Objective:To monitor the incidence of immune-related adverse events(irAEs)in patients treated with immune checkpoint inhibitors(ICIs)and programmed cell death protein-1(PD-1),and to evaluate the effectiveness of nursi...Objective:To monitor the incidence of immune-related adverse events(irAEs)in patients treated with immune checkpoint inhibitors(ICIs)and programmed cell death protein-1(PD-1),and to evaluate the effectiveness of nursing interventions using a quantitative scoring system.Methods:A retrospective analysis was performed on 65 cancer patients who received PD-1 therapy at the Oncology Department of Baotou Cancer Hospital from December 2023 to December 2024.The study examined the clinical features and blood test results related to irAEs.The National Cancer Institute’s Common Terminology Criteria for Adverse Events(NCI-CTCAE)was used to grade the severity of these events,which were classified into five levels.Based on the NCI-CTCAE scores,appropriate nursing measures were implemented,and a comprehensive risk assessment framework was developed.Results:The study group showed lower complication rates,overall incidence,and average hospital stay compared to the control group(P<0.05).Among the 65 patients,twenty-eight(43.07%)experienced a total of 35 irAEs,with 2(5.71%)being grade 3 or 4.The most frequent irAEs were dermatological conditions(34.29%),particularly rash with itching.The occurrence of irAEs did not correlate with patient gender,age,blood parameters(hemoglobin,white blood cell count,platelet count,etc.),or liver function(P>0.05),but it was associated with tumor type(P<0.05).Conclusion:PD-1 treatment is generally safe,with a low incidence of severe(grade 3 or higher)irAEs.Close monitoring is essential to ensure early detection,intervention,and management of irAEs,thereby maintaining a low level of adverse events and enhancing the safety and efficacy of PD-1 therapy.Implementing a quantitative risk scoring system for nursing care can decrease the rate of complications,enhance patient safety,and potentially reduce hospital stays and medical costs.展开更多
Objective To evaluate the clinical value of siltuximab in the treatment of Castleman disease based on multicriteria decision analysis(MCDA)and evidence and value:Impact on decision making(EVIDEM)framework.Methods The ...Objective To evaluate the clinical value of siltuximab in the treatment of Castleman disease based on multicriteria decision analysis(MCDA)and evidence and value:Impact on decision making(EVIDEM)framework.Methods The evidence matrix for quantitative analysis of MCDA was extracted through literature research,and the weight of each evaluation index was calculated by the maximum differentiation measure in conjoint analysis.Besides,the clinical value of siltuximab in the treatment of Castleman disease was analyzed quantitatively and qualitatively based on the results of expert questionnaire surveys.Results and Conclusion The clinical value score of siltuximab was 0.491,and the weight ratio of“therapeutic benefit”(15.39%),“drug effectiveness”(14.46%)and“drug safety”(11.43%)were the three largest.Among the indexes of“drug effectiveness”“drug safety”“patient reported outcome”“therapeutic benefit”and“non-medical cost”,siltuximab for Castleman disease was considered to be a more valuable treatment option than other first-line therapies.By qualitative analysis,57%experts believed that siltuximab was a better treatment option.The indexes that contribute the most to the overall clinical value of siltuximab are“therapeutic benefit”“drug effectiveness”and“quality of evidence”,while the indexes that have a negative impact on the clinical value of siltuximab is“drug treatment cost”.展开更多
[Objectives]To explore the clinical nursing value of predictive nursing intervention in patients with deep venous thrombosis of lower extremities after cesarean section.[Methods]From December 2022 to April 2023,105 pr...[Objectives]To explore the clinical nursing value of predictive nursing intervention in patients with deep venous thrombosis of lower extremities after cesarean section.[Methods]From December 2022 to April 2023,105 pregnant and lying-in women who were hospitalized in the Gynecology Department of Pingquan Hospital and underwent cesarean section and met the inclusion criteria were included as the study objects.According to the medical records,they were divided into observation group(n=52 cases)and control group(n=53 cases).The clinical experimental subjects were divided into two groups.One group was the control group with routine nursing,and the other group was the observation group with predictive nursing intervention.The number of cases of deep venous thrombosis of lower extremities in the two groups was recorded to evaluate the clinical value.[Results]The incidence of deep venous thrombosis of lower extremities in the two groups after cesarean section was compared,and it was suggested that the incidence of the observation group was lower than that of the control group(P<0.05).[Conclusions]Special predictive nursing intervention can greatly reduce the incidence of deep venous thrombosis of lower extremities after cesarean section,improve nursing satisfaction,and improve clinical efficacy,which is worthy of recommendation.展开更多
Objective: To investigate the clinical value of endodontics patients treated with calcium hydroxide preparation. Methods: The study cases were selected from the endodontics patients who visited our hospital during the...Objective: To investigate the clinical value of endodontics patients treated with calcium hydroxide preparation. Methods: The study cases were selected from the endodontics patients who visited our hospital during the period from January 2022 to December 2023, and 97 cases were randomly selected according to the numerical table method and divided into two groups. There were 49 cases in the control group and 48 cases in the experimental group. The control group received conventional therapy, while the experimental group received treatment with calcium hydroxide preparation, and the clinical value of the two different treatment modalities was observed and analyzed. Results: In the experimental group, 45 out of 48 patients (93.75%) showed effectiveness, compared to 39 out of 49 patients (79.59%) in the control group. The effectiveness rate was significantly higher in the experimental group (P < 0.05). Initially, the VAS scores between the two groups were similar (P > 0.05), but after 1 and 3 months of treatment, the scores decreased in both groups. However, the experimental group had a greater decrease, indicating lower pain levels (P < 0.05). The experimental group had fewer complications (8.33%) compared to the control group (24.49%), with a significant difference (P < 0.05). Satisfaction with treatment was higher in the experimental group (95.83%) compared to the control group (95.83%), resulting in an overall higher satisfaction rate in the experimental group (83.67%;P < 0.05). Conclusion: The treatment effect of endodontics with calcium hydroxide preparation is remarkable, which not only can effectively help patients to relieve their pain and reduce the incidence of complications but also plays an important role in improving patients’ satisfaction with treatment, which is worthwhile to be vigorously promoted in the clinic and learn from it.展开更多
Circular RNAs(circ RNAs),a class of endogenous RNA molecules,are produced by alternative splicing of precursor RNA and are covalently linked at the 5′and 3′ends.Recent studies have revealed that dysregulated circ RN...Circular RNAs(circ RNAs),a class of endogenous RNA molecules,are produced by alternative splicing of precursor RNA and are covalently linked at the 5′and 3′ends.Recent studies have revealed that dysregulated circ RNAs are closely related to the occurrence and progression of gastrointestinal malignancies.Accumulating evidence indicates that circ RNAs,including circ PVT1,circ LARP4,circ-SFMBT2,cir-ITCH,circ RNA_100782,circ_100395,circ-DONSON,hsa_circ_0001368,circ NRIP1,circ FAT1(e2),circ CCDC66,circ SMARCA5,circ-ZNF652,and circ_0030235 play important roles in the proliferation,differentiation,invasion,and metastasis of cancer cells through a variety of mechanisms,such as acting as micro RNA sponges,interacting with RNA-binding proteins,regulating gene transcription and alternative splicing,and being translated into proteins.With the characteristics of high abundance,high stability,extensive functions,and certain tissue-,time-and diseasespecific expressions,circ RNAs are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.展开更多
B and T-lymphocyte attenuator(BTLA)plays an immunosuppressive role by inhibiting T-and B-cell functions.BTLA is associated with a variety of diseases,especially cancer immunity.However,the function of BTLA in various ...B and T-lymphocyte attenuator(BTLA)plays an immunosuppressive role by inhibiting T-and B-cell functions.BTLA is associated with a variety of diseases,especially cancer immunity.However,the function of BTLA in various cancers and its clinical prognostic value have still not been comprehensively analyzed.This study aimed to identify the relationship between BTLA and cancer from the perspectives of differences in BTLA expression,its clinical value,immune infiltration,and the correlation with immune-related genes in various cancers.Data regarding mRNA expression,miRNA expression,lncRNA expression,and clinical data of patients of 33 existing cancers were collected from the TCGA database.Target miRNA of BTLA and the lncRNA that interacts with the target miRNA were obtained from the StarBase database.Based on bioinformatics analysis methods,the relationship between various types of cancers and BTLA was thoroughly investigated,and a competing endogenous RNA network of BTLA,target miRNA,and interacting lncRNA was constructed.The Kaplan-Meier(KM)prognostic analysis of BTLA and target miRNA(has-miR-137)in various types of cancers was completed using the KM plotter.BTLA expression varied in different cancers,with statistical significance in nine cancer types.KM plotter to analyze the overall survival(OS)and regression-free survival prognosis of cancer patients revealed that the BTLA expression was statistically different in the OS of 11 types of cancers out of 21 types of cancers;the OS of 8 type of cancers was also statistically different.Correlation analysis of tumor immune genes revealed a positive correlation of BTLA expression with immunosuppressive gene(CTLA4 and PDCD1)expression.Gene Set Enrichment Analysis showed that BTLA and its co-expressed genes mainly act through biological processes and pathways,including immune response regulation,cell surface receptor signaling pathway,antigen binding,antigen receptor-mediated signaling pathway,and leukocyte migration.BTLA has the potential as a prognostic marker for CLL,COAD,NSCLC,and OV and a diagnostic marker for CLL,COAD,and KIRC.BTLA has a close and complex relationship with the occurrence and development of tumors,and cancer immunotherapy for BTLA is worthy of further analysis.展开更多
Objective:To investigate the changes and the corresponding clinical value of serum cortisol levels in patients with hypertensive disorders during pregnancy.Methods:In this study,90 patients with different degrees of h...Objective:To investigate the changes and the corresponding clinical value of serum cortisol levels in patients with hypertensive disorders during pregnancy.Methods:In this study,90 patients with different degrees of hypertensive disorders during pregnancy who were admitted from August 2018 to August 2019 in our hospital were set as the research objects.90 cases were grouped according to the diagnostic criteria in Obstetrics and Gynecology,including 30 cases in each of the hypertension group,the preeclampsia group,and the eclampsia group.Another 30 healthy pregnant women were selected as the control group.The serum cortisol levels of pregnant women in the above four groups were measured.Results:Compared with the control group,the serum cortisol levels in the other three groups were significantly increased.In perinatal outcome,compared with the control group,the three groups of patients had an increase in Apgar score,preterm birth,stillbirth rate,growth restriction rate and neonatal asphyxia rate.There were significant differences between groups(P<0.05),and showed as gestational hypertension<preeclampsia<eclampsia.Conclusion:With the exacerbation of hypertensive disorders during pregnancy,the serum cortisol level continues to increase,which has a serious adverse effect on the prognosis of the perinatal infants.展开更多
Objective:This research studied the clinical value of implementing early rehabilitation in the nursing of patients with cerebral infarction.Methods:Eighty-four patients with cerebral infarction in Hubei Third People&#...Objective:This research studied the clinical value of implementing early rehabilitation in the nursing of patients with cerebral infarction.Methods:Eighty-four patients with cerebral infarction in Hubei Third People's Hospital from January 2019 to January 2021 were selected and divided into a control group and a study group using the digital table method in which routine care and early rehabilitation care were given respectively and the effects were observed.Results:Prior to the nursing intervention,there was no significant difference in the National Institutes of Health Stroke Scale(NIHSS)and Barthel index between the two groups of patients,P>0.05.After the nursing intervention,the NIHSS of the study group was lower than that of the control group whereas the Barthel index,Quality of Life Scale,and patient satisfaction in the study group were higher than the control group,P<0.05.Conclusion:The implementation of early rehabilitation in the nursing of patients with cerebral infarction can effectively improve their neurological function and quality of life in addition to a higher satisfaction among them.展开更多
Objective: this study is mainly to analyze the effect of pregnancy and oxytocin in the treatment of postpartum bleeding diseases. Methods: the study object, number and group division method are: in our cure postpartum...Objective: this study is mainly to analyze the effect of pregnancy and oxytocin in the treatment of postpartum bleeding diseases. Methods: the study object, number and group division method are: in our cure postpartum bleeding patients, 78 cases and random method, and as the name of the reference group, as another group, 39 cases of study group in the treatment of the accepted scheme for oxytocin, 39 cases of reference group in treatment received oxytocin, after the following indicators of two groups recorded analysis, respectively for quality of life, postpartum bleeding, clinical efficacy and shrinkage intensity, incidence of adverse reactions, etc. Results: in the clinical efficacy evaluation, the research group with total response rate was 94.87%, higher than the reference group with a total response rate of 71.79% (P <0.05);In the comparison of the improvement of quality of life in the study group and the reference group, it showed that the above indicators improved after the treatment. However, the obvious improvement was the research group (P <0.05);In the comparison of adverse reactions: the study group with total incidence of 5.13% was lower compared with the reference group with total incidence of 20.51% (P <0.05);The evaluation of the contractions intensity between the groups showed that the contractions were not improved significantly in the study group (P <0.05);In the statistics of the treatment satisfaction of the study group and the reference group, it is known that in the study group where the total satisfaction score was (95.65 ± 1.75) points was higher than the total satisfaction score was (76.54 ± 0.65) points (P <0.05);In the comparison of postpartum bleeding in the second group, the study group improved better after receiving treatment (P <0.05). Conclusion: the treatment of pregnancy plug and oxytonin is more effective in the treatment of postpartum bleeding patients, and can reduce the probability of adverse reactions, improve the situation of postpartum bleeding and weak contractions, and significantly improve the treatment satisfaction and quality of life.展开更多
Objective:To explore the application effect and clinical value of musculoskeletal ultrasound in the rehabilitation of hand function after flexor tendon rupture repair.Methods:In this study,72 patients were selected fr...Objective:To explore the application effect and clinical value of musculoskeletal ultrasound in the rehabilitation of hand function after flexor tendon rupture repair.Methods:In this study,72 patients were selected from among patients who underwent flexor tendon rupture repair of the hand in Yancheng Third People’s Hospital from May 2018 to May 2020;the patients were randomly divided into the control group(routine hand rehabilitation training)and the experimental group(musculoskeletal ultrasound and targeted hand rehabilitation training based on examination results)by die roll,with 34 cases in each group;the hand rehabilitation of the two groups were compared.Results:The excellent and good rate of the total active motion(TAM)of the experimental group(94.44%)was significantly higher than that of the control group(69.44%)(P<0.05);before treatment,there was no significant difference in the diameter and degree of stenosis of the artery in the finger between the two groups(P>0.05);after treatment,the degree of stenosis and the diameter of the artery of the experimental group were significantly better than those of the control group(P<0.05).Conclusion:For patients treated with flexor tendon rupture repair of the hand,the use of musculoskeletal ultrasound in the rehabilitation process can significantly improve the functional recovery of the hand;therefore,it is worthy of in-depth research,promotion,and application in clinical rehabilitation.展开更多
Objective:To study the clinical value of hepatitis B virus pregenomic RNA(HBV-pgRNA)detection in the treatment of hepatitis B.Methods:60 patients with hepatitis B were included in the study.Serum HBV-pgRNA and HBV DNA...Objective:To study the clinical value of hepatitis B virus pregenomic RNA(HBV-pgRNA)detection in the treatment of hepatitis B.Methods:60 patients with hepatitis B were included in the study.Serum HBV-pgRNA and HBV DNA levels in different phases of infection and during treatment were detected,and serum hepatitis B surface antigen(HbsAg)titer was detected by chemiluminescent immunoassay.DNA was extracted from liver biopsy tissue,and covalently closed circular DNA was detected to predict the therapeutic value in patients.Results:At the initial stage of treatment,the level of HBV-pgRNA in phase I,II,III,and IV showed a gradual decrease.Comparing the levels of HBV-pgRNA before and after treatment,we found that the level of HBV-pgRNA was significantly lower after treatment(P<0.05).Among the indicators for predicting HBsAg seroconversion,the accuracy of HBV-pgRNA level was 85.0%(51/60).Conclusion:The clinical value of HBV-pgRNA detection in the treatment of hepatitis B is high.展开更多
Objective: to analyze the immunoassay of thyroid cancer patients by chemiluminescence immunology method. Methods: from March 2020 to March 20, the investigation of the thyroid cancer patients were selected as the rese...Objective: to analyze the immunoassay of thyroid cancer patients by chemiluminescence immunology method. Methods: from March 2020 to March 20, the investigation of the thyroid cancer patients were selected as the research object, and based on the methods of digital random each group of 75 patients were divided into two groups in patients undergoing immune to enjoy chemiluminescence immune method, and the control group patients by analyzing radiation immunology, during this time they register for two separate immunological analysis time. The levels of thyroglobulin were examined, and the diagnostic accuracy was calculated and compared. Results: the detection levels of S. thiococcus in the observation group and the control group were 701.87±80.23 μ g/L and 637.68±65.17% μ g/L, respectively. Immunological examination was 27.63±4.12 minutes and 36.22±5.37 minutes, respectively. The diagnostic accuracy coefficients were 96.00 and 88.00%, respectively. Conclusion: the chemiluminescence immunoassay can not only reduce the test time, but also increase the accuracy of the test to some extent, so it needs to be used in clinic.展开更多
Objective: to consider the difference and characteristics of clinical diagnosis and treatment of mycoplasma pneumoniae pneumonia in children by X-ray and CT. Methods a total of 120 children with mycoplasma pneumoniae ...Objective: to consider the difference and characteristics of clinical diagnosis and treatment of mycoplasma pneumoniae pneumonia in children by X-ray and CT. Methods a total of 120 children with mycoplasma pneumoniae pneumonia received from the department of Pediatrics of our hospital during 2020/8-2020/8 were randomly divided into 2 groups. Among them, X-ray examination technique was selected in the observation group and CT examination technique was selected in the control group, with 60 cases in each group. The clinical diagnosis results of the two groups were compared. Results: There were abnormal changes in the lungs of all the children in the observation group. Finally, it was found that there was local shadow of lung parenchyma, patchy, and a little pleural effusion. The chest manifestations of the control group were different, and the typical manifestations were significantly enlarged hilar shadow and increased lung striae. In addition, the clinical diagnosis rate of the observation group was 96.67%, which was significantly higher than that of the control group (51.67%), indicating a significant difference in the above indicators (P < 0.05). Results: The clinical manifestations of mycoplasma pneumoniae pneumonia in children are not single, and they are diversified. Good diagnostic results can be obtained by using CT and X-ray technology for examination. However, the clinical diagnosis rate of CT technology is relatively high, so to ensure the accuracy and efficiency of clinical diagnosis results, It is usually necessary to carry out comprehensive evaluation based on clinical manifestations, changes in physical signs, laboratory examination structure, X-ray and CT examination, so as to bring support and guidance for timely and standardized treatment of children as soon as possible.展开更多
Objective: to explore the accuracy of routine test and biochemical test in the clinical diagnosis of adrenal cortical diseases. Methods: in accordance with the principle of random selection in this hospital in Septemb...Objective: to explore the accuracy of routine test and biochemical test in the clinical diagnosis of adrenal cortical diseases. Methods: in accordance with the principle of random selection in this hospital in September 2019 ~ 2020, 9 months were a total of 70 patients with adrenocortical disease in diagnosis experiment, will be more patients were divided into two groups, control group (n = 35) adopts the method of routine inspection, observation group (n = 35) are taking biochemical testing method, finally compare two groups of patients with the diagnosis accuracy. Results: the test accuracy of observation group was much higher than control group, and P < 0.05. Conclusion: compared with the conventional examination method, the application of biochemical examination technology in adrenal cortical diseases can effectively improve the accuracy of disease diagnosis, provide effective guidance for clinical treatment, has higher application value, and is worthy of popularization and application.展开更多
Objective: to study the clinical value of CT examination in patients with gastrointestinal perforation and abdominal infection. Methods: 200 patients with gastrointestinal perforation and abdominal infection who were ...Objective: to study the clinical value of CT examination in patients with gastrointestinal perforation and abdominal infection. Methods: 200 patients with gastrointestinal perforation and abdominal infection who were treated in our hospital from February 2016 to August 2019 were selected as the research objects. All patients underwent CT scanning. The results of doctors' reading were recorded and analyzed. The locations of gastrointestinal perforation were summarized and the CT manifestations were analyzed. Results: among the 200 patients, 164 had perforation of upper digestive tract and 36 had perforation of lower digestive tract. There were 91 cases (45.50%) of duodenal perforation, 73 cases (36.50%) of gastric perforation, 28 cases (14.00%) of appendiceal perforation and 8 cases (4.00%) of other intestinal perforation. The main sign of diagnosing digestive tract perforation is abdominal cavity gas accumulation, in which 52.00% of the patients show large amount of gas accumulation and 39.00% of the patients show small amount of gas accumulation;CT signs of abdominal infection include ascites and effusion, and signs of enlarged lymph nodes, abdominal abscess and peritoneal thickening also support abdominal infection. Conclusion: CT examination of patients with gastrointestinal perforation and abdominal cavity infection has high diagnostic value. Abdominal cavity gas accumulation and effusion are the main signs of CT diagnosis.展开更多
Objective: to explore the clinical application of Mongolian acupuncture combined with massage in the treatment of cervical spondylosis. Methods: 120 patients with cervical spondylosis admitted to our hospital from May...Objective: to explore the clinical application of Mongolian acupuncture combined with massage in the treatment of cervical spondylosis. Methods: 120 patients with cervical spondylosis admitted to our hospital from May 2020 to August 2020 were randomly divided into control group and experimental group, with 60 cases in each group. The experimental group was treated with Mongolian medicine combined with acupuncture and massage, while the control group was treated with routine acupuncture. The dizziness, headache, neck and shoulder pain and the effective rate of clinical treatment in the two groups were compared. Results: compared the symptom data, total effective rate, dizziness and neck and shoulder pain of the two groups, the curative effect of the experimental group was significantly better than that of the control group.展开更多
Objective: to explore the clinical value of platelet parameters and bone marrow smear for blood disease test. Methods: the 132 patients receiving platelet parameters and bone marrow smear test in our hospital were eve...Objective: to explore the clinical value of platelet parameters and bone marrow smear for blood disease test. Methods: the 132 patients receiving platelet parameters and bone marrow smear test in our hospital were evenly divided into 2 groups of 66 patients, namely control group (healthy population) and observation group (patients with blood diseases), with 33 patients in each group. The admission time was from July 1, 2020 to August 1, 2021. Results: the mean hematocrit (14.74 ± 3.19) FL and platelet volume distribution width (18.36 ± 1.38)% of the observation group were higher than those of the control group, while the platelet count of the observation group was significantly lower than that of the control group (239.64 ± 8.35)%, and the hematocrit was also lower than that of the control group (215.38 ± 5.36)*109. There was significant difference in platelet parameters between the two groups (P < 0.05);Compared with the control group, the distribution of platelets in the observation group was rare, single and occasional, the degree of bone marrow hyperplasia was more active, and megakaryocytes were immature megakaryocytes. Conclusion: through the platelet parameters combined with bone marrow smear test, it is found that there are significant changes in the relevant parameters of blood diseases and healthy people. Clinical test can provide an important basis for clinical treatment and contribute to the early detection of blood diseases.展开更多
Objective: to analyze the liver and kidney function test results and clinical value of 1000 patients with type 2 diabetes mellitus. Methods: 1000 patients with type 2 diabetes from January 2019 to December 2019 were s...Objective: to analyze the liver and kidney function test results and clinical value of 1000 patients with type 2 diabetes mellitus. Methods: 1000 patients with type 2 diabetes from January 2019 to December 2019 were selected as the research objects, and the liver and kidney functions of diabetic patients were examined. Results: 28.20% (282 / 1000) patients had abnormal liver function. Among the 282 cases, 213 were males and 69 were females, with a ratio of 3.09:1, aged 20-69 years, with an average age of (55.93 ± 3.46) years. Total bilirubin (TIBL) increased in 36 cases (12.77%). Direct bilirubin (DBIL) increased in 8 cases (2.47%). Albumin (ALB) decreased in 56 cases (19.86%). 224 cases (79.43%) had abnormal liver enzymes. Among 1000 cases of type 2 diabetes mellitus, 738 cases (73.80%) had abnormal renal function, 396 cases were male and 342 cases were female. The average age was (63.79 ± 3.26) years. Serum cystatin (Cys-C) increased in 632 cases (85.64%). There were 546 cases (73.89%) with elevated β 2-microglobulin (β 2-mg). Serum creatinine (SCR) increased in 306 cases (41.46%). Blood urea nitrogen (BUN) increased in 213 cases (28.86%). Conclusion: liver and kidney injury is common in patients with type 2 diabetes mellitus, and liver and kidney function should be routinely detected in clinical practice.展开更多
Objective: to study the clinical effect of mirena on endometrial atypical hyperplasia. Methods: data of patients with endometrial dysplasia admitted to our hospital from December 2016 to December 2020 were collected, ...Objective: to study the clinical effect of mirena on endometrial atypical hyperplasia. Methods: data of patients with endometrial dysplasia admitted to our hospital from December 2016 to December 2020 were collected, and 104 cases were selected to participate in the study. The observation group (52 cases) received mirena treatment, and the control group received conventional progesterone treatment. Results: the total effective rate (94.23%) and overall satisfaction rate (92.31%) in the observation group were significantly higher than that in the control group (P < 0.05), and the recurrence rate (1.92%) was significantly lower than that in the control group (P < 0.05). Conclusion: mirena has more ideal clinical effect in the treatment of endometrial atypical hyperplasia, which can effectively inhibit the disease and reduce recurrence, and is very safe and reliable.展开更多
Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control...Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control group (45 cases, using traditional hemolysin) and the study group (44 cases, using new hemolysin) were compared. Results: there were no statistically significant differences in the levels of red blood cells, white blood cells and platelets between the two groups (P > 0.05). The level of hemoglobin and satisfaction score in the study group were significantly higher than those in the control group (P < 0.05). The test time and cost in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: the new hemolysin has more application value in routine blood test.展开更多
基金Baotou City Health Science and Technology Plan(Project No.:2023wsjkkj109)。
文摘Objective:To monitor the incidence of immune-related adverse events(irAEs)in patients treated with immune checkpoint inhibitors(ICIs)and programmed cell death protein-1(PD-1),and to evaluate the effectiveness of nursing interventions using a quantitative scoring system.Methods:A retrospective analysis was performed on 65 cancer patients who received PD-1 therapy at the Oncology Department of Baotou Cancer Hospital from December 2023 to December 2024.The study examined the clinical features and blood test results related to irAEs.The National Cancer Institute’s Common Terminology Criteria for Adverse Events(NCI-CTCAE)was used to grade the severity of these events,which were classified into five levels.Based on the NCI-CTCAE scores,appropriate nursing measures were implemented,and a comprehensive risk assessment framework was developed.Results:The study group showed lower complication rates,overall incidence,and average hospital stay compared to the control group(P<0.05).Among the 65 patients,twenty-eight(43.07%)experienced a total of 35 irAEs,with 2(5.71%)being grade 3 or 4.The most frequent irAEs were dermatological conditions(34.29%),particularly rash with itching.The occurrence of irAEs did not correlate with patient gender,age,blood parameters(hemoglobin,white blood cell count,platelet count,etc.),or liver function(P>0.05),but it was associated with tumor type(P<0.05).Conclusion:PD-1 treatment is generally safe,with a low incidence of severe(grade 3 or higher)irAEs.Close monitoring is essential to ensure early detection,intervention,and management of irAEs,thereby maintaining a low level of adverse events and enhancing the safety and efficacy of PD-1 therapy.Implementing a quantitative risk scoring system for nursing care can decrease the rate of complications,enhance patient safety,and potentially reduce hospital stays and medical costs.
文摘Objective To evaluate the clinical value of siltuximab in the treatment of Castleman disease based on multicriteria decision analysis(MCDA)and evidence and value:Impact on decision making(EVIDEM)framework.Methods The evidence matrix for quantitative analysis of MCDA was extracted through literature research,and the weight of each evaluation index was calculated by the maximum differentiation measure in conjoint analysis.Besides,the clinical value of siltuximab in the treatment of Castleman disease was analyzed quantitatively and qualitatively based on the results of expert questionnaire surveys.Results and Conclusion The clinical value score of siltuximab was 0.491,and the weight ratio of“therapeutic benefit”(15.39%),“drug effectiveness”(14.46%)and“drug safety”(11.43%)were the three largest.Among the indexes of“drug effectiveness”“drug safety”“patient reported outcome”“therapeutic benefit”and“non-medical cost”,siltuximab for Castleman disease was considered to be a more valuable treatment option than other first-line therapies.By qualitative analysis,57%experts believed that siltuximab was a better treatment option.The indexes that contribute the most to the overall clinical value of siltuximab are“therapeutic benefit”“drug effectiveness”and“quality of evidence”,while the indexes that have a negative impact on the clinical value of siltuximab is“drug treatment cost”.
基金Chengde Science and Technology Plan Self-financing Project(202303A084).
文摘[Objectives]To explore the clinical nursing value of predictive nursing intervention in patients with deep venous thrombosis of lower extremities after cesarean section.[Methods]From December 2022 to April 2023,105 pregnant and lying-in women who were hospitalized in the Gynecology Department of Pingquan Hospital and underwent cesarean section and met the inclusion criteria were included as the study objects.According to the medical records,they were divided into observation group(n=52 cases)and control group(n=53 cases).The clinical experimental subjects were divided into two groups.One group was the control group with routine nursing,and the other group was the observation group with predictive nursing intervention.The number of cases of deep venous thrombosis of lower extremities in the two groups was recorded to evaluate the clinical value.[Results]The incidence of deep venous thrombosis of lower extremities in the two groups after cesarean section was compared,and it was suggested that the incidence of the observation group was lower than that of the control group(P<0.05).[Conclusions]Special predictive nursing intervention can greatly reduce the incidence of deep venous thrombosis of lower extremities after cesarean section,improve nursing satisfaction,and improve clinical efficacy,which is worthy of recommendation.
文摘Objective: To investigate the clinical value of endodontics patients treated with calcium hydroxide preparation. Methods: The study cases were selected from the endodontics patients who visited our hospital during the period from January 2022 to December 2023, and 97 cases were randomly selected according to the numerical table method and divided into two groups. There were 49 cases in the control group and 48 cases in the experimental group. The control group received conventional therapy, while the experimental group received treatment with calcium hydroxide preparation, and the clinical value of the two different treatment modalities was observed and analyzed. Results: In the experimental group, 45 out of 48 patients (93.75%) showed effectiveness, compared to 39 out of 49 patients (79.59%) in the control group. The effectiveness rate was significantly higher in the experimental group (P < 0.05). Initially, the VAS scores between the two groups were similar (P > 0.05), but after 1 and 3 months of treatment, the scores decreased in both groups. However, the experimental group had a greater decrease, indicating lower pain levels (P < 0.05). The experimental group had fewer complications (8.33%) compared to the control group (24.49%), with a significant difference (P < 0.05). Satisfaction with treatment was higher in the experimental group (95.83%) compared to the control group (95.83%), resulting in an overall higher satisfaction rate in the experimental group (83.67%;P < 0.05). Conclusion: The treatment effect of endodontics with calcium hydroxide preparation is remarkable, which not only can effectively help patients to relieve their pain and reduce the incidence of complications but also plays an important role in improving patients’ satisfaction with treatment, which is worthwhile to be vigorously promoted in the clinic and learn from it.
基金supported by the National Natural Science Foundation of China(Grant Nos.81702367 and 81772279)the Medical and Health Research Project of Zhejiang Province(Grant No.2018KY159)+1 种基金the Affiliated Hospital of Medical School of Ningbo University Youth Talent Cultivation Program(Grant No.FYQMKY202001)the Scientific Innovation Team Project of Ningbo(Grant No.2017C110019)。
文摘Circular RNAs(circ RNAs),a class of endogenous RNA molecules,are produced by alternative splicing of precursor RNA and are covalently linked at the 5′and 3′ends.Recent studies have revealed that dysregulated circ RNAs are closely related to the occurrence and progression of gastrointestinal malignancies.Accumulating evidence indicates that circ RNAs,including circ PVT1,circ LARP4,circ-SFMBT2,cir-ITCH,circ RNA_100782,circ_100395,circ-DONSON,hsa_circ_0001368,circ NRIP1,circ FAT1(e2),circ CCDC66,circ SMARCA5,circ-ZNF652,and circ_0030235 play important roles in the proliferation,differentiation,invasion,and metastasis of cancer cells through a variety of mechanisms,such as acting as micro RNA sponges,interacting with RNA-binding proteins,regulating gene transcription and alternative splicing,and being translated into proteins.With the characteristics of high abundance,high stability,extensive functions,and certain tissue-,time-and diseasespecific expressions,circ RNAs are expected to provide novel perspectives for the diagnoses and treatments of gastrointestinal malignancies.
基金funded by the Central to guide local scientific and Technological Development(ZYYDDFFZZJ-1)Natural Science Foundation of Gansu Province,China(No.18JR3RA052)+2 种基金Lanzhou Talent Innovation and Entrepreneurship Project Task Contract(No.2016-RC-56)Gansu Da Vinci Robot High-End Diagnosis and Treatment Team Construction Project,and Gansu Provincial Youth Science and Technology Fund Program(20JR10RA415)National Key Research and Development Program(No.2018YFC1311500).
文摘B and T-lymphocyte attenuator(BTLA)plays an immunosuppressive role by inhibiting T-and B-cell functions.BTLA is associated with a variety of diseases,especially cancer immunity.However,the function of BTLA in various cancers and its clinical prognostic value have still not been comprehensively analyzed.This study aimed to identify the relationship between BTLA and cancer from the perspectives of differences in BTLA expression,its clinical value,immune infiltration,and the correlation with immune-related genes in various cancers.Data regarding mRNA expression,miRNA expression,lncRNA expression,and clinical data of patients of 33 existing cancers were collected from the TCGA database.Target miRNA of BTLA and the lncRNA that interacts with the target miRNA were obtained from the StarBase database.Based on bioinformatics analysis methods,the relationship between various types of cancers and BTLA was thoroughly investigated,and a competing endogenous RNA network of BTLA,target miRNA,and interacting lncRNA was constructed.The Kaplan-Meier(KM)prognostic analysis of BTLA and target miRNA(has-miR-137)in various types of cancers was completed using the KM plotter.BTLA expression varied in different cancers,with statistical significance in nine cancer types.KM plotter to analyze the overall survival(OS)and regression-free survival prognosis of cancer patients revealed that the BTLA expression was statistically different in the OS of 11 types of cancers out of 21 types of cancers;the OS of 8 type of cancers was also statistically different.Correlation analysis of tumor immune genes revealed a positive correlation of BTLA expression with immunosuppressive gene(CTLA4 and PDCD1)expression.Gene Set Enrichment Analysis showed that BTLA and its co-expressed genes mainly act through biological processes and pathways,including immune response regulation,cell surface receptor signaling pathway,antigen binding,antigen receptor-mediated signaling pathway,and leukocyte migration.BTLA has the potential as a prognostic marker for CLL,COAD,NSCLC,and OV and a diagnostic marker for CLL,COAD,and KIRC.BTLA has a close and complex relationship with the occurrence and development of tumors,and cancer immunotherapy for BTLA is worthy of further analysis.
文摘Objective:To investigate the changes and the corresponding clinical value of serum cortisol levels in patients with hypertensive disorders during pregnancy.Methods:In this study,90 patients with different degrees of hypertensive disorders during pregnancy who were admitted from August 2018 to August 2019 in our hospital were set as the research objects.90 cases were grouped according to the diagnostic criteria in Obstetrics and Gynecology,including 30 cases in each of the hypertension group,the preeclampsia group,and the eclampsia group.Another 30 healthy pregnant women were selected as the control group.The serum cortisol levels of pregnant women in the above four groups were measured.Results:Compared with the control group,the serum cortisol levels in the other three groups were significantly increased.In perinatal outcome,compared with the control group,the three groups of patients had an increase in Apgar score,preterm birth,stillbirth rate,growth restriction rate and neonatal asphyxia rate.There were significant differences between groups(P<0.05),and showed as gestational hypertension<preeclampsia<eclampsia.Conclusion:With the exacerbation of hypertensive disorders during pregnancy,the serum cortisol level continues to increase,which has a serious adverse effect on the prognosis of the perinatal infants.
文摘Objective:This research studied the clinical value of implementing early rehabilitation in the nursing of patients with cerebral infarction.Methods:Eighty-four patients with cerebral infarction in Hubei Third People's Hospital from January 2019 to January 2021 were selected and divided into a control group and a study group using the digital table method in which routine care and early rehabilitation care were given respectively and the effects were observed.Results:Prior to the nursing intervention,there was no significant difference in the National Institutes of Health Stroke Scale(NIHSS)and Barthel index between the two groups of patients,P>0.05.After the nursing intervention,the NIHSS of the study group was lower than that of the control group whereas the Barthel index,Quality of Life Scale,and patient satisfaction in the study group were higher than the control group,P<0.05.Conclusion:The implementation of early rehabilitation in the nursing of patients with cerebral infarction can effectively improve their neurological function and quality of life in addition to a higher satisfaction among them.
文摘Objective: this study is mainly to analyze the effect of pregnancy and oxytocin in the treatment of postpartum bleeding diseases. Methods: the study object, number and group division method are: in our cure postpartum bleeding patients, 78 cases and random method, and as the name of the reference group, as another group, 39 cases of study group in the treatment of the accepted scheme for oxytocin, 39 cases of reference group in treatment received oxytocin, after the following indicators of two groups recorded analysis, respectively for quality of life, postpartum bleeding, clinical efficacy and shrinkage intensity, incidence of adverse reactions, etc. Results: in the clinical efficacy evaluation, the research group with total response rate was 94.87%, higher than the reference group with a total response rate of 71.79% (P <0.05);In the comparison of the improvement of quality of life in the study group and the reference group, it showed that the above indicators improved after the treatment. However, the obvious improvement was the research group (P <0.05);In the comparison of adverse reactions: the study group with total incidence of 5.13% was lower compared with the reference group with total incidence of 20.51% (P <0.05);The evaluation of the contractions intensity between the groups showed that the contractions were not improved significantly in the study group (P <0.05);In the statistics of the treatment satisfaction of the study group and the reference group, it is known that in the study group where the total satisfaction score was (95.65 ± 1.75) points was higher than the total satisfaction score was (76.54 ± 0.65) points (P <0.05);In the comparison of postpartum bleeding in the second group, the study group improved better after receiving treatment (P <0.05). Conclusion: the treatment of pregnancy plug and oxytonin is more effective in the treatment of postpartum bleeding patients, and can reduce the probability of adverse reactions, improve the situation of postpartum bleeding and weak contractions, and significantly improve the treatment satisfaction and quality of life.
文摘Objective:To explore the application effect and clinical value of musculoskeletal ultrasound in the rehabilitation of hand function after flexor tendon rupture repair.Methods:In this study,72 patients were selected from among patients who underwent flexor tendon rupture repair of the hand in Yancheng Third People’s Hospital from May 2018 to May 2020;the patients were randomly divided into the control group(routine hand rehabilitation training)and the experimental group(musculoskeletal ultrasound and targeted hand rehabilitation training based on examination results)by die roll,with 34 cases in each group;the hand rehabilitation of the two groups were compared.Results:The excellent and good rate of the total active motion(TAM)of the experimental group(94.44%)was significantly higher than that of the control group(69.44%)(P<0.05);before treatment,there was no significant difference in the diameter and degree of stenosis of the artery in the finger between the two groups(P>0.05);after treatment,the degree of stenosis and the diameter of the artery of the experimental group were significantly better than those of the control group(P<0.05).Conclusion:For patients treated with flexor tendon rupture repair of the hand,the use of musculoskeletal ultrasound in the rehabilitation process can significantly improve the functional recovery of the hand;therefore,it is worthy of in-depth research,promotion,and application in clinical rehabilitation.
基金supported by the grant from SPPH Foundation for Development of Science and Technology(2021BJ-26)International Science and Technology Cooperation Projects of Shaanxi Province(2022KW-14).
文摘Objective:To study the clinical value of hepatitis B virus pregenomic RNA(HBV-pgRNA)detection in the treatment of hepatitis B.Methods:60 patients with hepatitis B were included in the study.Serum HBV-pgRNA and HBV DNA levels in different phases of infection and during treatment were detected,and serum hepatitis B surface antigen(HbsAg)titer was detected by chemiluminescent immunoassay.DNA was extracted from liver biopsy tissue,and covalently closed circular DNA was detected to predict the therapeutic value in patients.Results:At the initial stage of treatment,the level of HBV-pgRNA in phase I,II,III,and IV showed a gradual decrease.Comparing the levels of HBV-pgRNA before and after treatment,we found that the level of HBV-pgRNA was significantly lower after treatment(P<0.05).Among the indicators for predicting HBsAg seroconversion,the accuracy of HBV-pgRNA level was 85.0%(51/60).Conclusion:The clinical value of HBV-pgRNA detection in the treatment of hepatitis B is high.
文摘Objective: to analyze the immunoassay of thyroid cancer patients by chemiluminescence immunology method. Methods: from March 2020 to March 20, the investigation of the thyroid cancer patients were selected as the research object, and based on the methods of digital random each group of 75 patients were divided into two groups in patients undergoing immune to enjoy chemiluminescence immune method, and the control group patients by analyzing radiation immunology, during this time they register for two separate immunological analysis time. The levels of thyroglobulin were examined, and the diagnostic accuracy was calculated and compared. Results: the detection levels of S. thiococcus in the observation group and the control group were 701.87±80.23 μ g/L and 637.68±65.17% μ g/L, respectively. Immunological examination was 27.63±4.12 minutes and 36.22±5.37 minutes, respectively. The diagnostic accuracy coefficients were 96.00 and 88.00%, respectively. Conclusion: the chemiluminescence immunoassay can not only reduce the test time, but also increase the accuracy of the test to some extent, so it needs to be used in clinic.
文摘Objective: to consider the difference and characteristics of clinical diagnosis and treatment of mycoplasma pneumoniae pneumonia in children by X-ray and CT. Methods a total of 120 children with mycoplasma pneumoniae pneumonia received from the department of Pediatrics of our hospital during 2020/8-2020/8 were randomly divided into 2 groups. Among them, X-ray examination technique was selected in the observation group and CT examination technique was selected in the control group, with 60 cases in each group. The clinical diagnosis results of the two groups were compared. Results: There were abnormal changes in the lungs of all the children in the observation group. Finally, it was found that there was local shadow of lung parenchyma, patchy, and a little pleural effusion. The chest manifestations of the control group were different, and the typical manifestations were significantly enlarged hilar shadow and increased lung striae. In addition, the clinical diagnosis rate of the observation group was 96.67%, which was significantly higher than that of the control group (51.67%), indicating a significant difference in the above indicators (P < 0.05). Results: The clinical manifestations of mycoplasma pneumoniae pneumonia in children are not single, and they are diversified. Good diagnostic results can be obtained by using CT and X-ray technology for examination. However, the clinical diagnosis rate of CT technology is relatively high, so to ensure the accuracy and efficiency of clinical diagnosis results, It is usually necessary to carry out comprehensive evaluation based on clinical manifestations, changes in physical signs, laboratory examination structure, X-ray and CT examination, so as to bring support and guidance for timely and standardized treatment of children as soon as possible.
文摘Objective: to explore the accuracy of routine test and biochemical test in the clinical diagnosis of adrenal cortical diseases. Methods: in accordance with the principle of random selection in this hospital in September 2019 ~ 2020, 9 months were a total of 70 patients with adrenocortical disease in diagnosis experiment, will be more patients were divided into two groups, control group (n = 35) adopts the method of routine inspection, observation group (n = 35) are taking biochemical testing method, finally compare two groups of patients with the diagnosis accuracy. Results: the test accuracy of observation group was much higher than control group, and P < 0.05. Conclusion: compared with the conventional examination method, the application of biochemical examination technology in adrenal cortical diseases can effectively improve the accuracy of disease diagnosis, provide effective guidance for clinical treatment, has higher application value, and is worthy of popularization and application.
文摘Objective: to study the clinical value of CT examination in patients with gastrointestinal perforation and abdominal infection. Methods: 200 patients with gastrointestinal perforation and abdominal infection who were treated in our hospital from February 2016 to August 2019 were selected as the research objects. All patients underwent CT scanning. The results of doctors' reading were recorded and analyzed. The locations of gastrointestinal perforation were summarized and the CT manifestations were analyzed. Results: among the 200 patients, 164 had perforation of upper digestive tract and 36 had perforation of lower digestive tract. There were 91 cases (45.50%) of duodenal perforation, 73 cases (36.50%) of gastric perforation, 28 cases (14.00%) of appendiceal perforation and 8 cases (4.00%) of other intestinal perforation. The main sign of diagnosing digestive tract perforation is abdominal cavity gas accumulation, in which 52.00% of the patients show large amount of gas accumulation and 39.00% of the patients show small amount of gas accumulation;CT signs of abdominal infection include ascites and effusion, and signs of enlarged lymph nodes, abdominal abscess and peritoneal thickening also support abdominal infection. Conclusion: CT examination of patients with gastrointestinal perforation and abdominal cavity infection has high diagnostic value. Abdominal cavity gas accumulation and effusion are the main signs of CT diagnosis.
文摘Objective: to explore the clinical application of Mongolian acupuncture combined with massage in the treatment of cervical spondylosis. Methods: 120 patients with cervical spondylosis admitted to our hospital from May 2020 to August 2020 were randomly divided into control group and experimental group, with 60 cases in each group. The experimental group was treated with Mongolian medicine combined with acupuncture and massage, while the control group was treated with routine acupuncture. The dizziness, headache, neck and shoulder pain and the effective rate of clinical treatment in the two groups were compared. Results: compared the symptom data, total effective rate, dizziness and neck and shoulder pain of the two groups, the curative effect of the experimental group was significantly better than that of the control group.
文摘Objective: to explore the clinical value of platelet parameters and bone marrow smear for blood disease test. Methods: the 132 patients receiving platelet parameters and bone marrow smear test in our hospital were evenly divided into 2 groups of 66 patients, namely control group (healthy population) and observation group (patients with blood diseases), with 33 patients in each group. The admission time was from July 1, 2020 to August 1, 2021. Results: the mean hematocrit (14.74 ± 3.19) FL and platelet volume distribution width (18.36 ± 1.38)% of the observation group were higher than those of the control group, while the platelet count of the observation group was significantly lower than that of the control group (239.64 ± 8.35)%, and the hematocrit was also lower than that of the control group (215.38 ± 5.36)*109. There was significant difference in platelet parameters between the two groups (P < 0.05);Compared with the control group, the distribution of platelets in the observation group was rare, single and occasional, the degree of bone marrow hyperplasia was more active, and megakaryocytes were immature megakaryocytes. Conclusion: through the platelet parameters combined with bone marrow smear test, it is found that there are significant changes in the relevant parameters of blood diseases and healthy people. Clinical test can provide an important basis for clinical treatment and contribute to the early detection of blood diseases.
文摘Objective: to analyze the liver and kidney function test results and clinical value of 1000 patients with type 2 diabetes mellitus. Methods: 1000 patients with type 2 diabetes from January 2019 to December 2019 were selected as the research objects, and the liver and kidney functions of diabetic patients were examined. Results: 28.20% (282 / 1000) patients had abnormal liver function. Among the 282 cases, 213 were males and 69 were females, with a ratio of 3.09:1, aged 20-69 years, with an average age of (55.93 ± 3.46) years. Total bilirubin (TIBL) increased in 36 cases (12.77%). Direct bilirubin (DBIL) increased in 8 cases (2.47%). Albumin (ALB) decreased in 56 cases (19.86%). 224 cases (79.43%) had abnormal liver enzymes. Among 1000 cases of type 2 diabetes mellitus, 738 cases (73.80%) had abnormal renal function, 396 cases were male and 342 cases were female. The average age was (63.79 ± 3.26) years. Serum cystatin (Cys-C) increased in 632 cases (85.64%). There were 546 cases (73.89%) with elevated β 2-microglobulin (β 2-mg). Serum creatinine (SCR) increased in 306 cases (41.46%). Blood urea nitrogen (BUN) increased in 213 cases (28.86%). Conclusion: liver and kidney injury is common in patients with type 2 diabetes mellitus, and liver and kidney function should be routinely detected in clinical practice.
文摘Objective: to study the clinical effect of mirena on endometrial atypical hyperplasia. Methods: data of patients with endometrial dysplasia admitted to our hospital from December 2016 to December 2020 were collected, and 104 cases were selected to participate in the study. The observation group (52 cases) received mirena treatment, and the control group received conventional progesterone treatment. Results: the total effective rate (94.23%) and overall satisfaction rate (92.31%) in the observation group were significantly higher than that in the control group (P < 0.05), and the recurrence rate (1.92%) was significantly lower than that in the control group (P < 0.05). Conclusion: mirena has more ideal clinical effect in the treatment of endometrial atypical hyperplasia, which can effectively inhibit the disease and reduce recurrence, and is very safe and reliable.
文摘Objective: to discuss the clinical value of new hemolysin and traditional hemolysin in blood routine examination. Methods: a total of 89 blood routine test subjects were selected from our hospital. The average control group (45 cases, using traditional hemolysin) and the study group (44 cases, using new hemolysin) were compared. Results: there were no statistically significant differences in the levels of red blood cells, white blood cells and platelets between the two groups (P > 0.05). The level of hemoglobin and satisfaction score in the study group were significantly higher than those in the control group (P < 0.05). The test time and cost in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: the new hemolysin has more application value in routine blood test.
