The Louzidian metamorphic core complex (LMCC) in southern Chifeng is located on the northern margin of the North China craton. Structural analyses of the LMCC and its extensional detachment system indicate that the LM...The Louzidian metamorphic core complex (LMCC) in southern Chifeng is located on the northern margin of the North China craton. Structural analyses of the LMCC and its extensional detachment system indicate that the LMCC experienced two-stage extension. The ductile regime experienced top-to-northeast shearing extension and the brittle detachment fault underwent top-down-outwards slipping. Between these two stages, a semi-ductile regime recorded the transition from ductile to brittle. The hanging wall of the detachment fault is similar to those classic supradetachment basins in western North America. Analyses of provenance and paleocurrent directions in the basins show that there were two filling stages. In the early stage, materials came from the southwest margin of the basin and the hanging wall of the detachment system and were transported from southwest to northeast; while in the late stage, deposits were derived from the footwall of the detachment fault and transported outwards to the two sides of the core complex. Since the filling period of the basins is from the late Jurassic to the late Cretaceous and it is coeval with the extension, the two filling stages reflect the two-stage history of the detachment fault. The large-scale late Jurassic underplating in the deep crust of the Chifeng area led to thickening and heating of the middle-upper crust and trigged the extension at depths and volcanism on the surface. In the early Cretaceous the upper plate of the detachment fault moved northeastwards and sediments were transported from southwest to northeast, while in the late Cretaceous the core complex was uplifted rapidly, the original basin was separated by the uplifted core, and lower-plate-derived debris was deposited in the adjacent upper-plate basins of the detachment fault. Evidentially, the development of the supradetachment basins were controlled by the extension and in turn the fillings in the basins recorded information of the extension, which has provided new evidence for kinematic interpretation of the Louzidian core complex.展开更多
Three tectonic units have been recognized in the Chifeng area, Inner Mongolia, from north to south, including the Qiganmiao accretionary prism, Jiefangyingzi arc belt and Sidaozhangpeng molasse basin, which formed an ...Three tectonic units have been recognized in the Chifeng area, Inner Mongolia, from north to south, including the Qiganmiao accretionary prism, Jiefangyingzi arc belt and Sidaozhangpeng molasse basin, which formed an Andeantype active continent margin during the early to middle Paleozoic. The Qiganmiao accretionary prism is characterized by a mélange that consists of gabbro, two-mica quartz schist and basic volcanic rock blocks and heterogeneously deformed marble matrix. Two zircon U-Pb ages of 446.0±6.3 Ma and 1104±27 Ma have been acquired and been interpreted as the metamorphic and forming ages for the gabbro and two-mica quartz schist, respectively. The prism formed during the early to middle Paleozoic southward subduction of the Paleo Asian Ocean(PAO) and represents a suture between the North China craton(NCC) and Central Asian Orogenic Belt(CAOB). The Jiefangyingzi arc belt consists of pluton complex and volcanic rocks of the Xibiehe and Badangshan Formations, and Geochronology analysis indicates that the development of it can be divided into two stages. The first stage is represented by the Xibiehe Formation volcanic rocks, which belong to the subalkaline series, enriched LREE and LILE and depleted HFSE, with negative Eu anomalies, and plot in the volcanic arc field in discrimination diagrams. These characters indicate that the Xibiehe Formation results from to the continental arc magmatic activity related to the subduction of the PAO during 400–420 Ma. Magmatism of the second stage in 380–390 Ma consists of the Badangshan Formation volcanic rocks. Geochemistry analysis reveals that rhyolite, basaltic andesite and basalt of the Badangshan Formation were developed in continental margin arc setting. Moreover, the basaltic andesite and basalt display positive Sr anomalies, and the basalt have very low Nb/La values, suggesting that fluid is involved in magma evolution and the basalts were contaminated by continental crust. The sequence of Sidaozhangpeng molasse basin is characterized by proximity, coarseness and large thickness, similar to the proximity molasses basin. According to our field investigation, geochronological and geochemical data, combined with previous research in this area, a tectonic evolutionary model for Andes-type active continental margin of the CAOB has been proposed, including a development of the subduction-free PAO before 446 Ma, a subduction of the PAO and arc-related magmatism during 446–380 Ma, and formation of a molasse basin during 380–360 Ma.展开更多
Objective To observe clinical efficacy of Ch/J：eng Yingyuan manipulation for migraine and its effects on endothelin （ET） and nitric oxide （NO）. Methods One hundred and seventeen cases were randomly divided into a...Objective To observe clinical efficacy of Ch/J：eng Yingyuan manipulation for migraine and its effects on endothelin （ET） and nitric oxide （NO）. Methods One hundred and seventeen cases were randomly divided into a treatment group （59 cases） and a control group （58 cases）. The Chifeng Yingyuan manipulation was applied in the treatment group while oral administration of flunarizine hydrochloride capsules was applied in the control group for consecutive 4 weeks. Before and after the treatment, the clinical efficacy and migraine score in both groups were compared; radioimmunoassay was used to test level of ET while nitrate reductase method was for level of NO. Results Compared between two groups, the total effective rate was 91.5% in the treatment group, which was superior to 70.7% in the control group （P〈0.05）. After the treatment, the migraine scores were both significantly decreased in two groups （P〈0.05, P〈0.01）, which was more obvious in the treatment group （P〈0.05）. The level of ET and NO was significantly changed after treatment （P〈0.05, P〈0.01）. Compared between two groups, the improvement of ET and NO in the treatment group was better than that in the control group （both P〈0.05）. Conclusion The Chifeng Yingyuan manipulation has positive effect on migraine without any adverse reaction, which could maintain cerebrovascular vasomotor function by regulating level of ET and NO in the plasma.展开更多
OBJECTIVE:To examine the nephroprotective mechanism of modified Huangqi Chifeng decoction(加味黄芪赤风汤,MHCD)in immunoglobulin A nephropathy(IgAN)rats.METHODS:To establish the IgAN rat model,the bovine serum albumin,...OBJECTIVE:To examine the nephroprotective mechanism of modified Huangqi Chifeng decoction(加味黄芪赤风汤,MHCD)in immunoglobulin A nephropathy(IgAN)rats.METHODS:To establish the IgAN rat model,the bovine serum albumin,lipopolysaccharide,and carbon tetrachloride 4 method was employed.The rats were then randomly assigned to the control,model,telmisartan,and high-,medium-,and low-dose MHCD groups,and were administered the respective treatments via intragastric administration for 8 weeks.The levels of 24-h urinary protein,serum creatinine(CRE),and blood urea nitrogen(BUN)were measured in each group.Pathological alterations were detected.IgA deposition was visualized through the use of immunofluorescence staining.The ultrastructure of the kidney was observed using a transmission electron microscope.The expression levels of interleukin-6(IL-6),monocyte chemoattractant protein-1(MCP-1),and transforming growth factor-β1(TGF-β1)were examined by immunohistochemistry and quantitative polymerase chain reaction.Levels of toll-like receptor 4(TLR4),myeloid differentiation factor 88(MyD88),and nuclear factor-kappa B(NF-κB)P65,were examined by immunohistochemistry,Western blotting,and quantitative polymerase chain reaction.RESULTS:The 24-h urine protein level in each group increased significantly at week 6,and worsen from then on.But this process can be reversed by treatments of telmisartan,and high-,medium-,and low-dose of MHCD,and these treatments did not affect renal function.Telmisartan,and high-,and medium-dose of MHCD reduced IgA deposition.Renal histopathology demonstrated the protective effect of high-,medium-,and low-dose of MHCD against kidney injury.The expression levels of MCP-1,IL-6,and TGF-β1 in kidney tissues were downregulated by low,medium and high doses of MHCD treatment.Additionally,treatment of low,medium and high doses of MHCD decreased the protein and mRNA levels of TLR4,MyD88,and NF-κB.CONCLUSIONS:MHCD exerted nephroprotective effects on IgAN rats,and MHCD regulated the expressions of key targets in TLR4/MyD88/NF-κB signaling pathway,thereby alleviating renal inflammation by inhibiting MCP-1,IL-6 expressions,and ameliorating renal fibrosis by inhibiting TGF-β1 expression.展开更多
Bulk-rock elements,isotopes,and zircon U–Pb ages are reported for magmatic rocks in the Dongzi–Changhanboluo Pb–Zn ore district in Chifeng,Inner Mongolia,China.Zircon U–Pb dating identified four stages of magmatis...Bulk-rock elements,isotopes,and zircon U–Pb ages are reported for magmatic rocks in the Dongzi–Changhanboluo Pb–Zn ore district in Chifeng,Inner Mongolia,China.Zircon U–Pb dating identified four stages of magmatism:Late Silurian gabbroic diorite(*420 Ma),Middle Permian monzonite(*274 Ma),Late Jurassic quartz porphyry and ignimbrite,breccia tuff(153–158 Ma)and Early Cretaceous andesitic porphyrite(*127 Ma).Integrating field observations,geochronology,and element and isotope geochemistry indicated a complex petrogenetic history of the magmatic rocks.The gabbroic diorite may have been sourced from EM1-type mantle.The source of the monzonite may have been mantle metasomatized by melt from the subducting plate.The Jurassic volcaniclastic rocks formed in a medium-pressure,high-temperature environment,possibly in the background of crustal thickening in a syncollisional stage and an early postcollisional stage.During this process,shaly sedimentary rocks were brought into the deep crust and heated,followed by the rapid isostatic uplift of the crust,which caused partial melting of the sedimentary rocks.Quartz monzonite porphyry and quartz porphyry formed by partial melting of mantle metasomatized by subducted sediments,but the quartz porphyry experienced high-degree differentiation and evolution.The andesitic porphyrite has characteristics similar to those of Permian monzonite,indicating that its source area was also the zone of mantle metasomatized by subducted sediment.The late Silurian and Permian magmatic rocks in this area most likely formed against a continental arc background related to the subduction of the Paleo-Asian Ocean Plate beneath the North China Plate.The Late Jurassic magmatic rocks suggest that the northern margin of the North China Craton may have been in a postcollisional setting during the Late Jurassic,with no obvious crustal thinning.The Cretaceous andesitic porphyrite may have formed against the background of lithospheric extension and thinning.According to the comprehensive analysis of geological characteristics,diagenetic and metallogenic epochs,and Pb isotope data,the formation of ore bodies in the Dongzi–Changhanboluo ore district was closely related to the Jurassic quartz porphyry.展开更多
Chifeng is a concentrated mining area for non-ferrous metal minerals,as well as a key prevention and control area for heavyduty enterprises.This situation necessitates an efective ecological and human health risk asse...Chifeng is a concentrated mining area for non-ferrous metal minerals,as well as a key prevention and control area for heavyduty enterprises.This situation necessitates an efective ecological and human health risk assessment of heavy metal(loid)s driven by the wide distribution of metal ore processing,mining,and smelting factories in Hexigten Banner and Bairin Left Banner.We conducted surveys to assess the levels of heavy metal(loid)s(Cr,As,Pb,Cd,and Hg)in the topsoil and groundwater of the areas.The results indicated that the concentrations of As,Cd,and Pb in partial soil samples exceeded the environmental quality standards of Grade II.Based on contamination assessments,such as geoaccumulation indices and pollution indices,we inferred that Cd,Pb,and As were primary pollutants in topsoil.Potential ecological risks when considered as part of the average risk indices(RI)are up to 1626.40 and 2818.76,respectively,in the two areas.Comparative analysis revealed that Cd posed a very high potential ecological risk,followed by As.Moreover,the evaluation showed that the three exposure pathways of carcinogenic and non-carcinogenic risk followed a descending order:inhalation>ingestion>dermal contact,except for Pb.Arsenic in topsoil posed a potential non-carcinogenic risk to human health,while there were no adverse efects of As in groundwater.In addition,the average total carcinogenic risk for As in the two areas,as well as the risk of Pb in the topsoil of Bairin Left Banner and all the fve heavy metal(loid)s in groundwater,exceeded human tolerance.Pb–Zn mines caused higher human health risks.In addition,the tandem contamination of heavy metal(loid)s in soil and groundwater was not obvious.This research study provides a basis for pollution remediation to control heavy industry-induced ecological and health risks of heavy metal(loid)s.展开更多
In order to understand the current demand of the medical staffs for nursing workers in Chifeng and to explore the practical management mode of nursing workers,150 doctors and nurses were randomly selected from general...In order to understand the current demand of the medical staffs for nursing workers in Chifeng and to explore the practical management mode of nursing workers,150 doctors and nurses were randomly selected from general tertiary hospitals in Chifeng to participate in a questionnaire survey.The objective of this study was to investigate the demand of nursing workers in tertiary hospitals in Chifeng and the satisfaction of medical staffs toward the existing nursing work.The results of the investigation were analyzed to provide countermeasures and suggestions for the nursing work in Chifeng.展开更多
To solve the problems of rural revitalization performance research,a quantitative model of non-oriented range-wide EBM(Epsilon-Based Measure)-GML(Global-Malmquist)based on VRS(Variable Returns to Scale)conditions incl...To solve the problems of rural revitalization performance research,a quantitative model of non-oriented range-wide EBM(Epsilon-Based Measure)-GML(Global-Malmquist)based on VRS(Variable Returns to Scale)conditions including non-desired outputs is constructed.A comprehensive spatio-temporal heterogeneity research index system of rural revitalization performance is also constructed.Taking the typical rural in Chifeng City as an example,the panel data from 2016-2020 are selected for empirical analysis,the conclusions and countermeasures are suggested as follows:1)In general,the rural revitalization performance of Chifeng City increases significantly during the five-year period,with significant spatio-temporal heterogeneity.The overall analysis shows that the overall performance value of rural revitalization in Chifeng City is 0.683 from 2016 to 2020.The highest performance value is 1 and the lowest performance value is 0.389.The performance growth rate increases year by year,with an average annual growth rate of 4.46%.2)From 2016 to 2020,the GML index of rural revitalization performance in Chifeng City is 1.174,showing an increasing trend.Based on the range of change of GML index,Chifeng City can be classified into three types:Continuous improvement,fluctuating improvement and fluctuating decline.3)Niujiayingzi,Guandongche,Zhaidamu,and Qiangangtai rural have the highest degree of technological progress.展开更多
The Louzidian ductile shear zone at the south of Chifeng strikes NE-SW and dips SE at low-medium- angles. This ductile shear zone is mainly composed of granitic mylonite, which grades structurally upward into a chlori...The Louzidian ductile shear zone at the south of Chifeng strikes NE-SW and dips SE at low-medium- angles. This ductile shear zone is mainly composed of granitic mylonite, which grades structurally upward into a chloritized zone, a microbreccia zone, a brittle fault and a gouge zone. All these zones share similar planar attitudes, but contain different linear attitudes and kinematic indicators. Finite strain measurements were performed on feldspar porphyroclasts using the Fry method. These meas- urements yield Fulin indexes of 1.25―3.30, Lode's parameters of -0.535―-0.112 and strain parameters of 0.41―0.75 for the protomylonite, respectively. These data are plotted within the apparent constric- tional field in Fulin and Hossack diagrams. In contrast, for the mylonite, corresponding parameters are 0.99―1.43, -0.176―-0.004 and 0.63―0.82, respectively, and located in the apparent constrictional field close to the plane strain. The mean kinematic vorticity numbers of the protomylonite and mylonite by using three methods of polar Mohr circle, porphyroclast hyperbolic and oblique foliation, are in the range of 0.67―0.95, suggesting that the ductile shearing is accommodated by general shearing that is dominated by simple shear. Combination of the finite strain and kinematic vorticity indicates that shear type was lengthening shear and resulted in L-tectonite at the initial stage of deformation and the shear type gradually changed into lengthening-thinning shear and produced L-S-tectonite with the uplifting of the shear zone and accumulating of strain. These kinds of shear types only produce a/ab strain facies, so the lineation in the ductile shear zone could not deflect 90° in the progressively deformation.展开更多
Objective To explore the effect of Modified Hangqi Chifeng Decoction(MHCD)on levels of collagen typeⅣ(ColⅣ),matrix metalloproteinase-2(MMP-2),tissue inhibitor of metalloproteinase-2(TIMP-2)in extracellular matrix(EC...Objective To explore the effect of Modified Hangqi Chifeng Decoction(MHCD)on levels of collagen typeⅣ(ColⅣ),matrix metalloproteinase-2(MMP-2),tissue inhibitor of metalloproteinase-2(TIMP-2)in extracellular matrix(ECM)of glomerular mesangial cells(GMCs)in LPS induced mice.Methods Normal serum and telmisartan,high,medium,low dose MHCD containing展开更多
As'China’s hometown of nonferrous metals',Chifeng City is the biggest concentration zone in Inner Mongolia’s nonferrous metals industry.Copper resources accounts for 17% of the whole region,lead resource acc...As'China’s hometown of nonferrous metals',Chifeng City is the biggest concentration zone in Inner Mongolia’s nonferrous metals industry.Copper resources accounts for 17% of the whole region,lead resource accounts for 35%,zinc resource accounts for 30%,tungsten resource accounts for 42%,tin resource accounts for 88%,molybdenum resource accounts for 15%,gold resource accounts展开更多
基金supported by the National Natural Science Foundation of China(grant 40102017)the Doctoral Program of Higher Education(grant 2000000128).
文摘The Louzidian metamorphic core complex (LMCC) in southern Chifeng is located on the northern margin of the North China craton. Structural analyses of the LMCC and its extensional detachment system indicate that the LMCC experienced two-stage extension. The ductile regime experienced top-to-northeast shearing extension and the brittle detachment fault underwent top-down-outwards slipping. Between these two stages, a semi-ductile regime recorded the transition from ductile to brittle. The hanging wall of the detachment fault is similar to those classic supradetachment basins in western North America. Analyses of provenance and paleocurrent directions in the basins show that there were two filling stages. In the early stage, materials came from the southwest margin of the basin and the hanging wall of the detachment system and were transported from southwest to northeast; while in the late stage, deposits were derived from the footwall of the detachment fault and transported outwards to the two sides of the core complex. Since the filling period of the basins is from the late Jurassic to the late Cretaceous and it is coeval with the extension, the two filling stages reflect the two-stage history of the detachment fault. The large-scale late Jurassic underplating in the deep crust of the Chifeng area led to thickening and heating of the middle-upper crust and trigged the extension at depths and volcanism on the surface. In the early Cretaceous the upper plate of the detachment fault moved northeastwards and sediments were transported from southwest to northeast, while in the late Cretaceous the core complex was uplifted rapidly, the original basin was separated by the uplifted core, and lower-plate-derived debris was deposited in the adjacent upper-plate basins of the detachment fault. Evidentially, the development of the supradetachment basins were controlled by the extension and in turn the fillings in the basins recorded information of the extension, which has provided new evidence for kinematic interpretation of the Louzidian core complex.
基金supported by grants from National Key R&D Program of China (2017YFC0601302)the NSF of China (41672214)Geological Survey Project of China Geological Survey (DD20189612, DD20190004).
文摘Three tectonic units have been recognized in the Chifeng area, Inner Mongolia, from north to south, including the Qiganmiao accretionary prism, Jiefangyingzi arc belt and Sidaozhangpeng molasse basin, which formed an Andeantype active continent margin during the early to middle Paleozoic. The Qiganmiao accretionary prism is characterized by a mélange that consists of gabbro, two-mica quartz schist and basic volcanic rock blocks and heterogeneously deformed marble matrix. Two zircon U-Pb ages of 446.0±6.3 Ma and 1104±27 Ma have been acquired and been interpreted as the metamorphic and forming ages for the gabbro and two-mica quartz schist, respectively. The prism formed during the early to middle Paleozoic southward subduction of the Paleo Asian Ocean(PAO) and represents a suture between the North China craton(NCC) and Central Asian Orogenic Belt(CAOB). The Jiefangyingzi arc belt consists of pluton complex and volcanic rocks of the Xibiehe and Badangshan Formations, and Geochronology analysis indicates that the development of it can be divided into two stages. The first stage is represented by the Xibiehe Formation volcanic rocks, which belong to the subalkaline series, enriched LREE and LILE and depleted HFSE, with negative Eu anomalies, and plot in the volcanic arc field in discrimination diagrams. These characters indicate that the Xibiehe Formation results from to the continental arc magmatic activity related to the subduction of the PAO during 400–420 Ma. Magmatism of the second stage in 380–390 Ma consists of the Badangshan Formation volcanic rocks. Geochemistry analysis reveals that rhyolite, basaltic andesite and basalt of the Badangshan Formation were developed in continental margin arc setting. Moreover, the basaltic andesite and basalt display positive Sr anomalies, and the basalt have very low Nb/La values, suggesting that fluid is involved in magma evolution and the basalts were contaminated by continental crust. The sequence of Sidaozhangpeng molasse basin is characterized by proximity, coarseness and large thickness, similar to the proximity molasses basin. According to our field investigation, geochronological and geochemical data, combined with previous research in this area, a tectonic evolutionary model for Andes-type active continental margin of the CAOB has been proposed, including a development of the subduction-free PAO before 446 Ma, a subduction of the PAO and arc-related magmatism during 446–380 Ma, and formation of a molasse basin during 380–360 Ma.
文摘Objective To observe clinical efficacy of Ch/J：eng Yingyuan manipulation for migraine and its effects on endothelin （ET） and nitric oxide （NO）. Methods One hundred and seventeen cases were randomly divided into a treatment group （59 cases） and a control group （58 cases）. The Chifeng Yingyuan manipulation was applied in the treatment group while oral administration of flunarizine hydrochloride capsules was applied in the control group for consecutive 4 weeks. Before and after the treatment, the clinical efficacy and migraine score in both groups were compared; radioimmunoassay was used to test level of ET while nitrate reductase method was for level of NO. Results Compared between two groups, the total effective rate was 91.5% in the treatment group, which was superior to 70.7% in the control group （P〈0.05）. After the treatment, the migraine scores were both significantly decreased in two groups （P〈0.05, P〈0.01）, which was more obvious in the treatment group （P〈0.05）. The level of ET and NO was significantly changed after treatment （P〈0.05, P〈0.01）. Compared between two groups, the improvement of ET and NO in the treatment group was better than that in the control group （both P〈0.05）. Conclusion The Chifeng Yingyuan manipulation has positive effect on migraine without any adverse reaction, which could maintain cerebrovascular vasomotor function by regulating level of ET and NO in the plasma.
基金Joint Innovation Fundation of JIICM:Health Management of Chronic Kidney Disease Based on Integrated Traditional Chinese And Western Medicine(No.2021IR009)Natural Science Foundation-funded Project:the Mechanism of Modified Huangqi Chifeng Decoction Protect Damaged Podocyte via Cross-Talking of PI3K/AKT/mTOR and AMPK/mTOR/ULK1 Signaling Pathway Regulate Autophapy(No.81873300)+1 种基金the Central Publicinterest Scientific Institution Basal Research Fund of the China Academy of Chinese Medical Sciences:Comprehensive Evaluation of Clinical efficacy of Modified Huangqi Chifeng Decoction on IgA Nephropathy(No.ZZ11-023)the Beijing Municipal of Science and Technology Major Project:Evaluation of Clinical Efficacy of Modified Huangqi Chifeng Decoction in Treating Proteinuria in IgA Nephropathy Based on"Deficiency-Wind-Blood-Stasis-Toxicity"Mechanism in Chinese Medicine(No.Z191100006619063)。
文摘OBJECTIVE:To examine the nephroprotective mechanism of modified Huangqi Chifeng decoction(加味黄芪赤风汤,MHCD)in immunoglobulin A nephropathy(IgAN)rats.METHODS:To establish the IgAN rat model,the bovine serum albumin,lipopolysaccharide,and carbon tetrachloride 4 method was employed.The rats were then randomly assigned to the control,model,telmisartan,and high-,medium-,and low-dose MHCD groups,and were administered the respective treatments via intragastric administration for 8 weeks.The levels of 24-h urinary protein,serum creatinine(CRE),and blood urea nitrogen(BUN)were measured in each group.Pathological alterations were detected.IgA deposition was visualized through the use of immunofluorescence staining.The ultrastructure of the kidney was observed using a transmission electron microscope.The expression levels of interleukin-6(IL-6),monocyte chemoattractant protein-1(MCP-1),and transforming growth factor-β1(TGF-β1)were examined by immunohistochemistry and quantitative polymerase chain reaction.Levels of toll-like receptor 4(TLR4),myeloid differentiation factor 88(MyD88),and nuclear factor-kappa B(NF-κB)P65,were examined by immunohistochemistry,Western blotting,and quantitative polymerase chain reaction.RESULTS:The 24-h urine protein level in each group increased significantly at week 6,and worsen from then on.But this process can be reversed by treatments of telmisartan,and high-,medium-,and low-dose of MHCD,and these treatments did not affect renal function.Telmisartan,and high-,and medium-dose of MHCD reduced IgA deposition.Renal histopathology demonstrated the protective effect of high-,medium-,and low-dose of MHCD against kidney injury.The expression levels of MCP-1,IL-6,and TGF-β1 in kidney tissues were downregulated by low,medium and high doses of MHCD treatment.Additionally,treatment of low,medium and high doses of MHCD decreased the protein and mRNA levels of TLR4,MyD88,and NF-κB.CONCLUSIONS:MHCD exerted nephroprotective effects on IgAN rats,and MHCD regulated the expressions of key targets in TLR4/MyD88/NF-κB signaling pathway,thereby alleviating renal inflammation by inhibiting MCP-1,IL-6 expressions,and ameliorating renal fibrosis by inhibiting TGF-β1 expression.
基金financially supported by the National Natural Science Foundation of China(No.41602101)。
文摘Bulk-rock elements,isotopes,and zircon U–Pb ages are reported for magmatic rocks in the Dongzi–Changhanboluo Pb–Zn ore district in Chifeng,Inner Mongolia,China.Zircon U–Pb dating identified four stages of magmatism:Late Silurian gabbroic diorite(*420 Ma),Middle Permian monzonite(*274 Ma),Late Jurassic quartz porphyry and ignimbrite,breccia tuff(153–158 Ma)and Early Cretaceous andesitic porphyrite(*127 Ma).Integrating field observations,geochronology,and element and isotope geochemistry indicated a complex petrogenetic history of the magmatic rocks.The gabbroic diorite may have been sourced from EM1-type mantle.The source of the monzonite may have been mantle metasomatized by melt from the subducting plate.The Jurassic volcaniclastic rocks formed in a medium-pressure,high-temperature environment,possibly in the background of crustal thickening in a syncollisional stage and an early postcollisional stage.During this process,shaly sedimentary rocks were brought into the deep crust and heated,followed by the rapid isostatic uplift of the crust,which caused partial melting of the sedimentary rocks.Quartz monzonite porphyry and quartz porphyry formed by partial melting of mantle metasomatized by subducted sediments,but the quartz porphyry experienced high-degree differentiation and evolution.The andesitic porphyrite has characteristics similar to those of Permian monzonite,indicating that its source area was also the zone of mantle metasomatized by subducted sediment.The late Silurian and Permian magmatic rocks in this area most likely formed against a continental arc background related to the subduction of the Paleo-Asian Ocean Plate beneath the North China Plate.The Late Jurassic magmatic rocks suggest that the northern margin of the North China Craton may have been in a postcollisional setting during the Late Jurassic,with no obvious crustal thinning.The Cretaceous andesitic porphyrite may have formed against the background of lithospheric extension and thinning.According to the comprehensive analysis of geological characteristics,diagenetic and metallogenic epochs,and Pb isotope data,the formation of ore bodies in the Dongzi–Changhanboluo ore district was closely related to the Jurassic quartz porphyry.
基金the National Natural Science Foundation of China(No.42072284,No.42027801,No.41877186)the National Key R&D Program of China(2021YFC2902004)+1 种基金the Major Science and Technology Projects of Inner Mongolia Autonomous Region(2020ZD0020-4)the Fundamental Research Funds for the Central Universities(2022YQSH01,2020YJSSH01,2021YJSSH01)。
文摘Chifeng is a concentrated mining area for non-ferrous metal minerals,as well as a key prevention and control area for heavyduty enterprises.This situation necessitates an efective ecological and human health risk assessment of heavy metal(loid)s driven by the wide distribution of metal ore processing,mining,and smelting factories in Hexigten Banner and Bairin Left Banner.We conducted surveys to assess the levels of heavy metal(loid)s(Cr,As,Pb,Cd,and Hg)in the topsoil and groundwater of the areas.The results indicated that the concentrations of As,Cd,and Pb in partial soil samples exceeded the environmental quality standards of Grade II.Based on contamination assessments,such as geoaccumulation indices and pollution indices,we inferred that Cd,Pb,and As were primary pollutants in topsoil.Potential ecological risks when considered as part of the average risk indices(RI)are up to 1626.40 and 2818.76,respectively,in the two areas.Comparative analysis revealed that Cd posed a very high potential ecological risk,followed by As.Moreover,the evaluation showed that the three exposure pathways of carcinogenic and non-carcinogenic risk followed a descending order:inhalation>ingestion>dermal contact,except for Pb.Arsenic in topsoil posed a potential non-carcinogenic risk to human health,while there were no adverse efects of As in groundwater.In addition,the average total carcinogenic risk for As in the two areas,as well as the risk of Pb in the topsoil of Bairin Left Banner and all the fve heavy metal(loid)s in groundwater,exceeded human tolerance.Pb–Zn mines caused higher human health risks.In addition,the tandem contamination of heavy metal(loid)s in soil and groundwater was not obvious.This research study provides a basis for pollution remediation to control heavy industry-induced ecological and health risks of heavy metal(loid)s.
文摘In order to understand the current demand of the medical staffs for nursing workers in Chifeng and to explore the practical management mode of nursing workers,150 doctors and nurses were randomly selected from general tertiary hospitals in Chifeng to participate in a questionnaire survey.The objective of this study was to investigate the demand of nursing workers in tertiary hospitals in Chifeng and the satisfaction of medical staffs toward the existing nursing work.The results of the investigation were analyzed to provide countermeasures and suggestions for the nursing work in Chifeng.
基金Research on Local Knowledge Mapping and Planning Application Strategies of Traditional Rural in Qinba Mountains(No.19YJAZH107)Humanities and Social Sciences Research Planning Fund,Ministry of Education,China.
文摘To solve the problems of rural revitalization performance research,a quantitative model of non-oriented range-wide EBM(Epsilon-Based Measure)-GML(Global-Malmquist)based on VRS(Variable Returns to Scale)conditions including non-desired outputs is constructed.A comprehensive spatio-temporal heterogeneity research index system of rural revitalization performance is also constructed.Taking the typical rural in Chifeng City as an example,the panel data from 2016-2020 are selected for empirical analysis,the conclusions and countermeasures are suggested as follows:1)In general,the rural revitalization performance of Chifeng City increases significantly during the five-year period,with significant spatio-temporal heterogeneity.The overall analysis shows that the overall performance value of rural revitalization in Chifeng City is 0.683 from 2016 to 2020.The highest performance value is 1 and the lowest performance value is 0.389.The performance growth rate increases year by year,with an average annual growth rate of 4.46%.2)From 2016 to 2020,the GML index of rural revitalization performance in Chifeng City is 1.174,showing an increasing trend.Based on the range of change of GML index,Chifeng City can be classified into three types:Continuous improvement,fluctuating improvement and fluctuating decline.3)Niujiayingzi,Guandongche,Zhaidamu,and Qiangangtai rural have the highest degree of technological progress.
基金Supported by the National Natural Science Foundation of China (Grant Nos. 40102017, 40572123 and the 40472101)Doctoral Programme of Higher Educa-tion (Grant No. 2000000128)
文摘The Louzidian ductile shear zone at the south of Chifeng strikes NE-SW and dips SE at low-medium- angles. This ductile shear zone is mainly composed of granitic mylonite, which grades structurally upward into a chloritized zone, a microbreccia zone, a brittle fault and a gouge zone. All these zones share similar planar attitudes, but contain different linear attitudes and kinematic indicators. Finite strain measurements were performed on feldspar porphyroclasts using the Fry method. These meas- urements yield Fulin indexes of 1.25―3.30, Lode's parameters of -0.535―-0.112 and strain parameters of 0.41―0.75 for the protomylonite, respectively. These data are plotted within the apparent constric- tional field in Fulin and Hossack diagrams. In contrast, for the mylonite, corresponding parameters are 0.99―1.43, -0.176―-0.004 and 0.63―0.82, respectively, and located in the apparent constrictional field close to the plane strain. The mean kinematic vorticity numbers of the protomylonite and mylonite by using three methods of polar Mohr circle, porphyroclast hyperbolic and oblique foliation, are in the range of 0.67―0.95, suggesting that the ductile shearing is accommodated by general shearing that is dominated by simple shear. Combination of the finite strain and kinematic vorticity indicates that shear type was lengthening shear and resulted in L-tectonite at the initial stage of deformation and the shear type gradually changed into lengthening-thinning shear and produced L-S-tectonite with the uplifting of the shear zone and accumulating of strain. These kinds of shear types only produce a/ab strain facies, so the lineation in the ductile shear zone could not deflect 90° in the progressively deformation.
文摘Objective To explore the effect of Modified Hangqi Chifeng Decoction(MHCD)on levels of collagen typeⅣ(ColⅣ),matrix metalloproteinase-2(MMP-2),tissue inhibitor of metalloproteinase-2(TIMP-2)in extracellular matrix(ECM)of glomerular mesangial cells(GMCs)in LPS induced mice.Methods Normal serum and telmisartan,high,medium,low dose MHCD containing
文摘As'China’s hometown of nonferrous metals',Chifeng City is the biggest concentration zone in Inner Mongolia’s nonferrous metals industry.Copper resources accounts for 17% of the whole region,lead resource accounts for 35%,zinc resource accounts for 30%,tungsten resource accounts for 42%,tin resource accounts for 88%,molybdenum resource accounts for 15%,gold resource accounts
