Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesi...Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.展开更多
Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal ...Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.展开更多
The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuli...The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuling Mountain Area from various perspectives, including geographical indication products, geographical indication trademarks, China s geographical indication products mutually recognized and protected with the EU, geographical indication standards, and the exclusive geographical indication logo. It studies the regional public brand characteristics of Chinese authentic medicinal herbs, based on hometown of authentic Chinese medicinal herbs, advantageous regions of characteristic agricultural products, important agricultural cultural heritage, national famous and excellent new agricultural products, national characteristic agricultural products, geographical indication Chinese well-known trademarks, advantageous regions of characteristic agricultural products, and regional public brands of agricultural products. It analyzes the main problems in the protection of geographical indications and the creation of regional public brands, and proposes suggestions for building high-quality authentic medicinal herb bases, developing new quality productivity in the authentic medicinal herb industry, implementing regional brand strategies for authentic medicinal herbs, constructing a new development pattern of dual circulation authentic medicinal herbs, etc.展开更多
Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、...Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。展开更多
As a Hong Kong deputy to the NPC,Li has prioritized the policy needs of the TCM industry and the practical challenges faced by enterprises.DURING the“two sessions”in March 2026,the high-quality development and inter...As a Hong Kong deputy to the NPC,Li has prioritized the policy needs of the TCM industry and the practical challenges faced by enterprises.DURING the“two sessions”in March 2026,the high-quality development and international promotion of traditional Chinese medicine(TCM)emerged as a trending topic of discussion.Tommy Li,a Hong Kong deputy to the 14th National People’s Congress(NPC)and president of the Federation of the Hong Kong Chinese Medicine Practitioners and Chinese Medicines Traders Association,has dedicated decades to the development of the TCM industry.展开更多
In the Chinese lunar calendar,2026 ushers in the Year of the Horse,a creature that has carried humanity across continents and through centuries.More than a marker of time,the horse embodies vitality,courage,and the re...In the Chinese lunar calendar,2026 ushers in the Year of the Horse,a creature that has carried humanity across continents and through centuries.More than a marker of time,the horse embodies vitality,courage,and the relentless spirit to move forward,qualities that resonate not only in China but across the landscapes of many African societies.展开更多
China Basics Chief Director:Dong Qiang Length:10 Episodes Producer:Henan Broadcasting System Broadcasting Platform:Bilibili The dragon is the totem of Chinese culture,and its many offspring symbolize the inclusive spi...China Basics Chief Director:Dong Qiang Length:10 Episodes Producer:Henan Broadcasting System Broadcasting Platform:Bilibili The dragon is the totem of Chinese culture,and its many offspring symbolize the inclusive spirit that the Chinese people pursue.Through the tales of the dragon’s nine sons,the film showcases the exceptional character qualities that are reflected in the Chinese people,including literary and artistic prowess,strength,courage,as well as an unyielding commitment to progress.Taking an indepth look into archaeological artifacts,ancient relics,and folk legends,the series reveals how these dragon offspring are depicted in palaces,temples,and various utensils,highlighting the Chinese people’s enduring hopes for good fortune and peace.The intriguing stories also help audiences better understand the cultural codes embedded within traditional Chinese architecture and artifacts.展开更多
At the IEC,Chinese experts have been contributing their expertise to international standardization.As one of them,Ma Dejun has grown from an inexperienced explorer in the field of standardization into a distinguished ...At the IEC,Chinese experts have been contributing their expertise to international standardization.As one of them,Ma Dejun has grown from an inexperienced explorer in the field of standardization into a distinguished expert driving the development of international standards in key sectors over the past 35 years.He was presented with the 2025 Lord Kelvin Award at the 89th IEC General Meeting held in New Delhi,India,in September 2025.Thus,he became the first Chinese expert to receive the highest honor bestowed by the IEC.In an exclusive interview with Ma Dejun,he reviewed his original aspiration behind his decades-long journey in international standardization,shared his experience and insights on promoting international standards,and looked forward to China's future role on the international standardiz ation stage.展开更多
Aims and Scope Chinese Journal of Polymer Science(CJPS)is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry,Chinese Academy of Sciences.CJPS is edited ...Aims and Scope Chinese Journal of Polymer Science(CJPS)is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry,Chinese Academy of Sciences.CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included.展开更多
Born in Penglai,Shandong Province in 1942,Jiang Baolin is currently working as a doctoral supervisor at the Chinese National Academy of Arts.He’s also a committee member and researcher at the China National Academy o...Born in Penglai,Shandong Province in 1942,Jiang Baolin is currently working as a doctoral supervisor at the Chinese National Academy of Arts.He’s also a committee member and researcher at the China National Academy of Painting.He graduated from Zhejiang Academy of Fine Arts(now China Academy of Art),studying under such masters as Lu Yanshao and Gu Kunbo,and later pursued his master’s degree at the Central Academy of Fine Arts,sitting at the feet of masters like Li Keran.展开更多
The Thursday flight from China to Zimbabwe’s capital Harare has become a permanent,welcome feature.While there are a handful of returning locals and international aid workers,the overwhelming majority are Chinese cit...The Thursday flight from China to Zimbabwe’s capital Harare has become a permanent,welcome feature.While there are a handful of returning locals and international aid workers,the overwhelming majority are Chinese citizens.展开更多
Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for...Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide.展开更多
Dream-Building in Tangwangcheng Chief Director:Chen Xichan Length:Four Episodes Producers:The Third Division of Xinjiang Production and Construction Corps and Hunan Broadcasting System Broadcasting Platforms:Mango TV,...Dream-Building in Tangwangcheng Chief Director:Chen Xichan Length:Four Episodes Producers:The Third Division of Xinjiang Production and Construction Corps and Hunan Broadcasting System Broadcasting Platforms:Mango TV,Tencent Video,Youku,and bilibili.展开更多
History has never been driven by comfort,nor shaped solely by inheritance.Its most significant turning points have emerged from those with youth,conviction and courage ingrained in them.Progress starts when young peop...History has never been driven by comfort,nor shaped solely by inheritance.Its most significant turning points have emerged from those with youth,conviction and courage ingrained in them.Progress starts when young people not only dream but also take action.Sometimes,the boldest move is not to run towards the glow of cities,but to turn back-to one’s soil,roots and forgotten home-and help it to flourish.展开更多
Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogen...Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogenesis owing to their multi-component and multi-target properties.This review focuses on the mechanisms of action of TCM monomers(e.g.,curcumin,tanshinone IIA,and ginsenoside)through the modulation of key pathways,such as HIF-1α,VEGF/VEGFRs,and Notch signaling,and explores their modulatory effects on the tumor microenvironment(e.g.,tumor-associated macrophage polarization).Despite the low toxicity and multi-targeting advantages of TCM,their clinical translation is still limited by low bioavailability and standardization difficulties.In this review,we further analyze the role of modern approaches,such as nanocarriers(liposomes,polymer nanoparticles,metal-coordinated nanomaterials,and plant exosome-like vesicles),in overcoming these bottlenecks and propose a strategy of combining TCM with chemotherapy,radiotherapy,and immunotherapy to overcome drug resistance and enhance therapeutic efficacy.By integrating traditional wisdom with cutting-edge technologies,anti-angiogenesis research in TCM is expected to contribute to the development of safer and more effective individualised cancer treatment.展开更多
In recent months,Beijing has witnessed a steady stream of high-profile diplomatic visits.Leaders from the United Kingdom,Canada,Germany,Finland,and Ireland have made their way to China,with economic cooperation consis...In recent months,Beijing has witnessed a steady stream of high-profile diplomatic visits.Leaders from the United Kingdom,Canada,Germany,Finland,and Ireland have made their way to China,with economic cooperation consistently topping the agenda.This“wave of visits,”as noted by international observers,is far from coincidental.It underscores a profound global sentiment:amidst a turbulent international landscape marked by geopolitical tensions and economic uncertainty,China stands out as a crucial anchor of stability and growth.展开更多
Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish ...Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.展开更多
基金supported by the National Natural Science Foundation of China(No.82360238,82071245)。
文摘Cancer pain is one of the most prevalent and debilitating symptoms in patients with advanced malignancies,arising from multifactorial mechanisms involving peripheral,central,and systemic pathways.Conventional analgesics,including opioids and nonsteroidal anti-inflammatory drugs,are often limited by their insufficient efficacy,tolerance,and risk of dependence.Traditional Chinese Medicine(TCM),characterized by its multi-component,multi-target,and systemic regulatory properties,has shown promising potential in cancer pain management.This review provides a comprehensive overview of the clinical classification and underlying mechanisms of cancer pain(including nerve infiltration,dysregulation of inflammatory mediators and ion channels,central sensitization,neuro-immune crosstalk,metabolic reprogramming,and gut-brain axis impairment),as well as the analgesic effects of representative TCM agents in cancer pain management.For example,bioactive components such as tetrahydroberberine,levo-tetrahydropalmatine,and piperine exert analgesic effects,thereby improving the quality of life of patients by inhibiting inflammatory cascades,regulating neurotransmitter systems,and preserving neural integrity.Commonly used preclinical models,including bone cancer pain,pancreatic cancer pain,and chemotherapy-induced peripheral neuropathy models,are summarized for their utility in mechanistic studies and efficacy evaluations.This review also discusses the current limitations of clinical evidence,such as small sample sizes,short follow-up periods,and limited translation from animal models,alongside major challenges in standardization,mechanistic elucidation,and clinical trial design.Future directions should focus on precise pain phenotyping,integrated multi-target interventions,rigorous efficacy safety validation,and innovations in drug delivery to facilitate the standardization and global adoption of TCM in cancer pain management.
基金Supported by the Project of National Social Science Fund of China(22CMZ015).
文摘Chinese medicinal materials are the material basis for the inheritance and development of traditional Chinese medicine.Intellectual property protection for the entire industrial chain of traditional Chinese medicinal materials promotes the inheritance and innovation of traditional Chinese medicine,and contributes to rural revitalization and the building of an agricultural power.This article provides an overview of the traditional Chinese medicinal materials in Hubei Province.It conducts a detailed investigation into the intellectual property resources of the province s traditional Chinese medicinal materials from aspects such as traditional knowledge,genetic resources,new plant varieties,patents,geographical indications,and trademarks.It analyzes the eight main problems in the protection,inheritance,and innovative development of intellectual property rights,and puts forward corresponding suggestions,such as establishing an intellectual property rights rule system for specific fields of traditional Chinese medicinal materials,promoting the"Famous Brand Action in Rural Areas",and building a"Hubei s Sixteen Superior Herbs"cluster of traditional Chinese medicinal materials.
基金Supported by the Project of National Social Science Fund of China (22CMZ015).
文摘The concept of geographical indication is similar to the idea of authentic medicinal herbs in traditional Chinese medicine. This paper examines the geographical indication (GI) resources of medicinal herbs in the Wuling Mountain Area from various perspectives, including geographical indication products, geographical indication trademarks, China s geographical indication products mutually recognized and protected with the EU, geographical indication standards, and the exclusive geographical indication logo. It studies the regional public brand characteristics of Chinese authentic medicinal herbs, based on hometown of authentic Chinese medicinal herbs, advantageous regions of characteristic agricultural products, important agricultural cultural heritage, national famous and excellent new agricultural products, national characteristic agricultural products, geographical indication Chinese well-known trademarks, advantageous regions of characteristic agricultural products, and regional public brands of agricultural products. It analyzes the main problems in the protection of geographical indications and the creation of regional public brands, and proposes suggestions for building high-quality authentic medicinal herb bases, developing new quality productivity in the authentic medicinal herb industry, implementing regional brand strategies for authentic medicinal herbs, constructing a new development pattern of dual circulation authentic medicinal herbs, etc.
文摘Chinese Journal of Integrative Medicine《中国结合医学杂志》是由中国中西医结合学会、中国中医科学院主办的国际性学术期刊,旨在促进结合医学及替代医学的国际交流,及时发表结合医学或替代医学领域的最新进展、趋势以及临床实践、科学研究、教育、保健方面经验和成果的科学论文。1995年创刊,由中国科学院院士陈可冀担任主编。设有述评、专题笔谈、论著、临床经验、病例报道、综述、药物相互作用、法规指南、学术探讨、思路与方法、跨学科知识、会议纪要、书评、读者来信等栏目。
文摘As a Hong Kong deputy to the NPC,Li has prioritized the policy needs of the TCM industry and the practical challenges faced by enterprises.DURING the“two sessions”in March 2026,the high-quality development and international promotion of traditional Chinese medicine(TCM)emerged as a trending topic of discussion.Tommy Li,a Hong Kong deputy to the 14th National People’s Congress(NPC)and president of the Federation of the Hong Kong Chinese Medicine Practitioners and Chinese Medicines Traders Association,has dedicated decades to the development of the TCM industry.
文摘In the Chinese lunar calendar,2026 ushers in the Year of the Horse,a creature that has carried humanity across continents and through centuries.More than a marker of time,the horse embodies vitality,courage,and the relentless spirit to move forward,qualities that resonate not only in China but across the landscapes of many African societies.
文摘China Basics Chief Director:Dong Qiang Length:10 Episodes Producer:Henan Broadcasting System Broadcasting Platform:Bilibili The dragon is the totem of Chinese culture,and its many offspring symbolize the inclusive spirit that the Chinese people pursue.Through the tales of the dragon’s nine sons,the film showcases the exceptional character qualities that are reflected in the Chinese people,including literary and artistic prowess,strength,courage,as well as an unyielding commitment to progress.Taking an indepth look into archaeological artifacts,ancient relics,and folk legends,the series reveals how these dragon offspring are depicted in palaces,temples,and various utensils,highlighting the Chinese people’s enduring hopes for good fortune and peace.The intriguing stories also help audiences better understand the cultural codes embedded within traditional Chinese architecture and artifacts.
文摘At the IEC,Chinese experts have been contributing their expertise to international standardization.As one of them,Ma Dejun has grown from an inexperienced explorer in the field of standardization into a distinguished expert driving the development of international standards in key sectors over the past 35 years.He was presented with the 2025 Lord Kelvin Award at the 89th IEC General Meeting held in New Delhi,India,in September 2025.Thus,he became the first Chinese expert to receive the highest honor bestowed by the IEC.In an exclusive interview with Ma Dejun,he reviewed his original aspiration behind his decades-long journey in international standardization,shared his experience and insights on promoting international standards,and looked forward to China's future role on the international standardiz ation stage.
文摘Aims and Scope Chinese Journal of Polymer Science(CJPS)is a monthly journal published in English and sponsored by the Chinese Chemical Society and the Institute of Chemistry,Chinese Academy of Sciences.CJPS is edited by a distinguished Editorial Board headed by Professor Qi-Feng Zhou and supported by an International Advisory Board in which many famous active polymer scientists all over the world are included.
文摘Born in Penglai,Shandong Province in 1942,Jiang Baolin is currently working as a doctoral supervisor at the Chinese National Academy of Arts.He’s also a committee member and researcher at the China National Academy of Painting.He graduated from Zhejiang Academy of Fine Arts(now China Academy of Art),studying under such masters as Lu Yanshao and Gu Kunbo,and later pursued his master’s degree at the Central Academy of Fine Arts,sitting at the feet of masters like Li Keran.
文摘The Thursday flight from China to Zimbabwe’s capital Harare has become a permanent,welcome feature.While there are a handful of returning locals and international aid workers,the overwhelming majority are Chinese citizens.
基金supported by the National Natural Science Foundation of China(No.82203343)the National Postdoctoral Program for Innovative Talents of China(No.BX20220273)+3 种基金China Postdoctoral Science Foundation(No.2022M712874)Henan Province Key Research and Development Promotion Special Project(Science and Technology)in 2023(No.232102311007)Henan Province Key Scientific Research Project of Colleges and Universities in 2023(No.23A310007)the Outstanding Youth Project of Henan Provincial Natural Science Foundation(No.252300421123)。
文摘Traditional Chinese medicine(TCM)has garnered increasing attention globally,with its modernization becoming a prominent research focus both within China and internationally.However,the lack of a precise definition for TCM modernization has hindered clear guidance for its development.Additionally,cancer remains a significant global public health challenge,largely untreatable with current methods.Therefore,a comprehensive understanding of TCM modernization is crucial for its evolution,revolution,drug discovery,and cancer therapy.This study provides an overview of the history,theory,characteristics,and evolution of TCM,highlighting its potential in cancer prevention and treatment.We propose a definition for TCM modernization,innovative Chinese medicine(ICM),and elucidate strategies to elevate TCM from a supporting role to a leading one.Electronic databases such as PubMed,Web of Science,ScienceDirect,and Clinical Trials were utilized to retrieve relevant literature spanning from 1979 to 2024,with most publications being from the last five years,using keywords like“Traditional Chinese medicine”,“Cancer”,“Mechanism”,and“Clinical trial”.In this study,we introduce the theory of TCM modernization following target identification and initial compound screening:ICM,defined by“3 D”elements:definite active ingredient composition and content,determined functional mechanism,and detection through evidence-based medicine.Overall,the“3 D”definition of ICM will establish a standard for ICM,accelerate TCM modernization,enhance drug discovery targeting cancer and various human diseases,and benefit patients worldwide.
文摘Dream-Building in Tangwangcheng Chief Director:Chen Xichan Length:Four Episodes Producers:The Third Division of Xinjiang Production and Construction Corps and Hunan Broadcasting System Broadcasting Platforms:Mango TV,Tencent Video,Youku,and bilibili.
文摘History has never been driven by comfort,nor shaped solely by inheritance.Its most significant turning points have emerged from those with youth,conviction and courage ingrained in them.Progress starts when young people not only dream but also take action.Sometimes,the boldest move is not to run towards the glow of cities,but to turn back-to one’s soil,roots and forgotten home-and help it to flourish.
基金supported by the Xinglin Scholars Nursery Program Talent Fund of Chengdu University of Traditional Chinese Medicine(MPRC2023005).
文摘Tumor growth depends on neoangiogenesis,and current anti-angiogenic therapies face limitations owing to side effects and drug resistance.Traditional Chinese medicines(TCM)have shown potential to inhibit tumor angiogenesis owing to their multi-component and multi-target properties.This review focuses on the mechanisms of action of TCM monomers(e.g.,curcumin,tanshinone IIA,and ginsenoside)through the modulation of key pathways,such as HIF-1α,VEGF/VEGFRs,and Notch signaling,and explores their modulatory effects on the tumor microenvironment(e.g.,tumor-associated macrophage polarization).Despite the low toxicity and multi-targeting advantages of TCM,their clinical translation is still limited by low bioavailability and standardization difficulties.In this review,we further analyze the role of modern approaches,such as nanocarriers(liposomes,polymer nanoparticles,metal-coordinated nanomaterials,and plant exosome-like vesicles),in overcoming these bottlenecks and propose a strategy of combining TCM with chemotherapy,radiotherapy,and immunotherapy to overcome drug resistance and enhance therapeutic efficacy.By integrating traditional wisdom with cutting-edge technologies,anti-angiogenesis research in TCM is expected to contribute to the development of safer and more effective individualised cancer treatment.
文摘In recent months,Beijing has witnessed a steady stream of high-profile diplomatic visits.Leaders from the United Kingdom,Canada,Germany,Finland,and Ireland have made their way to China,with economic cooperation consistently topping the agenda.This“wave of visits,”as noted by international observers,is far from coincidental.It underscores a profound global sentiment:amidst a turbulent international landscape marked by geopolitical tensions and economic uncertainty,China stands out as a crucial anchor of stability and growth.
基金General Program of National Natural Science Foundation of China(82474390)Construction Project of Pudong New Area Famous TCM Studios(National Pilot Zone for TCM Development,Shanghai)(PDZY-2025-0716)Shanghai Municipal Science and Technology Program Project Shanghai Key Laboratory of Health Identification and Assessment(21DZ2271000).
文摘Objective To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine(TCM)with machine learning algorithms.The proposed model seeks to establish a TCM-informed tool for early depression screening,thereby bridging traditional diagnostic principles with modern computational approaches.Methods The study included patients with depression who visited the Shanghai Pudong New Area Mental Health Center from October 1,2022 to October 1,2023,as well as students and teachers from Shanghai University of Traditional Chinese Medicine during the same period as the healthy control group.Videos of 3–10 s were captured using a Xiaomi Pad 5,and the TCM spirit and expressions were determined by TCM experts(at least 3 out of 5 experts agreed to determine the category of TCM spirit and expressions).Basic information,facial images,and interview information were collected through a portable TCM intelligent analysis and diagnosis device,and facial diagnosis features were extracted using the Open CV computer vision library technology.Statistical analysis methods such as parametric and non-parametric tests were used to analyze the baseline data,TCM spirit and expression features,and facial diagnosis feature parameters of the two groups,to compare the differences in TCM spirit and expression and facial features.Five machine learning algorithms,including extreme gradient boosting(XGBoost),decision tree(DT),Bernoulli naive Bayes(BernoulliNB),support vector machine(SVM),and k-nearest neighbor(KNN)classification,were used to construct a depression recognition model based on the fusion of TCM spirit and expression features.The performance of the model was evaluated using metrics such as accuracy,precision,and the area under the receiver operating characteristic(ROC)curve(AUC).The model results were explained using the Shapley Additive exPlanations(SHAP).Results A total of 93 depression patients and 87 healthy individuals were ultimately included in this study.There was no statistically significant difference in the baseline characteristics between the two groups(P>0.05).The differences in the characteristics of the spirit and expressions in TCM and facial features between the two groups were shown as follows.(i)Quantispirit facial analysis revealed that depression patients exhibited significantly reduced facial spirit and luminance compared with healthy controls(P<0.05),with characteristic features such as sad expressions,facial erythema,and changes in the lip color ranging from erythematous to cyanotic.(ii)Depressed patients exhibited significantly lower values in facial complexion L,lip L,and a values,and gloss index,but higher values in facial complexion a and b,lip b,low gloss index,and matte index(all P<0.05).(iii)The results of multiple models show that the XGBoost-based depression recognition model,integrating the TCM“spirit-expression”diagnostic framework,achieved an accuracy of 98.61%and significantly outperformed four benchmark algorithms—DT,BernoulliNB,SVM,and KNN(P<0.01).(iv)The SHAP visualization results show that in the recognition model constructed by the XGBoost algorithm,the complexion b value,categories of facial spirit,high gloss index,low gloss index,categories of facial expression and texture features have significant contribution to the model.Conclusion This study demonstrates that integrating TCM spirit-expression diagnostic features with machine learning enables the construction of a high-precision depression detection model,offering a novel paradigm for objective depression diagnosis.
