This essay examines the autobiography of Chen Hengzhe （1890-1976） （see Appendix）, a relatively less studied woman writer, historian, and critic in modem China. Through the study in four aspects, namely, the pursui...This essay examines the autobiography of Chen Hengzhe （1890-1976） （see Appendix）, a relatively less studied woman writer, historian, and critic in modem China. Through the study in four aspects, namely, the pursuit of modem education, simple appearance, great leaders, and the ambassadors of culture, the author＇s research indicates that Chen＇s construction of＂new woman＂ has been influenced by complex historical and cultural forces such as the Chinese traditional culture, Western culture, and the iconoclastic spirit of ＂the New Culture Movement＂. Meanwhile, Chen＇s gender consciousness is also an important element. Moreover, Chen＇s pioneering standing and her own experiences of studying abroad makes her take the lead in conceiving women＇s leadership and their roles in global culture communications. In the late Qing and the early Republic, traditional values and norms of womanhood were severely challenged. Chen＇s construction of＂new woman＂ is her conscious effort to define a new womanhood and is an integral part of the ongoing exploration of Chinese women for modem womanhood. Through the examination of Chen＇s ＂new woman＂, this paper seeks to enrich our understanding of the complexity of modem Chinese women＇s exploration of modem womanhood.展开更多
Chen Hengzhe is one of the earliest novelists at the beginning of new literature.Her novels depict the tragic real life with a serious and profound realistic tone and meditate on the emotional problems of life with th...Chen Hengzhe is one of the earliest novelists at the beginning of new literature.Her novels depict the tragic real life with a serious and profound realistic tone and meditate on the emotional problems of life with the unique perspective and delicate psychology of women.Her novels,with the sincerest feelings and pure thoughts,show her desire for individual enlightenment and group enlightenment by means of fairy tales and fables.展开更多
From May 20 to 24,2025,CIIS President Chen Bo led a delegation to visit India.During the visit,the delegation attended the 20th meeting of the Shanghai Cooperation Organization(SCO)Forum hosted by the Indian Council o...From May 20 to 24,2025,CIIS President Chen Bo led a delegation to visit India.During the visit,the delegation attended the 20th meeting of the Shanghai Cooperation Organization(SCO)Forum hosted by the Indian Council of World Affairs(ICWA)and had in-depth exchanges with all participants on topics such as security,sustainable development and cultural cooperation in the SCO region.The delegation also had meetings with the Vivekananda International Foundation(VIF)and the Institute of Chinese Studies(ICS)in India.展开更多
Within the Huasheng Textile Industrial Park in Wudi Economic Development Zone,Binzhou,Shandong,a impressive figure over 1.8 meters tall shuttles back and forth between home and production workshop.Chen Hailin,Chairman...Within the Huasheng Textile Industrial Park in Wudi Economic Development Zone,Binzhou,Shandong,a impressive figure over 1.8 meters tall shuttles back and forth between home and production workshop.Chen Hailin,Chairman of Shandong Huasheng Textile Group Co.,Ltd.and leader of Hong Kong Huasheng Group,has the boots-on-the-ground confidence when discussing technological breakthroughs.展开更多
Objective:EPF3 is a fibrinolysin monomer isolated and purified from Pheretima vulgaris Chen,an earthworm used in traditional Chinese medicine as Dilong for treating blood stasis syndrome.Its composition,anticoagulant ...Objective:EPF3 is a fibrinolysin monomer isolated and purified from Pheretima vulgaris Chen,an earthworm used in traditional Chinese medicine as Dilong for treating blood stasis syndrome.Its composition,anticoagulant and fibrinolytic activities,and relevant mechanisms have been confirmed through in vitro experiments.However,whether it has antithrombotic effects in vivo and can be absorbed by the gastrointestinal tract is unknown.This study evaluates the antithrombotic effect in zebrafish and investigates the gastrointestinal stability and intestinal absorption mechanism of this protein in vitro.Methods:The antithrombotic effect of EPF3 in vivo was verified using the zebrafish thrombus model induced by arachidonic acid and FeCl3.Then,the protein bands of EPF3 incubated with simulated gastric fluid(SGF),simulated intestinal fluid(SIF),and homogenate of Caco-2 cells(HC2C)were analyzed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis to evaluate its gastrointestinal stability.Finally,the transport behavior and absorption mechanism of EPF3 were studied using Caco-2 cell monolayer.Results:EPF3 could significantly enhance the returned blood volume and blood flow velocity in zebrafish with platelet aggregation thrombus induced by arachidonic acid.It could also prolong the formation time of tail artery thrombus and increase the blood flow velocity in zebrafish with vessel injury thrombus induced by FeCl3.EPF3 was stable in SIF and HC2C and unstable in SGF.The permeability of EPF3 in Caco-2 monolayer was time-dependent and concentration-dependent.The efflux ratio was less than1.2 during transport,and the transport behavior was not affected by inhibitors.EPF3 could reversibly reduce the expression of tight junction-related proteins,including zonula occludens-1,occludin,and claudin-1 in Caco-2 cells.Conclusion:EPF3 could play a thrombolytic and antithrombotic role in zebrafish.It could be transported and absorbed into the intestine through cellular bypass pathway by opening the intestinal epithelium tight junction.This study provides a scientific explanation for the antithrombotic effect of earthworm and provides a basis for the feasibility of subsequent development of EPF3 as an antithrombotic enteric-soluble preparation.Please cite this article as:Zhong WL,Yang JQ,Liu H,Wu YL,Shen HJ,Li PY,Du SY.Antithrombotic effect in zebrafish of a fibrinolytic protein EPF3 from Dilong(Pheretima vulgaris Chen)and its transport mechanism in Caco-2 monolayer through cell bypass pathway.J Integr Med.2025;23(4):415–428.展开更多
BACKGROUND Gastric cancer is a growing clinical challenge,particularly due to the increased risk of postoperative gastroesophageal reflux disease(GERD)following surgical treatment.traditional Chinese medicine(TCM),inc...BACKGROUND Gastric cancer is a growing clinical challenge,particularly due to the increased risk of postoperative gastroesophageal reflux disease(GERD)following surgical treatment.traditional Chinese medicine(TCM),including acupuncture and herbal medicine,has been proposed as an adjunctive therapy to promote gastrointestinal recovery and alleviate GERD symptoms.AIM To retrospectively study the clinical efficacy of modified Lou Bei Er Chen decoction combined with acupuncture in treating patients with GERD after radical gastrectomy due to gastric cancer.METHODS A retrospective study was conducted,including patients with gastric cancer or malignant tumors of the stomach from January 2019 to December 2023 in the Affiliated Taizhou People’s Hospital of Nanjing Medical University.Patients with a TCM diagnosis of qi depression and phlegm obstruction(n=128)were selected on the basis of prescription and treatment principles.They were then divided into a control group(n=61)and an observation group(n=67).The control group received treatment with Western medicine domperidone.The observation group were treated with Lou Bei Er Chen decoction orally,with acupuncture at specific RESULTS The observation group showed significantly shorter times for first flatus,defecation,bowel sound recovery,and initiation of nasogastric enteral nutrition than the control group(P<0.05).Upon treatment,the two groups demonstrated a significant reduction in gastrointestinal dysfunction scores,with a more significant reduction in the observation group(P<0.001).The GERD-Q scores significantly decreased after 8 weeks of treatment in the two groups(P<0.05),with a significant reduction in the observation group(P<0.05),compared with baseline.The TCM syndrome scores significantly decreased after 4 and 8 weeks of treatment in the two groups(P<0.05),with a significant reduction in the observation group(P<0.05).The effective rate of the observation group after 8 weeks of treatment was significantly higher than that after 4 weeks(χ2=13.648,P=0.003),and it was significantly higher than that of control group(χ2=13.879,P=0.003).CONCLUSION Lou Bei Er Chen decoction combined with acupuncture treatment can effectively alleviate clinical symptoms in patients GERD after gastric cancer surgery and improve their life quality.It is worthy of further promotion and application.展开更多
Iince rising to fame in 1987 on the television drama Sunshine After Rain,Singaporean artist Edmund Chen has starred in many films and TV series.He has also been active in theatre,hosting programs,and-more recently-pub...Iince rising to fame in 1987 on the television drama Sunshine After Rain,Singaporean artist Edmund Chen has starred in many films and TV series.He has also been active in theatre,hosting programs,and-more recently-publishing.Chen has authored 15 picture books and two art activity books for children,earning recognition as Southeast Asia’s Best Emerging Children’s Author.Today,he remains a prominent figure in public,not just as an actor but also as a writer and illustrator.展开更多
Xin Xiu Ben Cao(《新修本草》Newly Revised Materia Medica)is China’s first national pharmacopoeia and holds significant importance in the history of Chinese herbal medicine.However,it was lost by the time of the North...Xin Xiu Ben Cao(《新修本草》Newly Revised Materia Medica)is China’s first national pharmacopoeia and holds significant importance in the history of Chinese herbal medicine.However,it was lost by the time of the Northern Song dynasty.Japanese envoys to the Tang dynasty brought this text back to Japan,where it was preserved in manuscript form at Ninna-ji Temple(仁和寺)in Kyoto,although it gradually fell into obscurity.In the 19th century,Japanese physicians and scholars such as the Fukui family(福井家),the Asai family(浅井家),the Kojima family(小岛家),and Kariya Ekisai(狩谷棭斋)discovered fragments of Xin Xiu Ben Cao,transcribed them,and gradually disseminated them.During his travels to Japan from 1888 to 1889,the Chinese envoy Fu Yunlong(傅云龙),along with Chen Ju(陈榘),acquired and published this text.The reproduced edition shows that the text consists of eleven volumes,eight of which were originally from the Kojima family’s collection.Volume 3 was transcribed by Kojima Naozane(小岛尚真)based on his father’s compiled edition.The Kojima family’s manuscripts were later acquired by Arai Masatake(新井政毅),the owner of the Arai Bunko(新井文库),and after his passing,they were dispersed among booksellers.The seals printed in the book reveal that the Qing Legation in Japan and Chinese literati who traveled to Japan jointly appreciated and studied this text.By comparing it with other scroll and album-format manuscripts,it becomes evident that the layout of this fragment differs from the scroll format but is closer to the album format.展开更多
文摘This essay examines the autobiography of Chen Hengzhe （1890-1976） （see Appendix）, a relatively less studied woman writer, historian, and critic in modem China. Through the study in four aspects, namely, the pursuit of modem education, simple appearance, great leaders, and the ambassadors of culture, the author＇s research indicates that Chen＇s construction of＂new woman＂ has been influenced by complex historical and cultural forces such as the Chinese traditional culture, Western culture, and the iconoclastic spirit of ＂the New Culture Movement＂. Meanwhile, Chen＇s gender consciousness is also an important element. Moreover, Chen＇s pioneering standing and her own experiences of studying abroad makes her take the lead in conceiving women＇s leadership and their roles in global culture communications. In the late Qing and the early Republic, traditional values and norms of womanhood were severely challenged. Chen＇s construction of＂new woman＂ is her conscious effort to define a new womanhood and is an integral part of the ongoing exploration of Chinese women for modem womanhood. Through the examination of Chen＇s ＂new woman＂, this paper seeks to enrich our understanding of the complexity of modem Chinese women＇s exploration of modem womanhood.
文摘Chen Hengzhe is one of the earliest novelists at the beginning of new literature.Her novels depict the tragic real life with a serious and profound realistic tone and meditate on the emotional problems of life with the unique perspective and delicate psychology of women.Her novels,with the sincerest feelings and pure thoughts,show her desire for individual enlightenment and group enlightenment by means of fairy tales and fables.
文摘From May 20 to 24,2025,CIIS President Chen Bo led a delegation to visit India.During the visit,the delegation attended the 20th meeting of the Shanghai Cooperation Organization(SCO)Forum hosted by the Indian Council of World Affairs(ICWA)and had in-depth exchanges with all participants on topics such as security,sustainable development and cultural cooperation in the SCO region.The delegation also had meetings with the Vivekananda International Foundation(VIF)and the Institute of Chinese Studies(ICS)in India.
文摘Within the Huasheng Textile Industrial Park in Wudi Economic Development Zone,Binzhou,Shandong,a impressive figure over 1.8 meters tall shuttles back and forth between home and production workshop.Chen Hailin,Chairman of Shandong Huasheng Textile Group Co.,Ltd.and leader of Hong Kong Huasheng Group,has the boots-on-the-ground confidence when discussing technological breakthroughs.
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.2020-JYB-ZDGG-032)National Natural Science Foundation of China(No.82104352)。
文摘Objective:EPF3 is a fibrinolysin monomer isolated and purified from Pheretima vulgaris Chen,an earthworm used in traditional Chinese medicine as Dilong for treating blood stasis syndrome.Its composition,anticoagulant and fibrinolytic activities,and relevant mechanisms have been confirmed through in vitro experiments.However,whether it has antithrombotic effects in vivo and can be absorbed by the gastrointestinal tract is unknown.This study evaluates the antithrombotic effect in zebrafish and investigates the gastrointestinal stability and intestinal absorption mechanism of this protein in vitro.Methods:The antithrombotic effect of EPF3 in vivo was verified using the zebrafish thrombus model induced by arachidonic acid and FeCl3.Then,the protein bands of EPF3 incubated with simulated gastric fluid(SGF),simulated intestinal fluid(SIF),and homogenate of Caco-2 cells(HC2C)were analyzed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis to evaluate its gastrointestinal stability.Finally,the transport behavior and absorption mechanism of EPF3 were studied using Caco-2 cell monolayer.Results:EPF3 could significantly enhance the returned blood volume and blood flow velocity in zebrafish with platelet aggregation thrombus induced by arachidonic acid.It could also prolong the formation time of tail artery thrombus and increase the blood flow velocity in zebrafish with vessel injury thrombus induced by FeCl3.EPF3 was stable in SIF and HC2C and unstable in SGF.The permeability of EPF3 in Caco-2 monolayer was time-dependent and concentration-dependent.The efflux ratio was less than1.2 during transport,and the transport behavior was not affected by inhibitors.EPF3 could reversibly reduce the expression of tight junction-related proteins,including zonula occludens-1,occludin,and claudin-1 in Caco-2 cells.Conclusion:EPF3 could play a thrombolytic and antithrombotic role in zebrafish.It could be transported and absorbed into the intestine through cellular bypass pathway by opening the intestinal epithelium tight junction.This study provides a scientific explanation for the antithrombotic effect of earthworm and provides a basis for the feasibility of subsequent development of EPF3 as an antithrombotic enteric-soluble preparation.Please cite this article as:Zhong WL,Yang JQ,Liu H,Wu YL,Shen HJ,Li PY,Du SY.Antithrombotic effect in zebrafish of a fibrinolytic protein EPF3 from Dilong(Pheretima vulgaris Chen)and its transport mechanism in Caco-2 monolayer through cell bypass pathway.J Integr Med.2025;23(4):415–428.
文摘BACKGROUND Gastric cancer is a growing clinical challenge,particularly due to the increased risk of postoperative gastroesophageal reflux disease(GERD)following surgical treatment.traditional Chinese medicine(TCM),including acupuncture and herbal medicine,has been proposed as an adjunctive therapy to promote gastrointestinal recovery and alleviate GERD symptoms.AIM To retrospectively study the clinical efficacy of modified Lou Bei Er Chen decoction combined with acupuncture in treating patients with GERD after radical gastrectomy due to gastric cancer.METHODS A retrospective study was conducted,including patients with gastric cancer or malignant tumors of the stomach from January 2019 to December 2023 in the Affiliated Taizhou People’s Hospital of Nanjing Medical University.Patients with a TCM diagnosis of qi depression and phlegm obstruction(n=128)were selected on the basis of prescription and treatment principles.They were then divided into a control group(n=61)and an observation group(n=67).The control group received treatment with Western medicine domperidone.The observation group were treated with Lou Bei Er Chen decoction orally,with acupuncture at specific RESULTS The observation group showed significantly shorter times for first flatus,defecation,bowel sound recovery,and initiation of nasogastric enteral nutrition than the control group(P<0.05).Upon treatment,the two groups demonstrated a significant reduction in gastrointestinal dysfunction scores,with a more significant reduction in the observation group(P<0.001).The GERD-Q scores significantly decreased after 8 weeks of treatment in the two groups(P<0.05),with a significant reduction in the observation group(P<0.05),compared with baseline.The TCM syndrome scores significantly decreased after 4 and 8 weeks of treatment in the two groups(P<0.05),with a significant reduction in the observation group(P<0.05).The effective rate of the observation group after 8 weeks of treatment was significantly higher than that after 4 weeks(χ2=13.648,P=0.003),and it was significantly higher than that of control group(χ2=13.879,P=0.003).CONCLUSION Lou Bei Er Chen decoction combined with acupuncture treatment can effectively alleviate clinical symptoms in patients GERD after gastric cancer surgery and improve their life quality.It is worthy of further promotion and application.
文摘Iince rising to fame in 1987 on the television drama Sunshine After Rain,Singaporean artist Edmund Chen has starred in many films and TV series.He has also been active in theatre,hosting programs,and-more recently-publishing.Chen has authored 15 picture books and two art activity books for children,earning recognition as Southeast Asia’s Best Emerging Children’s Author.Today,he remains a prominent figure in public,not just as an actor but also as a writer and illustrator.
文摘Xin Xiu Ben Cao(《新修本草》Newly Revised Materia Medica)is China’s first national pharmacopoeia and holds significant importance in the history of Chinese herbal medicine.However,it was lost by the time of the Northern Song dynasty.Japanese envoys to the Tang dynasty brought this text back to Japan,where it was preserved in manuscript form at Ninna-ji Temple(仁和寺)in Kyoto,although it gradually fell into obscurity.In the 19th century,Japanese physicians and scholars such as the Fukui family(福井家),the Asai family(浅井家),the Kojima family(小岛家),and Kariya Ekisai(狩谷棭斋)discovered fragments of Xin Xiu Ben Cao,transcribed them,and gradually disseminated them.During his travels to Japan from 1888 to 1889,the Chinese envoy Fu Yunlong(傅云龙),along with Chen Ju(陈榘),acquired and published this text.The reproduced edition shows that the text consists of eleven volumes,eight of which were originally from the Kojima family’s collection.Volume 3 was transcribed by Kojima Naozane(小岛尚真)based on his father’s compiled edition.The Kojima family’s manuscripts were later acquired by Arai Masatake(新井政毅),the owner of the Arai Bunko(新井文库),and after his passing,they were dispersed among booksellers.The seals printed in the book reveal that the Qing Legation in Japan and Chinese literati who traveled to Japan jointly appreciated and studied this text.By comparing it with other scroll and album-format manuscripts,it becomes evident that the layout of this fragment differs from the scroll format but is closer to the album format.
