The classical chi-squared goodness of fit test assumes the number of classes is fixed,meanwhile the test statistic has a limiting chi-square distribution under the null hypothesis.It is well known that the number of c...The classical chi-squared goodness of fit test assumes the number of classes is fixed,meanwhile the test statistic has a limiting chi-square distribution under the null hypothesis.It is well known that the number of classes varying with sample size in the test has attached more and more attention.However,in this situation,there is not theoretical results for the asymptotic property of such chi-squared test statistic.This paper proves the consistency of chi-squared test with varying number of classes under some conditions.Meanwhile,the authors also give a convergence rate of KolmogorovSimirnov distance between the test statistic and corresponding chi-square distributed random variable.In addition,a real example and simulation results validate the reasonability of theoretical result and the superiority of chi-squared test with varying number of classes.展开更多
A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function an...A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function and cumulative distribution function is presented. The statistical features of the Generalized Kumaraswamy Generalized Power Gompertz distribution are systematically derived and adequately studied. The estimation of the model parameters in the absence of censoring and under-right censoring is performed using the method of maximum likelihood. The test statistic for right-censored data, criteria test for GKGPG distribution, estimated matrix Ŵ, Ĉ, and Ĝ, criteria test Y<sup>2</sup>n</sub>, alongside the quadratic form of the test statistic is derived. Mean simulated values of maximum likelihood estimates and their corresponding square mean errors are presented and confirmed to agree closely with the true parameter values. Simulated levels of significance for Y<sup>2</sup>n</sub> (γ) test for the GKGPG model against their theoretical values were recorded. We conclude that the null hypothesis for which simulated samples are fitted by GKGPG distribution is widely validated for the different levels of significance considered. From the summary of the results of the strength of a specific type of braided cord dataset on the GKGPG model, it is observed that the proposed GKGPG model fits the data set for a significance level ε = 0.05.展开更多
Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining...Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining technique that overcomes these issues by using impact to create strong bonds without melting the substrate materials.This study investigates the weldability of aluminum alloy Al-5754 with Al-7075 and MARS 380 steel,used in armouring solutions of defense systems,by the use of MPW.In this work,weldability windows are investigated by varying standoff distances between the coating material and its substrate(0.25-4.5 mm)and discharge energies(5-13 kJ)with both O-shape and U-shape inductors.Mechanical strength of the welded joints were assessed through single lap shear tests,identifying optimal welding parameters.Then,the velocity profiles of the flyer plates were measured using heterodyne velocimetry to understand the dynamics of the impact.Then,substructures assembled with the optimal welding conditions were subjected to ballistic testing using 7.62 mm×51 mm NATO and 9 mm×19 mm Parabellum munitions to evaluate the resilience of the welds under ballistic impact.The outcomes demonstrate that MPW effectively joins Al-5754 with both Al-7075 and MARS 380,producing robust welds capable of withstanding ballistic impacts under certain conditions.This research advances the application of MPW in lightweight ballistic protection of defense systems,contributing to the development of more resilient and lighter protective structures.展开更多
It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and er...It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and erythropoietic protoporphyria(EPP),which has not been previously documented.CASE SUMMARY We present a rare case of coexisting GS and EPP in a 23-year-old Chinese male with a long history of jaundice and recently found splenomegaly.Serial nonspecific hemolysis screening tests yielded inconsistent results,and investigations for common hemolytic etiologies were negative.However,Levitt’s carbon monoxide breath test,which measures erythrocyte lifespan(the gold-standard marker of hemolysis),demonstrated significant hemolysis,revealing a markedly shortened erythrocyte lifespan of 11 days(normal average 120 days).Genetic testing subsequently confirmed EPP with a homozygous ferrochelatase gene mutation and GS with a heterozygous uridine diphosphate glucuronosyl trans-ferase 1A1 gene mutation.CONCLUSION The rapid,non-invasive Levitt’s carbon monoxide breath test resolved the diagnostic challenge posed by a rare and complex cause of hyperbilirubinemia.展开更多
Modeling non coding background sequences appropriately is important for the detection of regulatory elements from DNA sequences. Based on the chi square statistic test, some explanations about why to choose higher ...Modeling non coding background sequences appropriately is important for the detection of regulatory elements from DNA sequences. Based on the chi square statistic test, some explanations about why to choose higher order Markov chain model and how to automatically select the proper order are given in this paper. The chi square test is first run on synthetic data sets to show that it can efficiently find the proper order of Markov chain. Using chi square test, distinct higher order context dependences inherent in ten sets of sequences of yeast S.cerevisiae from other literature have been found. So the Markov chain with higher order would be more suitable for modeling the non coding background sequences than an independent model.展开更多
The application of frequency distribution statistics to data provides objective means to assess the nature of the data distribution and viability of numerical models that are used to visualize and interpret data.Two c...The application of frequency distribution statistics to data provides objective means to assess the nature of the data distribution and viability of numerical models that are used to visualize and interpret data.Two commonly used tools are the kernel density estimation and reduced chi-squared statistic used in combination with a weighted mean.Due to the wide applicability of these tools,we present a Java-based computer application called KDX to facilitate the visualization of data and the utilization of these numerical tools.展开更多
X-ray pulsar-based navigation is a revolutionary technology which is capable of providing the required navigation information in the solar system. Performing as an important pulsar-based navigation technique, the Sign...X-ray pulsar-based navigation is a revolutionary technology which is capable of providing the required navigation information in the solar system. Performing as an important pulsar-based navigation technique, the Significance Enhancement of Pulse-profile with Orbit-dynamics(SEPO)can estimate orbital elements by using the distortion of pulse profile. Based on the SEPO technique,we propose a grouping bi-chi-squared technique and adopt the observations of Rossi X-ray Timing Explorer(RXTE) to carry out experimental verification. The pulsar timing is refined to determine spin parameters of the Crab pulsar(PSR B0531+21) during the observation periods, and a short-term dynamic model for RXTE satellite is established by considering the effects of diverse perturbations.Experimental results suggest that the position and velocity errors are 16.3 km(3σ) and 13.3 m/s(3σ) with two adjacent observations split by one day(exposure time of 1.5 ks), outperforming those of the POLAR experiment whose results are 19.2 km(3σ) and 432 m/s(3σ). The approach provided is particularly applicable to the estimation of orbital elements via using high-flux observations.展开更多
We study the asymptotics tot the statistic of chi-square in type Ⅱ error. By the contraction principle, the large deviations and moderate deviations are obtained, and the rate function of moderate deviations can be c...We study the asymptotics tot the statistic of chi-square in type Ⅱ error. By the contraction principle, the large deviations and moderate deviations are obtained, and the rate function of moderate deviations can be calculated explicitly which is a squared function.展开更多
In large sample studies where distributions may be skewed and not readily transformed to symmetry, it may be of greater interest to compare different distributions in terms of percentiles rather than means. For exampl...In large sample studies where distributions may be skewed and not readily transformed to symmetry, it may be of greater interest to compare different distributions in terms of percentiles rather than means. For example, it may be more informative to compare two or more populations with respect to their within population distributions by testing the hypothesis that their corresponding respective 10th, 50th, and 90th percentiles are equal. As a generalization of the median test, the proposed test statistic is asymptotically distributed as Chi-square with degrees of freedom dependent upon the number of percentiles tested and constraints of the null hypothesis. Results from simulation studies are used to validate the nominal 0.05 significance level under the null hypothesis, and asymptotic power properties that are suitable for testing equality of percentile profiles against selected profile discrepancies for a variety of underlying distributions. A pragmatic example is provided to illustrate the comparison of the percentile profiles for four body mass index distributions.展开更多
Zero-inflated distributions are common in statistical problems where there is interest in testing homogeneity of two or more independent groups. Often, the underlying distribution that has an inflated number of zero-v...Zero-inflated distributions are common in statistical problems where there is interest in testing homogeneity of two or more independent groups. Often, the underlying distribution that has an inflated number of zero-valued observations is asymmetric, and its functional form may not be known or easily characterized. In this case, comparisons of the groups in terms of their respective percentiles may be appropriate as these estimates are nonparametric and more robust to outliers and other irregularities. The median test is often used to compare distributions with similar but asymmetric shapes but may be uninformative when there are excess zeros or dissimilar shapes. For zero-inflated distributions, it is useful to compare the distributions with respect to their proportion of zeros, coupled with the comparison of percentile profiles for the observed non-zero values. A simple chi-square test for simultaneous testing of these two components is proposed, applicable to both continuous and discrete data. Results of simulation studies are reported to summarize empirical power under several scenarios. We give recommendations for the minimum sample size which is necessary to achieve suitable test performance in specific examples.展开更多
NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a nec...NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a necessary option for the detection of existing exhaust emission standards. At present, there is limited and scattered information on knowledge and test methods of NOx sensors, the research of NOx sensors has become a challenging research topic at home and abroad. Based on these requirements, the article systematically integrates the knowledge of principle and testing methods. First of all, through introducing functional description of NOx sensors and the basic principle of NOx sensors, the relevant scholars can have an overall understanding of the product and master the operation mode of products. Secondly, the current status of performance test bench and methods of NOx sensors were described, which can contribute to having a clear understanding of the development process. After that, a new structure of NOx sensors test bench was purposed, which contains six major units including standard gas source, gas mixing unit, analyzer measurement unit, sensor measurement unit, data processing and display unit, exhaust gas treatment unit. And the test bench was validated. The experimental results show that the test bench has the advantages of high-repeatability, high reliability and low cost. And it can realize automatic detection of multiple target values, which is worthy further promotion. Thereby, the article can contribute to the development of its technology indirectly.展开更多
Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely int...Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely integrated into routine clinical diagnostics of gastric cancer to guide personalized treatment.Human epidermal growth factor receptor 2(HER2)was the first molecular biomarker to be used in gastric cancer with trastuzumab being the first approved targeted therapy for HER2-positive gastric cancer.Programmed death-ligand 1 positivity and microsatellite instability can guide the use of immunotherapies,such as pembrolizumab and nivolumab.More recently,zolbetuximab has been approved for patients with claudin 18.2-positive diseases in some countries.More targeted therapies,including savolitinib for MET-positive patients,are currently under clinical investigation.However,the clinical application of these diagnostic approaches could be hampered by many existing challenges,including invasive and costly sampling methods,variability in immunohistochemistry interpretation,high costs and long turnaround times for next-generation sequencing,the absence of standardized and clinically validated diagnostic cut-off values for some biomarkers,and tumor heterogeneity.Novel testing and analysis techniques,such as artificial intelligence-assisted image analysis and multiplex immunohistochemistry,and emerging therapeutic strategies,including combination therapies that integrate immune checkpoint inhibitors with targeted therapies,offer potential solutions to some of these challenges.This article reviews recent progress in gastric cancer testing,outlines current challenges,and explores future directions for biomarker testing and targeted therapy for gastric cancer.展开更多
The rapid progress in the construction of heavy-haul and high-speed railways has led to a surge in rail defects and unforeseen failures.Addressing this issue necessitates the implementation of more sophisticated rail ...The rapid progress in the construction of heavy-haul and high-speed railways has led to a surge in rail defects and unforeseen failures.Addressing this issue necessitates the implementation of more sophisticated rail inspection methods,specifically involving real-time,precise detection,and assessment of rail defects.Current applications fail to address the evolving requirements,prompting the need for advancements.This paper provides a summary of various types of rail defects and outlines both traditional and innovative non-destructive inspection techniques,examining their fundamental features,benefits,drawbacks,and practical suitability for railway track inspection.It also explores potential enhancements to equipment and software.The comprehensive review draws upon pertinent international research and review papers.Furthermore,the paper introduces a fusion of inspection methods aimed at enhancing the overall reliability of defect detection.展开更多
The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analys...The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.展开更多
The mechanical behavior of cohesive soil is sensitized to drying-wetting cycles under confinements.However,the hydromechanical coupling effect has not been considered in current constitutive models.A macro-micro analy...The mechanical behavior of cohesive soil is sensitized to drying-wetting cycles under confinements.However,the hydromechanical coupling effect has not been considered in current constitutive models.A macro-micro analysis scheme is proposed in this paper to investigate the soil deformation behavior under the coupling of stress and drying-wetting cycles.A new device is developed based on CT(computerized tomography)workstation to apply certain normal and shear stresses on a soil specimen during drying-wetting cycles.A series of tests are conducted on a type of loess with various coupling of stress paths and drying-wetting cycles.At macroscopic level,stress sensor and laser sensor are used to acquire stress and strain,respectively.The shear and volumetric strain increase during the first few drying-wetting cycles and then become stable.The increase of the shear stress level or confining pressure would cause higher increase rate and the value of shear strain in the process of drying-wetting cycles.At microscopic level,the grayscale value(GSV)of CT scanning image is characterized as the proportion of soil particles to voids.A fabric state parameter is proposed to characterize soil microstructures under the influence of stress and drying-wetting cycle.Test results indicate that the macroand micro-responses show high consistence and relevance.The stress and drying-wetting cycles would both induce collapse of the soil microstructure,which dominants degradation of the soil mechanical properties.The evolution of the macro-mechanical property of soil exhibits a positive linear relationship with the micro-evolution of the fabric state parameter.展开更多
基金supported by the Natural Science Foundation of China under Grant Nos.11071022,11028103,11231010,11471223,BCMIISthe Beijing Municipal Educational Commission Foundation under Grant Nos.KZ201410028030,KM201210028005Jishou University Subject in 2014(No:14JD035)
文摘The classical chi-squared goodness of fit test assumes the number of classes is fixed,meanwhile the test statistic has a limiting chi-square distribution under the null hypothesis.It is well known that the number of classes varying with sample size in the test has attached more and more attention.However,in this situation,there is not theoretical results for the asymptotic property of such chi-squared test statistic.This paper proves the consistency of chi-squared test with varying number of classes under some conditions.Meanwhile,the authors also give a convergence rate of KolmogorovSimirnov distance between the test statistic and corresponding chi-square distributed random variable.In addition,a real example and simulation results validate the reasonability of theoretical result and the superiority of chi-squared test with varying number of classes.
文摘A new six-parameter continuous distribution called the Generalized Kumaraswamy Generalized Power Gompertz (GKGPG) distribution is proposed in this study, a graphical illustration of the probability density function and cumulative distribution function is presented. The statistical features of the Generalized Kumaraswamy Generalized Power Gompertz distribution are systematically derived and adequately studied. The estimation of the model parameters in the absence of censoring and under-right censoring is performed using the method of maximum likelihood. The test statistic for right-censored data, criteria test for GKGPG distribution, estimated matrix Ŵ, Ĉ, and Ĝ, criteria test Y<sup>2</sup>n</sub>, alongside the quadratic form of the test statistic is derived. Mean simulated values of maximum likelihood estimates and their corresponding square mean errors are presented and confirmed to agree closely with the true parameter values. Simulated levels of significance for Y<sup>2</sup>n</sub> (γ) test for the GKGPG model against their theoretical values were recorded. We conclude that the null hypothesis for which simulated samples are fitted by GKGPG distribution is widely validated for the different levels of significance considered. From the summary of the results of the strength of a specific type of braided cord dataset on the GKGPG model, it is observed that the proposed GKGPG model fits the data set for a significance level ε = 0.05.
基金funded on the one hand by Agence de l'Innovation de Défense(AID)grant reference number 2021650044on the other hand by Ecole Centrale de Nantes。
文摘Joining dissimilar materials encounters significant engineering challenges due to the contrast in material properties that makes conventional welding not feasible.Magnetic Pulse Welding(MPW)offers a solidstate joining technique that overcomes these issues by using impact to create strong bonds without melting the substrate materials.This study investigates the weldability of aluminum alloy Al-5754 with Al-7075 and MARS 380 steel,used in armouring solutions of defense systems,by the use of MPW.In this work,weldability windows are investigated by varying standoff distances between the coating material and its substrate(0.25-4.5 mm)and discharge energies(5-13 kJ)with both O-shape and U-shape inductors.Mechanical strength of the welded joints were assessed through single lap shear tests,identifying optimal welding parameters.Then,the velocity profiles of the flyer plates were measured using heterodyne velocimetry to understand the dynamics of the impact.Then,substructures assembled with the optimal welding conditions were subjected to ballistic testing using 7.62 mm×51 mm NATO and 9 mm×19 mm Parabellum munitions to evaluate the resilience of the welds under ballistic impact.The outcomes demonstrate that MPW effectively joins Al-5754 with both Al-7075 and MARS 380,producing robust welds capable of withstanding ballistic impacts under certain conditions.This research advances the application of MPW in lightweight ballistic protection of defense systems,contributing to the development of more resilient and lighter protective structures.
文摘It is challenging to diagnose isolated hyperbilirubinemia with rare and complex etiologies under the constraints of traditional testing conditions.Herein,we present a rare case of coexisting Gilbert syndrome(GS)and erythropoietic protoporphyria(EPP),which has not been previously documented.CASE SUMMARY We present a rare case of coexisting GS and EPP in a 23-year-old Chinese male with a long history of jaundice and recently found splenomegaly.Serial nonspecific hemolysis screening tests yielded inconsistent results,and investigations for common hemolytic etiologies were negative.However,Levitt’s carbon monoxide breath test,which measures erythrocyte lifespan(the gold-standard marker of hemolysis),demonstrated significant hemolysis,revealing a markedly shortened erythrocyte lifespan of 11 days(normal average 120 days).Genetic testing subsequently confirmed EPP with a homozygous ferrochelatase gene mutation and GS with a heterozygous uridine diphosphate glucuronosyl trans-ferase 1A1 gene mutation.CONCLUSION The rapid,non-invasive Levitt’s carbon monoxide breath test resolved the diagnostic challenge posed by a rare and complex cause of hyperbilirubinemia.
文摘Modeling non coding background sequences appropriately is important for the detection of regulatory elements from DNA sequences. Based on the chi square statistic test, some explanations about why to choose higher order Markov chain model and how to automatically select the proper order are given in this paper. The chi square test is first run on synthetic data sets to show that it can efficiently find the proper order of Markov chain. Using chi square test, distinct higher order context dependences inherent in ten sets of sequences of yeast S.cerevisiae from other literature have been found. So the Markov chain with higher order would be more suitable for modeling the non coding background sequences than an independent model.
文摘The application of frequency distribution statistics to data provides objective means to assess the nature of the data distribution and viability of numerical models that are used to visualize and interpret data.Two commonly used tools are the kernel density estimation and reduced chi-squared statistic used in combination with a weighted mean.Due to the wide applicability of these tools,we present a Java-based computer application called KDX to facilitate the visualization of data and the utilization of these numerical tools.
基金the National Natural Science Foundation of China(No.62103313)the Space Optoelectronic Measurement&Perception Laboratory of BICE,China(No.LabSOMP-2020-06)the Central Universities,China(No.JC2007).
文摘X-ray pulsar-based navigation is a revolutionary technology which is capable of providing the required navigation information in the solar system. Performing as an important pulsar-based navigation technique, the Significance Enhancement of Pulse-profile with Orbit-dynamics(SEPO)can estimate orbital elements by using the distortion of pulse profile. Based on the SEPO technique,we propose a grouping bi-chi-squared technique and adopt the observations of Rossi X-ray Timing Explorer(RXTE) to carry out experimental verification. The pulsar timing is refined to determine spin parameters of the Crab pulsar(PSR B0531+21) during the observation periods, and a short-term dynamic model for RXTE satellite is established by considering the effects of diverse perturbations.Experimental results suggest that the position and velocity errors are 16.3 km(3σ) and 13.3 m/s(3σ) with two adjacent observations split by one day(exposure time of 1.5 ks), outperforming those of the POLAR experiment whose results are 19.2 km(3σ) and 432 m/s(3σ). The approach provided is particularly applicable to the estimation of orbital elements via using high-flux observations.
基金the National Natural Science Foundation of China (10571139)
文摘We study the asymptotics tot the statistic of chi-square in type Ⅱ error. By the contraction principle, the large deviations and moderate deviations are obtained, and the rate function of moderate deviations can be calculated explicitly which is a squared function.
文摘In large sample studies where distributions may be skewed and not readily transformed to symmetry, it may be of greater interest to compare different distributions in terms of percentiles rather than means. For example, it may be more informative to compare two or more populations with respect to their within population distributions by testing the hypothesis that their corresponding respective 10th, 50th, and 90th percentiles are equal. As a generalization of the median test, the proposed test statistic is asymptotically distributed as Chi-square with degrees of freedom dependent upon the number of percentiles tested and constraints of the null hypothesis. Results from simulation studies are used to validate the nominal 0.05 significance level under the null hypothesis, and asymptotic power properties that are suitable for testing equality of percentile profiles against selected profile discrepancies for a variety of underlying distributions. A pragmatic example is provided to illustrate the comparison of the percentile profiles for four body mass index distributions.
文摘Zero-inflated distributions are common in statistical problems where there is interest in testing homogeneity of two or more independent groups. Often, the underlying distribution that has an inflated number of zero-valued observations is asymmetric, and its functional form may not be known or easily characterized. In this case, comparisons of the groups in terms of their respective percentiles may be appropriate as these estimates are nonparametric and more robust to outliers and other irregularities. The median test is often used to compare distributions with similar but asymmetric shapes but may be uninformative when there are excess zeros or dissimilar shapes. For zero-inflated distributions, it is useful to compare the distributions with respect to their proportion of zeros, coupled with the comparison of percentile profiles for the observed non-zero values. A simple chi-square test for simultaneous testing of these two components is proposed, applicable to both continuous and discrete data. Results of simulation studies are reported to summarize empirical power under several scenarios. We give recommendations for the minimum sample size which is necessary to achieve suitable test performance in specific examples.
文摘NOx sensors, as a core component of diesel engine exhaust treatment system, play an important role in exhaust emission control, which can accurately and quickly detect the NOx and O2 concentration. It has become a necessary option for the detection of existing exhaust emission standards. At present, there is limited and scattered information on knowledge and test methods of NOx sensors, the research of NOx sensors has become a challenging research topic at home and abroad. Based on these requirements, the article systematically integrates the knowledge of principle and testing methods. First of all, through introducing functional description of NOx sensors and the basic principle of NOx sensors, the relevant scholars can have an overall understanding of the product and master the operation mode of products. Secondly, the current status of performance test bench and methods of NOx sensors were described, which can contribute to having a clear understanding of the development process. After that, a new structure of NOx sensors test bench was purposed, which contains six major units including standard gas source, gas mixing unit, analyzer measurement unit, sensor measurement unit, data processing and display unit, exhaust gas treatment unit. And the test bench was validated. The experimental results show that the test bench has the advantages of high-repeatability, high reliability and low cost. And it can realize automatic detection of multiple target values, which is worthy further promotion. Thereby, the article can contribute to the development of its technology indirectly.
基金support by grants from Capital’s Funds for Health Improvement and Research(Grant No.2024-2-1024)Beijing Natural Science Foundation(Grant No.7232018).
文摘Advances in the identification of molecular biomarkers and the development of targeted therapies have enhanced the prognosis of patients with advanced gastric cancer.Several established biomarkers have been widely integrated into routine clinical diagnostics of gastric cancer to guide personalized treatment.Human epidermal growth factor receptor 2(HER2)was the first molecular biomarker to be used in gastric cancer with trastuzumab being the first approved targeted therapy for HER2-positive gastric cancer.Programmed death-ligand 1 positivity and microsatellite instability can guide the use of immunotherapies,such as pembrolizumab and nivolumab.More recently,zolbetuximab has been approved for patients with claudin 18.2-positive diseases in some countries.More targeted therapies,including savolitinib for MET-positive patients,are currently under clinical investigation.However,the clinical application of these diagnostic approaches could be hampered by many existing challenges,including invasive and costly sampling methods,variability in immunohistochemistry interpretation,high costs and long turnaround times for next-generation sequencing,the absence of standardized and clinically validated diagnostic cut-off values for some biomarkers,and tumor heterogeneity.Novel testing and analysis techniques,such as artificial intelligence-assisted image analysis and multiplex immunohistochemistry,and emerging therapeutic strategies,including combination therapies that integrate immune checkpoint inhibitors with targeted therapies,offer potential solutions to some of these challenges.This article reviews recent progress in gastric cancer testing,outlines current challenges,and explores future directions for biomarker testing and targeted therapy for gastric cancer.
文摘The rapid progress in the construction of heavy-haul and high-speed railways has led to a surge in rail defects and unforeseen failures.Addressing this issue necessitates the implementation of more sophisticated rail inspection methods,specifically involving real-time,precise detection,and assessment of rail defects.Current applications fail to address the evolving requirements,prompting the need for advancements.This paper provides a summary of various types of rail defects and outlines both traditional and innovative non-destructive inspection techniques,examining their fundamental features,benefits,drawbacks,and practical suitability for railway track inspection.It also explores potential enhancements to equipment and software.The comprehensive review draws upon pertinent international research and review papers.Furthermore,the paper introduces a fusion of inspection methods aimed at enhancing the overall reliability of defect detection.
文摘The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.
基金funded by National Key R&D Program of China(Grant No.2023YFC3007001)Beijing Natural Science Foundation(Grant No.8244053)China Postdoctoral Science Foundation(Grant No.2024M754065).
文摘The mechanical behavior of cohesive soil is sensitized to drying-wetting cycles under confinements.However,the hydromechanical coupling effect has not been considered in current constitutive models.A macro-micro analysis scheme is proposed in this paper to investigate the soil deformation behavior under the coupling of stress and drying-wetting cycles.A new device is developed based on CT(computerized tomography)workstation to apply certain normal and shear stresses on a soil specimen during drying-wetting cycles.A series of tests are conducted on a type of loess with various coupling of stress paths and drying-wetting cycles.At macroscopic level,stress sensor and laser sensor are used to acquire stress and strain,respectively.The shear and volumetric strain increase during the first few drying-wetting cycles and then become stable.The increase of the shear stress level or confining pressure would cause higher increase rate and the value of shear strain in the process of drying-wetting cycles.At microscopic level,the grayscale value(GSV)of CT scanning image is characterized as the proportion of soil particles to voids.A fabric state parameter is proposed to characterize soil microstructures under the influence of stress and drying-wetting cycle.Test results indicate that the macroand micro-responses show high consistence and relevance.The stress and drying-wetting cycles would both induce collapse of the soil microstructure,which dominants degradation of the soil mechanical properties.The evolution of the macro-mechanical property of soil exhibits a positive linear relationship with the micro-evolution of the fabric state parameter.
