Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-lin...Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-linker to improve the structural stability and mechanical properties. The microstructure, physicochemical and mechanical properties, in vitro bioactivity and cellular biocompatibility of the scaffolds were investigated. The results indicated that BG component was successfully incorporated into the BG-C-A scaffolds through a facile BG sol-immersing method and the original interconnected microstructure could be well preserved. The obtained BG-C-A scaffolds showed improved mechanical properties and structural stability as compared to C-A scaffolds. At the same time, they presented excellent in vitro bioactivity and cellular compatibility. All these results demonstrated that these BG-C-A scaffolds have promising potential for tissue engineering.展开更多
Neuropathologies include the deterioration and damage of the nervous system,especially neurons present in the brain,spinal cord and peripheral nervous system.Damage or alternations in neurons makes their structure and...Neuropathologies include the deterioration and damage of the nervous system,especially neurons present in the brain,spinal cord and peripheral nervous system.Damage or alternations in neurons makes their structure and functionality abnormal.Every year over 90,000 people get affected by neurodegenerative diseases in the USA.Among all the neurological pathologies,展开更多
基金supported by the National Natural Science Foundation of China(No. 51773209)the National Basic Research Program(No. 2017YFC1103300)the Strategic Priority Research Program of Chinese Academy of Sciences(No. XDB12020300)
文摘Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-linker to improve the structural stability and mechanical properties. The microstructure, physicochemical and mechanical properties, in vitro bioactivity and cellular biocompatibility of the scaffolds were investigated. The results indicated that BG component was successfully incorporated into the BG-C-A scaffolds through a facile BG sol-immersing method and the original interconnected microstructure could be well preserved. The obtained BG-C-A scaffolds showed improved mechanical properties and structural stability as compared to C-A scaffolds. At the same time, they presented excellent in vitro bioactivity and cellular compatibility. All these results demonstrated that these BG-C-A scaffolds have promising potential for tissue engineering.
文摘Neuropathologies include the deterioration and damage of the nervous system,especially neurons present in the brain,spinal cord and peripheral nervous system.Damage or alternations in neurons makes their structure and functionality abnormal.Every year over 90,000 people get affected by neurodegenerative diseases in the USA.Among all the neurological pathologies,
