[Objectives]To investigate the chemical composition,antioxidant property,and nematicidal activity of Cucumis metuliferus and establish a theoretical foundation for the development of botanical nematicides.[Methods]The...[Objectives]To investigate the chemical composition,antioxidant property,and nematicidal activity of Cucumis metuliferus and establish a theoretical foundation for the development of botanical nematicides.[Methods]The compounds were isolated and purified using silica gel,reversed-phase medium,low-pressure gel Sephadex LH-20 column chromatography,and preparative high-performance liquid chromatography.Their identification was based on physicochemical properties,various spectral analyses,and data reported in the literature.Subsequently,the nematicidal and antioxidant activities of the isolated compounds were evaluated.[Results]A total of four compounds were isolated from C.metuliferus,which were identified as isovitexin-2″-O-glucoside(compound 1),9E,11E-(13-oxo)tridecadienoic acid(compound 2),2E,4E-tridecadienedioic acid(compound 3),and 9E,11E-(13-hydroxy)tridecadienoic acid(compound 4).Compound 1 demonstrated a notable degree of antioxidant activity,achieving a DPPH scavenging rate of 49.40%at a mass concentration of 1 mg/mL.Additionally,compounds 1,3,and 4 exhibited varying levels of nematicidal activity.Specifically,compound 1 displayed strong nematicidal activity at a concentration of 2.0 mg/mL,resulting in a mortality rate of 90.5%against nematodes.Furthermore,compounds 3 and 4 achieved a mortality rate of 100%against nematodes at a concentration of 0.25 mg/mL.[Conclusions]This study reports the first isolation of four compounds:isovitexin-2″-O-glucoside,9E,11E-(13-oxo)tridecadienoic acid,2E,4E-tridecadienedioic acid,and 9E,11E-(13-hydroxy)tridecadienoic acid from C.metuliferus.Notably,2E,4E-tridecadienedioic acid and 9E,11E-(13-oxo)tridecadienoic acid are identified as novel natural products.Among these compounds,isovitexin-2″-O-glucoside,9E,11E-(13-oxo)tridecadienoic acid,and 9E,11E-(13-hydroxy)tridecadienoic acid exhibit nematicidal activity,whereas isovitexin-2″-O-glucoside demonstrates antioxidant properties.展开更多
BACKGROUND Fruits of Gardenia jasminoides(G.jasminoides)have extremely high medicinal value.However,the quality and traits of the plants vary significantly based on their provenances.In addition,the behaviour of the k...BACKGROUND Fruits of Gardenia jasminoides(G.jasminoides)have extremely high medicinal value.However,the quality and traits of the plants vary significantly based on their provenances.In addition,the behaviour of the known bioactive components,such as geniposide and crocin,has been the primary focus of the research on G.jasminoides.However,the identification of unknown bioactive components and their metabolomics remains underexplored.Therefore,analysing the metabolic differences between gardenias from different sources is essential to provide a comprehensive theoretical basis for the evaluation of G.jasminoides and germplasm resource identification.AIM To systematically evaluate the morphology,secondary metabolites,typical active ingredients,and antioxidant activity of wild G.jasminoides fruits.METHODS Gardenia fruits were collected from different provenances.Metabolites were identified via ultra-high-performance liquid chromatography–tandem mass spectrometry(UPLC-MS/MS).The metabolic differences were compared using hierarchical cluster analysis(HCA).The antioxidant capacity was evaluated using 2,2-diphenyl-1-picrylhydrazyl radical scavenging assays and ferric reducing antioxidant power assays,and its correlation with typical active ingredients was analysed.RESULTS A total of 444 and 240 metabolites were identified using UPLC-MS/MS in positive and negative ion modes,respectively.The HCA results of the flavonoids indicated that the higher content of flavonoids was in the fruits from Lukou.The differential analysis of metabolites in fruits from Shaoyang,Miluo and Lukou showed that the fruit from Miluo had the highest upregulated differential metabolites.CONCLUSION The metabolic characteristics of the Ningxiang and Xiangxi extracts were similar,while those of Lukou,Miluo and Shaoyang extracts differed significantly.展开更多
Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma...Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma,PR)and yellow wine.It is a classical therapy for chest stuffiness and pain syndrome and is widely used in the clinical treatment of coronary heart disease.It also shows significant therapeutic effects on pulmonary heart disease,hyperlipidemia,and arrhythmia.This study conducted a literature review and collected information on GXBD from databases such as PubMed,Web of Science,China National Knowledge Infrastructure,and ScienceDirect.The result indicated that the main active ingredients of GXBD are steroids,flavonoids,terpenoids,alkaloids,amino acids,and organic acids.Trigonelline,macrostemonoside and cucurbitacin B can provide reference for its quality control.GXBD may exert therapeutic effects on coronary heart disease through AMPK,PI3K-AKT,oxLDL,VEGF,and NF-κB signal pathways.This review provides a comprehensive analysis and summary of the chemical composition and in vivo metabolism of three traditional Chinese medicines(TF,AMB,and PR),along with an evaluation of the chemical composition,quality control,pharmacological effects,and clinical application of GXBD.Based on these,areas requiring further research on GXBD have been proposed to provide a reference for its further development and new drug research.展开更多
As a traditional medicinal and edible herb,Danggui(Angelicae Sinensis Radix)exhibits pharmacological activities closely associated with its characteristic chemical components,such as volatile oils(e.g.,ligustilide),or...As a traditional medicinal and edible herb,Danggui(Angelicae Sinensis Radix)exhibits pharmacological activities closely associated with its characteristic chemical components,such as volatile oils(e.g.,ligustilide),organic acids(e.g.,ferulic acid),and polysaccharides.It demonstrates a wide range of pharmacological effects,including anti-inflammatory and immunomodulatory properties,cardiovascular and cerebrovascular protection,neuroprotective functions,blood glucose regulation,antitumor activity,and hematopoietic promotion.Clinically,Danggui(Angelicae Sinensis Radix)is often combined with other Chinese herbs to treat immune-related disorders,cardiovascular and cerebrovascular diseases,neurodegenerative conditions,diabetes,and cancer.Although existing studies have identified some active components,the mechanisms and pharmacological roles of many others remain underexplored.Future research should focus on systematically analyzing diverse active constituents such as flavonoids,coumarins,amino acids,bioactive peptides,trace elements,and vitamins.Integrating multiomics and molecular docking technologies will help elucidate key targets and molecular mechanisms underlying its anti-inflammatory,antioxidant,and immunomodulatory effects,thereby facilitating the development of precise therapies based on multicomponent synergy.Additionally,in-depth investigation of herb-pairing effects and establishment of scientific quality control standards are essential to expand clinical applications and enhance the medicinal value of this traditional herb.展开更多
The chemical composition of dew is closely related to the air quality.Since 2013,China has promulgated a series of laws and regulations focused on air pollution control,and remarkable results have been achieved over t...The chemical composition of dew is closely related to the air quality.Since 2013,China has promulgated a series of laws and regulations focused on air pollution control,and remarkable results have been achieved over the past decade.As an indicator of near-surface air quality,the chemical composition of dew obviously changes.The dew quality was affected mainly by the local air quality.The mean dew pH was 6.3±0.4(n=186)from 2013 to 2023,and the order of ions was SO_(4)^(2-)(3180.7±3592.0μeq/L)>NH_(4)^(+)(2552.3±2971.8μeq/L)>Ca^(2+)(1006.2±945.5μeq/L)>NO_(3)^(-)(397.2±511.0μeq/L)>Cl^(-)(152.3±133.4μeq/L)>K^(+)(149.4±191.6μeq/L)>F^(-)(133.0±110.3μeq/L)>Na^(+)(123.8±94.9μeq/L)>Mg^(2+)(83.3±65.6μeq/L).The dew quality deteriorated on hazy days.There were no haze events during the condensation period after 2020,which caused a significant reduction in the concentration of the main ions in the dew.Over the past decade,electrical conductivity(EC),total dissolved solids(TDS),PM_(2.5) and PM_(10),as well as major ions(SO_(4)^(2-),NO_(3)^(-),NH_(4)^(+),Ca^(2+),Cl^(-),Na^(+),F^(-),K^(+)and Mg^(2+))in dew,have all tended to decrease.The annualmean NO_(3)^(-)concentration in 2023 was 86.5%lower than that in 2013,with values of 79.3%for SO_(4)^(2-),77.3%for Ca^(2+),76.7%for NH_(4)^(+),74.6%for K^(+),65.4%for Mg^(2+),63.4%for Na^(+),61.7%for Cl^(-),and 60.3%for F^(-).展开更多
This paper systematically categorizes the primary composition of star anise(Illicium verum),including volatile oils,flavonoids,phenolic acids,and sesquiterpene lactones,and further analyzes the pharmacological activit...This paper systematically categorizes the primary composition of star anise(Illicium verum),including volatile oils,flavonoids,phenolic acids,and sesquiterpene lactones,and further analyzes the pharmacological activities,such as antibacterial,analgesic,anti-inflammatory,and antioxidant effects.Additionally,it summarizes key aspects of extraction techniques,analytical methods,and fresh material processing technologies.The objective is to provide a robust foundation for enhancing research methods and technological standards related to star anise,thereby improving resource utilization efficiency and facilitating its industrial applications.展开更多
Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other...Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other components,which have various activities:anti-inflammatory,immune system regulation,antiviral,anti-aging,detoxification,and protection of the liver,lungs,and kidneys.JFG has broad potential therapeutic applications.The mechanisms of JFG’s actions are primarily associated with signaling pathways such as TLR4/NF-κB,PI3K/AKT,and MAPK.This article reviews the research progress on JFG,including chemical composition,pharmacologic effects,mechanism of action,safety,clinical application,etc.,serving as a foundation for future research and clinical applications.展开更多
Lysimachia capillipes(L.capillipes)Hemsl,belong to primulaceae pearl vegetables genus,is a treasure in traditional Chinese medicine.It has the effects of invigorating qi and tonifying deficiency,dispelling wind and ac...Lysimachia capillipes(L.capillipes)Hemsl,belong to primulaceae pearl vegetables genus,is a treasure in traditional Chinese medicine.It has the effects of invigorating qi and tonifying deficiency,dispelling wind and activating blood,awakening the brain,relieving cough and regulating menstruation.With the development of modern medicine,the active components and therapeutic mechanisms of L.capillipes Hemsl have been gradually revealed.The present report systematically reviews the chemical composition and biological activities of L.capillipes Hemsl,to provide scientific basis and reference for detailed research on L.capillipes Hemsl.展开更多
Angelica sinensis(A.sinensis),as a kind of Chinese medicine,has the effects of tonifying blood,promoting blood circulation,regulating menstrual flow,relieving pain,moistening bowel and so on.By consulting Sciencedirec...Angelica sinensis(A.sinensis),as a kind of Chinese medicine,has the effects of tonifying blood,promoting blood circulation,regulating menstrual flow,relieving pain,moistening bowel and so on.By consulting Sciencedirect database and Web of Science database,163 related articles were found,of which 36 were related to chemical composition and pharmacological activities of A.sinensis.In this paper,the chemical structures and different derivatives were systematically summarized by reviewing relevant literatures,and the pharmacological effects were also summarized.展开更多
Boenninghausenia sessilicarpa Lévl.is a commonly used folk medicine in southwest Yunnan.It has the effects of clearing heat and detoxifying,promoting qi circulation and activating blood circulation.It is used to ...Boenninghausenia sessilicarpa Lévl.is a commonly used folk medicine in southwest Yunnan.It has the effects of clearing heat and detoxifying,promoting qi circulation and activating blood circulation.It is used to treat various conditions such as colds,tonsillitis,mumps,lung-heat induced cough and asthma,abdominal distension and pain,pyelonephritis,gangrene of the extremities,low back pain,and bruises from falls and injuries.This paper summarizes recent research progress on the chemical constituents and pharmacological activities of Boenninghausenia sessilicarpa Lévl.,aiming to advance fundamental and clinical studies on this plant and provide a reference for enhanced medical utilization.展开更多
The chemical compositions of volatile oil from fruiting body of Armillaria luteo-virens in Qinghai Province were firstly analyzed with GC-MS and its relevant compositions were detected by calculating chromatographic p...The chemical compositions of volatile oil from fruiting body of Armillaria luteo-virens in Qinghai Province were firstly analyzed with GC-MS and its relevant compositions were detected by calculating chromatographic peak area with normalized method. 21 peaks were separated and 13 compositions were identified which were mainly unsaturated fatty acids, taking 97.1% of the total volatile oil.展开更多
Through field experiment,special biological fertilizer and cake fertilizer were applied collectively to tobacco,and chemical compositions of Wanxi flue-cured tobacco leaves were researched.The results showed that the ...Through field experiment,special biological fertilizer and cake fertilizer were applied collectively to tobacco,and chemical compositions of Wanxi flue-cured tobacco leaves were researched.The results showed that the increase of biological organic fertilizer would significantly improve soil nutrient supplying capacity.Compared with conventional fertilization,the contents of reducing sugar,total sugar and starch in different parts of tobaccos which were applied with biological organic fertilizer were closer to standards of excellent tobacco.In the treatment,the ratio of reducing sugar and nicotine in tobacco was more suitable in middle and lower parts of the plant and the contents of total N,nicotine and chlorine in tobacco were lowered,improving tobacco quality.展开更多
[Objective] The research was aimed to study the main chemical composi- tions of rice straw in the three different areas of Jiangsu Province. [Method] The cellulose, hemicellulose, lignin and crude ash of rice straw co...[Objective] The research was aimed to study the main chemical composi- tions of rice straw in the three different areas of Jiangsu Province. [Method] The cellulose, hemicellulose, lignin and crude ash of rice straw collected in Huaian, Changzhou and Zhenjiang of Jiangsu Province during 2011-2013 were determined. [Result] The change trends of cellulose and hemicellulose in three arrears in differ- ent years were consistent. The cellulose content increased after falling, and hemi- cellulose content presented declining tendency. The lignin content of rice straw fist rose then declined in Huaian and Changzhou in different years, while it presented the declining tendency in Zhenjiang. The ash content of rice straw changed little and was all less than 65% in the three areas in different years. And the chemical composition of rice straw changed significantly in different years. [Conclusion] The research could provide basis for high added-value use of crop straw.展开更多
The composition and antimicrobial activities of the essential oil of Aconitum tanguticum from the southern part of Gansu Province of China were investigated. The essential oil of aerial parts was obtained by hydrodist...The composition and antimicrobial activities of the essential oil of Aconitum tanguticum from the southern part of Gansu Province of China were investigated. The essential oil of aerial parts was obtained by hydrodistillation with a 0.7% （v/w） yield. The chemical composition of the essential oil was analyzed by gas chromatography-mass spectrometry （GC-MS） method. Thirty-five compounds were characterized in the oil, which were mainly monoterpenoids （41.7%） and sequiterpenoids （12.7%）. The main compounds in the oil were （-）-tran-pinecarvyl acetate （15.6%）, heptane （14.88%）, cineole （6.82%）, 3-pinanone （3.64%）, pinocamphone （3.34%）, cadinol （2.93%）, and cubenol （2.33%）. These compounds are identified for the first time in Aconitum tanguticum. The antimicrobial activities of the oil were evaluated against 9 bacteria strains, 1 yeast strain and 3 fungi strains using agar diffusion and broth microdilution methods. It showed strong inhibition against Fusarium semitectum and methicillin-resistant Staphlococcus aureus, low activity against Escheriehia eoli, but no effect against Epidermophyton floccosum. Its MIC values ranged from 0.125 5.000 mg/mL. Thirty-five compounds are newly identified in Aconitum tanguticum.展开更多
The pre-precipitation processes of γ＇ phase in Ni-Al-Ti alloy with different chemical compositions are investigated by microscopic phase-field dynamics model. The simulation results show that the early precip...The pre-precipitation processes of γ＇ phase in Ni-Al-Ti alloy with different chemical compositions are investigated by microscopic phase-field dynamics model. The simulation results show that the early precipitated phase with L10 structure is formed before the formation of γ＇ phase. With the increase of Al content, the composition of precipitated phase is transformed from the co-existence of γ＇ phase and material phase into single y phase. Furthermore, excessive Al content can stimulate the production of γ＇ phase, and the conversion time from L10 phase to L12 phase will lag behind other samples with lower Al con-tent. By analyzing the occupation probability of Ti, it can be found that the solid solution strengthening effect of Ti is reduced with the increase of Al component.展开更多
To better understand the potential causes of visibility impairment in autumn and winter in Chengdu,relative humidity(RH),visibility,the concentrations of PM2.5 and its chemical components were on-line measured continu...To better understand the potential causes of visibility impairment in autumn and winter in Chengdu,relative humidity(RH),visibility,the concentrations of PM2.5 and its chemical components were on-line measured continuously in Chengdu from Nov.2016 to Jan.2017.Six obvious haze episodes occurred in Chengdu,with the total time of haze episodes accounted for more than 90%of the total observation period,and higher NO2 concentrations and RH were related to the high particle concentrations in haze episodes.The visibility decreased in a non-linear tendency under different RH conditions with the increase of PM2.5 concentrations,which was more sensitive to RH under lower PM2.5 concentrations.The threshold concentration of PM2.5 got more smaller with the increase of RH.During the entire observation period,organic matter(OM)was the largest contributor(31.12%to extinction coefficient(bext)),followed by NH4NO3 and(NH4)2SO4 with 28.03%and 23.01%,respectively.However,with the visibility impairment from Type I(visibility>10 km)to Type IV(visibility≤2 km),the contribution of OM to bextdecreased from 38.12%to 26.77%,while the contribution of NH4NO3 and(NH4)2SO4 to bextincreased from 19.09%and 20.20%to 34.29%and 24.35%,respectively,and NH4NO3 became the largest contributor to bextat Type IV.The results showed that OM and NH4NO3 were the key components of PM2.5 for visibility impairment in Chengdu,indicating that the control of precursors emissions of carbonaceous species and NH4NO3 could effectively improve the visibility in Chengdu.展开更多
During November–December 2010 aerosol scattering coefficients were monitored using a single-waved （525 nm） Nephelometer at a regional monitoring station in the central Pearl River Delta region and 24-hr fine partic...During November–December 2010 aerosol scattering coefficients were monitored using a single-waved （525 nm） Nephelometer at a regional monitoring station in the central Pearl River Delta region and 24-hr fine particle （PM 2.5） samples were also collected during the period using quartz filters for the analysis of major chemical components including organic carbon （OC）,elemental carbon （EC）,sulfate,nitrate and ammonium.In average,these five components accounted for about 85% of PM 2.5 mass and contributed 42% （OC）,19% （SO 4 2 -）,12% （NO 3 -）,8.4% （NH 4＋） and 3.7% （EC）,to PM 2.5 mass.A relatively higher mass scattering efficiency of 5.3 m 2/g was obtained for fine particles based on the linear regression between scattering coefficients and PM 2.5 mass concentrations.Chemical extinction budget based on IMPROVE approach revealed that ammonium sulfate,particulate organic matter,ammonium nitrate and EC in average contributed about 32%,28%,20% and 6% to the light extinction coefficients,respectively.展开更多
In the present work,the fruits of four Morus species,namely Morus alba (white mulberry),Morus nigra (black mulberry),Morus laevigata (large white fruit),and Morus laevigata (large black fruit),were analyzed for proxim...In the present work,the fruits of four Morus species,namely Morus alba (white mulberry),Morus nigra (black mulberry),Morus laevigata (large white fruit),and Morus laevigata (large black fruit),were analyzed for proximate composition,essential minerals,and antioxidant potentials.For this purpose,the ripe fruits were collected from the northern regions of Pakistan.The major nutritional components moisture,ash,lipids,proteins,fibres,carbohydrates,and total sugar) were found to be in the suitable range along with good computed energy.Total dry weight,pH,and titratable acidity (percent citric acid) were (17.60±1.94)–(21.97±2.34) mg/100 g,(3.20±0.07)–(4.78±0.15),and (0.84±0.40)%–(2.00±0.08)%,respectively.Low riboflavin (vitamin B2) and niacin (vitamin B3) contents were recorded in all the fruits,while ascorbic acid (vitamin C) was in the range from (15.20±1.25) to (17.03±1.71) mg/100 g fresh weight (FW).The mulberry fruits were rich with regard to the total phenol and alkaloid contents,having values of (880±7.20)–(1650±12.25) mg/100 g FW and (390±3.22)–(660±5.25) mg/100 g FW,respectively.Sufficient quantities of essential macro-(K,Ca,Mg,and Na) and micro-(Fe,Zn,and Ni) elements were found in all the fruits.K was the predominant element with concentration ranging from (1270±9.36) to (1731±11.50) mg/100 g,while Ca,Na,and Mg contents were (440±3.21)–(576±7.37),(260±3.86)–(280±3.50),and (240±3.51)–(360±4.20) mg/100 g,respectivly.The decreasing order of micro-minerals was Fe>Zn>Ni.The radical scavenging activity of methanolic extract of fruits was concentration-dependent and showed a correlation with total phenolic constituents of the respective fruits.Based on the results obtained,mulberry fruits were found to serve as a potential source of food diet and natural antioxidants.展开更多
Concentrations of atmospheric PM10 and chemical components （including twenty-one elements, nine ions, organic carbon （OC） and elemental carbon （EC）） were measured at five sites in a heavily industrial region of ...Concentrations of atmospheric PM10 and chemical components （including twenty-one elements, nine ions, organic carbon （OC） and elemental carbon （EC）） were measured at five sites in a heavily industrial region of Shenzhen, China in 2005. Results showed that PM10 concentrations exhibited the highest values at 264 μg/m3 at the site near a harbor with the influence of harbor activities. Sulfur exhibited the highest concentrations （from 2419 to 3995 ng/m3） of all the studied elements, which may be related to the influence of coal used as fuel in this area for industrial plants. This was verified by the high mass percentages of SO42-, which accounted for 34.3%-39.7% of the total ions. NO3-/SO42- ratios varied from 0.64-0.71, which implies coal combustion was predominant compared with vehicle emission. The anion/cation ratios range was close to 0.95, indicating anion deficiency in this region. The harbor site showed the highest OC and EC concentrations, with the influence of emission from vessels. Secondary organic carbon accounted for about 22.6%-38.7% of OC, with the highest percentage occurring at the site adjacent to a coal-fired power plant and wood plant. The mass closure model performed well in this heavily industrial region, with significant correlation obtained between chemically determined and gravimetrically measured PM10 mass. The main constituents of PM10 were found to be organic materials （30.9%-69.5%）, followed by secondary inorganic aerosol （7.9%-25.0%）, crustal materials （6.7%-13.8%）, elemental carbon （3.5%-10.8%）, sea salt （2.4%-6.2%） and trace elements （2.0%-4.9%） in this heavily industrialized region. Principal component analysis indicated that the main sources for particulate matter in this industrial region were crustal materials and coal/wood combustion, oil combustion, secondary aerosols, industrial processes and vehicle emission.展开更多
Dust events occurred frequently in Beijing in recent years. In this work, 120 aerosol samples were collected in two typical dust events (21-22 March and 15 May) and a non-dust period in Beijing from March to May 2001....Dust events occurred frequently in Beijing in recent years. In this work, 120 aerosol samples were collected in two typical dust events (21-22 March and 15 May) and a non-dust period in Beijing from March to May 2001. Samples were analyzed for major elemental components by the Proton Induced X-ray Emission (PIXE) method. Results show that the enrichment factors of crustal elements such as Mg, Al, and Ti had little differences between the dust period and the non-dust period in Beijing, while the enrichment factors of other elements that have a relation to anthropogenic emissions were very low during the dust period. The results derived by using multivariate factor analysis from the observation data show that the sources such as soil dust, industry, and fuel combustion were among the major contributors to the particles in Beijing.展开更多
基金Supported by Natural Science Foundation Project of Xinjiang Uygur Autonomous Region(2021D01B59)Youth Science and Technology Backbone Project of Xinjiang Academy of Agricultural Sciences(XJNKQ-2021011)+2 种基金General Program of Hainan Natural Science Foundation(319MS109)Major Science and Technology Program of Hainan Province(ZDKJ2021005)Specific Research Fund of the Innovation Platform for Academicians of Hainan Province(YSPTZX202141).
文摘[Objectives]To investigate the chemical composition,antioxidant property,and nematicidal activity of Cucumis metuliferus and establish a theoretical foundation for the development of botanical nematicides.[Methods]The compounds were isolated and purified using silica gel,reversed-phase medium,low-pressure gel Sephadex LH-20 column chromatography,and preparative high-performance liquid chromatography.Their identification was based on physicochemical properties,various spectral analyses,and data reported in the literature.Subsequently,the nematicidal and antioxidant activities of the isolated compounds were evaluated.[Results]A total of four compounds were isolated from C.metuliferus,which were identified as isovitexin-2″-O-glucoside(compound 1),9E,11E-(13-oxo)tridecadienoic acid(compound 2),2E,4E-tridecadienedioic acid(compound 3),and 9E,11E-(13-hydroxy)tridecadienoic acid(compound 4).Compound 1 demonstrated a notable degree of antioxidant activity,achieving a DPPH scavenging rate of 49.40%at a mass concentration of 1 mg/mL.Additionally,compounds 1,3,and 4 exhibited varying levels of nematicidal activity.Specifically,compound 1 displayed strong nematicidal activity at a concentration of 2.0 mg/mL,resulting in a mortality rate of 90.5%against nematodes.Furthermore,compounds 3 and 4 achieved a mortality rate of 100%against nematodes at a concentration of 0.25 mg/mL.[Conclusions]This study reports the first isolation of four compounds:isovitexin-2″-O-glucoside,9E,11E-(13-oxo)tridecadienoic acid,2E,4E-tridecadienedioic acid,and 9E,11E-(13-hydroxy)tridecadienoic acid from C.metuliferus.Notably,2E,4E-tridecadienedioic acid and 9E,11E-(13-oxo)tridecadienoic acid are identified as novel natural products.Among these compounds,isovitexin-2″-O-glucoside,9E,11E-(13-oxo)tridecadienoic acid,and 9E,11E-(13-hydroxy)tridecadienoic acid exhibit nematicidal activity,whereas isovitexin-2″-O-glucoside demonstrates antioxidant properties.
基金Supported by The Forestry Science and Technology Innovation Funded Project of Hunan Forestry Bureau,No.XLKY202221。
文摘BACKGROUND Fruits of Gardenia jasminoides(G.jasminoides)have extremely high medicinal value.However,the quality and traits of the plants vary significantly based on their provenances.In addition,the behaviour of the known bioactive components,such as geniposide and crocin,has been the primary focus of the research on G.jasminoides.However,the identification of unknown bioactive components and their metabolomics remains underexplored.Therefore,analysing the metabolic differences between gardenias from different sources is essential to provide a comprehensive theoretical basis for the evaluation of G.jasminoides and germplasm resource identification.AIM To systematically evaluate the morphology,secondary metabolites,typical active ingredients,and antioxidant activity of wild G.jasminoides fruits.METHODS Gardenia fruits were collected from different provenances.Metabolites were identified via ultra-high-performance liquid chromatography–tandem mass spectrometry(UPLC-MS/MS).The metabolic differences were compared using hierarchical cluster analysis(HCA).The antioxidant capacity was evaluated using 2,2-diphenyl-1-picrylhydrazyl radical scavenging assays and ferric reducing antioxidant power assays,and its correlation with typical active ingredients was analysed.RESULTS A total of 444 and 240 metabolites were identified using UPLC-MS/MS in positive and negative ion modes,respectively.The HCA results of the flavonoids indicated that the higher content of flavonoids was in the fruits from Lukou.The differential analysis of metabolites in fruits from Shaoyang,Miluo and Lukou showed that the fruit from Miluo had the highest upregulated differential metabolites.CONCLUSION The metabolic characteristics of the Ningxiang and Xiangxi extracts were similar,while those of Lukou,Miluo and Shaoyang extracts differed significantly.
基金National Natural ScienceFoundation of China (grant number: 81973696).
文摘Gualou-Xiebai-Banxia Decoction(GXBD)is a traditional Chinese herbal formula including four traditional Chinese medicines:Gualou(Trichosanthis Fructus,TF),Xiebai(Allii Macrostemonis Bulbus,AMB),Banxia(Pinelliae Rhizoma,PR)and yellow wine.It is a classical therapy for chest stuffiness and pain syndrome and is widely used in the clinical treatment of coronary heart disease.It also shows significant therapeutic effects on pulmonary heart disease,hyperlipidemia,and arrhythmia.This study conducted a literature review and collected information on GXBD from databases such as PubMed,Web of Science,China National Knowledge Infrastructure,and ScienceDirect.The result indicated that the main active ingredients of GXBD are steroids,flavonoids,terpenoids,alkaloids,amino acids,and organic acids.Trigonelline,macrostemonoside and cucurbitacin B can provide reference for its quality control.GXBD may exert therapeutic effects on coronary heart disease through AMPK,PI3K-AKT,oxLDL,VEGF,and NF-κB signal pathways.This review provides a comprehensive analysis and summary of the chemical composition and in vivo metabolism of three traditional Chinese medicines(TF,AMB,and PR),along with an evaluation of the chemical composition,quality control,pharmacological effects,and clinical application of GXBD.Based on these,areas requiring further research on GXBD have been proposed to provide a reference for its further development and new drug research.
基金Key Scientific Research Projects of Henan Higher Education Institutions(21A320018).
文摘As a traditional medicinal and edible herb,Danggui(Angelicae Sinensis Radix)exhibits pharmacological activities closely associated with its characteristic chemical components,such as volatile oils(e.g.,ligustilide),organic acids(e.g.,ferulic acid),and polysaccharides.It demonstrates a wide range of pharmacological effects,including anti-inflammatory and immunomodulatory properties,cardiovascular and cerebrovascular protection,neuroprotective functions,blood glucose regulation,antitumor activity,and hematopoietic promotion.Clinically,Danggui(Angelicae Sinensis Radix)is often combined with other Chinese herbs to treat immune-related disorders,cardiovascular and cerebrovascular diseases,neurodegenerative conditions,diabetes,and cancer.Although existing studies have identified some active components,the mechanisms and pharmacological roles of many others remain underexplored.Future research should focus on systematically analyzing diverse active constituents such as flavonoids,coumarins,amino acids,bioactive peptides,trace elements,and vitamins.Integrating multiomics and molecular docking technologies will help elucidate key targets and molecular mechanisms underlying its anti-inflammatory,antioxidant,and immunomodulatory effects,thereby facilitating the development of precise therapies based on multicomponent synergy.Additionally,in-depth investigation of herb-pairing effects and establishment of scientific quality control standards are essential to expand clinical applications and enhance the medicinal value of this traditional herb.
基金supported by the Natural Science Foundation of Jilin Province(No.YDZJ202401369ZYTS)the National Natural Science Foundation of China(No.42175140).
文摘The chemical composition of dew is closely related to the air quality.Since 2013,China has promulgated a series of laws and regulations focused on air pollution control,and remarkable results have been achieved over the past decade.As an indicator of near-surface air quality,the chemical composition of dew obviously changes.The dew quality was affected mainly by the local air quality.The mean dew pH was 6.3±0.4(n=186)from 2013 to 2023,and the order of ions was SO_(4)^(2-)(3180.7±3592.0μeq/L)>NH_(4)^(+)(2552.3±2971.8μeq/L)>Ca^(2+)(1006.2±945.5μeq/L)>NO_(3)^(-)(397.2±511.0μeq/L)>Cl^(-)(152.3±133.4μeq/L)>K^(+)(149.4±191.6μeq/L)>F^(-)(133.0±110.3μeq/L)>Na^(+)(123.8±94.9μeq/L)>Mg^(2+)(83.3±65.6μeq/L).The dew quality deteriorated on hazy days.There were no haze events during the condensation period after 2020,which caused a significant reduction in the concentration of the main ions in the dew.Over the past decade,electrical conductivity(EC),total dissolved solids(TDS),PM_(2.5) and PM_(10),as well as major ions(SO_(4)^(2-),NO_(3)^(-),NH_(4)^(+),Ca^(2+),Cl^(-),Na^(+),F^(-),K^(+)and Mg^(2+))in dew,have all tended to decrease.The annualmean NO_(3)^(-)concentration in 2023 was 86.5%lower than that in 2013,with values of 79.3%for SO_(4)^(2-),77.3%for Ca^(2+),76.7%for NH_(4)^(+),74.6%for K^(+),65.4%for Mg^(2+),63.4%for Na^(+),61.7%for Cl^(-),and 60.3%for F^(-).
基金Supported by Project of Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine(GXZYA20230001)Research Fund Project of Guangxi Zhuang Autonomous Region Medicinal Botanical Garden(202304).
文摘This paper systematically categorizes the primary composition of star anise(Illicium verum),including volatile oils,flavonoids,phenolic acids,and sesquiterpene lactones,and further analyzes the pharmacological activities,such as antibacterial,analgesic,anti-inflammatory,and antioxidant effects.Additionally,it summarizes key aspects of extraction techniques,analytical methods,and fresh material processing technologies.The objective is to provide a robust foundation for enhancing research methods and technological standards related to star anise,thereby improving resource utilization efficiency and facilitating its industrial applications.
基金supported by the Key R&D Program of Shandong Province,China(No.2024TZXD067,2022SFGC0105)Natural Science Foundation of Shandong Province(No.ZR2023QB021)+2 种基金Young Taishan Scholarship to Xuekui Xia(No.tsqn202103100)Jinan Talent Project for Universities(No.2021GXRC062,202228088)Key innovation Project and Science,Education and Industry Integration Innovation Pilot Project of Qilu University of Technology(Shandong Academy of Sciences)(No.2022JBZ01-06,2024ZDZX03,2023RCKY214).
文摘Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other components,which have various activities:anti-inflammatory,immune system regulation,antiviral,anti-aging,detoxification,and protection of the liver,lungs,and kidneys.JFG has broad potential therapeutic applications.The mechanisms of JFG’s actions are primarily associated with signaling pathways such as TLR4/NF-κB,PI3K/AKT,and MAPK.This article reviews the research progress on JFG,including chemical composition,pharmacologic effects,mechanism of action,safety,clinical application,etc.,serving as a foundation for future research and clinical applications.
基金supported by National Nature Science Foundation of China(81973284)Scientific Research Foundation of the Education Department of Liaoning Province(LJKZ0944).
文摘Lysimachia capillipes(L.capillipes)Hemsl,belong to primulaceae pearl vegetables genus,is a treasure in traditional Chinese medicine.It has the effects of invigorating qi and tonifying deficiency,dispelling wind and activating blood,awakening the brain,relieving cough and regulating menstruation.With the development of modern medicine,the active components and therapeutic mechanisms of L.capillipes Hemsl have been gradually revealed.The present report systematically reviews the chemical composition and biological activities of L.capillipes Hemsl,to provide scientific basis and reference for detailed research on L.capillipes Hemsl.
基金financially supported by National Nature Science Foundation of China(81973284)Scientific Research Foundation of the Education Department of Liaoning Province(LJKZ0944).
文摘Angelica sinensis(A.sinensis),as a kind of Chinese medicine,has the effects of tonifying blood,promoting blood circulation,regulating menstrual flow,relieving pain,moistening bowel and so on.By consulting Sciencedirect database and Web of Science database,163 related articles were found,of which 36 were related to chemical composition and pharmacological activities of A.sinensis.In this paper,the chemical structures and different derivatives were systematically summarized by reviewing relevant literatures,and the pharmacological effects were also summarized.
文摘Boenninghausenia sessilicarpa Lévl.is a commonly used folk medicine in southwest Yunnan.It has the effects of clearing heat and detoxifying,promoting qi circulation and activating blood circulation.It is used to treat various conditions such as colds,tonsillitis,mumps,lung-heat induced cough and asthma,abdominal distension and pain,pyelonephritis,gangrene of the extremities,low back pain,and bruises from falls and injuries.This paper summarizes recent research progress on the chemical constituents and pharmacological activities of Boenninghausenia sessilicarpa Lévl.,aiming to advance fundamental and clinical studies on this plant and provide a reference for enhanced medical utilization.
基金the National Natural Science Foundation of China (30460083)the Key Science and Technology Project of Chinese Ministry of Education (205164)~~
文摘The chemical compositions of volatile oil from fruiting body of Armillaria luteo-virens in Qinghai Province were firstly analyzed with GC-MS and its relevant compositions were detected by calculating chromatographic peak area with normalized method. 21 peaks were separated and 13 compositions were identified which were mainly unsaturated fatty acids, taking 97.1% of the total volatile oil.
文摘Through field experiment,special biological fertilizer and cake fertilizer were applied collectively to tobacco,and chemical compositions of Wanxi flue-cured tobacco leaves were researched.The results showed that the increase of biological organic fertilizer would significantly improve soil nutrient supplying capacity.Compared with conventional fertilization,the contents of reducing sugar,total sugar and starch in different parts of tobaccos which were applied with biological organic fertilizer were closer to standards of excellent tobacco.In the treatment,the ratio of reducing sugar and nicotine in tobacco was more suitable in middle and lower parts of the plant and the contents of total N,nicotine and chlorine in tobacco were lowered,improving tobacco quality.
基金Supported by the Speical Fund for Agro-Scientific Research in the Public Interest(201003063)~~
文摘[Objective] The research was aimed to study the main chemical composi- tions of rice straw in the three different areas of Jiangsu Province. [Method] The cellulose, hemicellulose, lignin and crude ash of rice straw collected in Huaian, Changzhou and Zhenjiang of Jiangsu Province during 2011-2013 were determined. [Result] The change trends of cellulose and hemicellulose in three arrears in differ- ent years were consistent. The cellulose content increased after falling, and hemi- cellulose content presented declining tendency. The lignin content of rice straw fist rose then declined in Huaian and Changzhou in different years, while it presented the declining tendency in Zhenjiang. The ash content of rice straw changed little and was all less than 65% in the three areas in different years. And the chemical composition of rice straw changed significantly in different years. [Conclusion] The research could provide basis for high added-value use of crop straw.
基金National Natural Science Foundation of China(Grant No.30471133).
文摘The composition and antimicrobial activities of the essential oil of Aconitum tanguticum from the southern part of Gansu Province of China were investigated. The essential oil of aerial parts was obtained by hydrodistillation with a 0.7% （v/w） yield. The chemical composition of the essential oil was analyzed by gas chromatography-mass spectrometry （GC-MS） method. Thirty-five compounds were characterized in the oil, which were mainly monoterpenoids （41.7%） and sequiterpenoids （12.7%）. The main compounds in the oil were （-）-tran-pinecarvyl acetate （15.6%）, heptane （14.88%）, cineole （6.82%）, 3-pinanone （3.64%）, pinocamphone （3.34%）, cadinol （2.93%）, and cubenol （2.33%）. These compounds are identified for the first time in Aconitum tanguticum. The antimicrobial activities of the oil were evaluated against 9 bacteria strains, 1 yeast strain and 3 fungi strains using agar diffusion and broth microdilution methods. It showed strong inhibition against Fusarium semitectum and methicillin-resistant Staphlococcus aureus, low activity against Escheriehia eoli, but no effect against Epidermophyton floccosum. Its MIC values ranged from 0.125 5.000 mg/mL. Thirty-five compounds are newly identified in Aconitum tanguticum.
基金National Natural Science Foundation of China(Nos.U1610123,51674226,51574207,51574206,51274175)International Cooperation Project of the Ministry of Science and Technology of China(No.2014DFA50320)Science and Technology Major Project of Shanxi Province(No.MC2016-06)
文摘The pre-precipitation processes of γ＇ phase in Ni-Al-Ti alloy with different chemical compositions are investigated by microscopic phase-field dynamics model. The simulation results show that the early precipitated phase with L10 structure is formed before the formation of γ＇ phase. With the increase of Al content, the composition of precipitated phase is transformed from the co-existence of γ＇ phase and material phase into single y phase. Furthermore, excessive Al content can stimulate the production of γ＇ phase, and the conversion time from L10 phase to L12 phase will lag behind other samples with lower Al con-tent. By analyzing the occupation probability of Ti, it can be found that the solid solution strengthening effect of Ti is reduced with the increase of Al component.
基金supported by Sichuan Science and Technology Program (Nos. 2018SZ0316, 2018SZDZX0023)the Research on Forecasting Technology of Heavy Pollution Weather
文摘To better understand the potential causes of visibility impairment in autumn and winter in Chengdu,relative humidity(RH),visibility,the concentrations of PM2.5 and its chemical components were on-line measured continuously in Chengdu from Nov.2016 to Jan.2017.Six obvious haze episodes occurred in Chengdu,with the total time of haze episodes accounted for more than 90%of the total observation period,and higher NO2 concentrations and RH were related to the high particle concentrations in haze episodes.The visibility decreased in a non-linear tendency under different RH conditions with the increase of PM2.5 concentrations,which was more sensitive to RH under lower PM2.5 concentrations.The threshold concentration of PM2.5 got more smaller with the increase of RH.During the entire observation period,organic matter(OM)was the largest contributor(31.12%to extinction coefficient(bext)),followed by NH4NO3 and(NH4)2SO4 with 28.03%and 23.01%,respectively.However,with the visibility impairment from Type I(visibility>10 km)to Type IV(visibility≤2 km),the contribution of OM to bextdecreased from 38.12%to 26.77%,while the contribution of NH4NO3 and(NH4)2SO4 to bextincreased from 19.09%and 20.20%to 34.29%and 24.35%,respectively,and NH4NO3 became the largest contributor to bextat Type IV.The results showed that OM and NH4NO3 were the key components of PM2.5 for visibility impairment in Chengdu,indicating that the control of precursors emissions of carbonaceous species and NH4NO3 could effectively improve the visibility in Chengdu.
基金supported by the National Natural Science Foundation of China (No. 40821003,41025012)NSFC-Guangdong Joint Funds (No. U0833003)+1 种基金the Natural Science Foundation of Guangdong (No. 7118013)the Bureau of Science,Technology and Information of Guangzhou (No. 2010U1-E00601-2)
文摘During November–December 2010 aerosol scattering coefficients were monitored using a single-waved （525 nm） Nephelometer at a regional monitoring station in the central Pearl River Delta region and 24-hr fine particle （PM 2.5） samples were also collected during the period using quartz filters for the analysis of major chemical components including organic carbon （OC）,elemental carbon （EC）,sulfate,nitrate and ammonium.In average,these five components accounted for about 85% of PM 2.5 mass and contributed 42% （OC）,19% （SO 4 2 -）,12% （NO 3 -）,8.4% （NH 4＋） and 3.7% （EC）,to PM 2.5 mass.A relatively higher mass scattering efficiency of 5.3 m 2/g was obtained for fine particles based on the linear regression between scattering coefficients and PM 2.5 mass concentrations.Chemical extinction budget based on IMPROVE approach revealed that ammonium sulfate,particulate organic matter,ammonium nitrate and EC in average contributed about 32%,28%,20% and 6% to the light extinction coefficients,respectively.
文摘In the present work,the fruits of four Morus species,namely Morus alba (white mulberry),Morus nigra (black mulberry),Morus laevigata (large white fruit),and Morus laevigata (large black fruit),were analyzed for proximate composition,essential minerals,and antioxidant potentials.For this purpose,the ripe fruits were collected from the northern regions of Pakistan.The major nutritional components moisture,ash,lipids,proteins,fibres,carbohydrates,and total sugar) were found to be in the suitable range along with good computed energy.Total dry weight,pH,and titratable acidity (percent citric acid) were (17.60±1.94)–(21.97±2.34) mg/100 g,(3.20±0.07)–(4.78±0.15),and (0.84±0.40)%–(2.00±0.08)%,respectively.Low riboflavin (vitamin B2) and niacin (vitamin B3) contents were recorded in all the fruits,while ascorbic acid (vitamin C) was in the range from (15.20±1.25) to (17.03±1.71) mg/100 g fresh weight (FW).The mulberry fruits were rich with regard to the total phenol and alkaloid contents,having values of (880±7.20)–(1650±12.25) mg/100 g FW and (390±3.22)–(660±5.25) mg/100 g FW,respectively.Sufficient quantities of essential macro-(K,Ca,Mg,and Na) and micro-(Fe,Zn,and Ni) elements were found in all the fruits.K was the predominant element with concentration ranging from (1270±9.36) to (1731±11.50) mg/100 g,while Ca,Na,and Mg contents were (440±3.21)–(576±7.37),(260±3.86)–(280±3.50),and (240±3.51)–(360±4.20) mg/100 g,respectivly.The decreasing order of micro-minerals was Fe>Zn>Ni.The radical scavenging activity of methanolic extract of fruits was concentration-dependent and showed a correlation with total phenolic constituents of the respective fruits.Based on the results obtained,mulberry fruits were found to serve as a potential source of food diet and natural antioxidants.
基金supported by the Research and Applicationof Supported Technology for Ecologic Effect Assessment and Decision-Making of the Large Scale Energy Base Pattern (No. 2012BAC10B01)the National Natural Science Foundation of China (No. 21277132)
文摘Concentrations of atmospheric PM10 and chemical components （including twenty-one elements, nine ions, organic carbon （OC） and elemental carbon （EC）） were measured at five sites in a heavily industrial region of Shenzhen, China in 2005. Results showed that PM10 concentrations exhibited the highest values at 264 μg/m3 at the site near a harbor with the influence of harbor activities. Sulfur exhibited the highest concentrations （from 2419 to 3995 ng/m3） of all the studied elements, which may be related to the influence of coal used as fuel in this area for industrial plants. This was verified by the high mass percentages of SO42-, which accounted for 34.3%-39.7% of the total ions. NO3-/SO42- ratios varied from 0.64-0.71, which implies coal combustion was predominant compared with vehicle emission. The anion/cation ratios range was close to 0.95, indicating anion deficiency in this region. The harbor site showed the highest OC and EC concentrations, with the influence of emission from vessels. Secondary organic carbon accounted for about 22.6%-38.7% of OC, with the highest percentage occurring at the site adjacent to a coal-fired power plant and wood plant. The mass closure model performed well in this heavily industrial region, with significant correlation obtained between chemically determined and gravimetrically measured PM10 mass. The main constituents of PM10 were found to be organic materials （30.9%-69.5%）, followed by secondary inorganic aerosol （7.9%-25.0%）, crustal materials （6.7%-13.8%）, elemental carbon （3.5%-10.8%）, sea salt （2.4%-6.2%） and trace elements （2.0%-4.9%） in this heavily industrialized region. Principal component analysis indicated that the main sources for particulate matter in this industrial region were crustal materials and coal/wood combustion, oil combustion, secondary aerosols, industrial processes and vehicle emission.
基金supported by China National Key Basic Research Science Foundation Project(G1999043400)the Hundred Talents Program(Global Environmental Change)by the Chinese Academy of Sciences+1 种基金the National Natural Science Foundation of China(No.40205017)Social Commonweal Research Project(2002DIA20012)by the Ministry of Science and Technology of China.
文摘Dust events occurred frequently in Beijing in recent years. In this work, 120 aerosol samples were collected in two typical dust events (21-22 March and 15 May) and a non-dust period in Beijing from March to May 2001. Samples were analyzed for major elemental components by the Proton Induced X-ray Emission (PIXE) method. Results show that the enrichment factors of crustal elements such as Mg, Al, and Ti had little differences between the dust period and the non-dust period in Beijing, while the enrichment factors of other elements that have a relation to anthropogenic emissions were very low during the dust period. The results derived by using multivariate factor analysis from the observation data show that the sources such as soil dust, industry, and fuel combustion were among the major contributors to the particles in Beijing.
