A fully integrated class-E power amplifier（PA） at 2.4 GHz implemented in a 0. 18 μm 6-metal-layer mixed/RF CMOS （ complementary metal-oxide-semiconductor transistor ） technology is presented. A two-stage amplific...A fully integrated class-E power amplifier（PA） at 2.4 GHz implemented in a 0. 18 μm 6-metal-layer mixed/RF CMOS （ complementary metal-oxide-semiconductor transistor ） technology is presented. A two-stage amplification structure is chosen for this PA. The driving stage produces a high swing switch signal by using resonation technology. The output stage is designed as a class-E topology to realize the power amplification. Under a 1.2 V power supply, the PA delivers a maximum output power of 8. 8 dBm with a power-added efficiency （PAE） of 44%. A new power control method for the class-E power amplifier is described. By changing the amplitude and duty cycle of the signal which enters the class-E switch transistor, the output power can be covered from - 3 to 8. 8 dBm through a three-bit control word. The proposed PA can be used in low power applications, such as wireless sensor networks and biotelemetry systems.展开更多
This paper presents a 1.8 GHz class-E controlled power amplifier (PA). The proposed power amplifier is designed with two-stage architecture. The main advantage of the proposed technique for output control power is a h...This paper presents a 1.8 GHz class-E controlled power amplifier (PA). The proposed power amplifier is designed with two-stage architecture. The main advantage of the proposed technique for output control power is a high 37 dB output power dynamic range with good average power adding efficiency. The measurement results show that the PA achieves a high power gain of 23 dBm and power added efficiency (PAE) by 38%. The circuit was post layout simulated in a standard 0.18 μm CMOS technology.展开更多
We present and propose a complete and iterative integrated-circuit and electro-magnetic（EM） co-design methodology and procedure for a low-voltage sub-1 GHz class-E PA.The presented class-E PA consists of the onchip ...We present and propose a complete and iterative integrated-circuit and electro-magnetic（EM） co-design methodology and procedure for a low-voltage sub-1 GHz class-E PA.The presented class-E PA consists of the onchip power transistor,the on-chip gate driving circuits,the off-chip tunable LC load network and the off-chip LC ladder low pass filter.The design methodology includes an explicit design equation based circuit components values＇ analysis and numerical derivation,output power targeted transistor size and low pass filter design,and power efficiency oriented design optimization.The proposed design procedure includes the power efficiency oriented LC network tuning,the detailed circuit/EM co-simulation plan on integrated circuit level,package level and PCB level to ensure an accurate simulation to measurement match and first pass design success.The proposed PA is targeted to achieve more than 15 dBm output power delivery and 40% power efficiency at 433 MHz frequency band with 1.5 V low voltage supply.The LC load network is designed to be off-chip for the purpose of easy tuning and optimization.The same circuit can be extended to all sub-1 GHz applications with the same tuning and optimization on the load network at different frequencies.The amplifier is implemented in 0.13 μm CMOS technology with a core area occupation of 400 μm by 300 μm.Measurement results showed that it provided power delivery of 16.42 dBm at antenna with efficiency of 40.6%.A harmonics suppression of 44 dBc is achieved,making it suitable for massive deployment of IoT devices.展开更多
The efficiency of inductive power links driven by Class-E amplifiers may deteriorate due to variation in the coupling coefficient when the relative position of the radio frequency (RF) coils changes.To solve this prob...The efficiency of inductive power links driven by Class-E amplifiers may deteriorate due to variation in the coupling coefficient when the relative position of the radio frequency (RF) coils changes.To solve this problem,a new design methodology of power links is presented in this paper.The aim of the new design is to use the feedback signal,which is a phase difference between the driving signal and the output current of the Class-E amplifier,to adjust the duty cycle and angular frequency of the driving signal to maintain the optimum state of the inductive power link,and to adjust the supply voltage to keep the output power constant when the coupling coefficient of the RF coils changes.The parameter adjustments with respect to the coupling coefficient and the feedback signal are derived from the design equation of the inductive power link.To validate the feedback control rules,a prototype of the inductive power link was constructed,and its performance validated with the coupling coefficient set at 0.2 and a duty cycle of 0.5.The experimental results showed that,by adjusting the duty cycle,the angular frequency,and the supply voltage,the power link can be kept in optimal operation with a constant output power when the coupling coefficient changes from 0.2 to 0.1 to 0.25.展开更多
传统双向E型无线电能传输(wireless power transfer,WPT)拓扑易进入硬开关状态,导致电能传输效率低。针对此,该文提出无线电能传输系统的改进E^(#)型拓扑及其移相控制策略。首先,构建软开关状态负载范围更宽的双向E^(#)型WPT电路拓扑数...传统双向E型无线电能传输(wireless power transfer,WPT)拓扑易进入硬开关状态,导致电能传输效率低。针对此,该文提出无线电能传输系统的改进E^(#)型拓扑及其移相控制策略。首先,构建软开关状态负载范围更宽的双向E^(#)型WPT电路拓扑数学模型,分析并提取电路实现软开关工作状态的关键变量与约束条件,理论上证明所提拓扑的有效性。然后,推导电路中线圈互感和负载阻抗等参数的解析关系式,并基于此提出可保证系统在负载时始终处于最佳工作状态的移相控制策略。该策略通过控制开关管的门极驱动信号相位,使谐振元件内部储存的能量提前或者滞后释放,从而将开关管修正回软开关状态。最后,通过仿真和实验验证所提双向E^(#)型WPT系统的有效性。实验结果表明,所提方法可保证在5~30Ω的负载范围内电路工作在软开关状态,该范围内的电能传输效率峰值达84.3%。展开更多
无线电能传输(Wireless Power Transmission,WPT)系统在实际应用中存在高频功率源电能转换效率低、阻抗匹配不精准等问题,因此文章设计一种磁耦合谐振式高效无线电能传输装置,在保证无线电能传输切实可行的前提下,提升系统整体性能。首...无线电能传输(Wireless Power Transmission,WPT)系统在实际应用中存在高频功率源电能转换效率低、阻抗匹配不精准等问题,因此文章设计一种磁耦合谐振式高效无线电能传输装置,在保证无线电能传输切实可行的前提下,提升系统整体性能。首先,构建等效电路模型,分析WPT系统的传输效率、功率特性;其次,详细分析E类放大器的工作原理,并给出参数设计方法;再次,研究接收端整流调压电路的阻抗匹配问题,为提高无线电能传输功率和效率提供参考;最后,通过仿真验证磁耦合谐振式无线电能传输系统的可行性,输出功率为168.91 W,效率为91.52%。展开更多
Objective:To compare the genotype frequencies of HLA class-ⅡDRB1 alleles in Giardia(G.)lamblia-infected children.Methods:A total of 490 Egyptian children aged 2-16 years were subjected to microscopic stool examinatio...Objective:To compare the genotype frequencies of HLA class-ⅡDRB1 alleles in Giardia(G.)lamblia-infected children.Methods:A total of 490 Egyptian children aged 2-16 years were subjected to microscopic stool examination to detect G.lamblia infection,and to exclude other intestinal pathogens.On the basis of their microscopic findings,a group of 80 children were chosen as giardiasis cases,another 80 children were confirmed as Giardia free control group by immunochromatographic test,and the remaining children were excluded.Both giardiasis and control groups were then subjected to blood examination to identify their genetic type of HLA-DRB1 alleles.Results:HLA class-ⅡDRB1*03:01 and DRB1*13:01 alleles were significantly associated with G.lamblia infection(P<0.001 for each variable).On the other hand,HLA class-ⅡDRB1*04:02,DRB1*10:01,DRB1*14:01 and DRB1*15:01 alleles were significantly demonstrated in Giardia free children.However,other HLA-DRB1 alleles did not show any significant association with giardiasis.Conclusions:HLA class-ⅡDRB1*03,DRB1*13,DRB1*04,DRB1*10,DRB1*14 and DRB1*15 alleles may be involved in the establishment of host immune response to G.lamblia infection.展开更多
AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was c...AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral therapy. Myeloid DCs were isolated from the peripheral blood of each subject using CD1c(BDCA1)+ DC isolation Kit. Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus(HCV) viral proteins followed by LPS stimulation. Phenotyping was done by flowcytometry and gene expression profiling was evaluated by real-time PCR.RESULTS: Non-responders [sustained virological response(SVR)-ve] to conventional antiviral therapy had significantly higher expression of genes associated with interferon responsive element such as IDO1 and PD-L1(6-fold) and negative regulators of JAK-STAT pathway such as SOCS(6-fold) as compared to responders(SVR+ve) to antiviral therapy. The downregulated genes in non-responders included factors involved in antigen processing and presentation mainly belonging to major histocompatibility complex(MHC) Class-Ⅱ family as HLA-DP, HLA-DQ(2-fold) and superoxide dismutase(2-fold). Cells grown in the presence of HCV viral proteins had genes downregulated for factors involved in innate response, interferon signaling, DC maturation and co-stimulatory signaling to T-cells, while the genes for cytokine signaling and Toll-like receptors(4-fold) were upregulated as compared to cells grown in absence of viral proteins.CONCLUSION: Underexpressed MHC class-Ⅱ genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs.展开更多
基金The National High Technology Research and Development Program of China(863 Program)(No.2007AA01Z2A7)
文摘A fully integrated class-E power amplifier（PA） at 2.4 GHz implemented in a 0. 18 μm 6-metal-layer mixed/RF CMOS （ complementary metal-oxide-semiconductor transistor ） technology is presented. A two-stage amplification structure is chosen for this PA. The driving stage produces a high swing switch signal by using resonation technology. The output stage is designed as a class-E topology to realize the power amplification. Under a 1.2 V power supply, the PA delivers a maximum output power of 8. 8 dBm with a power-added efficiency （PAE） of 44%. A new power control method for the class-E power amplifier is described. By changing the amplitude and duty cycle of the signal which enters the class-E switch transistor, the output power can be covered from - 3 to 8. 8 dBm through a three-bit control word. The proposed PA can be used in low power applications, such as wireless sensor networks and biotelemetry systems.
文摘This paper presents a 1.8 GHz class-E controlled power amplifier (PA). The proposed power amplifier is designed with two-stage architecture. The main advantage of the proposed technique for output control power is a high 37 dB output power dynamic range with good average power adding efficiency. The measurement results show that the PA achieves a high power gain of 23 dBm and power added efficiency (PAE) by 38%. The circuit was post layout simulated in a standard 0.18 μm CMOS technology.
基金supported by the National Natural Science Foundation of China(No.61574125)the Industry Innovation Project of Suzhou City of China(No.SYG201641)
文摘We present and propose a complete and iterative integrated-circuit and electro-magnetic（EM） co-design methodology and procedure for a low-voltage sub-1 GHz class-E PA.The presented class-E PA consists of the onchip power transistor,the on-chip gate driving circuits,the off-chip tunable LC load network and the off-chip LC ladder low pass filter.The design methodology includes an explicit design equation based circuit components values＇ analysis and numerical derivation,output power targeted transistor size and low pass filter design,and power efficiency oriented design optimization.The proposed design procedure includes the power efficiency oriented LC network tuning,the detailed circuit/EM co-simulation plan on integrated circuit level,package level and PCB level to ensure an accurate simulation to measurement match and first pass design success.The proposed PA is targeted to achieve more than 15 dBm output power delivery and 40% power efficiency at 433 MHz frequency band with 1.5 V low voltage supply.The LC load network is designed to be off-chip for the purpose of easy tuning and optimization.The same circuit can be extended to all sub-1 GHz applications with the same tuning and optimization on the load network at different frequencies.The amplifier is implemented in 0.13 μm CMOS technology with a core area occupation of 400 μm by 300 μm.Measurement results showed that it provided power delivery of 16.42 dBm at antenna with efficiency of 40.6%.A harmonics suppression of 44 dBc is achieved,making it suitable for massive deployment of IoT devices.
基金Project (No.60271031) supported by the National Natural Science Foundation of China
文摘The efficiency of inductive power links driven by Class-E amplifiers may deteriorate due to variation in the coupling coefficient when the relative position of the radio frequency (RF) coils changes.To solve this problem,a new design methodology of power links is presented in this paper.The aim of the new design is to use the feedback signal,which is a phase difference between the driving signal and the output current of the Class-E amplifier,to adjust the duty cycle and angular frequency of the driving signal to maintain the optimum state of the inductive power link,and to adjust the supply voltage to keep the output power constant when the coupling coefficient of the RF coils changes.The parameter adjustments with respect to the coupling coefficient and the feedback signal are derived from the design equation of the inductive power link.To validate the feedback control rules,a prototype of the inductive power link was constructed,and its performance validated with the coupling coefficient set at 0.2 and a duty cycle of 0.5.The experimental results showed that,by adjusting the duty cycle,the angular frequency,and the supply voltage,the power link can be kept in optimal operation with a constant output power when the coupling coefficient changes from 0.2 to 0.1 to 0.25.
文摘传统双向E型无线电能传输(wireless power transfer,WPT)拓扑易进入硬开关状态,导致电能传输效率低。针对此,该文提出无线电能传输系统的改进E^(#)型拓扑及其移相控制策略。首先,构建软开关状态负载范围更宽的双向E^(#)型WPT电路拓扑数学模型,分析并提取电路实现软开关工作状态的关键变量与约束条件,理论上证明所提拓扑的有效性。然后,推导电路中线圈互感和负载阻抗等参数的解析关系式,并基于此提出可保证系统在负载时始终处于最佳工作状态的移相控制策略。该策略通过控制开关管的门极驱动信号相位,使谐振元件内部储存的能量提前或者滞后释放,从而将开关管修正回软开关状态。最后,通过仿真和实验验证所提双向E^(#)型WPT系统的有效性。实验结果表明,所提方法可保证在5~30Ω的负载范围内电路工作在软开关状态,该范围内的电能传输效率峰值达84.3%。
文摘无线电能传输(Wireless Power Transmission,WPT)系统在实际应用中存在高频功率源电能转换效率低、阻抗匹配不精准等问题,因此文章设计一种磁耦合谐振式高效无线电能传输装置,在保证无线电能传输切实可行的前提下,提升系统整体性能。首先,构建等效电路模型,分析WPT系统的传输效率、功率特性;其次,详细分析E类放大器的工作原理,并给出参数设计方法;再次,研究接收端整流调压电路的阻抗匹配问题,为提高无线电能传输功率和效率提供参考;最后,通过仿真验证磁耦合谐振式无线电能传输系统的可行性,输出功率为168.91 W,效率为91.52%。
文摘Objective:To compare the genotype frequencies of HLA class-ⅡDRB1 alleles in Giardia(G.)lamblia-infected children.Methods:A total of 490 Egyptian children aged 2-16 years were subjected to microscopic stool examination to detect G.lamblia infection,and to exclude other intestinal pathogens.On the basis of their microscopic findings,a group of 80 children were chosen as giardiasis cases,another 80 children were confirmed as Giardia free control group by immunochromatographic test,and the remaining children were excluded.Both giardiasis and control groups were then subjected to blood examination to identify their genetic type of HLA-DRB1 alleles.Results:HLA class-ⅡDRB1*03:01 and DRB1*13:01 alleles were significantly associated with G.lamblia infection(P<0.001 for each variable).On the other hand,HLA class-ⅡDRB1*04:02,DRB1*10:01,DRB1*14:01 and DRB1*15:01 alleles were significantly demonstrated in Giardia free children.However,other HLA-DRB1 alleles did not show any significant association with giardiasis.Conclusions:HLA class-ⅡDRB1*03,DRB1*13,DRB1*04,DRB1*10,DRB1*14 and DRB1*15 alleles may be involved in the establishment of host immune response to G.lamblia infection.
基金Supported by Council of Scientific and Industrial Research,No.27(0262)12/EMR-II
文摘AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 virus.METHODS: This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral therapy. Myeloid DCs were isolated from the peripheral blood of each subject using CD1c(BDCA1)+ DC isolation Kit. Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus(HCV) viral proteins followed by LPS stimulation. Phenotyping was done by flowcytometry and gene expression profiling was evaluated by real-time PCR.RESULTS: Non-responders [sustained virological response(SVR)-ve] to conventional antiviral therapy had significantly higher expression of genes associated with interferon responsive element such as IDO1 and PD-L1(6-fold) and negative regulators of JAK-STAT pathway such as SOCS(6-fold) as compared to responders(SVR+ve) to antiviral therapy. The downregulated genes in non-responders included factors involved in antigen processing and presentation mainly belonging to major histocompatibility complex(MHC) Class-Ⅱ family as HLA-DP, HLA-DQ(2-fold) and superoxide dismutase(2-fold). Cells grown in the presence of HCV viral proteins had genes downregulated for factors involved in innate response, interferon signaling, DC maturation and co-stimulatory signaling to T-cells, while the genes for cytokine signaling and Toll-like receptors(4-fold) were upregulated as compared to cells grown in absence of viral proteins.CONCLUSION: Underexpressed MHC class-Ⅱ genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs.
