Previous studies in different ethnic groups show changes in heart rate, respiratory rate, cortisol cycle, and sleep-wake cycle throughout life. Our purpose is to verify such changes by comparing the values of each var...Previous studies in different ethnic groups show changes in heart rate, respiratory rate, cortisol cycle, and sleep-wake cycle throughout life. Our purpose is to verify such changes by comparing the values of each variable before and after puberty. Puberty is associated with the end of growth and is an important point in our theoretical framework: when growth ends, changes occur in the geometry of the biological system. At the same time, this causes phase changes in the oscillatory variables, which are seen as chronodisruption. The results confirm the changes found by other authors in the evolution of the variables throughout life. Then, we can conclude that the variables studied present phase changes when growth ends, in accordance with the proposed theoretical framework.展开更多
Background Circadian health refers to individuals’well-being and balance in terms of their circadian rhythm.It is influenced by external cues.In adults,a close relationship between circadian-related alterations and o...Background Circadian health refers to individuals’well-being and balance in terms of their circadian rhythm.It is influenced by external cues.In adults,a close relationship between circadian-related alterations and obesity has been described.However,studies in children are scarce,and circadian health and its association with obesity have not been evaluated globally.We aimed to assess whether circadian health differed between children with and without obesity as determined by a global circadian score(GCS)in a school-age population.Methods Four hundred and thirty-two children(7–12 years)were recruited in Spain.Non-invasive tools were used to calculate the GCS:(1)7-day rhythm of wrist temperature(T),activity(A),position(P),an integrative variable that combines T,A,and P(TAP);(2)cortisol;and(3)7-day food and sleep records.Body mass index,body fat percentage,waist circumference(WC),melatonin concentration,and cardiometabolic marker levels were determined.Results Circadian health,as assessed by the GCS,differed among children with obesity,overweight,and normal weight,with poorer circadian health among children with obesity.Children with obesity and abdominal obesity had 3.54 and 2.39 greater odds of having poor circadian health,respectively,than did those with normal weight or low WC.The percentage of rhythmicity,a marker of the robustness of the TAP rhythm,and the amplitude,both components of the GCS,decreased with increasing obesity.Different lifestyle behaviors were involved in the association between circadian health and obesity,particularly protein intake(P=0.024),physical activity level(P=0.076)and chronotype(P=0.029).Conclusions The GCS can capture the relationship between circadian health and obesity in school-age children.Protein intake,physical activity level,and chronotype were involved in this association.Early intervention based on improving circadian health may help to prevent childhood obesity.展开更多
文摘Previous studies in different ethnic groups show changes in heart rate, respiratory rate, cortisol cycle, and sleep-wake cycle throughout life. Our purpose is to verify such changes by comparing the values of each variable before and after puberty. Puberty is associated with the end of growth and is an important point in our theoretical framework: when growth ends, changes occur in the geometry of the biological system. At the same time, this causes phase changes in the oscillatory variables, which are seen as chronodisruption. The results confirm the changes found by other authors in the evolution of the variables throughout life. Then, we can conclude that the variables studied present phase changes when growth ends, in accordance with the proposed theoretical framework.
基金supported by the Spanish Society for the Study of Obesity(SEEDO)with the award of the 1st XLS Medical Scholarship for obesity research and by the Spanish Government of Investigation,Development and Innovation(SAF2017-84135-R)including FEDER co-fundingthe Autonomous Community of the Region of Murcia through the Seneca Foundation(20795/PI/18)NIDDK R01DK105072 granted to Marta Garaulet.
文摘Background Circadian health refers to individuals’well-being and balance in terms of their circadian rhythm.It is influenced by external cues.In adults,a close relationship between circadian-related alterations and obesity has been described.However,studies in children are scarce,and circadian health and its association with obesity have not been evaluated globally.We aimed to assess whether circadian health differed between children with and without obesity as determined by a global circadian score(GCS)in a school-age population.Methods Four hundred and thirty-two children(7–12 years)were recruited in Spain.Non-invasive tools were used to calculate the GCS:(1)7-day rhythm of wrist temperature(T),activity(A),position(P),an integrative variable that combines T,A,and P(TAP);(2)cortisol;and(3)7-day food and sleep records.Body mass index,body fat percentage,waist circumference(WC),melatonin concentration,and cardiometabolic marker levels were determined.Results Circadian health,as assessed by the GCS,differed among children with obesity,overweight,and normal weight,with poorer circadian health among children with obesity.Children with obesity and abdominal obesity had 3.54 and 2.39 greater odds of having poor circadian health,respectively,than did those with normal weight or low WC.The percentage of rhythmicity,a marker of the robustness of the TAP rhythm,and the amplitude,both components of the GCS,decreased with increasing obesity.Different lifestyle behaviors were involved in the association between circadian health and obesity,particularly protein intake(P=0.024),physical activity level(P=0.076)and chronotype(P=0.029).Conclusions The GCS can capture the relationship between circadian health and obesity in school-age children.Protein intake,physical activity level,and chronotype were involved in this association.Early intervention based on improving circadian health may help to prevent childhood obesity.
