达,这种异常的ALB低表达、IL-34高表达与患者不良预后有关,且二者对患者预后的影响呈交互作用。
