Since the 21st century,the Huang–Huai–Hai River Basin(HHHRB)in China has experienced increased frequency and severity of drought–flood abrupt alternation(DFAA)events during early summer,characterized by droughts in...Since the 21st century,the Huang–Huai–Hai River Basin(HHHRB)in China has experienced increased frequency and severity of drought–flood abrupt alternation(DFAA)events during early summer,characterized by droughts in June followed by floods in July.The 2024 event was the most severe since 1981.This study demonstrates that such compound extreme events are closely linked to anomalous subseasonal evolution of large-scale atmospheric circulation.During the drought phase,the East Asian subtropical westerly jet(EAJ)shifts southward,and the western Pacific subtropical high(WPSH)exhibits anomalous strengthening with its western ridge line displaced southward.The flood phase is characterized by acceleration of the EAJ,westward extension of the WPSH,and enhanced southwestern moisture transport from the western Pacific.Beyond these typical features,the 2024 early summer circulation exhibited unique characteristics:Anomalous northeastward intensification of the WPSH facilitated merged moisture influx from both the Indian Ocean and the western Pacific along the southeast pathway into the HHHRB in July,resulting in the highest net moisture inflow at the southern boundary of the HHHRB since 1981.The synergistic effects of multiple factors primarily explain the exceptionally intense DFAA event in 2024.展开更多
BACKGROUND Although circulating tumor cells(CTCs)have been the focus of consideration for a decade,a categorized cell-based diagnostic strategy is unavailable.The personalized management and complementary/analytical-s...BACKGROUND Although circulating tumor cells(CTCs)have been the focus of consideration for a decade,a categorized cell-based diagnostic strategy is unavailable.The personalized management and complementary/analytical-strategy of data require an alphabetic guide.Therefore,we aimed to determine the behavior of CTCs in tumor and blood in order to provide the hypothetical-based agenda in the brain neoplasms.Exploring the protein expression(PE)using a single cell-based method would clarify the heterogeneity and diversity in tumor and blood,which are key events in the evolution in brain tumors.In fact,heterogeneity,diversity,and evolution are required for cancer initiation and progression.AIM To explore CTCs in brain tumors and blood cells and to assay intensity of PE through personalized insight.METHODS The focal population included 14 patients with meningioma,and four patients with metastatic brain tumors(T).PE was assayed by immunofluorescence in tumors cells and CTCs in 18 patients with brain tumors.Ratio test was applied between the T cells and CTCs in tumor tissue and in vascular system.T/CTC ratio-based classification of PE in macrophage chemoattractant chemokine ligand 2(CCL2),vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),CD133,cyclin E,neurofilament marker,cytokeratin 19,and leukocyte common antigen(CD45)were investigated.RESULTS Total analyzed cells ranged between 10794-92283 for tumor cells and between 117-2870 for CTCs.Characteristics of histopathologic and status of an ataxiatelangiectasia mutated polymorphism(D1853N)in 18 patients affected with brain tumors were also provided.The course of evolution and metastatic event relied on the elevated protein expression in CTCs,which could be considered as a prognostic value.Diverse protein expression of the migrated cells into the blood stream and the tumor was indicative of the occurrence of evolution.Besides,the harmonic co-expression between CCL2/EGF and CCL2/VEGF could facilitate the tumor progression including the metastatic event.Expression of these proteins in the migrated vasculature and into the buccal tissue offered a non-invasive followup detection in neoplastic disorders.PE-exploration of neurofilament marker/CD133/VEGF of the CTCs in meningioma and cytokeratin 19/CD45/cyclin E in the patients with metastatic brain tumor would clarify the tumor biology of the brain neoplastic disorders.CONCLUSION The alphabetical base of the evolutionary mechanisms relies on dual-,triple-,and multi-models with diverse intensity of expression.In fact,cross-talk between initiative and the complementary channels defines the evolutionary insight in cancer.A diverse-model of protein expression,including low,medium,and high intensity,is the key requirement for the completed model.The cluster of cells with diverse expression and remarkable co-expression between CCL2/EGF/VEGF and NM/CD133/VEGF in CTCs may be indicative of probable invasiveness of the tumor.Furthermore,the mode of cytokeratin-19+/CD45-can be traced in the metastatic patients.展开更多
[Objective]The research aimed to analyze formation reason of ＂ 0902＂ blizzard in northeast China. [Method]By using timely observation data,NCEP reanalysis data and Doppler radar data at Baishan station,blizzard proc...[Objective]The research aimed to analyze formation reason of ＂ 0902＂ blizzard in northeast China. [Method]By using timely observation data,NCEP reanalysis data and Doppler radar data at Baishan station,blizzard process in southeast part of northeast China during 12-13 February,2009 was analyzed. [Result]Snowfall zone of the blizzard process was wide,snowfall was more,snowfall gradient was big,and snowfall time relatively concentrated. These characteristics reflected that the blizzard process had significant convection characteristics. Baroclinic disturbance at high-altitude straight frontal zone and ground warm frontogenesis caused by eastward movement and northward advancement of North China low vortex at low altitude were the circulation characteristics in the process. Water vapor from the sea went northward as southwest airflow,and strongly converged in blizzard zone,which provided sufficient water vapor condition for the blizzard. Before heavy snowfall occurred,there was accumulation process of heat and energy. Conditional symmetric instability was main unstable mechanism of the blizzard. During heavy snowfall period,ascending branch of secondary vertical circulation at exit zone of high-altitude jet coupled with ascending branch of secondary vertical circulation of warm frontegenesis at low layer,inducing strong development of the vertical motion. Doppler radar intensity echo revealed that it was easy to generate blizzard in the area where echo intensity was consistently above 20 dBz. Strong wind velocity convergence zone at radical velocity field especially adverse wind zone was favorable for the generation of blizzard. [Conclusion]The research could provide reference for blizzard forecast in northeast China.展开更多
The Ordos Basin is a large-scale sedimentary basin in northwestern China. The hydrostratigraphic units from bottom to top are pre-Cambrian metamorphic rocks, Lower Paleozoic carbonate rocks, Upper Paleozoic to Mesozoi...The Ordos Basin is a large-scale sedimentary basin in northwestern China. The hydrostratigraphic units from bottom to top are pre-Cambrian metamorphic rocks, Lower Paleozoic carbonate rocks, Upper Paleozoic to Mesozoic clastic rocks and Cenozoic deposits. The total thickness is up to 6000 m. Three groundwater systems are present in the Ordos Basin, based on the geological settings, i.e. the karst groundwater system, the Cretaceous clastic groundwater system and the Quaternary groundwater system. This paper describes systematically the groundwater flow patterns of each system and overall assessment of groundwater resources.展开更多
The process went generally through three different stages: 1. Highly planned distribution stage (Before 1978) Before1978, the Chinese auto circulation system had witnessed the changes of" unified allocation by ce...The process went generally through three different stages: 1. Highly planned distribution stage (Before 1978) Before1978, the Chinese auto circulation system had witnessed the changes of" unified allocation by central government" which played the main role while making the local government subsidiary. Yet, the whole process of auto production and circulation had been controlled by both central and local governments. Therefore, strictly speaking,展开更多
基金supported by the National Natural Science Foundation of China[grant numbers U2142207 and U2342205]the National Key R&D Program of China[grant number 2024YFC3013100]China Meteorological Administration(CMA)Youth Innovation Team[CMA2024QN06].
文摘Since the 21st century,the Huang–Huai–Hai River Basin(HHHRB)in China has experienced increased frequency and severity of drought–flood abrupt alternation(DFAA)events during early summer,characterized by droughts in June followed by floods in July.The 2024 event was the most severe since 1981.This study demonstrates that such compound extreme events are closely linked to anomalous subseasonal evolution of large-scale atmospheric circulation.During the drought phase,the East Asian subtropical westerly jet(EAJ)shifts southward,and the western Pacific subtropical high(WPSH)exhibits anomalous strengthening with its western ridge line displaced southward.The flood phase is characterized by acceleration of the EAJ,westward extension of the WPSH,and enhanced southwestern moisture transport from the western Pacific.Beyond these typical features,the 2024 early summer circulation exhibited unique characteristics:Anomalous northeastward intensification of the WPSH facilitated merged moisture influx from both the Indian Ocean and the western Pacific along the southeast pathway into the HHHRB in July,resulting in the highest net moisture inflow at the southern boundary of the HHHRB since 1981.The synergistic effects of multiple factors primarily explain the exceptionally intense DFAA event in 2024.
基金Supported by Tehran University of Medical Sciences,Research deputy under project,No.32208-30-04-95.
文摘BACKGROUND Although circulating tumor cells(CTCs)have been the focus of consideration for a decade,a categorized cell-based diagnostic strategy is unavailable.The personalized management and complementary/analytical-strategy of data require an alphabetic guide.Therefore,we aimed to determine the behavior of CTCs in tumor and blood in order to provide the hypothetical-based agenda in the brain neoplasms.Exploring the protein expression(PE)using a single cell-based method would clarify the heterogeneity and diversity in tumor and blood,which are key events in the evolution in brain tumors.In fact,heterogeneity,diversity,and evolution are required for cancer initiation and progression.AIM To explore CTCs in brain tumors and blood cells and to assay intensity of PE through personalized insight.METHODS The focal population included 14 patients with meningioma,and four patients with metastatic brain tumors(T).PE was assayed by immunofluorescence in tumors cells and CTCs in 18 patients with brain tumors.Ratio test was applied between the T cells and CTCs in tumor tissue and in vascular system.T/CTC ratio-based classification of PE in macrophage chemoattractant chemokine ligand 2(CCL2),vascular endothelial growth factor(VEGF),epidermal growth factor(EGF),CD133,cyclin E,neurofilament marker,cytokeratin 19,and leukocyte common antigen(CD45)were investigated.RESULTS Total analyzed cells ranged between 10794-92283 for tumor cells and between 117-2870 for CTCs.Characteristics of histopathologic and status of an ataxiatelangiectasia mutated polymorphism(D1853N)in 18 patients affected with brain tumors were also provided.The course of evolution and metastatic event relied on the elevated protein expression in CTCs,which could be considered as a prognostic value.Diverse protein expression of the migrated cells into the blood stream and the tumor was indicative of the occurrence of evolution.Besides,the harmonic co-expression between CCL2/EGF and CCL2/VEGF could facilitate the tumor progression including the metastatic event.Expression of these proteins in the migrated vasculature and into the buccal tissue offered a non-invasive followup detection in neoplastic disorders.PE-exploration of neurofilament marker/CD133/VEGF of the CTCs in meningioma and cytokeratin 19/CD45/cyclin E in the patients with metastatic brain tumor would clarify the tumor biology of the brain neoplastic disorders.CONCLUSION The alphabetical base of the evolutionary mechanisms relies on dual-,triple-,and multi-models with diverse intensity of expression.In fact,cross-talk between initiative and the complementary channels defines the evolutionary insight in cancer.A diverse-model of protein expression,including low,medium,and high intensity,is the key requirement for the completed model.The cluster of cells with diverse expression and remarkable co-expression between CCL2/EGF/VEGF and NM/CD133/VEGF in CTCs may be indicative of probable invasiveness of the tumor.Furthermore,the mode of cytokeratin-19+/CD45-can be traced in the metastatic patients.
文摘[Objective]The research aimed to analyze formation reason of ＂ 0902＂ blizzard in northeast China. [Method]By using timely observation data,NCEP reanalysis data and Doppler radar data at Baishan station,blizzard process in southeast part of northeast China during 12-13 February,2009 was analyzed. [Result]Snowfall zone of the blizzard process was wide,snowfall was more,snowfall gradient was big,and snowfall time relatively concentrated. These characteristics reflected that the blizzard process had significant convection characteristics. Baroclinic disturbance at high-altitude straight frontal zone and ground warm frontogenesis caused by eastward movement and northward advancement of North China low vortex at low altitude were the circulation characteristics in the process. Water vapor from the sea went northward as southwest airflow,and strongly converged in blizzard zone,which provided sufficient water vapor condition for the blizzard. Before heavy snowfall occurred,there was accumulation process of heat and energy. Conditional symmetric instability was main unstable mechanism of the blizzard. During heavy snowfall period,ascending branch of secondary vertical circulation at exit zone of high-altitude jet coupled with ascending branch of secondary vertical circulation of warm frontegenesis at low layer,inducing strong development of the vertical motion. Doppler radar intensity echo revealed that it was easy to generate blizzard in the area where echo intensity was consistently above 20 dBz. Strong wind velocity convergence zone at radical velocity field especially adverse wind zone was favorable for the generation of blizzard. [Conclusion]The research could provide reference for blizzard forecast in northeast China.
文摘The Ordos Basin is a large-scale sedimentary basin in northwestern China. The hydrostratigraphic units from bottom to top are pre-Cambrian metamorphic rocks, Lower Paleozoic carbonate rocks, Upper Paleozoic to Mesozoic clastic rocks and Cenozoic deposits. The total thickness is up to 6000 m. Three groundwater systems are present in the Ordos Basin, based on the geological settings, i.e. the karst groundwater system, the Cretaceous clastic groundwater system and the Quaternary groundwater system. This paper describes systematically the groundwater flow patterns of each system and overall assessment of groundwater resources.
文摘The process went generally through three different stages: 1. Highly planned distribution stage (Before 1978) Before1978, the Chinese auto circulation system had witnessed the changes of" unified allocation by central government" which played the main role while making the local government subsidiary. Yet, the whole process of auto production and circulation had been controlled by both central and local governments. Therefore, strictly speaking,
