One hundred and five patients with primary unipolar depression were randomly divided into three groups： drug group （Seroxat administration）, acupuncture group （Seroxat plus acupunc- ture）, and electroacupuncture ...One hundred and five patients with primary unipolar depression were randomly divided into three groups： drug group （Seroxat administration）, acupuncture group （Seroxat plus acupunc- ture）, and electroacupuncture group （Seroxat plus acupuncture plus electroacupuncture）. Patients＇ symptoms were evaluated using a psychometric questionnaire, the Symptom Check- list-90, before intervention and after 2, 4, 6 and 10 weeks of treatment. The individual factor scores and the total score from the Symptom Checldist-90 reduced in all three groups as treat- ment progressed. In the acupuncture and electroacupuncture groups, the total score and the factor scores for obsessive-compulsive symptoms, depression, and anxiety were significantly lower than those in the drug group. There was no significant difference in the factor scores or total scores between the acupuncture and electroacupuncture groups. Some factor scores in the electroacupuncture group, such as somatization, depression, hostility, and phobic anxiety, were increased at 10 weeks compared with the respective score immediately after the course of electroacupuncture at 6 weeks. Our findings indicate that administration of Seroxat alone or in combination with acupuncture/electroacupuncture can produce a significant effect in patients with primary unipolar depression. Furthermore, acupuncture/electroacupuncture has a rapid onset of therapeutic effect and produces a noticeable improvement in obsessive-compulsive, de- pressive and anxiety symptoms.展开更多
肝细胞癌(hepatocellular carcinoma,HCC)是全球常见的恶性肿瘤,其治疗策略多样,其中钇-90微球选择性内放射治疗(Yttrium-90 microsphere selective internal radiation therapy,^(90)Y-SIRT)作为一种重要的局部治疗方式,在HCC的综合管...肝细胞癌(hepatocellular carcinoma,HCC)是全球常见的恶性肿瘤,其治疗策略多样,其中钇-90微球选择性内放射治疗(Yttrium-90 microsphere selective internal radiation therapy,^(90)Y-SIRT)作为一种重要的局部治疗方式,在HCC的综合管理中扮演着日益重要的角色。近年来,随着临床应用的深入,^(90)Y-SIRT在HCC治疗中积累了丰富的循证医学证据。在此背景下,美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)、欧洲肝脏学会(European Association for the Study of the Liver,EASL)、欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)、英国胃肠病学会(British Society of Gastroenterology,BSG)相继更新了HCC诊疗指南,并将^(90)Y-SIRT纳入治疗推荐体系。本文将以这些国际指南的推荐意见为核心,结合最新临床研究与临床实践经验,系统阐述^(90)Y-SIRT在HCC治疗中的应用价值。展开更多
For early hepatocellular carcinoma(HCC),curative therapies include surgical excision and radiofrequency ablation.Other treatment modes for advanced HCC involve transarterial chemoembolization.For HCC patients who do n...For early hepatocellular carcinoma(HCC),curative therapies include surgical excision and radiofrequency ablation.Other treatment modes for advanced HCC involve transarterial chemoembolization.For HCC patients who do not fit the Milan criteria or are waiting for liver transplantation(LT),studies of transarterial radioembolization with Yttrium-90(Y-90)demonstrated that Y-90 may accomplish a good downstaging or bridging effect before LT and can even achieve complete pathological necrosis.The present review discussed Y-90 radioembolization as a local regional treatment option for advanced and unresectable HCC,with a focus on neoadjuvant intervention before LT.展开更多
To counteract small sample size,severe class imbalance and high feature redundancy in 90-day mRS prediction after stroke,this study proposes a four-stage pipeline-“ADASYN re-sampling→clinical+statistical feature scr...To counteract small sample size,severe class imbalance and high feature redundancy in 90-day mRS prediction after stroke,this study proposes a four-stage pipeline-“ADASYN re-sampling→clinical+statistical feature screening→dimensionality reduction→5-fold cross-validation”-and benchmark composite deep-learning architectures.ADASYN first balances the minority classes in the original feature space.Next,a tri-level filter(clinical domain knowledge,variance threshold,mutual information)removes clinically meaningless or redundant variables,after which PCA compresses the remaining features while preserving critical neurological signatures(e.g.,brain-herniation history).Four hybrid CNN-RNN models are trained and compared under strict 5-fold cross-validation;the optimal ensemble yields stable,clinically interpretable probabilities that can support individualized rehabilitation planning.展开更多
基金supported by the National Science and Technology Support Program of China,No.2006BAI12B05-2the National Natural Science Foundation of China,No.30672768Key Discipline Construction Project of"211 Project"of Guangdong Province in China
文摘One hundred and five patients with primary unipolar depression were randomly divided into three groups： drug group （Seroxat administration）, acupuncture group （Seroxat plus acupunc- ture）, and electroacupuncture group （Seroxat plus acupuncture plus electroacupuncture）. Patients＇ symptoms were evaluated using a psychometric questionnaire, the Symptom Check- list-90, before intervention and after 2, 4, 6 and 10 weeks of treatment. The individual factor scores and the total score from the Symptom Checldist-90 reduced in all three groups as treat- ment progressed. In the acupuncture and electroacupuncture groups, the total score and the factor scores for obsessive-compulsive symptoms, depression, and anxiety were significantly lower than those in the drug group. There was no significant difference in the factor scores or total scores between the acupuncture and electroacupuncture groups. Some factor scores in the electroacupuncture group, such as somatization, depression, hostility, and phobic anxiety, were increased at 10 weeks compared with the respective score immediately after the course of electroacupuncture at 6 weeks. Our findings indicate that administration of Seroxat alone or in combination with acupuncture/electroacupuncture can produce a significant effect in patients with primary unipolar depression. Furthermore, acupuncture/electroacupuncture has a rapid onset of therapeutic effect and produces a noticeable improvement in obsessive-compulsive, de- pressive and anxiety symptoms.
文摘肝细胞癌(hepatocellular carcinoma,HCC)是全球常见的恶性肿瘤,其治疗策略多样,其中钇-90微球选择性内放射治疗(Yttrium-90 microsphere selective internal radiation therapy,^(90)Y-SIRT)作为一种重要的局部治疗方式,在HCC的综合管理中扮演着日益重要的角色。近年来,随着临床应用的深入,^(90)Y-SIRT在HCC治疗中积累了丰富的循证医学证据。在此背景下,美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)、欧洲肝脏学会(European Association for the Study of the Liver,EASL)、欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)、英国胃肠病学会(British Society of Gastroenterology,BSG)相继更新了HCC诊疗指南,并将^(90)Y-SIRT纳入治疗推荐体系。本文将以这些国际指南的推荐意见为核心,结合最新临床研究与临床实践经验,系统阐述^(90)Y-SIRT在HCC治疗中的应用价值。
文摘针对高压氢能加注场景下90 MPa隔膜式氢气压缩机面临的设备振动、氢腐蚀、膜片疲劳及密封失效等核心难题,通过气-固-液多物理场耦合仿真、抗氢脆结构创新、油气协同调控技术及复合膜腔型线设计,构建“设计-材料-工艺-安全-产业化”一体化解决方案。研究优化两列对称平衡型主机结构,采用配气盘内嵌式组合缸盖、一体化硬密封膜片与抛物线-圆弧复合膜腔型线,研发高低压一体化油泵驱动机构、波形弹簧气阀及高可靠性连杆衬套。性能测试结果表明,整机振动≤8 mm s、膜片寿命提升至8000 h以上、连杆衬套寿命突破50000 h、排气压力稳定达90 MPa(排气量500 m 3 h),国产化率达95%。该研究为高压氢能装备国产化与规模化应用提供关键技术支撑,设备性能达国际先进水平。
文摘For early hepatocellular carcinoma(HCC),curative therapies include surgical excision and radiofrequency ablation.Other treatment modes for advanced HCC involve transarterial chemoembolization.For HCC patients who do not fit the Milan criteria or are waiting for liver transplantation(LT),studies of transarterial radioembolization with Yttrium-90(Y-90)demonstrated that Y-90 may accomplish a good downstaging or bridging effect before LT and can even achieve complete pathological necrosis.The present review discussed Y-90 radioembolization as a local regional treatment option for advanced and unresectable HCC,with a focus on neoadjuvant intervention before LT.
基金Shanghai University of Engineering Science Undergraduate Innovation Training Program(Project No.:cx2521005)。
文摘To counteract small sample size,severe class imbalance and high feature redundancy in 90-day mRS prediction after stroke,this study proposes a four-stage pipeline-“ADASYN re-sampling→clinical+statistical feature screening→dimensionality reduction→5-fold cross-validation”-and benchmark composite deep-learning architectures.ADASYN first balances the minority classes in the original feature space.Next,a tri-level filter(clinical domain knowledge,variance threshold,mutual information)removes clinically meaningless or redundant variables,after which PCA compresses the remaining features while preserving critical neurological signatures(e.g.,brain-herniation history).Four hybrid CNN-RNN models are trained and compared under strict 5-fold cross-validation;the optimal ensemble yields stable,clinically interpretable probabilities that can support individualized rehabilitation planning.
