In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B(1), and A(2), along with three known sesquiterpenes(3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures a...In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B(1), and A(2), along with three known sesquiterpenes(3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3–5 were evaluated for their cytotoxic activity.展开更多
Thirteen new nitrogen-containing nardosinane-type sesquiterpenoids,clavukoelloids A-M(1-13)with unique acrylamide fragments vs.the reported general nardosinane-type sesquiterpenoids containing lactone,were isolated fr...Thirteen new nitrogen-containing nardosinane-type sesquiterpenoids,clavukoelloids A-M(1-13)with unique acrylamide fragments vs.the reported general nardosinane-type sesquiterpenoids containing lactone,were isolated from the soft coral Clavularia koellikeri collected from the South China Sea.The structures and absolute configurations of new compounds were unambiguously determined by analysis of spectroscopic data,CP3,DP4+,ECD spectra,and X-ray diffraction.Compound 6 showed anti-inflammatory activities and hepatoprotective activities in transgenic fluorescent zebrafish.展开更多
Two new dolabellane diterpenoids named clavudiol B(2)and clavirolide F(5),have been iso- lated from the soft coral Clavularia viridis,collected from Xisha Islands in the South China Sea.Their structures have been dete...Two new dolabellane diterpenoids named clavudiol B(2)and clavirolide F(5),have been iso- lated from the soft coral Clavularia viridis,collected from Xisha Islands in the South China Sea.Their structures have been determined as 2 and 5 by spectral analysis and chemical reactions.展开更多
基金supported by the Natural Science Foundation of China(Nos.81520108028,21672230,41506187,and 816013016)the SKLDR/SIMM Project(No.SIMM1501ZZ-03)
文摘In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B(1), and A(2), along with three known sesquiterpenes(3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3–5 were evaluated for their cytotoxic activity.
基金supported by the National Natural Science Foundation of China(Nos.U2006204,41776136,and 2181101213)。
文摘Thirteen new nitrogen-containing nardosinane-type sesquiterpenoids,clavukoelloids A-M(1-13)with unique acrylamide fragments vs.the reported general nardosinane-type sesquiterpenoids containing lactone,were isolated from the soft coral Clavularia koellikeri collected from the South China Sea.The structures and absolute configurations of new compounds were unambiguously determined by analysis of spectroscopic data,CP3,DP4+,ECD spectra,and X-ray diffraction.Compound 6 showed anti-inflammatory activities and hepatoprotective activities in transgenic fluorescent zebrafish.
基金the National Natural Science Foundation of China.
文摘Two new dolabellane diterpenoids named clavudiol B(2)and clavirolide F(5),have been iso- lated from the soft coral Clavularia viridis,collected from Xisha Islands in the South China Sea.Their structures have been determined as 2 and 5 by spectral analysis and chemical reactions.
