Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ...Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.展开更多
Objective:To evaluate the efficacy and safety of traditional Chinese exercises(TCE)in patients with diabetic peripheral neuropathy(DPN)and to recommend best practices for using TCE to improve neurological function,gly...Objective:To evaluate the efficacy and safety of traditional Chinese exercises(TCE)in patients with diabetic peripheral neuropathy(DPN)and to recommend best practices for using TCE to improve neurological function,glycemic control,and psychological well-being.Methods:Nine databases were searched from the inception to October 2024.Effect relationships were assessed using meta-analysis with Stata 17,and the methodological quality and certainty of the evidence were evaluated using standard tools.Results:Twelve studies comprising three study designs(nine randomized controlled,one quasi-exper-imental controlled,and two single-arm clinical trials),were identified.Compared with usual care,TCE improved various indicators and enhanced the nerve conduction velocities of the peroneal motor(mean difference[MD]=3.86 m/s,95%confidence interval[CI]:0.38 to 7.34,P=0.03),sural sensory(MD=4.15 m/s,95%CI:0.68 to 7.63,P=0.02),median motor(MD=3.84 m/s,95%CI:2.14 to 5.54,P<.001),and median sensory nerves(MD=6.14 m/s,95%CI:4.54 to 7.74,P<.001).TCE practices also reduced glycosylated hemoglobin level(MD=-0.59%,95%CI:-0.91 to-0.27,P<.001)and fasting blood glucose(standardized mean difference[SMD]=-1.08,95%CI:-1.79 to-0.37,P<.001).The overall quality of evidence was very low.Conclusion:The results indicate that TCE therapy improves certain outcomes in patients with DPN.Although the optimal type,intensity,frequency,and duration of TCE interventions are uncertain,these preliminary findings suggest that TCE should be further studied as a potentially affordable and effective treatment for DPN.展开更多
Background:This study examined the development of Tai Chi in Ottawa,Canada,focusing on:(1)traditions and modernization of Tai Chi in China's mainland;(2)the evolution of Ottawa’s Chinese community;and(3)the role ...Background:This study examined the development of Tai Chi in Ottawa,Canada,focusing on:(1)traditions and modernization of Tai Chi in China's mainland;(2)the evolution of Ottawa’s Chinese community;and(3)the role of Ottawa Tai Chi Chuan Association(OTCA)and Taoist Tai Chi Society(TTCS)-in promoting Tai Chi and traditional health practices rooted in Traditional Chinese Medicine(TCM)in Ottawa.Methods:Archive research was used to investigate origins,organizational structures,and programs of the associations.Documents were obtained from the personal collections,websites,and Ottawa Archives.Secondary literature on Tai Chi’s history in China and Chinese immigration to Ottawa provided contextual insights.Results:In the twentieth century,Tai Chi in China's mainland underwent significant transformations,aligning with nation-building,social reform,public health promotion,and cultural influence.Since the 1970s,the demographic composition of Canada’s Chinese community has become diversified.Some community members played a critical role in transmitting Tai Chi to Canada by establishing OTCA and TTCS.Through a variety of Tai Chi programs,workshops,and community engagement,OTCA and TTCS promoted Tai Chi as a holistic health practice rooted in TCM and traditional cultural principles in different approaches.OTCA primarily served the Chinese community,focusing on diverse forms,techniques,and theories.In contrast,Ottawa’s TTCS,as a satellite association,emphasized Taoist-inspired Tai Chi and cultivation passed down by the founder,Moy Linshin,to accommodate members from diverse cultural backgrounds.OTCA and TTCS created inclusive mind-body communities for individuals to engage in Tai Chi as a culturally meaningful practice and a means of fostering social connection and holistic wellness.Conclusion:OTCA and TTCS significantly revitalized while adapted Tai Chi and TCM practices to Western contexts,integrating its historical roots with western health ideas to establish it as a widely recognized mind-body discipline and alternative therapy.展开更多
Languages come from lives of people and characters are the conventional text symbol system in society.There are thou⁃sands of languages around the world,only less than half of which own the corresponding characters,an...Languages come from lives of people and characters are the conventional text symbol system in society.There are thou⁃sands of languages around the world,only less than half of which own the corresponding characters,and Chinese is one of the lan⁃guages that has the corresponding characters.Chinese characters are not only still in use today but also are the oldest and best pre⁃served characters all over the world,which because of the close connection with Han nationality and Han culture.The paper ex⁃plores the origin of Chinese pronunciation,the origin of Chinese writing,the development of Chinese,and the connection between Chinese and Han culture.Also,it is important and significant for people to know how to protect our own languages.展开更多
Tai Chi,a practice that combines elements of both exercise and mindfulness,offers a wide range of health benefits.The body of evidence concerning the impact of Tai Chi on diabetes has recently been growing.This editor...Tai Chi,a practice that combines elements of both exercise and mindfulness,offers a wide range of health benefits.The body of evidence concerning the impact of Tai Chi on diabetes has recently been growing.This editorial aims to provide a concise summary of the current state of evidence for Tai Chi's effects on individuals with type 2 diabetes(T2D).The review includes 3 randomized controlled trials(RCTs)and 5 systematic reviews and meta-analyses,all of which investigate the effectiveness of Tai Chi on various health outcomes in individuals with T2D.Tai Chi demonstrates a significant effect to enhance glycemic control,lower blood pressure,improve serum lipid profiles,reduce insulin resistance,positively influence obesity-related indices,and improve overall quality of life in individuals with T2D.However,it is noteworthy that recent RCTs have reported inconsistent findings regarding the effects of Tai Chi on glycemic control and insulin resistance.The author also delves into potential mechanisms by which Tai Chi may exert its influence on the human body.Finally,the editorial highlights the critical issues that warrant further exploration in the future.展开更多
Objective To evaluate the effect of Tai Chi and Qigong on patients with lumbar disc herniation(LDH).Methods Relevant data were retrieved from nine English and Chinese databases,including Cochrane Library,PubMed,and Wa...Objective To evaluate the effect of Tai Chi and Qigong on patients with lumbar disc herniation(LDH).Methods Relevant data were retrieved from nine English and Chinese databases,including Cochrane Library,PubMed,and Wanfang Data,etc.from inception to June 2024.All published randomized controlled trials assessing the effect of Tai Chi and Qigong on visual analog scale(VAS),Japanese Orthopedic Association(JOA)score,and other health indicators in participants with LDH compared to usual medical care or other treatments were included.Grey literature,trials involving the pushing of hands(Tui Shou)or Tai Chi with weapons,and trials with co-interventions(Tai Chi/Qigong plus another treatment)were excluded.Methodological quality was analyzed using the Cochrane risk of bias tool,and evidence quality was assessed using the Grading of Recommendations,Assessment,Development,and Evaluations(GRADE)tool.Results Fourteen trials(954 patients)were included in this study.Tai Chi and Qigong were associated with lower VAS pain scores(standardized mean difference−0.55,95%confidence interval[CI]−0.95 to−0.15,P=0.01),higher JOA scores(mean difference[MD]4.40,95%CI 2.62 to 6.18,P<.001)and straight leg raise test results(MD 9.40°,95%CI 7.64 to 11.15,P<0.001)in patients with LDH.Furthermore,compared with usual care,Tai Chi and Qigong showed enhanced effects on pain and JOA scores.When compared to other exercises or massage,the effect on pain scores was similar but that on JOA scores was significant.Conclusions Tai Chi and Qigong may have favorable effects on VAS pain and JOA scores compared with usual care,and on JOA scores compared with other exercises or massage in patients with LDH.Given the overall poor quality of the evidence,the results of current study should be interpreted cautiously.展开更多
High-energy-density fuels are important for volume-limited aerospace vehicles,but the increase in fuel energy density always leads to poor cryogenic performance.Herein,we investigated the transposed Paternò-B...High-energy-density fuels are important for volume-limited aerospace vehicles,but the increase in fuel energy density always leads to poor cryogenic performance.Herein,we investigated the transposed Paternò-Büchi reaction of biomass cyclic ketone and cyclic alkene to synthesize a new kind of alkyl-substituted polycyclic hydrocarbon fuel with high energy density and good cryogenic performance.The triplet-energy-quenching results and phosphorescent emission spectra reveal the sensitization mechanism of the reaction,including photosensitizer excitation,triplettriplet energy transfer,cyclization,and relaxation,and the possible reaction path was revealed by the density functional theory(DFT)calculations.The reaction conditions of photosensitizer type and addition,molar ratio of substrates,reaction temperature,and incident light intensity were optimized,with the target product yield achieving 65.5%.Moreover,the reaction dynamics of the reaction rate versus the light intensity are established.After the hydrogenation-deoxygenation reaction,three fuels with a high density of 0.864-0.938 g·ml^(-1) and a low freezing point of<-55℃ are obtained.This work provides a benign and effective approach to synthesize high-performance fuels.展开更多
基金supported by the National Natural Science Foundation of China,Nos.81730033,82171193(to XG)the Key Talent Project for Strengthening Health during the 13^(th)Five-Year Plan Period,No.ZDRCA2016069(to XG)+1 种基金the National Key R&D Program of China,No.2018YFC2001901(to XG)Jiangsu Provincial Medical Key Discipline,No.ZDXK202232(to XG)。
文摘Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.
基金funded by the Seed Funding of the Beijing University of Chinese Medicine(90011451310034).
文摘Objective:To evaluate the efficacy and safety of traditional Chinese exercises(TCE)in patients with diabetic peripheral neuropathy(DPN)and to recommend best practices for using TCE to improve neurological function,glycemic control,and psychological well-being.Methods:Nine databases were searched from the inception to October 2024.Effect relationships were assessed using meta-analysis with Stata 17,and the methodological quality and certainty of the evidence were evaluated using standard tools.Results:Twelve studies comprising three study designs(nine randomized controlled,one quasi-exper-imental controlled,and two single-arm clinical trials),were identified.Compared with usual care,TCE improved various indicators and enhanced the nerve conduction velocities of the peroneal motor(mean difference[MD]=3.86 m/s,95%confidence interval[CI]:0.38 to 7.34,P=0.03),sural sensory(MD=4.15 m/s,95%CI:0.68 to 7.63,P=0.02),median motor(MD=3.84 m/s,95%CI:2.14 to 5.54,P<.001),and median sensory nerves(MD=6.14 m/s,95%CI:4.54 to 7.74,P<.001).TCE practices also reduced glycosylated hemoglobin level(MD=-0.59%,95%CI:-0.91 to-0.27,P<.001)and fasting blood glucose(standardized mean difference[SMD]=-1.08,95%CI:-1.79 to-0.37,P<.001).The overall quality of evidence was very low.Conclusion:The results indicate that TCE therapy improves certain outcomes in patients with DPN.Although the optimal type,intensity,frequency,and duration of TCE interventions are uncertain,these preliminary findings suggest that TCE should be further studied as a potentially affordable and effective treatment for DPN.
文摘Background:This study examined the development of Tai Chi in Ottawa,Canada,focusing on:(1)traditions and modernization of Tai Chi in China's mainland;(2)the evolution of Ottawa’s Chinese community;and(3)the role of Ottawa Tai Chi Chuan Association(OTCA)and Taoist Tai Chi Society(TTCS)-in promoting Tai Chi and traditional health practices rooted in Traditional Chinese Medicine(TCM)in Ottawa.Methods:Archive research was used to investigate origins,organizational structures,and programs of the associations.Documents were obtained from the personal collections,websites,and Ottawa Archives.Secondary literature on Tai Chi’s history in China and Chinese immigration to Ottawa provided contextual insights.Results:In the twentieth century,Tai Chi in China's mainland underwent significant transformations,aligning with nation-building,social reform,public health promotion,and cultural influence.Since the 1970s,the demographic composition of Canada’s Chinese community has become diversified.Some community members played a critical role in transmitting Tai Chi to Canada by establishing OTCA and TTCS.Through a variety of Tai Chi programs,workshops,and community engagement,OTCA and TTCS promoted Tai Chi as a holistic health practice rooted in TCM and traditional cultural principles in different approaches.OTCA primarily served the Chinese community,focusing on diverse forms,techniques,and theories.In contrast,Ottawa’s TTCS,as a satellite association,emphasized Taoist-inspired Tai Chi and cultivation passed down by the founder,Moy Linshin,to accommodate members from diverse cultural backgrounds.OTCA and TTCS created inclusive mind-body communities for individuals to engage in Tai Chi as a culturally meaningful practice and a means of fostering social connection and holistic wellness.Conclusion:OTCA and TTCS significantly revitalized while adapted Tai Chi and TCM practices to Western contexts,integrating its historical roots with western health ideas to establish it as a widely recognized mind-body discipline and alternative therapy.
文摘Languages come from lives of people and characters are the conventional text symbol system in society.There are thou⁃sands of languages around the world,only less than half of which own the corresponding characters,and Chinese is one of the lan⁃guages that has the corresponding characters.Chinese characters are not only still in use today but also are the oldest and best pre⁃served characters all over the world,which because of the close connection with Han nationality and Han culture.The paper ex⁃plores the origin of Chinese pronunciation,the origin of Chinese writing,the development of Chinese,and the connection between Chinese and Han culture.Also,it is important and significant for people to know how to protect our own languages.
文摘Tai Chi,a practice that combines elements of both exercise and mindfulness,offers a wide range of health benefits.The body of evidence concerning the impact of Tai Chi on diabetes has recently been growing.This editorial aims to provide a concise summary of the current state of evidence for Tai Chi's effects on individuals with type 2 diabetes(T2D).The review includes 3 randomized controlled trials(RCTs)and 5 systematic reviews and meta-analyses,all of which investigate the effectiveness of Tai Chi on various health outcomes in individuals with T2D.Tai Chi demonstrates a significant effect to enhance glycemic control,lower blood pressure,improve serum lipid profiles,reduce insulin resistance,positively influence obesity-related indices,and improve overall quality of life in individuals with T2D.However,it is noteworthy that recent RCTs have reported inconsistent findings regarding the effects of Tai Chi on glycemic control and insulin resistance.The author also delves into potential mechanisms by which Tai Chi may exert its influence on the human body.Finally,the editorial highlights the critical issues that warrant further exploration in the future.
基金supported by a Seed Funding of the Beijing University of Chinese Medicine(90011451310034).
文摘Objective To evaluate the effect of Tai Chi and Qigong on patients with lumbar disc herniation(LDH).Methods Relevant data were retrieved from nine English and Chinese databases,including Cochrane Library,PubMed,and Wanfang Data,etc.from inception to June 2024.All published randomized controlled trials assessing the effect of Tai Chi and Qigong on visual analog scale(VAS),Japanese Orthopedic Association(JOA)score,and other health indicators in participants with LDH compared to usual medical care or other treatments were included.Grey literature,trials involving the pushing of hands(Tui Shou)or Tai Chi with weapons,and trials with co-interventions(Tai Chi/Qigong plus another treatment)were excluded.Methodological quality was analyzed using the Cochrane risk of bias tool,and evidence quality was assessed using the Grading of Recommendations,Assessment,Development,and Evaluations(GRADE)tool.Results Fourteen trials(954 patients)were included in this study.Tai Chi and Qigong were associated with lower VAS pain scores(standardized mean difference−0.55,95%confidence interval[CI]−0.95 to−0.15,P=0.01),higher JOA scores(mean difference[MD]4.40,95%CI 2.62 to 6.18,P<.001)and straight leg raise test results(MD 9.40°,95%CI 7.64 to 11.15,P<0.001)in patients with LDH.Furthermore,compared with usual care,Tai Chi and Qigong showed enhanced effects on pain and JOA scores.When compared to other exercises or massage,the effect on pain scores was similar but that on JOA scores was significant.Conclusions Tai Chi and Qigong may have favorable effects on VAS pain and JOA scores compared with usual care,and on JOA scores compared with other exercises or massage in patients with LDH.Given the overall poor quality of the evidence,the results of current study should be interpreted cautiously.
基金support from National Key Research and Development Program of China(2021YFC2103704)the National Natural Science Foundation of China(22222808,21978200)the Haihe Laboratory of Sustainable Chemical Transformations.
文摘High-energy-density fuels are important for volume-limited aerospace vehicles,but the increase in fuel energy density always leads to poor cryogenic performance.Herein,we investigated the transposed Paternò-Büchi reaction of biomass cyclic ketone and cyclic alkene to synthesize a new kind of alkyl-substituted polycyclic hydrocarbon fuel with high energy density and good cryogenic performance.The triplet-energy-quenching results and phosphorescent emission spectra reveal the sensitization mechanism of the reaction,including photosensitizer excitation,triplettriplet energy transfer,cyclization,and relaxation,and the possible reaction path was revealed by the density functional theory(DFT)calculations.The reaction conditions of photosensitizer type and addition,molar ratio of substrates,reaction temperature,and incident light intensity were optimized,with the target product yield achieving 65.5%.Moreover,the reaction dynamics of the reaction rate versus the light intensity are established.After the hydrogenation-deoxygenation reaction,three fuels with a high density of 0.864-0.938 g·ml^(-1) and a low freezing point of<-55℃ are obtained.This work provides a benign and effective approach to synthesize high-performance fuels.
