Check dams are widely constructed on China's Loess Plateau,which had a total number of 58,776 by the end of 2019.Great achievements in check dam construction have been gained regarding the economic and environment...Check dams are widely constructed on China's Loess Plateau,which had a total number of 58,776 by the end of 2019.Great achievements in check dam construction have been gained regarding the economic and environmental impacts.This study reviews the remarkable benefits of check dams on the land reclamation and environmental improvement on the Loess Plateau,and sediment reduction entering the Yellow River.However,the flood incidents on check dams have been frequently reported for the past decades,which has attracted more attention in the context of climate change and extreme rainfall events recently.Advances in the flood migration techniques achieved by the research group led by the first author have been highlighted to migrate the breach risk of check dams due to floods.The“family tree method”has been proposed to determine the survival status and critical rainfall threshold of each check dam in the complicated dam system.An updated dam breach flood evaluation framework and the corresponding numerical algorithm(i.e.,DB-IWHR)have been developed.Moreover,innovative types of water-release facilities for check dams,including geobag stepped spillway and prestressed concrete cylinder pipe in the underlying conduit,have been proposed and developed.Finally,the perspectives concerning the check dam construction on the Loess Plateau have been put forward.展开更多
在地方经济蓬勃发展与医药行业深刻变革的宏观背景下,培育高素质的临床试验协调员(Clinical Research Coordinator,简称CRC),已成为顺应社会需求、推进健康中国建设的关键举措。本文以四川护理职业学院针对药学专业开展的临床试验项目...在地方经济蓬勃发展与医药行业深刻变革的宏观背景下,培育高素质的临床试验协调员(Clinical Research Coordinator,简称CRC),已成为顺应社会需求、推进健康中国建设的关键举措。本文以四川护理职业学院针对药学专业开展的临床试验项目化教学试点为切入点,深入剖析其构建的创新医教协同培养模式,从人才培养实践、培养的关键问题与应对策略及培养成效等方面进行介绍。此培养模式在实践中取得了积极的成效,显著提升了学生的就业竞争力,为其他地区在CRC人才培养方面提供了极具价值的参考范例,助力行业整体人才培养水平的提升。展开更多
The implementation of the cascade check dam system, which integrates beam and closed-type dams, has been extensively adopted as a pivotal engineering measure for mitigating debris flow in Southwest China. In the post-...The implementation of the cascade check dam system, which integrates beam and closed-type dams, has been extensively adopted as a pivotal engineering measure for mitigating debris flow in Southwest China. In the post-debris flow events, it is imperative to quantitatively assess the volume of sediment volume captured by the cascade check dams and to monitor their impact on sediment dynamics. This study investigates the cascade check dams in Guanmenzi Gully, Beichuan County, Sichuan Province in Southwest China, surveying the reservoir topography of the dams on two occasions over a fiveyear period. The #3 closed-type dam, located in the upper upstream, the #2 closed-type dam, located in the middle stream(which was manually cleaned), and the beam dam, located in the downstream were all surveyed. A simplified yet accurate method was developed to estimate sediment volume within check dam reservoirs under complex topographic conditions. A combination of terrestrial surveys and Unmanned Aerial Vehicle(UAV) based surveys was employed, resulting in the acquisition of two high-resolution Digital Elevation Models(DEMs) at different temporal intervals. The utilization of DEMs of Difference(DoD) facilitated the quantification of terrain variations and the sediment transport. The following conclusions were obtained: firstly, it was found that the volume of sediment trapped in the reservoirs of #2 closed-type dam and #1 beam dam were almost the same, with #3 closed-type dam being the smallest. The validation of the results in conjunction with the geometric method demonstrated that the percentage error was less than 7%, proving the reliability of the results. In addition, an analysis of changes in the detailed topography of the reservoirs revealed that the sediment deposit occurred in areas distant from the structures, while erosion exhibited concentration in specific areas close to the dams. The percentage volume of sediment deposit was found to be significantly higher than that of erosion(all higher than 85%). Furthermore, the excessive sediment deposition reduces the storage capacity of closed-type check dams, whereas in the case of beam dams, the maximum erosion amount in the reservoir is 35.8 m~3 and the percentage of the maximum erosion amount is 14.00%. This suggests that the self-cleaning of beam dam can effectively slow down the sediment deposition process. Finally, the current study proposes an expression for storage capacity composition and suggests that, in engineering practice, emphasis should be placed on maintenance programs that synergize manual cleaning and self-cleaning of open-type check dams. The conclusions may facilitate the refinement of maintenance strategies of cascade check dams, thereby effectively preventing and mitigating debris flows.展开更多
BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychologi...BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.AIM To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung cancer.METHODS This study is a single-centre study.We randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January 2022.These elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care protocol.The differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were analyzed.RESULTS After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,psychological distress,and fatigue,improving their tendencies on the locus of control in psychology,and enhancing their life qualities.展开更多
Hesperidin is a dihydroflavonoids, accounting for more than 50% of the total flavonoids in Citri Reticulatae Pericarpium(CRP) of traditional Chinese medicine. It is an effective antioxidant and free radical scavenger ...Hesperidin is a dihydroflavonoids, accounting for more than 50% of the total flavonoids in Citri Reticulatae Pericarpium(CRP) of traditional Chinese medicine. It is an effective antioxidant and free radical scavenger that has anti-inflammatory, antiviral and hypoglycemic properties.The latest studies reported that hesperidin has a potential for novel coronavirus resistance. However, little is known about the synthesis regulation and accumulation site of hesperidin in plants. In this study, hesperidin synthase gene Crc1,6RhaT was cloned, and the protein can be completely transformed flavanone-7-O-glucoside into hesperidin in vitro and in vivo. Studies on biological characteristics of ovary walls and exocarps showed that the relative expression levels of the Crc1,6RhaT gene and protein decreased gradually with the development of citrus fruits, and the relative content of hesperidin firstly increased, then sequentially decreased. In situ hybridization results further revealed that Crc1,6RhaT transcription was mainly concentrated in the secretory cavity cells, which are revealed to be the site of flavonoid synthesis.Immunocytochemistry localization results showed that the Crc1,6RhaT was mainly located in the endoplasmic reticulum, nucleus and vacuole of secretory cells. We inferred that the Crc1,6RhaT was synthesized in the endoplasmic reticulum, then was transported into the vacuoles through enlarged vesicles at the end of the endoplasmic reticulum. Our results not only revealed that Crc1,6RhaT may be involved in the synthesis of hesperidin of the main bioactive substance in the medicinal plant Citrus reticulata ‘Chachi' fruit, but also provided novel insights into the main subcellular sites of hesperidin biosynthesis in vacuoles.展开更多
基金National Natural Science Foundation of China,Grant/Award Number:42330719National Natural Science Foundation of China,Grant/Award Number:U2443228+1 种基金Power Construction Corporation of China,Grant/Award Number:DJ-ZDXM-2021-51China Institute of Water Resources and Hydropower Research,Grant/Award Number:GE121003A0042022。
文摘Check dams are widely constructed on China's Loess Plateau,which had a total number of 58,776 by the end of 2019.Great achievements in check dam construction have been gained regarding the economic and environmental impacts.This study reviews the remarkable benefits of check dams on the land reclamation and environmental improvement on the Loess Plateau,and sediment reduction entering the Yellow River.However,the flood incidents on check dams have been frequently reported for the past decades,which has attracted more attention in the context of climate change and extreme rainfall events recently.Advances in the flood migration techniques achieved by the research group led by the first author have been highlighted to migrate the breach risk of check dams due to floods.The“family tree method”has been proposed to determine the survival status and critical rainfall threshold of each check dam in the complicated dam system.An updated dam breach flood evaluation framework and the corresponding numerical algorithm(i.e.,DB-IWHR)have been developed.Moreover,innovative types of water-release facilities for check dams,including geobag stepped spillway and prestressed concrete cylinder pipe in the underlying conduit,have been proposed and developed.Finally,the perspectives concerning the check dam construction on the Loess Plateau have been put forward.
文摘在地方经济蓬勃发展与医药行业深刻变革的宏观背景下,培育高素质的临床试验协调员(Clinical Research Coordinator,简称CRC),已成为顺应社会需求、推进健康中国建设的关键举措。本文以四川护理职业学院针对药学专业开展的临床试验项目化教学试点为切入点,深入剖析其构建的创新医教协同培养模式,从人才培养实践、培养的关键问题与应对策略及培养成效等方面进行介绍。此培养模式在实践中取得了积极的成效,显著提升了学生的就业竞争力,为其他地区在CRC人才培养方面提供了极具价值的参考范例,助力行业整体人才培养水平的提升。
基金jointly funded by the National Key R&D Program of China (2024YFC3012705)the CAS Light of West China Program (Grant Recipient:Wanyu Zhao)+1 种基金the National Natural Science Foundation of China (Grant No.42201095)the Postdoctoral Research Project Special Funding of Sichuan (Grant No.TB2023028)。
文摘The implementation of the cascade check dam system, which integrates beam and closed-type dams, has been extensively adopted as a pivotal engineering measure for mitigating debris flow in Southwest China. In the post-debris flow events, it is imperative to quantitatively assess the volume of sediment volume captured by the cascade check dams and to monitor their impact on sediment dynamics. This study investigates the cascade check dams in Guanmenzi Gully, Beichuan County, Sichuan Province in Southwest China, surveying the reservoir topography of the dams on two occasions over a fiveyear period. The #3 closed-type dam, located in the upper upstream, the #2 closed-type dam, located in the middle stream(which was manually cleaned), and the beam dam, located in the downstream were all surveyed. A simplified yet accurate method was developed to estimate sediment volume within check dam reservoirs under complex topographic conditions. A combination of terrestrial surveys and Unmanned Aerial Vehicle(UAV) based surveys was employed, resulting in the acquisition of two high-resolution Digital Elevation Models(DEMs) at different temporal intervals. The utilization of DEMs of Difference(DoD) facilitated the quantification of terrain variations and the sediment transport. The following conclusions were obtained: firstly, it was found that the volume of sediment trapped in the reservoirs of #2 closed-type dam and #1 beam dam were almost the same, with #3 closed-type dam being the smallest. The validation of the results in conjunction with the geometric method demonstrated that the percentage error was less than 7%, proving the reliability of the results. In addition, an analysis of changes in the detailed topography of the reservoirs revealed that the sediment deposit occurred in areas distant from the structures, while erosion exhibited concentration in specific areas close to the dams. The percentage volume of sediment deposit was found to be significantly higher than that of erosion(all higher than 85%). Furthermore, the excessive sediment deposition reduces the storage capacity of closed-type check dams, whereas in the case of beam dams, the maximum erosion amount in the reservoir is 35.8 m~3 and the percentage of the maximum erosion amount is 14.00%. This suggests that the self-cleaning of beam dam can effectively slow down the sediment deposition process. Finally, the current study proposes an expression for storage capacity composition and suggests that, in engineering practice, emphasis should be placed on maintenance programs that synergize manual cleaning and self-cleaning of open-type check dams. The conclusions may facilitate the refinement of maintenance strategies of cascade check dams, thereby effectively preventing and mitigating debris flows.
文摘BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.AIM To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung cancer.METHODS This study is a single-centre study.We randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January 2022.These elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care protocol.The differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were analyzed.RESULTS After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,psychological distress,and fatigue,improving their tendencies on the locus of control in psychology,and enhancing their life qualities.
基金supported by the National Natural Science Foundation of China (Grant No.32270381)Natural Science Foundation of Guangdong (Grant No.2022A1515011086)+2 种基金Key Realm R&D Program of Guangdong Province (Grant No.2020B020221001)Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams (Grant No.2019KJ125)Research Fund of Maoming Branch,Guangdong Laboratory for Lingnan Modern Agriculture (Grant No.2022KF009)。
文摘Hesperidin is a dihydroflavonoids, accounting for more than 50% of the total flavonoids in Citri Reticulatae Pericarpium(CRP) of traditional Chinese medicine. It is an effective antioxidant and free radical scavenger that has anti-inflammatory, antiviral and hypoglycemic properties.The latest studies reported that hesperidin has a potential for novel coronavirus resistance. However, little is known about the synthesis regulation and accumulation site of hesperidin in plants. In this study, hesperidin synthase gene Crc1,6RhaT was cloned, and the protein can be completely transformed flavanone-7-O-glucoside into hesperidin in vitro and in vivo. Studies on biological characteristics of ovary walls and exocarps showed that the relative expression levels of the Crc1,6RhaT gene and protein decreased gradually with the development of citrus fruits, and the relative content of hesperidin firstly increased, then sequentially decreased. In situ hybridization results further revealed that Crc1,6RhaT transcription was mainly concentrated in the secretory cavity cells, which are revealed to be the site of flavonoid synthesis.Immunocytochemistry localization results showed that the Crc1,6RhaT was mainly located in the endoplasmic reticulum, nucleus and vacuole of secretory cells. We inferred that the Crc1,6RhaT was synthesized in the endoplasmic reticulum, then was transported into the vacuoles through enlarged vesicles at the end of the endoplasmic reticulum. Our results not only revealed that Crc1,6RhaT may be involved in the synthesis of hesperidin of the main bioactive substance in the medicinal plant Citrus reticulata ‘Chachi' fruit, but also provided novel insights into the main subcellular sites of hesperidin biosynthesis in vacuoles.
