In this paper, a novel four dimensional hyper-chaotic system is coined based on the Chen system, which contains two quadratic terms and five system parameters. The proposed system can generate a hyper-chaotic attracto...In this paper, a novel four dimensional hyper-chaotic system is coined based on the Chen system, which contains two quadratic terms and five system parameters. The proposed system can generate a hyper-chaotic attractor in wide parameters regions. By using the center manifold theorem and the local bifurcation theory, a pitchfork bifurcation is demonstrated to arise at the zero equilibrium point. Numerical analysis demonstrates that the hyper-cha^tic system can generate complex dynamical behaviors, e.g., a direct transition from quasi-periodic behavior to hyper-chaotic behavior. Finally, an electronic circuit is designed to implement the hyper-chaotic system, the experimental results are consist with the numerical simulations, which verifies the existence of the hyper-chaotic attractor. Due to the complex dynamic behaviors, this new hyper-cha^tic system is useful in the secure communication.展开更多
This paper brings attention on the hybrid synchronization of the Chen hyper-chaotic system by using some simple controllers. We give the sufficient conditions for achieving the goal by using the Lyapunov stability the...This paper brings attention on the hybrid synchronization of the Chen hyper-chaotic system by using some simple controllers. We give the sufficient conditions for achieving the goal by using the Lyapunov stability theory, and we verify our conclusion by numerical simulations.展开更多
This paper investigates the boundedness of a kind of hyper-chaotic systems that have wide applications in the secure communications. In particular, an accurate bound esti- mation is attained for this kind of hyper-cha...This paper investigates the boundedness of a kind of hyper-chaotic systems that have wide applications in the secure communications. In particular, an accurate bound esti- mation is attained for this kind of hyper-chaotic systems. Then, the result is applied to the chaos synchronization. Some numerical simulations are also given to verify the corresponding theoretical results.展开更多
By introducing an additional state feedback into a three-dimensional autonomous chaotic attractor Lü system, this paper presents a novel four-dimensional continuous autonomous hyper-chaotic system which has only ...By introducing an additional state feedback into a three-dimensional autonomous chaotic attractor Lü system, this paper presents a novel four-dimensional continuous autonomous hyper-chaotic system which has only one equilibrium. There are only 8 terms in all four equations of the new hyper-chaotic system, which may be less than any other four-dimensional continuous autonomous hyper-chaotic systems generated by three-dimensional （3D） continuous autonomous chaotic systems. The hyper-chaotic system undergoes Hopf bifurcation when parameter c varies, and becomes the 3D modified Lü system when parameter k varies. Although the hyper-chaotic system does not undergo Hopf bifurcation when parameter k varies, many dynamic behaviours such as periodic attractor, quasi periodic attractor, chaotic attractor and hyper-chaotic attractor can be observed. A circuit is also designed when parameter k varies and the results of the circuit experiment are in good agreement with those of simulation.展开更多
The memristor is a kind of non-linear element with memory function,which can be applied to chaotic systems to increase signal randomness and complexity.In this paper,a new four-dimensional hyper-chaotic system is desi...The memristor is a kind of non-linear element with memory function,which can be applied to chaotic systems to increase signal randomness and complexity.In this paper,a new four-dimensional hyper-chaotic system is designed based on a flux controlled memristor model,which can generate complex chaotic attractors.The basic dynamic theory analysis and numerical simulations of the system,such as the stability of equilibrium points,the Lyapunov exponents and dimension,Poincare maps,the power spectrum,and the waveform graph prove that it has rich dynamic behaviors.Then,the circuit implementation of this system is established.The consistency of simulation program with integrated circuit emphasis(SPICE)simulation and numerical analysis proves the ability to generate chaos.Finally,a new image encryption scheme is designed by using the memristor-based hyper-chaotic system proposed in this paper.The scheme involves a total of two encryptions.By using different security analysis factors,the proposed algorithm is compared with other image encryption schemes,including correlation analysis,information entropy,etc.The results show that the proposed image encryption scheme has a large key space and presents a better encryption effect.展开更多
Modularized circuit designs for chaotic systems are introduced in this paper.Especially,a typical improved modularized design strategy is proposed and applied to a new hyper-chaotic system circuit implementation.In th...Modularized circuit designs for chaotic systems are introduced in this paper.Especially,a typical improved modularized design strategy is proposed and applied to a new hyper-chaotic system circuit implementation.In this paper,the detailed design procedures are described.Multisim simulations and physical experiments are conducted,and the simulation results are compared with Matlab simulation results for different system parameter pairs.These results are consistent with each other and they verify the existence of the hyper-chaotic attractor for this new hyper-chaotic system.展开更多
Within the Huasheng Textile Industrial Park in Wudi Economic Development Zone,Binzhou,Shandong,a impressive figure over 1.8 meters tall shuttles back and forth between home and production workshop.Chen Hailin,Chairman...Within the Huasheng Textile Industrial Park in Wudi Economic Development Zone,Binzhou,Shandong,a impressive figure over 1.8 meters tall shuttles back and forth between home and production workshop.Chen Hailin,Chairman of Shandong Huasheng Textile Group Co.,Ltd.and leader of Hong Kong Huasheng Group,has the boots-on-the-ground confidence when discussing technological breakthroughs.展开更多
Objective:EPF3 is a fibrinolysin monomer isolated and purified from Pheretima vulgaris Chen,an earthworm used in traditional Chinese medicine as Dilong for treating blood stasis syndrome.Its composition,anticoagulant ...Objective:EPF3 is a fibrinolysin monomer isolated and purified from Pheretima vulgaris Chen,an earthworm used in traditional Chinese medicine as Dilong for treating blood stasis syndrome.Its composition,anticoagulant and fibrinolytic activities,and relevant mechanisms have been confirmed through in vitro experiments.However,whether it has antithrombotic effects in vivo and can be absorbed by the gastrointestinal tract is unknown.This study evaluates the antithrombotic effect in zebrafish and investigates the gastrointestinal stability and intestinal absorption mechanism of this protein in vitro.Methods:The antithrombotic effect of EPF3 in vivo was verified using the zebrafish thrombus model induced by arachidonic acid and FeCl3.Then,the protein bands of EPF3 incubated with simulated gastric fluid(SGF),simulated intestinal fluid(SIF),and homogenate of Caco-2 cells(HC2C)were analyzed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis to evaluate its gastrointestinal stability.Finally,the transport behavior and absorption mechanism of EPF3 were studied using Caco-2 cell monolayer.Results:EPF3 could significantly enhance the returned blood volume and blood flow velocity in zebrafish with platelet aggregation thrombus induced by arachidonic acid.It could also prolong the formation time of tail artery thrombus and increase the blood flow velocity in zebrafish with vessel injury thrombus induced by FeCl3.EPF3 was stable in SIF and HC2C and unstable in SGF.The permeability of EPF3 in Caco-2 monolayer was time-dependent and concentration-dependent.The efflux ratio was less than1.2 during transport,and the transport behavior was not affected by inhibitors.EPF3 could reversibly reduce the expression of tight junction-related proteins,including zonula occludens-1,occludin,and claudin-1 in Caco-2 cells.Conclusion:EPF3 could play a thrombolytic and antithrombotic role in zebrafish.It could be transported and absorbed into the intestine through cellular bypass pathway by opening the intestinal epithelium tight junction.This study provides a scientific explanation for the antithrombotic effect of earthworm and provides a basis for the feasibility of subsequent development of EPF3 as an antithrombotic enteric-soluble preparation.Please cite this article as:Zhong WL,Yang JQ,Liu H,Wu YL,Shen HJ,Li PY,Du SY.Antithrombotic effect in zebrafish of a fibrinolytic protein EPF3 from Dilong(Pheretima vulgaris Chen)and its transport mechanism in Caco-2 monolayer through cell bypass pathway.J Integr Med.2025;23(4):415–428.展开更多
BACKGROUND Gastric cancer is a growing clinical challenge,particularly due to the increased risk of postoperative gastroesophageal reflux disease(GERD)following surgical treatment.traditional Chinese medicine(TCM),inc...BACKGROUND Gastric cancer is a growing clinical challenge,particularly due to the increased risk of postoperative gastroesophageal reflux disease(GERD)following surgical treatment.traditional Chinese medicine(TCM),including acupuncture and herbal medicine,has been proposed as an adjunctive therapy to promote gastrointestinal recovery and alleviate GERD symptoms.AIM To retrospectively study the clinical efficacy of modified Lou Bei Er Chen decoction combined with acupuncture in treating patients with GERD after radical gastrectomy due to gastric cancer.METHODS A retrospective study was conducted,including patients with gastric cancer or malignant tumors of the stomach from January 2019 to December 2023 in the Affiliated Taizhou People’s Hospital of Nanjing Medical University.Patients with a TCM diagnosis of qi depression and phlegm obstruction(n=128)were selected on the basis of prescription and treatment principles.They were then divided into a control group(n=61)and an observation group(n=67).The control group received treatment with Western medicine domperidone.The observation group were treated with Lou Bei Er Chen decoction orally,with acupuncture at specific RESULTS The observation group showed significantly shorter times for first flatus,defecation,bowel sound recovery,and initiation of nasogastric enteral nutrition than the control group(P<0.05).Upon treatment,the two groups demonstrated a significant reduction in gastrointestinal dysfunction scores,with a more significant reduction in the observation group(P<0.001).The GERD-Q scores significantly decreased after 8 weeks of treatment in the two groups(P<0.05),with a significant reduction in the observation group(P<0.05),compared with baseline.The TCM syndrome scores significantly decreased after 4 and 8 weeks of treatment in the two groups(P<0.05),with a significant reduction in the observation group(P<0.05).The effective rate of the observation group after 8 weeks of treatment was significantly higher than that after 4 weeks(χ2=13.648,P=0.003),and it was significantly higher than that of control group(χ2=13.879,P=0.003).CONCLUSION Lou Bei Er Chen decoction combined with acupuncture treatment can effectively alleviate clinical symptoms in patients GERD after gastric cancer surgery and improve their life quality.It is worthy of further promotion and application.展开更多
From May 20 to 24,2025,CIIS President Chen Bo led a delegation to visit India.During the visit,the delegation attended the 20th meeting of the Shanghai Cooperation Organization(SCO)Forum hosted by the Indian Council o...From May 20 to 24,2025,CIIS President Chen Bo led a delegation to visit India.During the visit,the delegation attended the 20th meeting of the Shanghai Cooperation Organization(SCO)Forum hosted by the Indian Council of World Affairs(ICWA)and had in-depth exchanges with all participants on topics such as security,sustainable development and cultural cooperation in the SCO region.The delegation also had meetings with the Vivekananda International Foundation(VIF)and the Institute of Chinese Studies(ICS)in India.展开更多
Iince rising to fame in 1987 on the television drama Sunshine After Rain,Singaporean artist Edmund Chen has starred in many films and TV series.He has also been active in theatre,hosting programs,and-more recently-pub...Iince rising to fame in 1987 on the television drama Sunshine After Rain,Singaporean artist Edmund Chen has starred in many films and TV series.He has also been active in theatre,hosting programs,and-more recently-publishing.Chen has authored 15 picture books and two art activity books for children,earning recognition as Southeast Asia’s Best Emerging Children’s Author.Today,he remains a prominent figure in public,not just as an actor but also as a writer and illustrator.展开更多
基金Project supported by the Natural Science Foundation of China (Grant Nos.61174094, 50977063, and 60904063)the Foundation of the Application Base and Frontier Technology Research Project of Tianjin, China (Grant No.10JCZDJC23100)the Development of Science and Technology Foundation of the Higher Education Institutions of Tianjin, China (Grant No.20080826)
文摘In this paper, a novel four dimensional hyper-chaotic system is coined based on the Chen system, which contains two quadratic terms and five system parameters. The proposed system can generate a hyper-chaotic attractor in wide parameters regions. By using the center manifold theorem and the local bifurcation theory, a pitchfork bifurcation is demonstrated to arise at the zero equilibrium point. Numerical analysis demonstrates that the hyper-cha^tic system can generate complex dynamical behaviors, e.g., a direct transition from quasi-periodic behavior to hyper-chaotic behavior. Finally, an electronic circuit is designed to implement the hyper-chaotic system, the experimental results are consist with the numerical simulations, which verifies the existence of the hyper-chaotic attractor. Due to the complex dynamic behaviors, this new hyper-cha^tic system is useful in the secure communication.
文摘This paper brings attention on the hybrid synchronization of the Chen hyper-chaotic system by using some simple controllers. We give the sufficient conditions for achieving the goal by using the Lyapunov stability theory, and we verify our conclusion by numerical simulations.
基金Supported by the National Natural Science Foundation of China(Grant Nos.1100118911071266)+1 种基金the Natural Science Foundation Project of CQ CSTC(Grant No.2010BB9218)the Fundamental Research Funds for the Central Universities(Grant No.CDJXS11100026)
文摘This paper investigates the boundedness of a kind of hyper-chaotic systems that have wide applications in the secure communications. In particular, an accurate bound esti- mation is attained for this kind of hyper-chaotic systems. Then, the result is applied to the chaos synchronization. Some numerical simulations are also given to verify the corresponding theoretical results.
基金supported by the National Natural Science Foundation of China (Grant Nos. 60774088 and 10772135)the Research Foundation from the Ministry of Education of China (Grant No. 107024)+2 种基金the Program for New Century Excellent Talents in University of China (NCET)the Application Base and Frontier Technology Project of Tianjin, China (Grant No.08JCZDJC21900)the Scientific Research Foundation for the Returned Overseas Scholars of the State Education Ministry
文摘By introducing an additional state feedback into a three-dimensional autonomous chaotic attractor Lü system, this paper presents a novel four-dimensional continuous autonomous hyper-chaotic system which has only one equilibrium. There are only 8 terms in all four equations of the new hyper-chaotic system, which may be less than any other four-dimensional continuous autonomous hyper-chaotic systems generated by three-dimensional （3D） continuous autonomous chaotic systems. The hyper-chaotic system undergoes Hopf bifurcation when parameter c varies, and becomes the 3D modified Lü system when parameter k varies. Although the hyper-chaotic system does not undergo Hopf bifurcation when parameter k varies, many dynamic behaviours such as periodic attractor, quasi periodic attractor, chaotic attractor and hyper-chaotic attractor can be observed. A circuit is also designed when parameter k varies and the results of the circuit experiment are in good agreement with those of simulation.
基金Project supported by the National Key Research and Development Program of China (Grant No. 2018YFB1306600)the National Natural Science Foundation of China (Grant Nos. 62076207 and 62076208)the Fundamental Science and Advanced Technology Research Foundation of Chongqing, China (Grant Nos. cstc2017jcyj BX0050)
文摘The memristor is a kind of non-linear element with memory function,which can be applied to chaotic systems to increase signal randomness and complexity.In this paper,a new four-dimensional hyper-chaotic system is designed based on a flux controlled memristor model,which can generate complex chaotic attractors.The basic dynamic theory analysis and numerical simulations of the system,such as the stability of equilibrium points,the Lyapunov exponents and dimension,Poincare maps,the power spectrum,and the waveform graph prove that it has rich dynamic behaviors.Then,the circuit implementation of this system is established.The consistency of simulation program with integrated circuit emphasis(SPICE)simulation and numerical analysis proves the ability to generate chaos.Finally,a new image encryption scheme is designed by using the memristor-based hyper-chaotic system proposed in this paper.The scheme involves a total of two encryptions.By using different security analysis factors,the proposed algorithm is compared with other image encryption schemes,including correlation analysis,information entropy,etc.The results show that the proposed image encryption scheme has a large key space and presents a better encryption effect.
基金supported by the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.61403395)the Natural Science Foundation of Tianjin,China(Grant No.13JCYBJC39000)+3 种基金the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry of Chinathe Fund from the Tianjin Key Laboratory of Civil Aircraft Airworthiness and Maintenance in Civil Aviation of China(Grant No.104003020106)the National Basic Research Program of China(Grant No.2014CB744904)the Fund for the Scholars of Civil Aviation University of China(Grant No.2012QD21x)
文摘Modularized circuit designs for chaotic systems are introduced in this paper.Especially,a typical improved modularized design strategy is proposed and applied to a new hyper-chaotic system circuit implementation.In this paper,the detailed design procedures are described.Multisim simulations and physical experiments are conducted,and the simulation results are compared with Matlab simulation results for different system parameter pairs.These results are consistent with each other and they verify the existence of the hyper-chaotic attractor for this new hyper-chaotic system.
文摘Within the Huasheng Textile Industrial Park in Wudi Economic Development Zone,Binzhou,Shandong,a impressive figure over 1.8 meters tall shuttles back and forth between home and production workshop.Chen Hailin,Chairman of Shandong Huasheng Textile Group Co.,Ltd.and leader of Hong Kong Huasheng Group,has the boots-on-the-ground confidence when discussing technological breakthroughs.
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.2020-JYB-ZDGG-032)National Natural Science Foundation of China(No.82104352)。
文摘Objective:EPF3 is a fibrinolysin monomer isolated and purified from Pheretima vulgaris Chen,an earthworm used in traditional Chinese medicine as Dilong for treating blood stasis syndrome.Its composition,anticoagulant and fibrinolytic activities,and relevant mechanisms have been confirmed through in vitro experiments.However,whether it has antithrombotic effects in vivo and can be absorbed by the gastrointestinal tract is unknown.This study evaluates the antithrombotic effect in zebrafish and investigates the gastrointestinal stability and intestinal absorption mechanism of this protein in vitro.Methods:The antithrombotic effect of EPF3 in vivo was verified using the zebrafish thrombus model induced by arachidonic acid and FeCl3.Then,the protein bands of EPF3 incubated with simulated gastric fluid(SGF),simulated intestinal fluid(SIF),and homogenate of Caco-2 cells(HC2C)were analyzed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis to evaluate its gastrointestinal stability.Finally,the transport behavior and absorption mechanism of EPF3 were studied using Caco-2 cell monolayer.Results:EPF3 could significantly enhance the returned blood volume and blood flow velocity in zebrafish with platelet aggregation thrombus induced by arachidonic acid.It could also prolong the formation time of tail artery thrombus and increase the blood flow velocity in zebrafish with vessel injury thrombus induced by FeCl3.EPF3 was stable in SIF and HC2C and unstable in SGF.The permeability of EPF3 in Caco-2 monolayer was time-dependent and concentration-dependent.The efflux ratio was less than1.2 during transport,and the transport behavior was not affected by inhibitors.EPF3 could reversibly reduce the expression of tight junction-related proteins,including zonula occludens-1,occludin,and claudin-1 in Caco-2 cells.Conclusion:EPF3 could play a thrombolytic and antithrombotic role in zebrafish.It could be transported and absorbed into the intestine through cellular bypass pathway by opening the intestinal epithelium tight junction.This study provides a scientific explanation for the antithrombotic effect of earthworm and provides a basis for the feasibility of subsequent development of EPF3 as an antithrombotic enteric-soluble preparation.Please cite this article as:Zhong WL,Yang JQ,Liu H,Wu YL,Shen HJ,Li PY,Du SY.Antithrombotic effect in zebrafish of a fibrinolytic protein EPF3 from Dilong(Pheretima vulgaris Chen)and its transport mechanism in Caco-2 monolayer through cell bypass pathway.J Integr Med.2025;23(4):415–428.
文摘BACKGROUND Gastric cancer is a growing clinical challenge,particularly due to the increased risk of postoperative gastroesophageal reflux disease(GERD)following surgical treatment.traditional Chinese medicine(TCM),including acupuncture and herbal medicine,has been proposed as an adjunctive therapy to promote gastrointestinal recovery and alleviate GERD symptoms.AIM To retrospectively study the clinical efficacy of modified Lou Bei Er Chen decoction combined with acupuncture in treating patients with GERD after radical gastrectomy due to gastric cancer.METHODS A retrospective study was conducted,including patients with gastric cancer or malignant tumors of the stomach from January 2019 to December 2023 in the Affiliated Taizhou People’s Hospital of Nanjing Medical University.Patients with a TCM diagnosis of qi depression and phlegm obstruction(n=128)were selected on the basis of prescription and treatment principles.They were then divided into a control group(n=61)and an observation group(n=67).The control group received treatment with Western medicine domperidone.The observation group were treated with Lou Bei Er Chen decoction orally,with acupuncture at specific RESULTS The observation group showed significantly shorter times for first flatus,defecation,bowel sound recovery,and initiation of nasogastric enteral nutrition than the control group(P<0.05).Upon treatment,the two groups demonstrated a significant reduction in gastrointestinal dysfunction scores,with a more significant reduction in the observation group(P<0.001).The GERD-Q scores significantly decreased after 8 weeks of treatment in the two groups(P<0.05),with a significant reduction in the observation group(P<0.05),compared with baseline.The TCM syndrome scores significantly decreased after 4 and 8 weeks of treatment in the two groups(P<0.05),with a significant reduction in the observation group(P<0.05).The effective rate of the observation group after 8 weeks of treatment was significantly higher than that after 4 weeks(χ2=13.648,P=0.003),and it was significantly higher than that of control group(χ2=13.879,P=0.003).CONCLUSION Lou Bei Er Chen decoction combined with acupuncture treatment can effectively alleviate clinical symptoms in patients GERD after gastric cancer surgery and improve their life quality.It is worthy of further promotion and application.
文摘From May 20 to 24,2025,CIIS President Chen Bo led a delegation to visit India.During the visit,the delegation attended the 20th meeting of the Shanghai Cooperation Organization(SCO)Forum hosted by the Indian Council of World Affairs(ICWA)and had in-depth exchanges with all participants on topics such as security,sustainable development and cultural cooperation in the SCO region.The delegation also had meetings with the Vivekananda International Foundation(VIF)and the Institute of Chinese Studies(ICS)in India.
文摘Iince rising to fame in 1987 on the television drama Sunshine After Rain,Singaporean artist Edmund Chen has starred in many films and TV series.He has also been active in theatre,hosting programs,and-more recently-publishing.Chen has authored 15 picture books and two art activity books for children,earning recognition as Southeast Asia’s Best Emerging Children’s Author.Today,he remains a prominent figure in public,not just as an actor but also as a writer and illustrator.
