The shear stress distribution in circular channels was modeled in this study using gene expression programming(GEP). 173 sets of reliable data were collected under four flow conditions for use in the training and test...The shear stress distribution in circular channels was modeled in this study using gene expression programming(GEP). 173 sets of reliable data were collected under four flow conditions for use in the training and testing stages. The effect of input variables on GEP modeling was studied and 15 different GEP models with individual, binary, ternary, and quaternary input combinations were investigated. The sensitivity analysis results demonstrate that dimensionless parameter y/P, where y is the transverse coordinate, and P is the wetted perimeter, is the most influential parameter with regard to the shear stress distribution in circular channels. GEP model 10, with the parameter y/P and Reynolds number(Re) as inputs, outperformed the other GEP models, with a coefficient of determination of 0.7814 for the testing data set. An equation was derived from the best GEP model and its results were compared with an artificial neural network(ANN) model and an equation based on the Shannon entropy proposed by other researchers. The GEP model, with an average RMSE of 0.0301, exhibits superior performance over the Shannon entropy-based equation, with an average RMSE of 0.1049, and the ANN model, with an average RMSE of 0.2815 for all flow depths.展开更多
AIM:To assess the effect of nitric oxide (NO) on the large conductance potassium channel (BKCa) in isolated circular (CM) and sling (SM) muscle cells and muscle strips from the cat lower esophageal sphincter (LES) to ...AIM:To assess the effect of nitric oxide (NO) on the large conductance potassium channel (BKCa) in isolated circular (CM) and sling (SM) muscle cells and muscle strips from the cat lower esophageal sphincter (LES) to determine its regulation of resting tone and relaxation.METHODS:Freshly enzymatically-digested and isolated circular smooth muscle cells were prepared from each LES region.To study outward K + currents,the perforated patch clamp technique was employed.To assess LES resting tone and relaxation,muscle strips were mounted in perfused organ baths.RESULTS:(1) Electrophysiological recordings from isolated cells:(a) CM was more depolarized than SM (-39.7 ± 0.8mV vs-48.1 ± 1.6 mV,P < 0.001),and maximal outward current was similar (27.1 ± 1.5 pA/pF vs 25.7 ± 2.0 pA/pF,P > 0.05);(b) The NO donor sodium nitroprusside (SNP) increased outward currents only in CM (25.9 ± 1.9 to 46.7 ± 4.2 pA/pF,P < 0.001) but not SM (23.2 ± 3.1 to 27.0 ± 3.4 pA/pF,P > 0.05);(c) SNP added in the presence of the BK Ca antagonist iberiotoxin (IbTX) produced no increase in the outward current in CM (17.0 ± 2.8 vs 13.7 ± 2.2,P > 0.05);and (d) L-NNA caused a small insignificant inhibition of outward K + currents in both muscles;and (2) Muscle strip studies:(a) Blockade of the nerves with tetrodotoxin (TTX),or BK Ca with IbTX had no significant effect on resting tone of either muscle;and (b) SNP reduced tone in both muscles,and was unaffected by the presence of TTX or IbTX.CONCLUSION:Exogenous NO activates BK Ca only in CM of the cat.However,as opposed to other species,exogenous NO-induced relaxation is predominantly by a non-BK Ca mechanism,and endogenous NO has minimal effect on resting tone.展开更多
A new channel estimation method for orthogonal frequency division multiplexing （OFDM） system with large subcarriers and serious intercarrier interference （ICI） is proposed. The channel frequency-domain （ CFD ） m...A new channel estimation method for orthogonal frequency division multiplexing （OFDM） system with large subcarriers and serious intercarrier interference （ICI） is proposed. The channel frequency-domain （ CFD ） matrix of each delay path is factorized to the product of a diagonal delay matrix and a circular ICI matrix in this model. To reduce the coefficient number, the circular ICI ma- trix is squeezed by using Hamming-window as the reshaping pulse in the transmitter. Meanwhile, the elements of the diagonal delay matrix are approximated with a discrete prolate spheroidal basis ex- pansion model （DPS-BEM）. A least-square （LS） estimator is used to estimate the reduced channel coefficients. The proposed method is theoretically derived and simulated. The simulation results in- dicate that the model has good performance and is appropriate for various channel environments. The method also has low complexity and good spectral efficiency.展开更多
This paper presents an experimental investigation of the circulation of the horseshoe vortex system within the equilibrium scour hole at a circular pier, with the data measured by an acoustic Doppler velocimeter （ADV...This paper presents an experimental investigation of the circulation of the horseshoe vortex system within the equilibrium scour hole at a circular pier, with the data measured by an acoustic Doppler velocimeter （ADV）. Velocity vector plots and vorticity contours of the flow field on the upstream plane of symmetry （y = 0 cm） and on the planes ：e3 cm away from the plane of symmetry Cv = ~3 cm） are presented. The vorticity and circulation of the horseshoe vortices were determined using the forward difference technique and Stokes theorem, respectively. The results show that the magnitudes of circulations are similar on the planes y = 3 cm and y = -3 cm, which are less than those on the plane y = 0 cm. The circulation decreases with the increase of flow shallowness, and increases with the densimetric Froude number. It also increases with the pier Reynolds number at a constant densimetric Froude number, or at a constant flow shallowness. The relative vortex strength （dimensionless circulation） decreases with the increase of the pier Reynolds number. Some empirical equations are proposed based on the results. The predicted circulation values with these equations match the measured data, which indicates that these equations can be used to estimate the circulation in future studies.展开更多
文摘The shear stress distribution in circular channels was modeled in this study using gene expression programming(GEP). 173 sets of reliable data were collected under four flow conditions for use in the training and testing stages. The effect of input variables on GEP modeling was studied and 15 different GEP models with individual, binary, ternary, and quaternary input combinations were investigated. The sensitivity analysis results demonstrate that dimensionless parameter y/P, where y is the transverse coordinate, and P is the wetted perimeter, is the most influential parameter with regard to the shear stress distribution in circular channels. GEP model 10, with the parameter y/P and Reynolds number(Re) as inputs, outperformed the other GEP models, with a coefficient of determination of 0.7814 for the testing data set. An equation was derived from the best GEP model and its results were compared with an artificial neural network(ANN) model and an equation based on the Shannon entropy proposed by other researchers. The GEP model, with an average RMSE of 0.0301, exhibits superior performance over the Shannon entropy-based equation, with an average RMSE of 0.1049, and the ANN model, with an average RMSE of 0.2815 for all flow depths.
基金Supported by A Postgraduate Fellowship Award to L'Heureux MC from the Department of Medicine,University of Torontoa doctoral research studentship and an Operating Grant from the Canadian Institutes of Health Research(Gaisano HY and Diamant NE)
文摘AIM:To assess the effect of nitric oxide (NO) on the large conductance potassium channel (BKCa) in isolated circular (CM) and sling (SM) muscle cells and muscle strips from the cat lower esophageal sphincter (LES) to determine its regulation of resting tone and relaxation.METHODS:Freshly enzymatically-digested and isolated circular smooth muscle cells were prepared from each LES region.To study outward K + currents,the perforated patch clamp technique was employed.To assess LES resting tone and relaxation,muscle strips were mounted in perfused organ baths.RESULTS:(1) Electrophysiological recordings from isolated cells:(a) CM was more depolarized than SM (-39.7 ± 0.8mV vs-48.1 ± 1.6 mV,P < 0.001),and maximal outward current was similar (27.1 ± 1.5 pA/pF vs 25.7 ± 2.0 pA/pF,P > 0.05);(b) The NO donor sodium nitroprusside (SNP) increased outward currents only in CM (25.9 ± 1.9 to 46.7 ± 4.2 pA/pF,P < 0.001) but not SM (23.2 ± 3.1 to 27.0 ± 3.4 pA/pF,P > 0.05);(c) SNP added in the presence of the BK Ca antagonist iberiotoxin (IbTX) produced no increase in the outward current in CM (17.0 ± 2.8 vs 13.7 ± 2.2,P > 0.05);and (d) L-NNA caused a small insignificant inhibition of outward K + currents in both muscles;and (2) Muscle strip studies:(a) Blockade of the nerves with tetrodotoxin (TTX),or BK Ca with IbTX had no significant effect on resting tone of either muscle;and (b) SNP reduced tone in both muscles,and was unaffected by the presence of TTX or IbTX.CONCLUSION:Exogenous NO activates BK Ca only in CM of the cat.However,as opposed to other species,exogenous NO-induced relaxation is predominantly by a non-BK Ca mechanism,and endogenous NO has minimal effect on resting tone.
基金Supported by the National Natural Science Foundation of China(61101131)
文摘A new channel estimation method for orthogonal frequency division multiplexing （OFDM） system with large subcarriers and serious intercarrier interference （ICI） is proposed. The channel frequency-domain （ CFD ） matrix of each delay path is factorized to the product of a diagonal delay matrix and a circular ICI matrix in this model. To reduce the coefficient number, the circular ICI ma- trix is squeezed by using Hamming-window as the reshaping pulse in the transmitter. Meanwhile, the elements of the diagonal delay matrix are approximated with a discrete prolate spheroidal basis ex- pansion model （DPS-BEM）. A least-square （LS） estimator is used to estimate the reduced channel coefficients. The proposed method is theoretically derived and simulated. The simulation results in- dicate that the model has good performance and is appropriate for various channel environments. The method also has low complexity and good spectral efficiency.
文摘This paper presents an experimental investigation of the circulation of the horseshoe vortex system within the equilibrium scour hole at a circular pier, with the data measured by an acoustic Doppler velocimeter （ADV）. Velocity vector plots and vorticity contours of the flow field on the upstream plane of symmetry （y = 0 cm） and on the planes ：e3 cm away from the plane of symmetry Cv = ~3 cm） are presented. The vorticity and circulation of the horseshoe vortices were determined using the forward difference technique and Stokes theorem, respectively. The results show that the magnitudes of circulations are similar on the planes y = 3 cm and y = -3 cm, which are less than those on the plane y = 0 cm. The circulation decreases with the increase of flow shallowness, and increases with the densimetric Froude number. It also increases with the pier Reynolds number at a constant densimetric Froude number, or at a constant flow shallowness. The relative vortex strength （dimensionless circulation） decreases with the increase of the pier Reynolds number. Some empirical equations are proposed based on the results. The predicted circulation values with these equations match the measured data, which indicates that these equations can be used to estimate the circulation in future studies.
