Hepatocellular carcinoma(HCC)presents challenges due to its high recurrence and metastasis rates and poor prognosis.While current clinical diagnostic and prognostic indicators exist,their accuracy remains imperfect du...Hepatocellular carcinoma(HCC)presents challenges due to its high recurrence and metastasis rates and poor prognosis.While current clinical diagnostic and prognostic indicators exist,their accuracy remains imperfect due to their biol-ogical complexity.Therefore,there is a quest to identify improved biomarkers for HCC diagnosis and prognosis.By combining long non-coding RNA(lncRNA)expression and somatic mutations,Duan et al identified five representative lncRNAs from 88 lncRNAs related to genomic instability(GI),forming a GI-derived lncRNA signature(LncSig).This signature outperforms previously re-ported LncSig and TP53 mutations in predicting HCC prognosis.In this editorial,we comprehensively evaluate the clinical application value of such prognostic evaluation model based on sequencing technology in terms of cost,time,and practicability.Additionally,we provide an overview of various prognostic models for HCC,aiding in a comprehensive understanding of research progress in pro-gnostic evaluation methods.展开更多
Objective: to detect serum thyroglobulin antibody (TG AB), peroxidase antibody (TPO AB) and thyroglobulin (TG) in patients with thyroid nodules. Methods: 80 patients with malignant TN were selected and divided into st...Objective: to detect serum thyroglobulin antibody (TG AB), peroxidase antibody (TPO AB) and thyroglobulin (TG) in patients with thyroid nodules. Methods: 80 patients with malignant TN were selected and divided into study group (32 cases, malignant TN group) and control group (48 cases, benign TN group) according to the postoperative pathological results. The levels of thyroid function (FT3, FT4 and TSH) and the positive rates of TG AB, TPO AB and TG (single positive rate and triple positive rate) were compared between the two groups. Results: compared with the two groups, the serum TSH level, the positive rate of TG AB, TPO AB and TG in the study group were higher (P < 0.05). Conclusion: the detection of serum TG AB, TPO AB and TG in patients with thyroid nodules can help to distinguish the benign and malignant nature of thyroid nodules, and have certain guiding significance for the determination of diagnosis and treatment plan of patients.展开更多
Objective: to explore the clinical application effect of biochemical test in the diagnosis of diabetes. Methods: this experiment is selected, our hospital admitted 60 cases of diabetes patients, as the object of this ...Objective: to explore the clinical application effect of biochemical test in the diagnosis of diabetes. Methods: this experiment is selected, our hospital admitted 60 cases of diabetes patients, as the object of this experiment. The treatment period was from April 2018 to June 2019. According to the disease of diabetes, they were divided into general diabetes group (experimental group) and observation group (diabetes complications group) for analysis. At the same time, normal patients receiving biochemical tests were selected as the detection objects. Among them, the concentrations of fasting blood glucose (FPG), OGTT(oral glucose tolerance test) and glycosylated hemoglobin (HbAlc) were compared. Results: the FPG, OGTT and HbAlc of the experimental group were significantly higher than those of the observation group and the healthy group (P<0.05), and the difference was statistically significant. Conclusion: in the clinical test, the biochemical test for the diagnosis of diabetes is helpful to distinguish the blood glucose of diabetes, and has the value of promotion.展开更多
Objective: this paper mainly studies the value of immune test in prenatal examination. Methods: from March 2018 to March 2020, 100 pregnant women in our hospital were selected as the research objects, and they were ra...Objective: this paper mainly studies the value of immune test in prenatal examination. Methods: from March 2018 to March 2020, 100 pregnant women in our hospital were selected as the research objects, and they were randomly divided into control group and observation group. Each group has 50 cases and use different inspection methods. The control group used routine prenatal examination. The observation group used immune test items on the basis of control group. The incidences of high-risk pregnancy were compared. Results: there were high-risk pregnancies in both groups, but the observation group took corresponding measures to control the pregnant women’s condition in time after the immune test. And its incidence of high-risk pregnancy was 4%, while the incidence of high-risk pregnancy of the conventional group was 30%, which was significantly higher than that of the observation group (P < 0.05). Conclusion: the clinical application value of immune test items in prenatal examination is significant. Immunization test is conducive to timely detect maternal high-risk pregnancy to a large extent, provides an important reference basis for the control of maternal high-risk pregnancy factors and helps to reduce the incidence of high-risk pregnancy.展开更多
Objective: to analyze the clinical application value of extended nursing in patients with heart failure complicated with arrhythmia. Methods: from February 2020 to February 2021, 74 cases of patients with heart failur...Objective: to analyze the clinical application value of extended nursing in patients with heart failure complicated with arrhythmia. Methods: from February 2020 to February 2021, 74 cases of patients with heart failure combined with arrhythmia were selected and divided into control group (n=37) and experimental group (n=37) by random number table. Conventional and extended nursing were given respectively. Cardiovascular function indexes and quality of life were evaluated before and after nursing, and then adverse reactions in the nursing process were compared. Results: in terms of cardiac function, there were no significant differences in each index before nursing, P > 0.05. After nursing, LVEF (58.25 7.36) in the experimental group was significantly higher than that in the control group, and LVDD (58.36 5.42) and LVDS (34.25 4.93) were significantly lower than that in the control group, P < 0.05. In terms of quality of life, the physical response (79.33 8.26), physiological function (80.12 8.78), mental state (80.26 8.28) and social activity (79.95 7.99) of the experimental group were significantly higher than those of the control group, P < 0.05;In terms of adverse reactions, the incidence of 10.81% (4/37) in the experimental group was significantly lower than that in the control group, P < 0.05. Conclusion: extended nursing for patients with heart failure combined with arrhythmia can effectively improve their cardiac function and quality of life, adverse reactions are relatively less than those of patients with conventional nursing.展开更多
Objective: the purpose of this experiment is to analyze the clinical application effect of blood sugar and urine sugar test in the diagnosis of diabetes. Methods: the subjects were selected from 100 diabetic patients ...Objective: the purpose of this experiment is to analyze the clinical application effect of blood sugar and urine sugar test in the diagnosis of diabetes. Methods: the subjects were selected from 100 diabetic patients treated in our hospital from December 2019 to December 2020. All patients will undergo urine sugar test and blood sugar test, and analyze the correlation between these two test methods. Results: through the comparison of experimental data, there is a significant positive correlation between the urine sugar level and the blood sugar level of diabetic patients. Among them, the decrease of urine sugar in 6 diabetic patients is negative, but the blood sugar and fasting blood sugar level of the patients still have a certain increase 2 hours after meal. Conclusion: according to the results, urine sugar test can be used in the initial diagnosis of diabetic patients. However, if you want to improve the accuracy of diagnosis, you need to combine the results of blood sugar test for comprehensive diagnosis, so as to improve the accuracy of diagnosis, early treatment of patients and improve the prognosis of patients.展开更多
BACKGROUND Early detection of acute appendicitis(AA)in pediatric cases,critical to avoiding life-threatening complications such as perforation or abscess,remains challenging.AIM To evaluate the utility of abdominal ul...BACKGROUND Early detection of acute appendicitis(AA)in pediatric cases,critical to avoiding life-threatening complications such as perforation or abscess,remains challenging.AIM To evaluate the utility of abdominal ultrasonography(AUS)in diagnosing pediatric AA.METHODS Overall,102 pediatric patients(aged 3-12 years)suspected of having AA were enrolled and divided into the AA(n=78)and non-AA(n=24)groups.All children underwent AUS and computed tomography(CT).Comparative analyses regarding general patient characteristics and appendix-specific parameters were conducted.The diagnostic performance of AUS and CT in pediatric AA was evaluated.RESULTS All appendix-related parameters were greater in the AA group than in the non-AA group.The areas under the receiver-operating characteristic curves for pediatric AA diagnosis using AUS,CT,and AUS+CT were 0.870,0.824,and 0.931(all P<0.001),respectively(AUS:94.87%sensitivity,79.17%specificity;CT:89.74%sensitivity,75.00%specificity;combined:98.72%sensitivity,87.50%specificity).The positive predictive value(PPV),negative predictive value(NPV),accuracy rate,positive detection rate,and misdiagnosis rate of AUS were 93.67%,82.61%,91.18%,72.55%,and 20.83%,respectively.CT had a slightly lower PPV(92.11%)and NPV(69.23%),along with accuracy,positive detection,and misdiagnosis rates of 86.27%,68.63%,and 25%,respectively.Their combination improved performance,yielding 96.25%PPV,95.45%NPV,96.08%accuracy,75.49%positive detection rate,and 12.50%misdiagnosis rate.CONCLUSION AUS demonstrates certain diagnostic potential in AA diagnosis in pediatric patients,and its combination with CT further improves diagnostic efficacy.展开更多
Objective: to explore the clinical significance of humanistic care in the nursing of patients with severe neurological diseases. Methods: 80 patients were selected from ICU, and this research activity was carried out ...Objective: to explore the clinical significance of humanistic care in the nursing of patients with severe neurological diseases. Methods: 80 patients were selected from ICU, and this research activity was carried out with the cooperation of patients. By drawing lots, two groups (experimental group and control group) were randomly established. On the basis of general care, the experimental group was given humanistic care, while the control group was not given humanistic care. The nursing intervention period was 2 months. After the end, relevant data indicators were counted and compared, and the effect of humanistic care was analyzed. Results: The scores of anxiety (SAS), depression (SDS), nursing satisfaction and symptom checklist score between the experimental group and the control group were statistically significant (P<0.05). Conclusion: patients with severe neurological diseases are more sensitive to their emotions, and the nursing experience during treatment is one of the decisive factors affecting the treatment effect of such patients. Adopting the concept of humanistic care and giving humanized care to patients is of great help to reduce patients' anxiety, depression and other negative emotions, and improve various symptoms of diseases, which can be applied in clinic to help improve the prognosis and speed up the recovery of the disease.展开更多
Objective To establish a risk prediction model for type 2 diabetes mellitus(T2DM)related overactive bladder(OAB),and to verify the diagnostic efficacy and clinical application value of the model.Methods The clinical d...Objective To establish a risk prediction model for type 2 diabetes mellitus(T2DM)related overactive bladder(OAB),and to verify the diagnostic efficacy and clinical application value of the model.Methods The clinical data of 298 patients with diabetes who underwent urodynamic examination in The First Affiliated Hospital of Wannan Medical College from January 2020 to October 2023 were analyzed retrospectively.According to the results of urodynamics,all the patients were divided into T2DM group(T2DM,n=218)and OAB group(OAB,n=80).The risk factors of OAB were analyzed by logistic regression,andd thepredictionmodel was established according to the risk factors.Receiver operating characteristic(ROC)curve,calibration diagram and decision curve analysis(DCA)were used to analyze and evaluate the diagnostic efficiency of the model.ResultsLogisticcregressionanalysis results showed that age,DM duration,BMI,HbA,c,DPN and OAB score(OABSS),were independent predictors for OAB.The nomogram model built based on the above risk factors had good predictive ability,and its area under ROC curve was 0.937.The correction curve showed that the predicted probability of OAB in patients with type 2 diabetes mellitus was basically parallel to the actual probability of urodynamic detection.The results of DCA showed that the model had high clinical value.Conclusion The nomogram model built by age,DM duration,OABSS,BMI,HbA,c,DPN has high predictive efficacy for OAB in patients with T2DM.展开更多
基金The National Key R&D Program of China(Key Special Project for Marine Environmental Security and Sustainable Development of Coral Reefs 2022-3.3),No.2022YFC3103-004001Scientific Research Foundation of Shanghai Municipal Health Commission of Changning District,No.20234Y038.
文摘Hepatocellular carcinoma(HCC)presents challenges due to its high recurrence and metastasis rates and poor prognosis.While current clinical diagnostic and prognostic indicators exist,their accuracy remains imperfect due to their biol-ogical complexity.Therefore,there is a quest to identify improved biomarkers for HCC diagnosis and prognosis.By combining long non-coding RNA(lncRNA)expression and somatic mutations,Duan et al identified five representative lncRNAs from 88 lncRNAs related to genomic instability(GI),forming a GI-derived lncRNA signature(LncSig).This signature outperforms previously re-ported LncSig and TP53 mutations in predicting HCC prognosis.In this editorial,we comprehensively evaluate the clinical application value of such prognostic evaluation model based on sequencing technology in terms of cost,time,and practicability.Additionally,we provide an overview of various prognostic models for HCC,aiding in a comprehensive understanding of research progress in pro-gnostic evaluation methods.
文摘Objective: to detect serum thyroglobulin antibody (TG AB), peroxidase antibody (TPO AB) and thyroglobulin (TG) in patients with thyroid nodules. Methods: 80 patients with malignant TN were selected and divided into study group (32 cases, malignant TN group) and control group (48 cases, benign TN group) according to the postoperative pathological results. The levels of thyroid function (FT3, FT4 and TSH) and the positive rates of TG AB, TPO AB and TG (single positive rate and triple positive rate) were compared between the two groups. Results: compared with the two groups, the serum TSH level, the positive rate of TG AB, TPO AB and TG in the study group were higher (P < 0.05). Conclusion: the detection of serum TG AB, TPO AB and TG in patients with thyroid nodules can help to distinguish the benign and malignant nature of thyroid nodules, and have certain guiding significance for the determination of diagnosis and treatment plan of patients.
文摘Objective: to explore the clinical application effect of biochemical test in the diagnosis of diabetes. Methods: this experiment is selected, our hospital admitted 60 cases of diabetes patients, as the object of this experiment. The treatment period was from April 2018 to June 2019. According to the disease of diabetes, they were divided into general diabetes group (experimental group) and observation group (diabetes complications group) for analysis. At the same time, normal patients receiving biochemical tests were selected as the detection objects. Among them, the concentrations of fasting blood glucose (FPG), OGTT(oral glucose tolerance test) and glycosylated hemoglobin (HbAlc) were compared. Results: the FPG, OGTT and HbAlc of the experimental group were significantly higher than those of the observation group and the healthy group (P<0.05), and the difference was statistically significant. Conclusion: in the clinical test, the biochemical test for the diagnosis of diabetes is helpful to distinguish the blood glucose of diabetes, and has the value of promotion.
文摘Objective: this paper mainly studies the value of immune test in prenatal examination. Methods: from March 2018 to March 2020, 100 pregnant women in our hospital were selected as the research objects, and they were randomly divided into control group and observation group. Each group has 50 cases and use different inspection methods. The control group used routine prenatal examination. The observation group used immune test items on the basis of control group. The incidences of high-risk pregnancy were compared. Results: there were high-risk pregnancies in both groups, but the observation group took corresponding measures to control the pregnant women’s condition in time after the immune test. And its incidence of high-risk pregnancy was 4%, while the incidence of high-risk pregnancy of the conventional group was 30%, which was significantly higher than that of the observation group (P < 0.05). Conclusion: the clinical application value of immune test items in prenatal examination is significant. Immunization test is conducive to timely detect maternal high-risk pregnancy to a large extent, provides an important reference basis for the control of maternal high-risk pregnancy factors and helps to reduce the incidence of high-risk pregnancy.
文摘Objective: to analyze the clinical application value of extended nursing in patients with heart failure complicated with arrhythmia. Methods: from February 2020 to February 2021, 74 cases of patients with heart failure combined with arrhythmia were selected and divided into control group (n=37) and experimental group (n=37) by random number table. Conventional and extended nursing were given respectively. Cardiovascular function indexes and quality of life were evaluated before and after nursing, and then adverse reactions in the nursing process were compared. Results: in terms of cardiac function, there were no significant differences in each index before nursing, P > 0.05. After nursing, LVEF (58.25 7.36) in the experimental group was significantly higher than that in the control group, and LVDD (58.36 5.42) and LVDS (34.25 4.93) were significantly lower than that in the control group, P < 0.05. In terms of quality of life, the physical response (79.33 8.26), physiological function (80.12 8.78), mental state (80.26 8.28) and social activity (79.95 7.99) of the experimental group were significantly higher than those of the control group, P < 0.05;In terms of adverse reactions, the incidence of 10.81% (4/37) in the experimental group was significantly lower than that in the control group, P < 0.05. Conclusion: extended nursing for patients with heart failure combined with arrhythmia can effectively improve their cardiac function and quality of life, adverse reactions are relatively less than those of patients with conventional nursing.
文摘Objective: the purpose of this experiment is to analyze the clinical application effect of blood sugar and urine sugar test in the diagnosis of diabetes. Methods: the subjects were selected from 100 diabetic patients treated in our hospital from December 2019 to December 2020. All patients will undergo urine sugar test and blood sugar test, and analyze the correlation between these two test methods. Results: through the comparison of experimental data, there is a significant positive correlation between the urine sugar level and the blood sugar level of diabetic patients. Among them, the decrease of urine sugar in 6 diabetic patients is negative, but the blood sugar and fasting blood sugar level of the patients still have a certain increase 2 hours after meal. Conclusion: according to the results, urine sugar test can be used in the initial diagnosis of diabetic patients. However, if you want to improve the accuracy of diagnosis, you need to combine the results of blood sugar test for comprehensive diagnosis, so as to improve the accuracy of diagnosis, early treatment of patients and improve the prognosis of patients.
文摘BACKGROUND Early detection of acute appendicitis(AA)in pediatric cases,critical to avoiding life-threatening complications such as perforation or abscess,remains challenging.AIM To evaluate the utility of abdominal ultrasonography(AUS)in diagnosing pediatric AA.METHODS Overall,102 pediatric patients(aged 3-12 years)suspected of having AA were enrolled and divided into the AA(n=78)and non-AA(n=24)groups.All children underwent AUS and computed tomography(CT).Comparative analyses regarding general patient characteristics and appendix-specific parameters were conducted.The diagnostic performance of AUS and CT in pediatric AA was evaluated.RESULTS All appendix-related parameters were greater in the AA group than in the non-AA group.The areas under the receiver-operating characteristic curves for pediatric AA diagnosis using AUS,CT,and AUS+CT were 0.870,0.824,and 0.931(all P<0.001),respectively(AUS:94.87%sensitivity,79.17%specificity;CT:89.74%sensitivity,75.00%specificity;combined:98.72%sensitivity,87.50%specificity).The positive predictive value(PPV),negative predictive value(NPV),accuracy rate,positive detection rate,and misdiagnosis rate of AUS were 93.67%,82.61%,91.18%,72.55%,and 20.83%,respectively.CT had a slightly lower PPV(92.11%)and NPV(69.23%),along with accuracy,positive detection,and misdiagnosis rates of 86.27%,68.63%,and 25%,respectively.Their combination improved performance,yielding 96.25%PPV,95.45%NPV,96.08%accuracy,75.49%positive detection rate,and 12.50%misdiagnosis rate.CONCLUSION AUS demonstrates certain diagnostic potential in AA diagnosis in pediatric patients,and its combination with CT further improves diagnostic efficacy.
文摘Objective: to explore the clinical significance of humanistic care in the nursing of patients with severe neurological diseases. Methods: 80 patients were selected from ICU, and this research activity was carried out with the cooperation of patients. By drawing lots, two groups (experimental group and control group) were randomly established. On the basis of general care, the experimental group was given humanistic care, while the control group was not given humanistic care. The nursing intervention period was 2 months. After the end, relevant data indicators were counted and compared, and the effect of humanistic care was analyzed. Results: The scores of anxiety (SAS), depression (SDS), nursing satisfaction and symptom checklist score between the experimental group and the control group were statistically significant (P<0.05). Conclusion: patients with severe neurological diseases are more sensitive to their emotions, and the nursing experience during treatment is one of the decisive factors affecting the treatment effect of such patients. Adopting the concept of humanistic care and giving humanized care to patients is of great help to reduce patients' anxiety, depression and other negative emotions, and improve various symptoms of diseases, which can be applied in clinic to help improve the prognosis and speed up the recovery of the disease.
文摘Objective To establish a risk prediction model for type 2 diabetes mellitus(T2DM)related overactive bladder(OAB),and to verify the diagnostic efficacy and clinical application value of the model.Methods The clinical data of 298 patients with diabetes who underwent urodynamic examination in The First Affiliated Hospital of Wannan Medical College from January 2020 to October 2023 were analyzed retrospectively.According to the results of urodynamics,all the patients were divided into T2DM group(T2DM,n=218)and OAB group(OAB,n=80).The risk factors of OAB were analyzed by logistic regression,andd thepredictionmodel was established according to the risk factors.Receiver operating characteristic(ROC)curve,calibration diagram and decision curve analysis(DCA)were used to analyze and evaluate the diagnostic efficiency of the model.ResultsLogisticcregressionanalysis results showed that age,DM duration,BMI,HbA,c,DPN and OAB score(OABSS),were independent predictors for OAB.The nomogram model built based on the above risk factors had good predictive ability,and its area under ROC curve was 0.937.The correction curve showed that the predicted probability of OAB in patients with type 2 diabetes mellitus was basically parallel to the actual probability of urodynamic detection.The results of DCA showed that the model had high clinical value.Conclusion The nomogram model built by age,DM duration,OABSS,BMI,HbA,c,DPN has high predictive efficacy for OAB in patients with T2DM.
