Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica...Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.展开更多
Brazil maintains a leading position in agricultural exports and stands as the world's foremost producer and user of bioinputs in agriculture.These bioinputs generate annual savings of billions of dollars that woul...Brazil maintains a leading position in agricultural exports and stands as the world's foremost producer and user of bioinputs in agriculture.These bioinputs generate annual savings of billions of dollars that would otherwise be allocated to chemical fertilizers and pesticides.The nation's regulatory framework enables bioinput agriculture and serves as a model for countries transitioning toward regenerative agriculture.Brazilian legislation categorizes bioinputs into:1)biofertilizers(extracts);2)biostimulants(plant growth-promoting and biocontrol agents);and 3)inoculants(active ingredient comprises one or more living microorganisms).The inoculation of soybeans with Bradyrhizobium strains provides approximately 90%of the nitrogen accumulated by this crop.Brazil has registered over six hundred inoculants,with at least 60%specifically designated for soybean cultivation.The annual sales of inoculants in Brazil reach approximately 120 million doses.Although beans(Phaseolus vulgaris and Vigna unguiculata)represent an essential food crop in Brazil's staple diet and benefit from inoculation,inoculant supply remains insufficient.Regarding biocontrol,soy,corn,sugarcane,and coffee rank among the most protected crops,employing biocontrol agents against bacteria,fungi,nematodes,and insects.Bacillus,Pseudomonas,Streptomyces,Rhizobium,Azotobacter,and Paenibacillus strains were predominantly cited in the 5,000+bioproduct patents filed between 2022 and 2024.Among fungal genera,Trichoderma,and Penicillium received the most citations.EMBRAPA's biobanks maintain over 10,000 strains of bacteria,fungi,and viruses for biocontrol,and 14,000 strains of nutrient-fixing and plant-growth promoters.Production challenges include quality control,particularly as on-farm production of inoculants becomes prevalent on larger farms,alongside product availability and supply limitations.Brazilian farmers maintain global competitiveness partly through reduced chemical fertilizer and pesticide costs enabled by bioinput usage.As components of regenerative agriculture,bioinputs enhance soil quality,decrease carbon footprints,and support Sustainable Development Goals.Brazil's leadership in microbial bioinput utilization stems from its extensive agricultural sector,rich microbial biodiversity,and progressive regulatory framework.展开更多
Graphite,encompassing both natural graphite and synthetic graphite,and graphene,have been extensively utilized and investigated as anode materials and additives in lithium-ion batteries(LIBs).In the pursuit of carbon ...Graphite,encompassing both natural graphite and synthetic graphite,and graphene,have been extensively utilized and investigated as anode materials and additives in lithium-ion batteries(LIBs).In the pursuit of carbon neutrality,LIBs are expected to play a pivotal role in reducing CO_(2)emissions by decreasing reliance on fossil fuels and enabling the integration of renewable energy sources.Owing to their technological maturity and exceptional electrochemical performance,the global production of graphite and graphene for LIBs is projected to continue expanding.Over the past decades,numerous researchers have concentrated on reducing the material and energy input whilst optimising the electrochemical performance of graphite and graphene,through novel synthesis methods and various modifications at the laboratory scale.This review provides a comprehensive examination of the manufacturing methods,environmental impact,research progress,and challenges associated with graphite and graphene in LIBs from an industrial perspective,with a particular focus on the carbon footprint of production processes.Additionally,it considers emerging challenges and future development directions of graphite and graphene,offering significant insights for ongoing and future research in the field of green LIBs.展开更多
The escalating accumulation of agro-industrial waste—exceeding 350 million tons annually from post-harvest residues,food processing,and aquaculture—poses serious environmental threats,including greenhouse gas emissi...The escalating accumulation of agro-industrial waste—exceeding 350 million tons annually from post-harvest residues,food processing,and aquaculture—poses serious environmental threats,including greenhouse gas emissions,groundwater contamination,and excessive landfill usage.Although conventional treatment methods such as composting,incineration,and recycling offer partial mitigation,they often fall short of delivering scalable,circular solutions.Microbial biorefineries have emerged as a transformative approach,enabling the conversion of diverse biomass streams into high-value renewable materials.Through microbial fermentation,agricultural and municipal waste can be repurposed into functional outputs such as nanocellulose,biochar,and biocompatible compounds with applications in packaging,pharmaceuticals,and cosmetics.This review critically examines the role of microbial systems in agro-waste valorization,highlighting recent advances in strain engineering,process integration,and bioproduct development.It also explores the regulatory and techno-economic frameworks required to scale these innovations within a biomass-driven circular economy,positioning microbial biorefineries as key enablers of sustainable material transitions.展开更多
The recovery of precious metals(PMs)from secondary resources is critical for addressing global supply-chain vulnerabilities and sustainable resource utilization.This review systematically examines the transformative p...The recovery of precious metals(PMs)from secondary resources is critical for addressing global supply-chain vulnerabilities and sustainable resource utilization.This review systematically examines the transformative potential of metal-organic frameworks(MOFs)as next-generation adsorbents for PM recovery,focusing on their synthesis,functionalization,and multiscale adsorption mechanisms.We critically analyze conventional pyrometallurgical and hydrometallurgical methods and highlight their limitations in terms of selectivity,energy consumption,and secondary pollution.In contrast,MOFs offer tunable porosity,abundant active sites,and tunable surface chemistry,enabling efficient PM capture via synergistic physical and chemical adsorption.Advanced modification techniques,including direct synthesis and post-synthetic modification,are reviewed to propose strategies for enhancing the adsorption kinetics and selectivity for Au,Ag,Pt,and Pd.Key structure-property relationships are established through multiscale characterization and thermodynamic models,revealing the critical roles of hierarchical porosity,soft donor atoms,and framework stability.Industrial challenges,such as aqueous stability and scalability,are addressed via Zr-O bond strengthening,hydrophobic functionalization,and support immobilization.This study consolidates the experimental and theoretical advances in MOF-based PM recovery and provides a roadmap for translating laboratory innovations into practical applications within the circular-economy framework.展开更多
The circular economy is an innovative concept of both production and consumption.It can reduce wastage,preserve resources,and minimize environmental effects with the help of recycling,recovering resources,and extendin...The circular economy is an innovative concept of both production and consumption.It can reduce wastage,preserve resources,and minimize environmental effects with the help of recycling,recovering resources,and extending the life of products.It works as a pathway to reduce environmental footprints by redesigning production-consumption systems.This review critically examines global circular economy strategies,policy approaches,and persistent barriers that shape environmental footprint outcomes across major sectors.Drawing on a structured narrative review and thematic synthesis,we integrate findings on key circular economy practices,Eco-design,product life extension,reuse,re-manufacturing,recycling,and resource recovery,and assess how they interact with policy instruments such as extended producer responsibility,ecodesign requirements,and waste governance reforms.The analysis highlights that reported benefits(e.g.,reduced material throughput,waste generation,and emissions)are frequently constrained by technological limitations(complex material streams,low-quality recyclate,energy-intensive processing),economic conditions(high upfront costs,weak markets for secondary materials,commodity price volatility),and institutional and behavioral factors(regulatory fragmentation,limited enforcement capacity,low consumer acceptance).We further synthesize methodological challenges in measuring“circularity”and footprint reductions,emphasizing boundary choices,rebound effects,and trade-offs such as increased energy demand or land and water pressures in bio-based substitution.By linking circular economy strategies,barriers,and outcomes in an integrative conceptual framework,the review clarifies why circular transitions often deliver partial gains and identifies leverage points for scaling effective,evidence-based policy and practice.展开更多
The environment and its preservation are becoming more and more dependent on ecological development in an age of accelerating climate risk,biodiversity loss,and pressures of pollution.This review summarizes the fronti...The environment and its preservation are becoming more and more dependent on ecological development in an age of accelerating climate risk,biodiversity loss,and pressures of pollution.This review summarizes the frontiers of innovation that are capable of enhancing integration of human development and ecological integrity,and how the interaction between technical,ecological,and institutional innovations can produce real-world results.We initially discuss developing ecological innovations that offer new opportunities to urban development,such as low-impact cities,ecological infrastructure,clean energy transitions,and biodiversity-informed siting,and digital decision-support systems enhancing planning and resource efficiency.Then,we evaluate progress in the field of preservation and restoration,with a particular focus on nature-based solutions,a process-based approach to restoration science,connectivity conservation,and a watershed-scale and seascape-scale approach to restore resilience and help recover biodiversity.In these spheres,we discover measurement,monitoring,and verification(MRV),one of the main pillars of scale alongside remote sensing,automated field monitoring,environmental Deoxyribonucleic Acid(DNA),and Artificial Intelligence(AI)-enabled analytics,increasing the range of trackable and manageable indices as well as creating new issues with baselines,uncertainty,and data ethics.Lastly,we compare governance,finance,and equity as key conversion processes that can turn innovations into sustainable dividends with authenticity principles,however,of additionality,permanence,and leakage avoidance,and with rightsbased and redistributive mechanisms and approaches that reinforce legitimacy.We end by providing a portfolio roadmap of prioritization of the interventions that have high co-benefits and the identification of critical research and institutional gaps to provide net-positive ecological results.展开更多
This study explores the use of black soldier fly larvae protein as a bio-based adhesive to produce particleboards from sugarcane bagasse.A comprehensive evaluation was conducted,including rheological characterization ...This study explores the use of black soldier fly larvae protein as a bio-based adhesive to produce particleboards from sugarcane bagasse.A comprehensive evaluation was conducted,including rheological characterization of the adhesive and physical–mechanical testing of the panels according to European standards.The black soldier fly larvae-based adhesive exhibited gel-like viscoelastic behavior,rapid partial structural recovery after shear,and favorable application properties.Particleboards manufactured with this adhesive and sugarcane bagasse achieved promising mechanical performance,with modulus of rupture and modulus of elasticity values of 30.2 and 3500 MPa,respectively.Internal bond strength exceeded 0.4 MPa,complying with European standard 312-3 specifications.For comparative purposes,a panel made with Eucalyptus grandis particles was also produced under the same conditions to demonstrate the versatility of the adhesive system.Compared to other bio-based and synthetic adhesives,this bio-based system showed competitive performance and derives from the bioconversion of organic residues.Protein adhesives were synthesized fromHermetia illucens larvae grown commercially on agriculturalwaste frompotato chip production,emphasizing the renewable origin of both the biomass and the final adhesive.These results highlight the potential of insect proteins as sustainable and circular alternatives for the wood panel industry.展开更多
The concepts of the circular economy(CE)are actively popularized as ways of minimizing waste products and the need to rely on virgin resources.Nevertheless,their sustainability is doubtful at a general level where eco...The concepts of the circular economy(CE)are actively popularized as ways of minimizing waste products and the need to rely on virgin resources.Nevertheless,their sustainability is doubtful at a general level where ecosystem functioning and ecosystem services(ES)are not given explicit attention.This review will combine both conceptual and empirical evidence of the connection between CE interventions and ES outcomes to enable more sustainable management of resources.We describe the effects of the CE strategies on the key environmental pressure pathways,altering ecosystem conditions,and impacting the delivery of regulating,provisioning,and cultural ecosystem services using a pressure condition-service framework.Analysis reveals that demand-side reduction and product life-extension strategies tend to offer more consistent ecosystem service co-benefits than recycling and recovery strategies because they do not involve production,and will cause less disturbance to the upstream environment.Contrastingly,recycling and recovery sustainability performance is highly dependent on the sources of energy,intensity of processing,and the safety of materials.Bio-based circularity has the potential to increase soil functionality and nutrient cycling,and mass application will result in trade-offs in terms of land competition and nutrient leakage.The sectoral analysis identifies the unique opportunities and threats in the agri-food systems,the built environment,plastics and textiles,electronics and critical minerals,and water and wastewater systems in terms of the burden displacement,local environmental pressures,and equity concerns.Harmonized reporting,coupled with supply-chain and spatial ecological assessment,threshold-conscious strategies that promote safe and regenerative circular systems should be put into the line of future research.展开更多
Stroke-induced alterations in cerebral blood flow trigger neurovascular remodeling,as manifested by the blood-brain barrier dysfunction and subs equent neurovascular repair activities such as angiogenesis.This process...Stroke-induced alterations in cerebral blood flow trigger neurovascular remodeling,as manifested by the blood-brain barrier dysfunction and subs equent neurovascular repair activities such as angiogenesis.This process involves neurovascular communication that facilitates the transport of mediators among cerebrovascular endothelial cells,pericytes,glial cells,and neurons,thereby transmitting signals from donor to recipient cells to elicit a collaborative response.展开更多
Owing to their intricate molecular frameworks and copious chiral centers,the structural identification and configurational assignment of natural products are challenging tasks.Comprehensive spectral data analysis is c...Owing to their intricate molecular frameworks and copious chiral centers,the structural identification and configurational assignment of natural products are challenging tasks.Comprehensive spectral data analysis is crucial for the confirmation of absolute configurations.Ignoring critical parameters will lead to false structure,which may confuse the total synthesis and drug development.Herein,the configurations of seven heterogeneous Pallavicinia diterpenoids(PDs) isolated from Pallavicinia liverworts are revised using a combination of single-crystal X-ray diffraction and electronic circular dichroism(ECD) calculations.Meanwhile,identification of five unprecedented PD heterodimers PD-dimers A-E(18-22) along with eleven previously undescribed PDs(5-9,13-17,23) obtained by the reinvestigation of the Chinese liverwort Pallavicinia subciliata have resulted in corrections and support the revised conclusions.展开更多
Reverse water-gas shift(RWGS) reaction-aided sustainable CO_(2) conversion has emerged as one promising and effective approach for simultaneously mitigating climate change and solidifying energy security.Molybdenum ca...Reverse water-gas shift(RWGS) reaction-aided sustainable CO_(2) conversion has emerged as one promising and effective approach for simultaneously mitigating climate change and solidifying energy security.Molybdenum carbide-based catalysts demonstrate excellent selectivity for sustainably transforming CO_(2) into CO product,but harsh carburization syntheses and insufficient catalytic activity and stability significantly hinder their related commercial applications.Herein,a facile "insideout" synthesis strategy was proposed to fabricate dispersed Cu clusters on sub-2 nm α-MoC nanoislands confined in pyridinic nitrogen-doped carbon(Cu-MoC/NC).This catalyst achieves the highest CO_(2) conversion rate of 2583.4 mmol_(CO_(2)) g_(cat)^(-1) h^(-1)compared to those of all reported Mo-based catalysts,and maintains excellent catalytic stability for 500 h under a low H_(2) partial pressure.Combined with X-ray absorption spectroscopy(XAS) and density functional theory(DFT) calculations,the electronegativity of pyridinic nitrogen intensifies the electron deficiency of α-MoC and strengthens the chemisorption of Cu clusters on α-MoC nanoislands surface,facilitating the electronic interaction and stability of Cu-MoC interface.This pyridinic nitrogenmodified Cu-MoC interface promotes the CO_(2) bridged adsorption at the interface and thus boosts C=O bond scissoring,inducing the transition of rate-limiting step and energy barrier reduction of the key intermediates.This interfacial engineering provides a sustainable and efficient strategy for improving both catalytic activity and stability of RWGS reaction to transform CO_(2) into value-added fuels and chemicals.展开更多
Aims and scope With the tenet of concerning ecology and serving economy,Ecological Economy focuses on the sustainable development of economy and environment,and puts attention on theories,methods and technical innovat...Aims and scope With the tenet of concerning ecology and serving economy,Ecological Economy focuses on the sustainable development of economy and environment,and puts attention on theories,methods and technical innovations concerning ecological/green economy,circular economy and ecological/green industry.The sustainable development of economy and society,and the sustainable development of the population,resource and environment are also within the concern of the journal.展开更多
This review sums up existing information on the environmental issues of critical materials in new energy vehicles(NEVs)on a combined mining to mobility approach.With the increase in the rate of NEV adoption,the enviro...This review sums up existing information on the environmental issues of critical materials in new energy vehicles(NEVs)on a combined mining to mobility approach.With the increase in the rate of NEV adoption,the environmental cost of operating vehicles will decline as the burden moves to upstream and downstream material life-cycle activities,such as extraction,beneficiation,refining,component manufacturing,use-phase performance,and end-of-life management.We focus on key material categories that provide electrified mobility,such as battery-related material(e.g.,Li,Ni,Co,Mn,graphite),high-performance motor-related material(e.g.,rare earth elements),conductive and lightweighting material(e.g.,Cu and Al).In the supply chain,the prevailing environmental forces consist of high energy requirements and related greenhouse gas emissions,excessive water consumption and water pollution risks,toxicity and human health issues pertaining to chemical inputs and metal discharges,land-use shift,and ecosystem and biodiversity effects.The review notes that there is high regional heterogeneity,which is fueled by ore grades,processing technologies,electricity mixes,and governance capacity,and that when measurements are narrowed to carbon measures,there is a risk of shifting the problem across geographies and categories of impacts.Mitigation pathways are analyzed,such as cleaner extraction and refining,material substitution and dematerialization,battery design,longevity and recyclability,and also the strategies of the circular economy,such as recycling and second-life use.Lastly,we establish research gaps in important areas of supply-chain data disclosure,multi-impact life-cycle assessment approaches,and integrated environmental-social analysis to enable sound policy formulation that can be used to achieve sustainable electrified mobility.展开更多
Rotating Single-Baseline Interferometer(RSBI)systems have attracted considerable attention for Direct Position Determination(DPD)due to their simplicity and high localization accuracy.Nevertheless,the growing complexi...Rotating Single-Baseline Interferometer(RSBI)systems have attracted considerable attention for Direct Position Determination(DPD)due to their simplicity and high localization accuracy.Nevertheless,the growing complexity of electromagnetic environments has led to scenarios with multiple time-frequency aliased sources,rendering conventional DPD methods for RSBI systems ineffective.Previous studies have predominantly concentrated on deploying antenna arrays and applying related signal-processing techniques for localization.Typically,these approaches necessitate that the number of physical antennas exceeds the number of sources.For RSBI systems already in practical operation,this would entail the installation of additional physical antennas,which implies equipment recycling and hardware upgrades.In numerous cases,such modifications are unfeasible.This paper proposes a novel Relative Offset-based Direct Position Determination(RO-DPD)method for RSBI systems that can handle multiple time-frequency aliased sources.The proposed method overcomes the challenge of simultaneous positioning without requiring hardware modifications by leveraging time accumulation and algorithmic enhancements.The implementation of the method involves three key steps.Firstly,the rotation of the interferometer is synthesized into a virtual Uniform Circular Array(UCA).Secondly,a novel estimation variable,termed relative offset,is introduced.The variable serves as an intermediate parameter to establish correlation equations between the positions of multiple time-frequency aliased sources and the intercepted signals.Thirdly,the relative offset model in the UCA is transformed into a virtual Uniform Linear Array(ULA)model,from which the cost function can be derived via the Spatial Smoothing(SS)MUSIC algorithm.Theoretical analysis and simulation results verify the effectiveness of the proposed method.Compared with traditional approaches,the RO-DPD method maintains the low complexity of RSBI systems while demonstrating robust performance in complex electromagnetic environments.展开更多
Recently,uniform circular array(UCA)based orbital angular momentum(OAM)beam steering schemes have been proposed to overcome the limitations of coaxial transmission.Unlike the traditional multiple-input-multiple-output...Recently,uniform circular array(UCA)based orbital angular momentum(OAM)beam steering schemes have been proposed to overcome the limitations of coaxial transmission.Unlike the traditional multiple-input-multiple-output(MIMO)beam steering,OAM beam steering includes both the OAM generation and the beam steering.Generally,the true time delay(TTD)or the phase shifter(PS)are required for beam steering in the radio domain.Previous studies suggest that TTD is preferred for wideband MIMO beam steering to avoid beam squint caused by PS.However,in this paper,we theoretically prove that to generate the OAM beam ideally,PS should be used,while TTD deteriorates the mode orthogonality,which is influenced by the relative bandwidth.Once the ideal OAM beam is generated,TTD is required to prevent beam squint.Based on this analysis,we propose to use the two-stage phase-shifting(TSPS)architecture for OAM beam steering:PS for OAM generation and TTD for beam steering.Simulation results suggest that compared to the spectrum efficiency(SE)of PS based OAM communication,the SE based on the TTD significantly declines as the relative bandwidth increases.Furthermore,OAM beam steering using the TSPS architecture greatly outperforms systems that adopt a single TTD or PS network.展开更多
Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and disability.Accurate predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic ...Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and disability.Accurate predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain undetermined.With innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental models.Differentially expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic stroke.Moreover,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.In particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic stroke.In this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.Findings from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.展开更多
Matrix metalloproteinases(MMPs)are essential enzymes involved in extracellular matrix degradation and remodeling.Such processes are integral to normal tissue homeostasis and several pathological conditions such as can...Matrix metalloproteinases(MMPs)are essential enzymes involved in extracellular matrix degradation and remodeling.Such processes are integral to normal tissue homeostasis and several pathological conditions such as cancer.Among these MMPs,MMP-13 plays a key role in cancer progression,driving tumor invasion,metastasis,and angiogenesis.Despite significant advancements in understanding its biology,therapeutic targeting of MMP-13 remains challenging owing to its complex and multifaceted regulatory mechanisms.Recent studies have underscored the pivotal role of non-coding RNAs(ncRNAs),including long ncRNAs,microRNAs,and circular RNAs,in modulating MMP-13 expression.This review provides a comprehensive analysis of MMP-13 regulation by several signaling pathways,the influence of ncRNAs on these signaling pathways,and MMP-13 expression during cancer progression and metastasis.Furthermore,we explored the clinical relevance of ncRNA-mediated regulatory networks,highlighting their potential as diagnostic biomarkers and therapeutic targets in various cancers.By unraveling these regulatory mechanisms,this review offers valuable insights into innovative strategies for cancer diagnosis and treatment and emphasizes the translational significance of ncRNA-mediated MMP-13 regulation in oncology.展开更多
A tunable oxidization and reduction strategy was proposed to directly regenerate spent LiFePO_(4)/C cathode materials by oxidizing excessive carbon powders with the addition of FePO_(4).Experimental results indicate t...A tunable oxidization and reduction strategy was proposed to directly regenerate spent LiFePO_(4)/C cathode materials by oxidizing excessive carbon powders with the addition of FePO_(4).Experimental results indicate that spent LiFePO_(4)/C cathode materials with good performance can be regenerated by roasting at 650℃ for 11 h with the addition ofLi_(2)CO_(3),FePO_(4),V_(2)O_(5),and glucose.V_(2)O_(5) is added to improve the cycle performance of regenerated cathode materials.Glucose is used to revitalize the carbon layers on the surface of spent LiFePO_(4)/C particles for improving their conductivity.The regenerated V-doped LiFePO_(4)/C shows an excellent electrochemical performance with the discharge specific capacity of 161.36 mA·h/g at 0.2C,under which the capacity retention is 97.85%after 100 cycles.展开更多
文摘Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.
基金funded in part by the Postgraduate Program of the Paulo de Góes Institute of Microbiology,Federal University of Rio de Janeiro(UFRJ),through the coordination of Higher Education Personnel Improvement(CAPES)(001),Brazilthe National Council for Scientific and Technological Development of Brazil(MCTI-CNPq)(309461/2019-7)+3 种基金the Rio de Janeiro State Research Support Foundation(FAPERJ),E26/200428/2023,Brazilthe support of Embrapa Agrobiology,the State Secretariat for Economic Development,Industry,Trade,and Services(SEDEICS),Brazilthe National Association for the Promotion and Innovation of the Biological Industry(ANPII-BIO)the CropLife biological products,and the Brazilian National Institute of Industrial Property(INPI)。
文摘Brazil maintains a leading position in agricultural exports and stands as the world's foremost producer and user of bioinputs in agriculture.These bioinputs generate annual savings of billions of dollars that would otherwise be allocated to chemical fertilizers and pesticides.The nation's regulatory framework enables bioinput agriculture and serves as a model for countries transitioning toward regenerative agriculture.Brazilian legislation categorizes bioinputs into:1)biofertilizers(extracts);2)biostimulants(plant growth-promoting and biocontrol agents);and 3)inoculants(active ingredient comprises one or more living microorganisms).The inoculation of soybeans with Bradyrhizobium strains provides approximately 90%of the nitrogen accumulated by this crop.Brazil has registered over six hundred inoculants,with at least 60%specifically designated for soybean cultivation.The annual sales of inoculants in Brazil reach approximately 120 million doses.Although beans(Phaseolus vulgaris and Vigna unguiculata)represent an essential food crop in Brazil's staple diet and benefit from inoculation,inoculant supply remains insufficient.Regarding biocontrol,soy,corn,sugarcane,and coffee rank among the most protected crops,employing biocontrol agents against bacteria,fungi,nematodes,and insects.Bacillus,Pseudomonas,Streptomyces,Rhizobium,Azotobacter,and Paenibacillus strains were predominantly cited in the 5,000+bioproduct patents filed between 2022 and 2024.Among fungal genera,Trichoderma,and Penicillium received the most citations.EMBRAPA's biobanks maintain over 10,000 strains of bacteria,fungi,and viruses for biocontrol,and 14,000 strains of nutrient-fixing and plant-growth promoters.Production challenges include quality control,particularly as on-farm production of inoculants becomes prevalent on larger farms,alongside product availability and supply limitations.Brazilian farmers maintain global competitiveness partly through reduced chemical fertilizer and pesticide costs enabled by bioinput usage.As components of regenerative agriculture,bioinputs enhance soil quality,decrease carbon footprints,and support Sustainable Development Goals.Brazil's leadership in microbial bioinput utilization stems from its extensive agricultural sector,rich microbial biodiversity,and progressive regulatory framework.
基金supported by European Union's Horizon Europe,UK Research and Innovation(UKRI).
文摘Graphite,encompassing both natural graphite and synthetic graphite,and graphene,have been extensively utilized and investigated as anode materials and additives in lithium-ion batteries(LIBs).In the pursuit of carbon neutrality,LIBs are expected to play a pivotal role in reducing CO_(2)emissions by decreasing reliance on fossil fuels and enabling the integration of renewable energy sources.Owing to their technological maturity and exceptional electrochemical performance,the global production of graphite and graphene for LIBs is projected to continue expanding.Over the past decades,numerous researchers have concentrated on reducing the material and energy input whilst optimising the electrochemical performance of graphite and graphene,through novel synthesis methods and various modifications at the laboratory scale.This review provides a comprehensive examination of the manufacturing methods,environmental impact,research progress,and challenges associated with graphite and graphene in LIBs from an industrial perspective,with a particular focus on the carbon footprint of production processes.Additionally,it considers emerging challenges and future development directions of graphite and graphene,offering significant insights for ongoing and future research in the field of green LIBs.
基金The authors would like to thank the Postgraduate Research Grant(PGRG)by Universiti Malaysia Terengganu[UMT/PGRG/2024/55527]for the financial support.
文摘The escalating accumulation of agro-industrial waste—exceeding 350 million tons annually from post-harvest residues,food processing,and aquaculture—poses serious environmental threats,including greenhouse gas emissions,groundwater contamination,and excessive landfill usage.Although conventional treatment methods such as composting,incineration,and recycling offer partial mitigation,they often fall short of delivering scalable,circular solutions.Microbial biorefineries have emerged as a transformative approach,enabling the conversion of diverse biomass streams into high-value renewable materials.Through microbial fermentation,agricultural and municipal waste can be repurposed into functional outputs such as nanocellulose,biochar,and biocompatible compounds with applications in packaging,pharmaceuticals,and cosmetics.This review critically examines the role of microbial systems in agro-waste valorization,highlighting recent advances in strain engineering,process integration,and bioproduct development.It also explores the regulatory and techno-economic frameworks required to scale these innovations within a biomass-driven circular economy,positioning microbial biorefineries as key enablers of sustainable material transitions.
基金supported by the National Natural Science Foundation of China(No.52304329)the Yunnan Fundamental Research Projects(No.202201BE070001-003),Guo Lin would like to acknowledge Xing Dian talent support program of Yunnan Province.
文摘The recovery of precious metals(PMs)from secondary resources is critical for addressing global supply-chain vulnerabilities and sustainable resource utilization.This review systematically examines the transformative potential of metal-organic frameworks(MOFs)as next-generation adsorbents for PM recovery,focusing on their synthesis,functionalization,and multiscale adsorption mechanisms.We critically analyze conventional pyrometallurgical and hydrometallurgical methods and highlight their limitations in terms of selectivity,energy consumption,and secondary pollution.In contrast,MOFs offer tunable porosity,abundant active sites,and tunable surface chemistry,enabling efficient PM capture via synergistic physical and chemical adsorption.Advanced modification techniques,including direct synthesis and post-synthetic modification,are reviewed to propose strategies for enhancing the adsorption kinetics and selectivity for Au,Ag,Pt,and Pd.Key structure-property relationships are established through multiscale characterization and thermodynamic models,revealing the critical roles of hierarchical porosity,soft donor atoms,and framework stability.Industrial challenges,such as aqueous stability and scalability,are addressed via Zr-O bond strengthening,hydrophobic functionalization,and support immobilization.This study consolidates the experimental and theoretical advances in MOF-based PM recovery and provides a roadmap for translating laboratory innovations into practical applications within the circular-economy framework.
文摘The circular economy is an innovative concept of both production and consumption.It can reduce wastage,preserve resources,and minimize environmental effects with the help of recycling,recovering resources,and extending the life of products.It works as a pathway to reduce environmental footprints by redesigning production-consumption systems.This review critically examines global circular economy strategies,policy approaches,and persistent barriers that shape environmental footprint outcomes across major sectors.Drawing on a structured narrative review and thematic synthesis,we integrate findings on key circular economy practices,Eco-design,product life extension,reuse,re-manufacturing,recycling,and resource recovery,and assess how they interact with policy instruments such as extended producer responsibility,ecodesign requirements,and waste governance reforms.The analysis highlights that reported benefits(e.g.,reduced material throughput,waste generation,and emissions)are frequently constrained by technological limitations(complex material streams,low-quality recyclate,energy-intensive processing),economic conditions(high upfront costs,weak markets for secondary materials,commodity price volatility),and institutional and behavioral factors(regulatory fragmentation,limited enforcement capacity,low consumer acceptance).We further synthesize methodological challenges in measuring“circularity”and footprint reductions,emphasizing boundary choices,rebound effects,and trade-offs such as increased energy demand or land and water pressures in bio-based substitution.By linking circular economy strategies,barriers,and outcomes in an integrative conceptual framework,the review clarifies why circular transitions often deliver partial gains and identifies leverage points for scaling effective,evidence-based policy and practice.
文摘The environment and its preservation are becoming more and more dependent on ecological development in an age of accelerating climate risk,biodiversity loss,and pressures of pollution.This review summarizes the frontiers of innovation that are capable of enhancing integration of human development and ecological integrity,and how the interaction between technical,ecological,and institutional innovations can produce real-world results.We initially discuss developing ecological innovations that offer new opportunities to urban development,such as low-impact cities,ecological infrastructure,clean energy transitions,and biodiversity-informed siting,and digital decision-support systems enhancing planning and resource efficiency.Then,we evaluate progress in the field of preservation and restoration,with a particular focus on nature-based solutions,a process-based approach to restoration science,connectivity conservation,and a watershed-scale and seascape-scale approach to restore resilience and help recover biodiversity.In these spheres,we discover measurement,monitoring,and verification(MRV),one of the main pillars of scale alongside remote sensing,automated field monitoring,environmental Deoxyribonucleic Acid(DNA),and Artificial Intelligence(AI)-enabled analytics,increasing the range of trackable and manageable indices as well as creating new issues with baselines,uncertainty,and data ethics.Lastly,we compare governance,finance,and equity as key conversion processes that can turn innovations into sustainable dividends with authenticity principles,however,of additionality,permanence,and leakage avoidance,and with rightsbased and redistributive mechanisms and approaches that reinforce legitimacy.We end by providing a portfolio roadmap of prioritization of the interventions that have high co-benefits and the identification of critical research and institutional gaps to provide net-positive ecological results.
基金supported by the Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)via grant Proyectos de Investigacion Plurianuales(PIP 2021:2894)Agencia I+D+i via grant Proyectos de Investigacion Cientifica y Tecnologica(PICT-2021-I-A-00294).
文摘This study explores the use of black soldier fly larvae protein as a bio-based adhesive to produce particleboards from sugarcane bagasse.A comprehensive evaluation was conducted,including rheological characterization of the adhesive and physical–mechanical testing of the panels according to European standards.The black soldier fly larvae-based adhesive exhibited gel-like viscoelastic behavior,rapid partial structural recovery after shear,and favorable application properties.Particleboards manufactured with this adhesive and sugarcane bagasse achieved promising mechanical performance,with modulus of rupture and modulus of elasticity values of 30.2 and 3500 MPa,respectively.Internal bond strength exceeded 0.4 MPa,complying with European standard 312-3 specifications.For comparative purposes,a panel made with Eucalyptus grandis particles was also produced under the same conditions to demonstrate the versatility of the adhesive system.Compared to other bio-based and synthetic adhesives,this bio-based system showed competitive performance and derives from the bioconversion of organic residues.Protein adhesives were synthesized fromHermetia illucens larvae grown commercially on agriculturalwaste frompotato chip production,emphasizing the renewable origin of both the biomass and the final adhesive.These results highlight the potential of insect proteins as sustainable and circular alternatives for the wood panel industry.
文摘The concepts of the circular economy(CE)are actively popularized as ways of minimizing waste products and the need to rely on virgin resources.Nevertheless,their sustainability is doubtful at a general level where ecosystem functioning and ecosystem services(ES)are not given explicit attention.This review will combine both conceptual and empirical evidence of the connection between CE interventions and ES outcomes to enable more sustainable management of resources.We describe the effects of the CE strategies on the key environmental pressure pathways,altering ecosystem conditions,and impacting the delivery of regulating,provisioning,and cultural ecosystem services using a pressure condition-service framework.Analysis reveals that demand-side reduction and product life-extension strategies tend to offer more consistent ecosystem service co-benefits than recycling and recovery strategies because they do not involve production,and will cause less disturbance to the upstream environment.Contrastingly,recycling and recovery sustainability performance is highly dependent on the sources of energy,intensity of processing,and the safety of materials.Bio-based circularity has the potential to increase soil functionality and nutrient cycling,and mass application will result in trade-offs in terms of land competition and nutrient leakage.The sectoral analysis identifies the unique opportunities and threats in the agri-food systems,the built environment,plastics and textiles,electronics and critical minerals,and water and wastewater systems in terms of the burden displacement,local environmental pressures,and equity concerns.Harmonized reporting,coupled with supply-chain and spatial ecological assessment,threshold-conscious strategies that promote safe and regenerative circular systems should be put into the line of future research.
基金supported by the National Natural Science Foundation of China,Nos.82171344(to ZY),82471313(to CKT)the Guangdong Basic and Applied Basic Research Foundation,China,Nos.2023B1515120035,2024A1515012035(to CKT)The Science and Technology Projects in Guangzhou Nos.2025A03J4169(to ZY)。
文摘Stroke-induced alterations in cerebral blood flow trigger neurovascular remodeling,as manifested by the blood-brain barrier dysfunction and subs equent neurovascular repair activities such as angiogenesis.This process involves neurovascular communication that facilitates the transport of mediators among cerebrovascular endothelial cells,pericytes,glial cells,and neurons,thereby transmitting signals from donor to recipient cells to elicit a collaborative response.
基金supported by the National Natural Science Foundation of China (Nos.82293682,82293684,and 82173703)。
文摘Owing to their intricate molecular frameworks and copious chiral centers,the structural identification and configurational assignment of natural products are challenging tasks.Comprehensive spectral data analysis is crucial for the confirmation of absolute configurations.Ignoring critical parameters will lead to false structure,which may confuse the total synthesis and drug development.Herein,the configurations of seven heterogeneous Pallavicinia diterpenoids(PDs) isolated from Pallavicinia liverworts are revised using a combination of single-crystal X-ray diffraction and electronic circular dichroism(ECD) calculations.Meanwhile,identification of five unprecedented PD heterodimers PD-dimers A-E(18-22) along with eleven previously undescribed PDs(5-9,13-17,23) obtained by the reinvestigation of the Chinese liverwort Pallavicinia subciliata have resulted in corrections and support the revised conclusions.
基金National Natural Science Foundation of China,Grant/Award Number:42377249,52476183National Key Research and Development Program of China,Grant/Award Number:2023YFD2201605。
文摘Reverse water-gas shift(RWGS) reaction-aided sustainable CO_(2) conversion has emerged as one promising and effective approach for simultaneously mitigating climate change and solidifying energy security.Molybdenum carbide-based catalysts demonstrate excellent selectivity for sustainably transforming CO_(2) into CO product,but harsh carburization syntheses and insufficient catalytic activity and stability significantly hinder their related commercial applications.Herein,a facile "insideout" synthesis strategy was proposed to fabricate dispersed Cu clusters on sub-2 nm α-MoC nanoislands confined in pyridinic nitrogen-doped carbon(Cu-MoC/NC).This catalyst achieves the highest CO_(2) conversion rate of 2583.4 mmol_(CO_(2)) g_(cat)^(-1) h^(-1)compared to those of all reported Mo-based catalysts,and maintains excellent catalytic stability for 500 h under a low H_(2) partial pressure.Combined with X-ray absorption spectroscopy(XAS) and density functional theory(DFT) calculations,the electronegativity of pyridinic nitrogen intensifies the electron deficiency of α-MoC and strengthens the chemisorption of Cu clusters on α-MoC nanoislands surface,facilitating the electronic interaction and stability of Cu-MoC interface.This pyridinic nitrogenmodified Cu-MoC interface promotes the CO_(2) bridged adsorption at the interface and thus boosts C=O bond scissoring,inducing the transition of rate-limiting step and energy barrier reduction of the key intermediates.This interfacial engineering provides a sustainable and efficient strategy for improving both catalytic activity and stability of RWGS reaction to transform CO_(2) into value-added fuels and chemicals.
文摘Aims and scope With the tenet of concerning ecology and serving economy,Ecological Economy focuses on the sustainable development of economy and environment,and puts attention on theories,methods and technical innovations concerning ecological/green economy,circular economy and ecological/green industry.The sustainable development of economy and society,and the sustainable development of the population,resource and environment are also within the concern of the journal.
文摘This review sums up existing information on the environmental issues of critical materials in new energy vehicles(NEVs)on a combined mining to mobility approach.With the increase in the rate of NEV adoption,the environmental cost of operating vehicles will decline as the burden moves to upstream and downstream material life-cycle activities,such as extraction,beneficiation,refining,component manufacturing,use-phase performance,and end-of-life management.We focus on key material categories that provide electrified mobility,such as battery-related material(e.g.,Li,Ni,Co,Mn,graphite),high-performance motor-related material(e.g.,rare earth elements),conductive and lightweighting material(e.g.,Cu and Al).In the supply chain,the prevailing environmental forces consist of high energy requirements and related greenhouse gas emissions,excessive water consumption and water pollution risks,toxicity and human health issues pertaining to chemical inputs and metal discharges,land-use shift,and ecosystem and biodiversity effects.The review notes that there is high regional heterogeneity,which is fueled by ore grades,processing technologies,electricity mixes,and governance capacity,and that when measurements are narrowed to carbon measures,there is a risk of shifting the problem across geographies and categories of impacts.Mitigation pathways are analyzed,such as cleaner extraction and refining,material substitution and dematerialization,battery design,longevity and recyclability,and also the strategies of the circular economy,such as recycling and second-life use.Lastly,we establish research gaps in important areas of supply-chain data disclosure,multi-impact life-cycle assessment approaches,and integrated environmental-social analysis to enable sound policy formulation that can be used to achieve sustainable electrified mobility.
基金partially supported by the National Natural Science Foundation of China(Nos.61901494,62101563)。
文摘Rotating Single-Baseline Interferometer(RSBI)systems have attracted considerable attention for Direct Position Determination(DPD)due to their simplicity and high localization accuracy.Nevertheless,the growing complexity of electromagnetic environments has led to scenarios with multiple time-frequency aliased sources,rendering conventional DPD methods for RSBI systems ineffective.Previous studies have predominantly concentrated on deploying antenna arrays and applying related signal-processing techniques for localization.Typically,these approaches necessitate that the number of physical antennas exceeds the number of sources.For RSBI systems already in practical operation,this would entail the installation of additional physical antennas,which implies equipment recycling and hardware upgrades.In numerous cases,such modifications are unfeasible.This paper proposes a novel Relative Offset-based Direct Position Determination(RO-DPD)method for RSBI systems that can handle multiple time-frequency aliased sources.The proposed method overcomes the challenge of simultaneous positioning without requiring hardware modifications by leveraging time accumulation and algorithmic enhancements.The implementation of the method involves three key steps.Firstly,the rotation of the interferometer is synthesized into a virtual Uniform Circular Array(UCA).Secondly,a novel estimation variable,termed relative offset,is introduced.The variable serves as an intermediate parameter to establish correlation equations between the positions of multiple time-frequency aliased sources and the intercepted signals.Thirdly,the relative offset model in the UCA is transformed into a virtual Uniform Linear Array(ULA)model,from which the cost function can be derived via the Spatial Smoothing(SS)MUSIC algorithm.Theoretical analysis and simulation results verify the effectiveness of the proposed method.Compared with traditional approaches,the RO-DPD method maintains the low complexity of RSBI systems while demonstrating robust performance in complex electromagnetic environments.
基金Shanghai 20246G Technology Innovation and Future Industry Development Project under grant 24DP1501204。
文摘Recently,uniform circular array(UCA)based orbital angular momentum(OAM)beam steering schemes have been proposed to overcome the limitations of coaxial transmission.Unlike the traditional multiple-input-multiple-output(MIMO)beam steering,OAM beam steering includes both the OAM generation and the beam steering.Generally,the true time delay(TTD)or the phase shifter(PS)are required for beam steering in the radio domain.Previous studies suggest that TTD is preferred for wideband MIMO beam steering to avoid beam squint caused by PS.However,in this paper,we theoretically prove that to generate the OAM beam ideally,PS should be used,while TTD deteriorates the mode orthogonality,which is influenced by the relative bandwidth.Once the ideal OAM beam is generated,TTD is required to prevent beam squint.Based on this analysis,we propose to use the two-stage phase-shifting(TSPS)architecture for OAM beam steering:PS for OAM generation and TTD for beam steering.Simulation results suggest that compared to the spectrum efficiency(SE)of PS based OAM communication,the SE based on the TTD significantly declines as the relative bandwidth increases.Furthermore,OAM beam steering using the TSPS architecture greatly outperforms systems that adopt a single TTD or PS network.
基金supported by the National Natural Science Foundation of China,Nos.82301486(to SL)and 82071325(to FY)Medjaden Academy&Research Foundation for Young Scientists,No.MJR202310040(to SL)+2 种基金Nanjing Medical University Science and Technique Development,No.NMUB20220060(to SL)Medical Scientific Research Project of Jiangsu Commission of Health,No.ZDA2020019(to JZ)Health China Buchang Zhiyuan Public Welfare Project for Heart and Brain Health,No.HIGHER202102(to QD).
文摘Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and disability.Accurate predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain undetermined.With innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental models.Differentially expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic stroke.Moreover,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.In particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic stroke.In this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.Findings from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.
基金Supported by the Anusandhan National Research Foundation,No.CRG/2023/000212.
文摘Matrix metalloproteinases(MMPs)are essential enzymes involved in extracellular matrix degradation and remodeling.Such processes are integral to normal tissue homeostasis and several pathological conditions such as cancer.Among these MMPs,MMP-13 plays a key role in cancer progression,driving tumor invasion,metastasis,and angiogenesis.Despite significant advancements in understanding its biology,therapeutic targeting of MMP-13 remains challenging owing to its complex and multifaceted regulatory mechanisms.Recent studies have underscored the pivotal role of non-coding RNAs(ncRNAs),including long ncRNAs,microRNAs,and circular RNAs,in modulating MMP-13 expression.This review provides a comprehensive analysis of MMP-13 regulation by several signaling pathways,the influence of ncRNAs on these signaling pathways,and MMP-13 expression during cancer progression and metastasis.Furthermore,we explored the clinical relevance of ncRNA-mediated regulatory networks,highlighting their potential as diagnostic biomarkers and therapeutic targets in various cancers.By unraveling these regulatory mechanisms,this review offers valuable insights into innovative strategies for cancer diagnosis and treatment and emphasizes the translational significance of ncRNA-mediated MMP-13 regulation in oncology.
基金National Natural Science Foundation of China(Nos.52174269,52374293)Science and Technology Innovation Program of Hunan Province,China(Nos.2024CK1009,2022RC1123)。
文摘A tunable oxidization and reduction strategy was proposed to directly regenerate spent LiFePO_(4)/C cathode materials by oxidizing excessive carbon powders with the addition of FePO_(4).Experimental results indicate that spent LiFePO_(4)/C cathode materials with good performance can be regenerated by roasting at 650℃ for 11 h with the addition ofLi_(2)CO_(3),FePO_(4),V_(2)O_(5),and glucose.V_(2)O_(5) is added to improve the cycle performance of regenerated cathode materials.Glucose is used to revitalize the carbon layers on the surface of spent LiFePO_(4)/C particles for improving their conductivity.The regenerated V-doped LiFePO_(4)/C shows an excellent electrochemical performance with the discharge specific capacity of 161.36 mA·h/g at 0.2C,under which the capacity retention is 97.85%after 100 cycles.
