Introduction.Specific gene fusions and their resultant fusion products,including chimeric ribonucleic acid(RNA)and protein,have long served as ideal tumor diagnostic markers and therapeutic targets.Despite this,only a...Introduction.Specific gene fusions and their resultant fusion products,including chimeric ribonucleic acid(RNA)and protein,have long served as ideal tumor diagnostic markers and therapeutic targets.Despite this,only a few systematic studies on chimeric RNAs have been conducted in prostate cancer(PCa).In this study,we summarize the discovery pipeline,formation mechanisms,method of action,and future perspectives of chimeric RNAs.We aim to provide a viewpoint for exploring novel targets for diagnosing or treating PCa.展开更多
基金supported by the China Scholarship Council(No.201906380075)Guangdong Province Natural Science Foundation(No.2023A1515011905).
文摘Introduction.Specific gene fusions and their resultant fusion products,including chimeric ribonucleic acid(RNA)and protein,have long served as ideal tumor diagnostic markers and therapeutic targets.Despite this,only a few systematic studies on chimeric RNAs have been conducted in prostate cancer(PCa).In this study,we summarize the discovery pipeline,formation mechanisms,method of action,and future perspectives of chimeric RNAs.We aim to provide a viewpoint for exploring novel targets for diagnosing or treating PCa.
