目的 检索、评价并整合免疫检查点抑制剂(ICIs)相关皮肤不良反应(irAEs)管理的相关证据。方法 系统检索循证决策支持系统BMJ Best Practice、JBI图书馆、Cochrane图书馆、英国国家卫生和临床优化研究所、苏格兰校际指南、Web of scienc...目的 检索、评价并整合免疫检查点抑制剂(ICIs)相关皮肤不良反应(irAEs)管理的相关证据。方法 系统检索循证决策支持系统BMJ Best Practice、JBI图书馆、Cochrane图书馆、英国国家卫生和临床优化研究所、苏格兰校际指南、Web of science、美国国立综合癌症网络等专业学会网站、PubMed、中国生物医学文献数据库、中国知网、万方中关于ICIs irAEs管理的指南、证据总结、专家共识、系统评价,检索时间限定为2013年1月1月-2022年10月31日。对检索的文献进行质量评价后,再对证据进行提取和整合。结果 共纳入9篇文献,其中包括4篇指南、1篇证据总结、4篇专家共识。经过阅读、提取和归纳,共总结出14条证据,包括培训、健康教育、评估与监测和治疗4个方面。结论 临床医护人员应应用最佳证据对ICIs irAEs进行规范管理,降低irAEs的发生。展开更多
High performance computer （HPC） is a complex huge system, of which the architecture design meets increasing difficulties and risks. Traditional methods, such as theoretical analysis, component-level simulation and s...High performance computer （HPC） is a complex huge system, of which the architecture design meets increasing difficulties and risks. Traditional methods, such as theoretical analysis, component-level simulation and sequential simulation, are not applicable to system-level simulations of HPC systems. Even the parallel simulation using large-scale parallel machines also have many difficulties in scalability, reliability, generality, as well as efficiency. According to the current needs of HPC architecture design, this paper proposes a system-level parallel simulation platform： ArchSim. We first introduce the architecture of ArchSim simulation platform which is composed of a global server （GS）, local server agents （LSA） and entities. Secondly, we emphasize some key techniques of ArchSim, including the synchronization protocol, the communication mechanism and the distributed checkpointing/restart mechanism. We then make a synthesized test of some main performance indices of ArchSim with the phold benchmark and analyze the extra overhead generated by ArchSim. Finally, based on ArchSim, we construct a parallel event-driven interconnection network simulator and a system-level simulator for a small scale HPC system with 256 processors. The results of the performance test and HPC system simulations demonstrate that ArchSim can achieve high speedup ratio and high scalability on parallel host machine and support system-level simulations for the architecture design of HPC systems.展开更多
基金supported by the National High Technology Research and Development 863 Program of China under Grant No. 2007AA01Z117the National Basic Research 973 Program of China under Grant No.2007CB310900
文摘High performance computer （HPC） is a complex huge system, of which the architecture design meets increasing difficulties and risks. Traditional methods, such as theoretical analysis, component-level simulation and sequential simulation, are not applicable to system-level simulations of HPC systems. Even the parallel simulation using large-scale parallel machines also have many difficulties in scalability, reliability, generality, as well as efficiency. According to the current needs of HPC architecture design, this paper proposes a system-level parallel simulation platform： ArchSim. We first introduce the architecture of ArchSim simulation platform which is composed of a global server （GS）, local server agents （LSA） and entities. Secondly, we emphasize some key techniques of ArchSim, including the synchronization protocol, the communication mechanism and the distributed checkpointing/restart mechanism. We then make a synthesized test of some main performance indices of ArchSim with the phold benchmark and analyze the extra overhead generated by ArchSim. Finally, based on ArchSim, we construct a parallel event-driven interconnection network simulator and a system-level simulator for a small scale HPC system with 256 processors. The results of the performance test and HPC system simulations demonstrate that ArchSim can achieve high speedup ratio and high scalability on parallel host machine and support system-level simulations for the architecture design of HPC systems.
