The interleukin-17 family is the key group of cytokines and displays a broad spectrum of biological functions,including regulating the inflammatory cascade in various autoimmune and inflammatory diseases,such as multi...The interleukin-17 family is the key group of cytokines and displays a broad spectrum of biological functions,including regulating the inflammatory cascade in various autoimmune and inflammatory diseases,such as multiple sclerosis,neuromyelitis optica spectrum disorder,myasthenia gravis,Guillain–Barre syndrome,acute disseminated encephalomyelitis,diabetes,inflammatory skin diseases,joint inflammation,and cancer.Although the function of the interleukin-17 family has attracted increasing research attention over many years,the expression,function,and regulation mechanisms of different interleukin-17 members are complicated and still only partially understood.Currently,the interleukin-17A pathway is considered a critical therapeutic target for numerous immune and chronic inflammatory diseases,with several monoclonal antibodies against interleukin-17A having been successfully used in clinical practice.Whether other interleukin-17 members have the potential to be targeted in other diseases is still debated.This review first summarizes the recent advancements in understanding the physicochemical properties,physiological functions,cellular origins,and downstream signaling pathways of different members and corresponding receptors of the interleukin-17 family.Subsequently,the function of interleukin-17 in various immune diseases is discussed,and the important role of interleukin-17 in the pathological process of immune diseases is demonstrated from multiple perspectives.Then,the current status of targeted interleukin-17 therapy is summarized,and the effectiveness and safety of targeted interleukin-17 therapy are analyzed.Finally,the clinical application prospects of targeting the interleukin-17 pathway are discussed.展开更多
Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promi...Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for therapeutic interventions.Exos derived from mesenchymal stem cells(MSCs)have significant immunomodulatory properties.They effectively regulate immune responses by modulating both innate and adaptive immunity.These Exos can inhibit excessive inflammatory responses and promote tissue repair.Moreover,they participate in antigen presentation,which is essential for activating immune responses.The cargo of these Exos,including ligands,proteins,and microRNAs,can suppress T cell activity or enhance the population of immunosuppressive cells to dampen the immune response.By inhibiting lymphocyte proliferation,acting on macrophages,and increasing the population of regulatory T cells,these Exos contribute to maintaining immune and metabolic homeostasis.Furthermore,they can activate immune-related signaling pathways or serve as vehicles to deliver microRNAs and other bioactive substances to target tumor cells,which holds potential for immunotherapy applications.Given the immense therapeutic potential of MSC-derived Exos,this review comprehensively explores their mechanisms of immune regulation and therapeutic applications in areas such as infection control,tumor suppression,and autoimmune disease management.This article aims to provide valuable insights into the mechanisms behind the actions of MSC-derived Exos,offering theoretical references for their future clinical utilization as cell-free drug preparations.展开更多
In this review research,the full bio-medical potential and application of the severe acute respiratory syndrome(SARS)-CoV-2 viruses are discussed in detail with the aim of discovering innovative treatment strategies i...In this review research,the full bio-medical potential and application of the severe acute respiratory syndrome(SARS)-CoV-2 viruses are discussed in detail with the aim of discovering innovative treatment strategies in virology and medicine.The SARS-CoV-2 which caused an international health crisis also unraveled an opportunity to gain from its pathogenic effects to treat the affected people.The study aims at testing whether the newly discovered SARS-CoV-2 can be used for therapeutic and clinical purposes.With in-depth analytics,this investigation issue endeavors to unearth new ways of fighting infectious diseases and to improve existing medical interventions.Beside scientific and practical significance the role of this work is vital.By learning the biologic and molecular mysteries of SARS-CoV-2,the researchers can create precise medicines and vaccines not only against COVID-19 but also the other infectious diseases as well.Furthermore,this recommendation may open the door to the future development of gene therapy and vaccine technology.In this sense,it combines multiple approaches,such as viral studies,immunology,and molecular biology.Laboratory experiments,computer program modeling and clinical trials are applied to detection of the SARS-COV-2 in therapeutic implementation.The principal conclusion and analysis of this research put forth the fact that SARS-CoV-2 can be utilized in anti-viral treatment,cancer therapy,and vaccine programs.The study results confirm the inherent adaptability of viruses like SARS-CoV-2 and emphasis on the development of specific therapeutic measures.It is valuable because of its potential to add to virology and medication,showing new ways for virus-based treatment.In addition,the impact of these results on treatments would be revolutionary,with potential to invent superior and flexible interventions against infectious disease.In short,the therapeutic use of SARS-CoV-2 can be regarded as a bold innovation with tremendous consequences for general health,and ultimately for medical science.展开更多
The integration of artificial intelligence(AI)into the realm of robotic urologic surgery represents a remarkable paradigm shift in the field of urology and surgical healthcare.AI,with its advanced data analysis and ma...The integration of artificial intelligence(AI)into the realm of robotic urologic surgery represents a remarkable paradigm shift in the field of urology and surgical healthcare.AI,with its advanced data analysis and machine learning capabilities,has not only expedited the evolution of robotic surgical procedures but also significantly improved diagnostic accuracy and surgical outcomes.展开更多
Objective:To explore the application value of a machine learning-based prediction model in assessing the prognosis of septic children in the pediatric intensive care unit(PICU)and provide data support for clinical dec...Objective:To explore the application value of a machine learning-based prediction model in assessing the prognosis of septic children in the pediatric intensive care unit(PICU)and provide data support for clinical decision-making.Methods:A total of 180 septic children admitted to the PICU of a tertiary hospital from January 2020 to December 2024 were selected.They were divided into a control group(90 cases,using traditional scoring methods to predict prognosis)and an observation group(90 cases,using a multivariable model based on machine learning algorithms to predict prognosis)according to the random number table method.General information,laboratory indicators,and clinical interventions were collected.Various models such as Random Forest(RF),Support Vector Machine(SVM),and Logistic Regression(LR)were established.The model performance was evaluated using ROC curve,AUC value,accuracy,sensitivity,and specificity.Results:The machine learning models performed better than traditional scoring methods in predicting the 28-day mortality rate of septic children.Among them,the RF model achieved an AUC value of 0.921,a sensitivity of 85.6%,and a specificity of 88.1%,which were significantly higher than the PIM3 score(AUC 0.762).The prediction accuracy and timeliness of clinical intervention in the observation group were significantly improved,leading to a shortened hospital stay and reduced mortality rate(p<0.05).Conclusion:The prediction model based on machine learning can more accurately assess the prognostic risk of septic children in PICU,showing good clinical application prospects and providing references for individualized treatment and optimal resource allocation.展开更多
Objective:To analyze the clinical application and effects of the body restraint reduction program for severe neurological patients.Methods:A total of 206 patients admitted to the neurology department of the hospital f...Objective:To analyze the clinical application and effects of the body restraint reduction program for severe neurological patients.Methods:A total of 206 patients admitted to the neurology department of the hospital from January 2022 to May 2025 were selected as the research subjects.Among them,102 patients from January 2022 to May 2025 were assigned to the observation group,and 104 patients during the same period served as the control group.In practice,the control group received conventional body restraint,while the observation group adopted the reduction program.The incidence of unplanned extubation and restraint-related complications were compared between the two groups.Results:The body restraint rate and complication rate in the observation group were significantly lower(P<0.05).After nurse training,their knowledge mastery and operational ability were significantly higher than before training(P<0.01).Conclusion:The body restraint reduction program for severe neurological patients can effectively reduce the restraint rate and complication incidence,while helping improve nurses’restraint management capabilities,serving as an effective means to enhance overall nursing quality.展开更多
BACKGROUND Pyogenic liver abscess(PLA)is a prevalent liver infection with gradual onset and severe symptoms,including fever,abdominal pain,jaundice,and vomiting.Complications like sepsis or toxic shock can also occur....BACKGROUND Pyogenic liver abscess(PLA)is a prevalent liver infection with gradual onset and severe symptoms,including fever,abdominal pain,jaundice,and vomiting.Complications like sepsis or toxic shock can also occur.AIM To investigate the clinical value of early ultrasound-guided percutaneous drainage(PCD)in PLA patients,specifically those with non-liquefied abscesses,and evaluate the feasibility of early intervention.METHODS This retrospective analysis included 143 patients with PLA who were admitted to the Department of General Surgery between January 2018 and March 2023.All patients underwent ultrasound-guided PCD.Based on the liquefaction status of the abscess,patients were divided into two groups:Liquefied group and nonliquefied group.Clinical outcomes,including puncture success rate,puncture duration,length of hospital stay,time to fever resolution,abscess shrinkage rate,and complication rates,were compared between the two groups.RESULTS The puncture success rate for all patients was 99.3%,with a postoperative complication rate of 5.59%,and no intraoperative deaths occurred.Compared to the liquefied group,the non-liquefied group had significantly shorter hospital stays(3.9±1.8 days vs 5.1±2.7 days),faster fever resolution(2.4±1.1 days vs 4.9±2.2 days),and quicker abscess shrinkage(>50%)(4.7±1.5 days vs 8.6±3.3 days)(P<0.05).There were no significant differences in puncture success rates or complication rates between the two groups.CONCLUSION Early ultrasound-guided PCD can be safely and effectively performed in PLA,even when the abscess is not fully liquefied or is non-liquefied,supporting the clinical feasibility of early intervention.展开更多
Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other...Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other components,which have various activities:anti-inflammatory,immune system regulation,antiviral,anti-aging,detoxification,and protection of the liver,lungs,and kidneys.JFG has broad potential therapeutic applications.The mechanisms of JFG’s actions are primarily associated with signaling pathways such as TLR4/NF-κB,PI3K/AKT,and MAPK.This article reviews the research progress on JFG,including chemical composition,pharmacologic effects,mechanism of action,safety,clinical application,etc.,serving as a foundation for future research and clinical applications.展开更多
As an appropriate technique in Traditional Chinese Medicine nursing,intradermal acupuncture involves inserting a small needle into the skin at an acupoint or within the skin to treat diseases.This fully embodies the c...As an appropriate technique in Traditional Chinese Medicine nursing,intradermal acupuncture involves inserting a small needle into the skin at an acupoint or within the skin to treat diseases.This fully embodies the characteristics of Traditional Chinese Medicine nursing techniques:simplicity,convenience,affordability,and effectiveness.Currently,intradermal acupuncture has been widely used in clinical practice.This paper introduces the history,mechanism of action,and principle of acupoint selection of intradermal acupuncture and summarizes the application of intradermal acupuncture in common internal medicine diseases to promote their dissemination and use.展开更多
Objective:To study the clinical application of Denghuo moxibustion in treating post-stroke constipation.Methods:This study included 50 patients with post-stroke constipation admitted from October 2020 to December 2021...Objective:To study the clinical application of Denghuo moxibustion in treating post-stroke constipation.Methods:This study included 50 patients with post-stroke constipation admitted from October 2020 to December 2021.They were randomly divided into two groups using the envelope method:25 patients in the observation group and 25 patients in the control group.The control group received only lactulose,while the observation group received Denghuo moxibustion in addition to lactulose.The efficacy,quality of life(PAC-QOL scale),and laboratory indicators[serum substance P(SP)and vasoactive intestinal peptide(VIP)]were compared between the two groups.Results:The efficacy of the observation group was significantly better than that of the control group(P<0.05).After treatment,the PAC-QOL scores of both groups decreased significantly,and the improvement in the observation group was more significant(P<0.05).Changes in laboratory indicators showed that VIP decreased significantly and SP increased significantly in both groups,and the improvement of these two indicators in the observation group was significantly better than that in the control group(P<0.05).Conclusion:Denghuo moxibustion can enhance the efficacy of lactulose by regulating intestinal neuropeptides and is an effective treatment for post-stroke constipation.展开更多
The intricate interactions between immune cells and tumors exert a profound influence on cancer progression and therapeutic efficacy.Within the tumor microenvironment,exosomes have emerged as pivotal mediators of inte...The intricate interactions between immune cells and tumors exert a profound influence on cancer progression and therapeutic efficacy.Within the tumor microenvironment,exosomes have emerged as pivotal mediators of intercellular communication,with their cargo of non-coding RNAs(ncRNAs)serving as key regulatory elements.This review examines the multifaceted roles of immune cell-derived exosomal ncRNAs in tumor biology.The involvement of various immune cells,including T cells,B cells,natural killer cells,macrophages,neutrophils,and myeloid-derived suppressor cells,in utilizing exosomal ncRNAs to regulate tumor initiation and progression is explored.Additionally,the biogenesis and delivery mechanisms of these immune cell-derived exosomal ncRNAs are discussed,alongside their potential clinical applications in cancer.展开更多
Colorectal cancer(CRC)is a common and deadly malignancy worldwide,causing high morbidity and mortality rates.Chemoresistance continues to be the major barrier to the effective treatment of CRC.Circular RNA(circRNA),a ...Colorectal cancer(CRC)is a common and deadly malignancy worldwide,causing high morbidity and mortality rates.Chemoresistance continues to be the major barrier to the effective treatment of CRC.Circular RNA(circRNA),a recently identified class of non-coding RNA,has become an emerging focus in CRC research due to its abundant presence and stability in extracellular vesicles(EVs).The circRNA of EVs(EVs-circRNA)is closely associated with CRC progression and plays a pivotal role in chemoresistance mechanisms.This paper investigates the circRNA mechanism underlying different chemoresistance scenarios in CRC and explores the dual role of EVs-circRNA in mediating chemotherapy resistance.Furthermore,EVs-circRNA,a non-invasive biomarker for liquid biopsies,holds significant promise in clinical applications,ranging from early CRC diagnosis to monitoring disease progression and assessing prognosis.These studies provide a new perspective for uncovering CRC pathogenesis and lay the foundation for precision therapy and personalized treatment strategies for CRC.In the future,therapeutic strategies targeting EVs-circRNAs are anticipated to revolutionize CRC treatment,leading to improved therapeutic outcomes and enhanced quality of life for patients.展开更多
Objective: To analyze the clinical effects of the patient participation health model in the health management of type 2 diabetes mellitus. Methods: A total of 124 patients with type 2 diabetes admitted to the hospital...Objective: To analyze the clinical effects of the patient participation health model in the health management of type 2 diabetes mellitus. Methods: A total of 124 patients with type 2 diabetes admitted to the hospital from June 2023 to June 2024 were randomly assigned to either the control group (64 patients) or the intervention group (60 patients). Patients in the control group received routine health management, while those in the intervention group were managed using a patient-participation health model with progressive, stage-based interventions. Outcomes were assessed based on blood glucose control, disease awareness, and self-management behaviors. Adverse reactions during health management were closely monitored in both groups. Results: Patients in the intervention group showed significantly better outcomes in blood glucose control, disease awareness, and self-management behaviors compared to the control group. Conclusion: The patient participation health model demonstrated significant clinical value, effectively enhancing self-management abilities, improving glycemic control, and increasing disease awareness. This model is recommended for widespread adoption in the health management of type 2 diabetes to achieve better therapeutic outcomes and improve patient quality of life.展开更多
Biofeedback is a behavioral intervention technology based on psychophysiology,which uses various electronic devices to collect the physiological activities of individuals in real time and provides them to themselves t...Biofeedback is a behavioral intervention technology based on psychophysiology,which uses various electronic devices to collect the physiological activities of individuals in real time and provides them to themselves through various ways,so that people can actively change their own physiological changes when they perceive the changes in some physiological functions of their own,and consciously control the physiological functions of various aspects of the autonomic nervous system within a fixed range.It can play a role in improving physical health status,preventing and treating some somatic diseases.Studies have shown that biofeedback relaxation training can make the training subjects learn to regulate their own physiological functions and psychological activities,improve negative emotional states such as depression and anxiety by regulating the body function,and can also be used to assist in the treatment of other clinical diseases.As a new psychological intervention,biofeedback relaxation training has great development potential and can be better applied to the prevention and treatment of physical and mental diseases in the general population in the future.展开更多
Researches on pharmacological action and drug development of Periplane- ta americana have demonstrated that it has wide medicinal value, low side effects and rich resources, having good application prospects in medici...Researches on pharmacological action and drug development of Periplane- ta americana have demonstrated that it has wide medicinal value, low side effects and rich resources, having good application prospects in medicine field. This article reviewed the researches on pharmacological action and clinical application of Periplaneta americana in order to provide references for the further research and devel- opment of Periplaneta americana medicines.展开更多
Levant cotton root is a folk traditional herb with a long history in China. This article gave a brief introduction on recent research work related to main com- position, pharmacologic effect and clinical application o...Levant cotton root is a folk traditional herb with a long history in China. This article gave a brief introduction on recent research work related to main com- position, pharmacologic effect and clinical application of levant cotton root and pro- posed existing problems and countermeasures for pharmaceutical industrialization.展开更多
Polymeric nanomedicine is a promising and rapidly evolving field.Among the different polymeric carriers,polymeric micelle(PM) with nanoscale size exhibit potent physical and biological advantages including excellent s...Polymeric nanomedicine is a promising and rapidly evolving field.Among the different polymeric carriers,polymeric micelle(PM) with nanoscale size exhibit potent physical and biological advantages including excellent solubility and pharmacokinetics,enhanced efficacy and lower toxicity.PM has garnered increasing intere st in research and in the clinic.This review will highlight the clinical outcomes of several PM-based formulations,and further summarized their preparation methods,strengths and challenges.展开更多
The formulation and device collectively constitute an inhalation drug product.Development of inhaled drugs must consider the compatibility between formulation and device in order to achieve the intended pharmaceutical...The formulation and device collectively constitute an inhalation drug product.Development of inhaled drugs must consider the compatibility between formulation and device in order to achieve the intended pharmaceutical performance and usability of the product to improve patient compliance with treatment instruction.From the points of formulation,device and patient use,this article summarizes the inhalation drugs,including pressurized metered dose inhaler(pMDI),dry powder inhaler(DPI),and nebulizer that are currently available in the US and UK markets.It also discusses the practical considerations for the development of inhalers and provides an update on the corresponding regulations of the FDA(U.S.Food and Drug Administration)and the EMA(European Medicines Agency).展开更多
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria.As an excellent candidate to overcome antibiotic resistance,antimicrobial pepti...The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria.As an excellent candidate to overcome antibiotic resistance,antimicrobial peptides(AMPs)that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity.These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action.This comprehensive review provides a broad overview of AMPs from the origin,structural characteristics,mechanisms of action,biological activities to clinical applications.We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.展开更多
Multidisciplinary team （MDT） model is a diagnostic and treatment model characterized by interdisciplinarity, integration, centralism, individualization, and precision and is becoming more common in the management of...Multidisciplinary team （MDT） model is a diagnostic and treatment model characterized by interdisciplinarity, integration, centralism, individualization, and precision and is becoming more common in the management of complex malignancies. MDT emphasizes team spirit and a personalized treatment strategy according to the actual condition of each patient. A cooperative and effective multidisciplinary team is an important guarantee for delivering high-quality services to patients. Under the guidance of a medical humanistic concept, MDT provides reasonable, effective, convenient, and a full range of excellent quality medical service to patients. The MDT maximizes patient benefits, and it is the developmental direction for large-scale general hospitals. At the same time, the MDT is also an important measure to strengthen the core competitiveness of hospitals. Here, we introduce the clinical application of the model in tumor therapy as well as the current state and development in our hospital.展开更多
基金supported by the National Natural Science Foundational of China(Key Program),No.U24A20692(to CJZ)the National Natural Science Foundational of China,Nos.82101414(to MLJ),82371355(to CJZ)+4 种基金the National Natural Science Foundational of China for Excellent Young Scholars,No.82022019(to CJZ)Sichuan Special Fund for Distinguished Young Scholars,No.24NSFJQ0052(to CJZ)The Innovation and Entrepreneurial Team of Sichuan Tianfu Emei Program,No.CZ2024018(to CJZ)Funding for Distinguished Young Scholars of Sichuan Provincial People’s Hospital,No.30420230005(to CJZ)Funding for Distinguished Young Scholars of University of Electronic Science and Technology of China,No.A1098531023601381(to CJZ)。
文摘The interleukin-17 family is the key group of cytokines and displays a broad spectrum of biological functions,including regulating the inflammatory cascade in various autoimmune and inflammatory diseases,such as multiple sclerosis,neuromyelitis optica spectrum disorder,myasthenia gravis,Guillain–Barre syndrome,acute disseminated encephalomyelitis,diabetes,inflammatory skin diseases,joint inflammation,and cancer.Although the function of the interleukin-17 family has attracted increasing research attention over many years,the expression,function,and regulation mechanisms of different interleukin-17 members are complicated and still only partially understood.Currently,the interleukin-17A pathway is considered a critical therapeutic target for numerous immune and chronic inflammatory diseases,with several monoclonal antibodies against interleukin-17A having been successfully used in clinical practice.Whether other interleukin-17 members have the potential to be targeted in other diseases is still debated.This review first summarizes the recent advancements in understanding the physicochemical properties,physiological functions,cellular origins,and downstream signaling pathways of different members and corresponding receptors of the interleukin-17 family.Subsequently,the function of interleukin-17 in various immune diseases is discussed,and the important role of interleukin-17 in the pathological process of immune diseases is demonstrated from multiple perspectives.Then,the current status of targeted interleukin-17 therapy is summarized,and the effectiveness and safety of targeted interleukin-17 therapy are analyzed.Finally,the clinical application prospects of targeting the interleukin-17 pathway are discussed.
基金Supported by the National Natural Science Foundation of China,No.82072537the General Project of Hunan Natural Science Foundation,No.2022JJ30412 and No.2021JJ30464.
文摘Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for therapeutic interventions.Exos derived from mesenchymal stem cells(MSCs)have significant immunomodulatory properties.They effectively regulate immune responses by modulating both innate and adaptive immunity.These Exos can inhibit excessive inflammatory responses and promote tissue repair.Moreover,they participate in antigen presentation,which is essential for activating immune responses.The cargo of these Exos,including ligands,proteins,and microRNAs,can suppress T cell activity or enhance the population of immunosuppressive cells to dampen the immune response.By inhibiting lymphocyte proliferation,acting on macrophages,and increasing the population of regulatory T cells,these Exos contribute to maintaining immune and metabolic homeostasis.Furthermore,they can activate immune-related signaling pathways or serve as vehicles to deliver microRNAs and other bioactive substances to target tumor cells,which holds potential for immunotherapy applications.Given the immense therapeutic potential of MSC-derived Exos,this review comprehensively explores their mechanisms of immune regulation and therapeutic applications in areas such as infection control,tumor suppression,and autoimmune disease management.This article aims to provide valuable insights into the mechanisms behind the actions of MSC-derived Exos,offering theoretical references for their future clinical utilization as cell-free drug preparations.
文摘In this review research,the full bio-medical potential and application of the severe acute respiratory syndrome(SARS)-CoV-2 viruses are discussed in detail with the aim of discovering innovative treatment strategies in virology and medicine.The SARS-CoV-2 which caused an international health crisis also unraveled an opportunity to gain from its pathogenic effects to treat the affected people.The study aims at testing whether the newly discovered SARS-CoV-2 can be used for therapeutic and clinical purposes.With in-depth analytics,this investigation issue endeavors to unearth new ways of fighting infectious diseases and to improve existing medical interventions.Beside scientific and practical significance the role of this work is vital.By learning the biologic and molecular mysteries of SARS-CoV-2,the researchers can create precise medicines and vaccines not only against COVID-19 but also the other infectious diseases as well.Furthermore,this recommendation may open the door to the future development of gene therapy and vaccine technology.In this sense,it combines multiple approaches,such as viral studies,immunology,and molecular biology.Laboratory experiments,computer program modeling and clinical trials are applied to detection of the SARS-COV-2 in therapeutic implementation.The principal conclusion and analysis of this research put forth the fact that SARS-CoV-2 can be utilized in anti-viral treatment,cancer therapy,and vaccine programs.The study results confirm the inherent adaptability of viruses like SARS-CoV-2 and emphasis on the development of specific therapeutic measures.It is valuable because of its potential to add to virology and medication,showing new ways for virus-based treatment.In addition,the impact of these results on treatments would be revolutionary,with potential to invent superior and flexible interventions against infectious disease.In short,the therapeutic use of SARS-CoV-2 can be regarded as a bold innovation with tremendous consequences for general health,and ultimately for medical science.
文摘The integration of artificial intelligence(AI)into the realm of robotic urologic surgery represents a remarkable paradigm shift in the field of urology and surgical healthcare.AI,with its advanced data analysis and machine learning capabilities,has not only expedited the evolution of robotic surgical procedures but also significantly improved diagnostic accuracy and surgical outcomes.
文摘Objective:To explore the application value of a machine learning-based prediction model in assessing the prognosis of septic children in the pediatric intensive care unit(PICU)and provide data support for clinical decision-making.Methods:A total of 180 septic children admitted to the PICU of a tertiary hospital from January 2020 to December 2024 were selected.They were divided into a control group(90 cases,using traditional scoring methods to predict prognosis)and an observation group(90 cases,using a multivariable model based on machine learning algorithms to predict prognosis)according to the random number table method.General information,laboratory indicators,and clinical interventions were collected.Various models such as Random Forest(RF),Support Vector Machine(SVM),and Logistic Regression(LR)were established.The model performance was evaluated using ROC curve,AUC value,accuracy,sensitivity,and specificity.Results:The machine learning models performed better than traditional scoring methods in predicting the 28-day mortality rate of septic children.Among them,the RF model achieved an AUC value of 0.921,a sensitivity of 85.6%,and a specificity of 88.1%,which were significantly higher than the PIM3 score(AUC 0.762).The prediction accuracy and timeliness of clinical intervention in the observation group were significantly improved,leading to a shortened hospital stay and reduced mortality rate(p<0.05).Conclusion:The prediction model based on machine learning can more accurately assess the prognostic risk of septic children in PICU,showing good clinical application prospects and providing references for individualized treatment and optimal resource allocation.
文摘Objective:To analyze the clinical application and effects of the body restraint reduction program for severe neurological patients.Methods:A total of 206 patients admitted to the neurology department of the hospital from January 2022 to May 2025 were selected as the research subjects.Among them,102 patients from January 2022 to May 2025 were assigned to the observation group,and 104 patients during the same period served as the control group.In practice,the control group received conventional body restraint,while the observation group adopted the reduction program.The incidence of unplanned extubation and restraint-related complications were compared between the two groups.Results:The body restraint rate and complication rate in the observation group were significantly lower(P<0.05).After nurse training,their knowledge mastery and operational ability were significantly higher than before training(P<0.01).Conclusion:The body restraint reduction program for severe neurological patients can effectively reduce the restraint rate and complication incidence,while helping improve nurses’restraint management capabilities,serving as an effective means to enhance overall nursing quality.
文摘BACKGROUND Pyogenic liver abscess(PLA)is a prevalent liver infection with gradual onset and severe symptoms,including fever,abdominal pain,jaundice,and vomiting.Complications like sepsis or toxic shock can also occur.AIM To investigate the clinical value of early ultrasound-guided percutaneous drainage(PCD)in PLA patients,specifically those with non-liquefied abscesses,and evaluate the feasibility of early intervention.METHODS This retrospective analysis included 143 patients with PLA who were admitted to the Department of General Surgery between January 2018 and March 2023.All patients underwent ultrasound-guided PCD.Based on the liquefaction status of the abscess,patients were divided into two groups:Liquefied group and nonliquefied group.Clinical outcomes,including puncture success rate,puncture duration,length of hospital stay,time to fever resolution,abscess shrinkage rate,and complication rates,were compared between the two groups.RESULTS The puncture success rate for all patients was 99.3%,with a postoperative complication rate of 5.59%,and no intraoperative deaths occurred.Compared to the liquefied group,the non-liquefied group had significantly shorter hospital stays(3.9±1.8 days vs 5.1±2.7 days),faster fever resolution(2.4±1.1 days vs 4.9±2.2 days),and quicker abscess shrinkage(>50%)(4.7±1.5 days vs 8.6±3.3 days)(P<0.05).There were no significant differences in puncture success rates or complication rates between the two groups.CONCLUSION Early ultrasound-guided PCD can be safely and effectively performed in PLA,even when the abscess is not fully liquefied or is non-liquefied,supporting the clinical feasibility of early intervention.
基金supported by the Key R&D Program of Shandong Province,China(No.2024TZXD067,2022SFGC0105)Natural Science Foundation of Shandong Province(No.ZR2023QB021)+2 种基金Young Taishan Scholarship to Xuekui Xia(No.tsqn202103100)Jinan Talent Project for Universities(No.2021GXRC062,202228088)Key innovation Project and Science,Education and Industry Integration Innovation Pilot Project of Qilu University of Technology(Shandong Academy of Sciences)(No.2022JBZ01-06,2024ZDZX03,2023RCKY214).
文摘Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other components,which have various activities:anti-inflammatory,immune system regulation,antiviral,anti-aging,detoxification,and protection of the liver,lungs,and kidneys.JFG has broad potential therapeutic applications.The mechanisms of JFG’s actions are primarily associated with signaling pathways such as TLR4/NF-κB,PI3K/AKT,and MAPK.This article reviews the research progress on JFG,including chemical composition,pharmacologic effects,mechanism of action,safety,clinical application,etc.,serving as a foundation for future research and clinical applications.
文摘As an appropriate technique in Traditional Chinese Medicine nursing,intradermal acupuncture involves inserting a small needle into the skin at an acupoint or within the skin to treat diseases.This fully embodies the characteristics of Traditional Chinese Medicine nursing techniques:simplicity,convenience,affordability,and effectiveness.Currently,intradermal acupuncture has been widely used in clinical practice.This paper introduces the history,mechanism of action,and principle of acupoint selection of intradermal acupuncture and summarizes the application of intradermal acupuncture in common internal medicine diseases to promote their dissemination and use.
基金Honghuagang District Science and Technology Plan Project of Zunyi City(Project No.:Zun Hong Ke He She Zi 202103)。
文摘Objective:To study the clinical application of Denghuo moxibustion in treating post-stroke constipation.Methods:This study included 50 patients with post-stroke constipation admitted from October 2020 to December 2021.They were randomly divided into two groups using the envelope method:25 patients in the observation group and 25 patients in the control group.The control group received only lactulose,while the observation group received Denghuo moxibustion in addition to lactulose.The efficacy,quality of life(PAC-QOL scale),and laboratory indicators[serum substance P(SP)and vasoactive intestinal peptide(VIP)]were compared between the two groups.Results:The efficacy of the observation group was significantly better than that of the control group(P<0.05).After treatment,the PAC-QOL scores of both groups decreased significantly,and the improvement in the observation group was more significant(P<0.05).Changes in laboratory indicators showed that VIP decreased significantly and SP increased significantly in both groups,and the improvement of these two indicators in the observation group was significantly better than that in the control group(P<0.05).Conclusion:Denghuo moxibustion can enhance the efficacy of lactulose by regulating intestinal neuropeptides and is an effective treatment for post-stroke constipation.
基金supported by the National Natural Science Foundation of China(No.82203056)the Natural Science Foundation of Liaoning Province(No.2023-BS-167)+1 种基金the Science and Technology Talent Innovation Support Plan of Dalian(NO.2022RQ091)the“1+X”program for Clinical Competency enhancement-Clinical Research Incubation Project of the Second Hospital of Dalian Medical University(No.2022LCYJYB01)。
文摘The intricate interactions between immune cells and tumors exert a profound influence on cancer progression and therapeutic efficacy.Within the tumor microenvironment,exosomes have emerged as pivotal mediators of intercellular communication,with their cargo of non-coding RNAs(ncRNAs)serving as key regulatory elements.This review examines the multifaceted roles of immune cell-derived exosomal ncRNAs in tumor biology.The involvement of various immune cells,including T cells,B cells,natural killer cells,macrophages,neutrophils,and myeloid-derived suppressor cells,in utilizing exosomal ncRNAs to regulate tumor initiation and progression is explored.Additionally,the biogenesis and delivery mechanisms of these immune cell-derived exosomal ncRNAs are discussed,alongside their potential clinical applications in cancer.
基金Supported by Open Project of National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,No.NCRCOP2023007.
文摘Colorectal cancer(CRC)is a common and deadly malignancy worldwide,causing high morbidity and mortality rates.Chemoresistance continues to be the major barrier to the effective treatment of CRC.Circular RNA(circRNA),a recently identified class of non-coding RNA,has become an emerging focus in CRC research due to its abundant presence and stability in extracellular vesicles(EVs).The circRNA of EVs(EVs-circRNA)is closely associated with CRC progression and plays a pivotal role in chemoresistance mechanisms.This paper investigates the circRNA mechanism underlying different chemoresistance scenarios in CRC and explores the dual role of EVs-circRNA in mediating chemotherapy resistance.Furthermore,EVs-circRNA,a non-invasive biomarker for liquid biopsies,holds significant promise in clinical applications,ranging from early CRC diagnosis to monitoring disease progression and assessing prognosis.These studies provide a new perspective for uncovering CRC pathogenesis and lay the foundation for precision therapy and personalized treatment strategies for CRC.In the future,therapeutic strategies targeting EVs-circRNAs are anticipated to revolutionize CRC treatment,leading to improved therapeutic outcomes and enhanced quality of life for patients.
文摘Objective: To analyze the clinical effects of the patient participation health model in the health management of type 2 diabetes mellitus. Methods: A total of 124 patients with type 2 diabetes admitted to the hospital from June 2023 to June 2024 were randomly assigned to either the control group (64 patients) or the intervention group (60 patients). Patients in the control group received routine health management, while those in the intervention group were managed using a patient-participation health model with progressive, stage-based interventions. Outcomes were assessed based on blood glucose control, disease awareness, and self-management behaviors. Adverse reactions during health management were closely monitored in both groups. Results: Patients in the intervention group showed significantly better outcomes in blood glucose control, disease awareness, and self-management behaviors compared to the control group. Conclusion: The patient participation health model demonstrated significant clinical value, effectively enhancing self-management abilities, improving glycemic control, and increasing disease awareness. This model is recommended for widespread adoption in the health management of type 2 diabetes to achieve better therapeutic outcomes and improve patient quality of life.
基金The Basic Scientific Research Project of Colleges and Universities in 2022:HRV and Brain Electrophysiological Mechanism of Electromyography Biofeedback in Improving Depression and Anxiety of College Students(Project No.:LJKMZ20221274)。
文摘Biofeedback is a behavioral intervention technology based on psychophysiology,which uses various electronic devices to collect the physiological activities of individuals in real time and provides them to themselves through various ways,so that people can actively change their own physiological changes when they perceive the changes in some physiological functions of their own,and consciously control the physiological functions of various aspects of the autonomic nervous system within a fixed range.It can play a role in improving physical health status,preventing and treating some somatic diseases.Studies have shown that biofeedback relaxation training can make the training subjects learn to regulate their own physiological functions and psychological activities,improve negative emotional states such as depression and anxiety by regulating the body function,and can also be used to assist in the treatment of other clinical diseases.As a new psychological intervention,biofeedback relaxation training has great development potential and can be better applied to the prevention and treatment of physical and mental diseases in the general population in the future.
基金Supported by the National Natural Science Foundation of China(30560181)the Major Project of Yunnan Province(2008IF012)~~
文摘Researches on pharmacological action and drug development of Periplane- ta americana have demonstrated that it has wide medicinal value, low side effects and rich resources, having good application prospects in medicine field. This article reviewed the researches on pharmacological action and clinical application of Periplaneta americana in order to provide references for the further research and devel- opment of Periplaneta americana medicines.
基金Supported by Hebei Academy of Agricultural and Forestry Sciences Development Fund(A2012070302)~~
文摘Levant cotton root is a folk traditional herb with a long history in China. This article gave a brief introduction on recent research work related to main com- position, pharmacologic effect and clinical application of levant cotton root and pro- posed existing problems and countermeasures for pharmaceutical industrialization.
基金financially supported by Fundamental Research Funds for the Central Universities(No.201964018)National Natural Science Foundation of China(No.31872754)Qingdao Program for Original Innovation and Fundamental Research(No.18-2-2-73-jch)。
文摘Polymeric nanomedicine is a promising and rapidly evolving field.Among the different polymeric carriers,polymeric micelle(PM) with nanoscale size exhibit potent physical and biological advantages including excellent solubility and pharmacokinetics,enhanced efficacy and lower toxicity.PM has garnered increasing intere st in research and in the clinic.This review will highlight the clinical outcomes of several PM-based formulations,and further summarized their preparation methods,strengths and challenges.
文摘The formulation and device collectively constitute an inhalation drug product.Development of inhaled drugs must consider the compatibility between formulation and device in order to achieve the intended pharmaceutical performance and usability of the product to improve patient compliance with treatment instruction.From the points of formulation,device and patient use,this article summarizes the inhalation drugs,including pressurized metered dose inhaler(pMDI),dry powder inhaler(DPI),and nebulizer that are currently available in the US and UK markets.It also discusses the practical considerations for the development of inhalers and provides an update on the corresponding regulations of the FDA(U.S.Food and Drug Administration)and the EMA(European Medicines Agency).
基金supported by grants from the National Natural Science Foundation of China (81770176)the special support plan for Zhejiang Province High-Level Talents (2019R52011)。
文摘The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria.As an excellent candidate to overcome antibiotic resistance,antimicrobial peptides(AMPs)that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity.These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action.This comprehensive review provides a broad overview of AMPs from the origin,structural characteristics,mechanisms of action,biological activities to clinical applications.We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
基金supported by a grant (No. Z151100002615031) from the Project of Science and Technology in Beijing, China
文摘Multidisciplinary team （MDT） model is a diagnostic and treatment model characterized by interdisciplinarity, integration, centralism, individualization, and precision and is becoming more common in the management of complex malignancies. MDT emphasizes team spirit and a personalized treatment strategy according to the actual condition of each patient. A cooperative and effective multidisciplinary team is an important guarantee for delivering high-quality services to patients. Under the guidance of a medical humanistic concept, MDT provides reasonable, effective, convenient, and a full range of excellent quality medical service to patients. The MDT maximizes patient benefits, and it is the developmental direction for large-scale general hospitals. At the same time, the MDT is also an important measure to strengthen the core competitiveness of hospitals. Here, we introduce the clinical application of the model in tumor therapy as well as the current state and development in our hospital.
