The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central n...The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems.展开更多
We propose a photon-photon collider based on synchrotron gamma sources driven by relativistic electron beams in hollow plasma channels.The collimated(with a divergence angle of~1 mrad)and ultrabrilliant(>10^(28)pho...We propose a photon-photon collider based on synchrotron gamma sources driven by relativistic electron beams in hollow plasma channels.The collimated(with a divergence angle of~1 mrad)and ultrabrilliant(>10^(28)photons s^(-1)·mrad^(-2)·mm^(-2)per 0.1% bandwidth at 0.6 MeV)photon beams are generated by strong electromagnetic fields induced by current filamentation instability,and up to~10^(6) Breit-Wheeler(BW)pairs can be created per shot.Notably,the usage of hollow plasma channels not only enhances synchrotron radiation,but also allows flexible control of the produced photon beams,ensuring the alignment of the two colliding beams and maximizing the two-photon BW process.This setup has the advantage of a clean background by eliminating the yield from the nonlinear BW process,and the signal-to-noise ratio is higher than 10^(2).展开更多
This study numerically examines the heat and mass transfer characteristics of two ternary nanofluids via converging and diverg-ing channels.Furthermore,the study aims to assess two ternary nanofluids combinations to d...This study numerically examines the heat and mass transfer characteristics of two ternary nanofluids via converging and diverg-ing channels.Furthermore,the study aims to assess two ternary nanofluids combinations to determine which configuration can provide better heat and mass transfer and lower entropy production,while ensuring cost efficiency.This work bridges the gap be-tween academic research and industrial feasibility by incorporating cost analysis,entropy generation,and thermal efficiency.To compare the velocity,temperature,and concentration profiles,we examine two ternary nanofluids,i.e.,TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O and TiO_(2)+SiO_(2)+Cu/H_(2)O,while considering the shape of nanoparticles.The velocity slip and Soret/Dufour effects are taken into consideration.Furthermore,regression analysis for Nusselt and Sherwood numbers of the model is carried out.The Runge-Kutta fourth-order method with shooting technique is employed to acquire the numerical solution of the governed system of ordinary differential equations.The flow pattern attributes of ternary nanofluids are meticulously examined and simulated with the fluc-tuation of flow-dominating parameters.Additionally,the influence of these parameters is demonstrated in the flow,temperature,and concentration fields.For variation in Eckert and Dufour numbers,TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O has a higher temperature than TiO_(2)+SiO_(2)+Cu/H_(2)O.The results obtained indicate that the ternary nanofluid TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O has a higher heat transfer rate,lesser entropy generation,greater mass transfer rate,and lower cost than that of TiO_(2)+SiO_(2)+Cu/H_(2)O ternary nanofluid.展开更多
Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered arou...Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered around the"Taihu Snow"brand,its products cover suite products (such as pillowcases,quilt covers,sheets),quilt cores,silk scarves and otheremerging retail products.展开更多
Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosi...Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosis,limits their patient applicability and long-term application.Therefore,it is necessary to screen novel therapeutic drugs for T2DM treatment that have high efficacy but few adverse effects.AMP-activated protein kinase(AMPK)stands out as one of the most powerful targets for T2DM treatment.It can be activated through energysensing or calcium signaling.Medications that activate AMPK through the energy-sensing mechanism exhibit remarkable potency,but they are accompanied by lactic acidosis,carrying an alarmingly high mortality rate.Interestingly,medications that activate AMPK through calcium signaling,such as gliclazide,seldom induce lactic acidosis.However,the efficacy of gliclazide is much lower than metformin.Therefore,it is necessary to explore targets that activate AMPK via calcium signaling to avoid lactic acidosis while maintaining high potency.Ion channels are the main controller of intracellular calcium flow.Specific agonists and inhibitors targeting ion channels have been reported to activate AMPK.In this review,we will summarize the structure and function of calcium-permeable ion channels and discuss the potential of targeting these calcium channels for T2DM treatment.展开更多
The huge carrier transfer resistance caused by large-sized"nitrogen pot"severely limits the photocatalytic performance of carbon nitride(CN).This study aims to explore the selection principle of metal ion br...The huge carrier transfer resistance caused by large-sized"nitrogen pot"severely limits the photocatalytic performance of carbon nitride(CN).This study aims to explore the selection principle of metal ion bridges for constructing dual carrier-transfer channels to delivery carriers to respectively active sites using photodegradation of phenol as the model reaction.Density functional theory(DFT)calculation was used to optimize the structure model of nitrogen vacancies(Nv,provide active sites for reduction of O_(2) and oxidation of phenol)and metal ions(Fe^(3+),Co^(2+),Ni^(2+)or Cu^(2+))co-modified CN,and screen metal ion bridges based on the three parameters including bonding state of metal ion and"nitrogen pot",electrostatic potential(ESP)distribution around the active sites,and three-electron bond length.Both calculation results and activity data show that Fe^(3+),Co^(2+)and Ni^(2+)can construct dual carrier-transfer channels to promote the degradation of phenol while Cu^(2+)cannot Ny and Fe^(3+)co-modified CN(Fe/N_(v)-CN)showed the best catalytic performance among various catalysts and was used as the model catalyst for the detailed characterization to verify the calculation results.This work provides not only the novel strategy for constructing dual carrier-transfer channels in CN,but also the crucial basis for computer simulation as a prediction tool of catalyst structure design rationality.展开更多
The distribution of the sediment material storage quantity along the debris flow channels(SMSQ_DFC)can provide a foundation for runoffgenerated debris flow prediction or susceptibility assessment.Current models for es...The distribution of the sediment material storage quantity along the debris flow channels(SMSQ_DFC)can provide a foundation for runoffgenerated debris flow prediction or susceptibility assessment.Current models for estimating SMSQ_DFC do not consider the capacity of the channel cross-section to accommodate sediment materials.This accommodation condition serves as a limiting factor in determining whether the expected surplus of sediment materials can ultimately be stored.To address this issue,a mass-conservative index was used to represent the balance of deposit materials at any cross-section,considering the influx from upstream,outflux to downstream,and accommodation capacity.Based on this index,a new model for estimating SMSQ_DFC was developed and subsequently evaluated.The evaluation results show that the model meets the accuracy requirements with average error rates of 14.06%for self-validation and 14.81%for generalization ability validation.To assess its practical applications,the model was applied to the Yeniu Gully in Wenchuan County,Sichuan Province,an area with detailed field survey data.The results show that the model exhibits a commendable performance.Compared to traditional theoretical and semi-theoretical statistical models,our model is easier to use(input parameters can be obtained using Geographic Information Systems(GIS)).The modeling parameters chosen in this study have more theoretical significance than those used in existing purely statistical models,offering more effective technical support for estimating SMSQ_DFC.展开更多
Constructing silicon(Si)-based composite electrodes that possess high energy density,long cycle life,and fast charging capability simultaneously is critical for the development of high performance lithium-ion batterie...Constructing silicon(Si)-based composite electrodes that possess high energy density,long cycle life,and fast charging capability simultaneously is critical for the development of high performance lithium-ion batteries for mitigating range anxiety and slow charging issues in new energy vehicles.Herein,a thick silicon/carbon composite electrode with vertically aligned channels in the thickness direction(VC-SC)is constructed by employing a bubble formation method.Both experimental characterizations and theoretical simulations confirm that the obtained vertical channel structure can effectively address the problem of sluggish ion transport caused by high tortuosity in conventional thick electrodes,conspicuously enhance reaction kinetics,reduce polarization and side reactions,mitigate stress,increase the utilization of active materials,and promote cycling stability of the thick electrode.Consequently,when paired with LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622),the VC-SC||NCM622 pouch type full cell(~6.0 mAh cm^(-2))exhibits significantly improved rate performance and capacity retention compared with the SC||NCM622 full cell with the conventional silicon/carbon composite electrode without channels(SC)as the anode.The assembled VC-SC||NCM622 pouch full cell with a high energy density of 490.3 Wh kg^(-1)also reveals a remarkable fast charging capability at a high current density of 2.0 mA cm^(-2),with a capacity retention of 72.0%after 500 cycles.展开更多
Covert communication guarantees the security of wireless communications via hiding the existence of the transmission.This paper focuses on the first and second order asymptotics of covert communication in the AWGN cha...Covert communication guarantees the security of wireless communications via hiding the existence of the transmission.This paper focuses on the first and second order asymptotics of covert communication in the AWGN channels.The covertness is measured by the total variation distance between the channel output distributions induced with and without the transmission.We provide the exact expressions of the maximum amount of information that can be transmitted with the maximum error probability and the total variation less than any small numbers.The energy detection and the random coding are employed to prove our results.We further compare our results with those under relative entropy.The results show how many additional amounts of information can be transmitted covertly when changing the covertness constraint to total variation.展开更多
In this paper,we investigate the performance of physical layer security(PLS)over reconfigurable intelligent surfaces(RIS)-aided wireless communication systems,where all fading channels are modeled with Fisher-Snedecor...In this paper,we investigate the performance of physical layer security(PLS)over reconfigurable intelligent surfaces(RIS)-aided wireless communication systems,where all fading channels are modeled with Fisher-Snedecor F distribution.Specifically,we consider a RIS with N reflecting elements between the transmitter and the legitimate receiver to develop a smart environment and also meliorate secure communications.In this regard,we derive the closed-form expressions for the secrecy outage probability(SOP)and average secrecy capacity(ASC).We also analyze the asymptotic behaviour of the SOP and ASC by exploiting the residue approach.Monte-Carlo(MC)simulation results are provided throughout to validate the correctness of the developed analytical results,showing that considering RIS in wireless communication systems has constructive effects on the secrecy performance.展开更多
The robustness of reference-frame-independent measurement-device-independent quantum key distribution(RFIMDI-QKD)against detection system vulnerabilities and its tolerance to reference frame drifts make it an ideal ch...The robustness of reference-frame-independent measurement-device-independent quantum key distribution(RFIMDI-QKD)against detection system vulnerabilities and its tolerance to reference frame drifts make it an ideal choice for hybrid channels.However,the impact of atmospheric turbulence on transmittance fluctuations remains a significant challenge for enhancing the performance of RFI-MDI-QKD.In this paper,we apply prefixed-threshold real-time selection and advantage distillation techniques to RFI-MDI-QKD in a hybrid channels scenario.Then,we analytically derive formulas for secret key rate in hybrid channels.Simulation results show that our modified scheme has apparent advances in both maximum tolerant loss and secure key rate compared to the fiber-only channel.Specifically,the result demonstrates that the maximum transmission distance can be improved by 15 km and 28 km when N=10^(12)and 10^(11).Our work not only provides a more robust key distribution protocol but also establishes a solid theoretical foundation for enhancing the performance of RFI-MDI-QKD in hybrid channels.展开更多
Reliable channel data helps characterize the limitations and performance boundaries of communication technologies accurately.However,channel measurement is highly costly and time-consuming,and taking actual measuremen...Reliable channel data helps characterize the limitations and performance boundaries of communication technologies accurately.However,channel measurement is highly costly and time-consuming,and taking actual measurement as the only channel data source may reduce efficiency because of the constraints of high testing difficulty and limited data volume.Although existing standard channel models can generate channel data,their authenticity and diversity cannot be guaranteed.To address this,we use deep learning methods to learn the attributes of limited measured data and propose a generative model based on generative adversarial networks to rapidly synthesize data.A software simulation platform is also established to verify that the proposed model can generate data that are statistically similar to the measured data while maintaining necessary randomness.The proposed algorithm and platform can be applied to channel data enhancement and serve channel modeling and algorithm evaluation applications with urgent needs for data.展开更多
Efficient selective adsorption and separation using porous frameworks are critical in many industrial processes,where adsorption energy and dynamic diffusion rate are predominant factors governing selectivity.They are...Efficient selective adsorption and separation using porous frameworks are critical in many industrial processes,where adsorption energy and dynamic diffusion rate are predominant factors governing selectivity.They are highly susceptible to framework charge,which plays a significant role in selective adsorption.Currently,ionic porous frameworks can be divided into two types.One of them is composed of a charged backbone and counter ions.The framework with zwitterionic channels is another type.It is composed of regular and alternating arrangements of cationic and anionic building units.Herein,we report a hydrogen-bonded ionic framework(HIF)of{(CN_(3)H_(6))_(2)[Ti(μ_(2)-O)(SO_(4))_(2)]}_nwith 1D channel exhibits unique adsorption selectivity for Ar against N_(2)and CO_(2).Density functional theory(DFT)results suggest that CO_(2)cannot be adsorbed by HIF at the experimental temperature due to a positive adsorption free energy.In addition,due to a relatively large diffusion barrier at 77 K,N_(2)molecules hardly diffuse in HIF channels,while Ar has a negligible diffusion barrier.The unique net positively-charged space in the channel is the key to the unusual phenomena,based on DFT simulations and structural analysis.The findings in this work proposes the new adsorption mechanism and provides unique perspective for special separation applications,such as isotope and noble gasses separations.展开更多
This research study focuses on addressing the limitations of current neuropathic pain(NP)treatments by developing a novel dual-target modulator,E0199,targeting both Na_(V)1.7,Na_(V)1.8,and Na_(V)1.9 and K_(V)7 channel...This research study focuses on addressing the limitations of current neuropathic pain(NP)treatments by developing a novel dual-target modulator,E0199,targeting both Na_(V)1.7,Na_(V)1.8,and Na_(V)1.9 and K_(V)7 channels,a crucial regulator in controlling NP symptoms.The objective of the study was to synthesize a compound capable of modulating these channels to alleviate NP.Through an experimental design involving both in vitro and in vivo methods,E0199 was tested for its efficacy on ion channels and its therapeutic potential in a chronic constriction injury(CCI)mouse model.The results demonstrated that E0199 significantly inhibited Na_(V)1.7,Na_(V)1.8,and Na_(V)1.9 channels with a particularly low half maximal inhibitory concentration(IC50)for Na_(V)1.9 by promoting sodium channel inactivation,and also effectively increased K_(V)7.2/7.3,K_(V)7.2,and K_(V)7.5 channels,excluding K_(V)7.1 by promoting potassium channel activation.This dual action significantly reduced the excitability of dorsal root ganglion neurons and alleviated pain hypersensitivity in mice at low doses,indicating a potent analgesic effect without affecting heart and skeletal muscle ion channels critically.The safety of E0199 was supported by neurobehavioral evaluations.Conclusively,E0199 represents a ground-breaking approach in NP treatment,showcasing the potential of dual-target small-molecule compounds in providing a more effective and safe therapeutic option for NP.This study introduces a promising direction for the future development of NP therapeutics.展开更多
Extremely large-scale multiple-input multiple-output(XL-MIMO)is regarded as a promis-ing technology for next-generation communication systems.However,this will expand the near-field(NF)range,rendering more users more ...Extremely large-scale multiple-input multiple-output(XL-MIMO)is regarded as a promis-ing technology for next-generation communication systems.However,this will expand the near-field(NF)range,rendering more users more likely to be located in the NF region.In this paper,we aim to answer two questions:What are the new characteristics of the NF channel?Is it necessary to develop new transciver techniques to maintain system performance within the NF region?To this end,we first review current NF channel models and analyze the differences between the existing 3GPP TR 38.901 channel model and the NF channel model,including the spherical wavefront and spatially non-stationarity.Then,we provide ex-amples on how these differences affect the XL-MIMO system performance in terms of beamforming gain and achievable rate.Simulation results demonstrate that,when using far-field(FF)technique under the NF channel,the maximum normalized beam gain loss is less than 3 dB for most users in the NF region de-fined by Rayleigh distance.Moreover,the achievable rate loss of beam training is less than 3%compared to that realized by NF technique.Finally,we demonstrate the necessity of employing NF transceiver techniques based on simulation results.展开更多
Power batteries serve as key components of new energy vehicles and are distinguished by their large capacity,long lifespan,high energy density,and stable operation.The strict temperature demands of power battery packs...Power batteries serve as key components of new energy vehicles and are distinguished by their large capacity,long lifespan,high energy density,and stable operation.The strict temperature demands of power battery packs necessitate the development of highly efficient thermal management systems.In this study,a converging-diverging liquid cooling channel featuring a wave shaped structure was designed and analyzed for 18,650-type lithium-ion batteries.To investigate the design methodology for flow channel structure,a thermal model for the heat generation rate of the 18,650-type battery was developed.A comparative analysis of four geometrical configurations of convergingdiverging channels.It identified the flat-bottomed channel achieves a maximum reduction of 20.6%in peak internal temperature compared to the other designs.Subsequently,the effects of the arc depth,cell spacing,and Reynolds number on the heat dissipation of the flat-bottomed flow channel were comprehensively investigated.The results demonstrated that increasing the Reynolds number,maximizing the arc depth of the converging-diverging structure,and reducing cell spacing considerably improved the cooling heat dissipation efficiency.Based on the particle swarm optimization algorithm,the optimal parameter combination of the battery pack was obtained at a discharge rate of 2C,comprising an arc depth of 8.5 mm,cell spacing of 1 mm,and Reynolds number of 700.The study provides valuable guidance and references for the practical design and implementation of thermal management systems in new energy vehicles.展开更多
The study of stretching surfaces has garnered significant attention due to its importance in a wide range of industrial and engineering functions,including the drawing of wires and plastic films,shrink film production...The study of stretching surfaces has garnered significant attention due to its importance in a wide range of industrial and engineering functions,including the drawing of wires and plastic films,shrink film production,polymer sheet extrusion,the manufacturing of glass fibers,and the manufacturing of polyester heat-shrink tubing.This research incorporates a Darcy-Forchheimer porous medium to account for the effects of porosity.The governing equations are transformed into a boundary value problem and solved semi-analytically using the Taylor wavelet method.The effects of various parameters are depicted through graphical analyses.The results show that for both converging and diverging stretching surfaces,an increase in the porosity parameter causes a decrease in the velocity field.Additionally,higher Reynolds numbers enhance inertial effects,leading to more pronounced velocity fluctuations.Stretching causes a consistent drop in velocity toward the center and an increase close to the walls in both types of channels,indicating that the volume percentage of nanoparticles influences the heat distribution.Notably,stretching induces a marked temperature drop at the channel's center.展开更多
This paper investigates the uplink spectral efficiency of distributed cell-free(CF)massive multiple-input multiple-output(mMIMO)networks with correlated Rayleigh fading channels based on three different channel estima...This paper investigates the uplink spectral efficiency of distributed cell-free(CF)massive multiple-input multiple-output(mMIMO)networks with correlated Rayleigh fading channels based on three different channel estimation schemes.Specifically,each access point(AP)first uses embedded pilots to estimate the channels of all users based on minimum mean-squared error(MMSE)estimation.Given the high computational cost of MMSE estimation,the low-complexity element-wise MMSE(EW-MMSE)channel estimator and the least-squares(LS)channel estimator without prior statistical information are also analyzed.To reduce non-coherent and coherent interference during uplink payload data transmission,simple centralized decoding(SCD)and large-scale fading decoding(LSFD)are examined.Then,the closedform expressions for uplink spectral efficiency(SE)using MMSE,EW-MMSE,and LS estimators are developed for maximum ratio(MR)combining under LSFD,where each AP may have any number of antennas.The sum SE maximization problem with uplink power control is formulated.Since the maximization problem is non-convex and challenging,a block coordinate descent approach based on the weighted MMSE method is used to get the optimal local solution.Numerical studies demonstrate that LSFD and efficient uplink power control can considerably increase SE in distributed CF m MIMO networks.展开更多
The construction of polar codes in corre-lated block fading channels is still an open issue to be solved.In this paper,to explicitly reveal the impact of correlation on error performance of polar coded diver-sity comm...The construction of polar codes in corre-lated block fading channels is still an open issue to be solved.In this paper,to explicitly reveal the impact of correlation on error performance of polar coded diver-sity communication systems,an integrated framework has been established to analyze the theoretical error performance of polar codes in correlated block fading channels.First,the upper bound on error probabil-ity of polarized channels is derived based on split po-lar spectrum,which is fully determined by covariance channel matrix as well as the block-wise weight distri-bution of the corresponding polar subcode.Further,to facilitate practical implementations,we design a con-struction metric named polarized correlation weight(PCW)to generate polar codes in correlated block fad-ing channels.Finally,simulation results on block error rate indicate that the proposed metric can exhibit both diversity gain and coding gain compared to the con-ventional methods under successive cancellation de-coding.展开更多
基金supported by the National Natural Science Foundation of China,Nos.81901098(to TC),82201668(to HL)Fujian Provincial Health Technology Project,No.2021QNA072(to HL)。
文摘The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that there are few clinical drugs that can improve the pathology these diseases by acting on potassium or calcium ions. Although a few novel ion-channelspecific modulators have been discovered, meaningful therapies have largely not yet been realized. The lack of target-specific drugs, their requirement to cross the blood–brain barrier, and their exact underlying mechanisms all need further attention. This review aims to explain the urgent problems that need research progress and provide comprehensive information aiming to arouse the research community's interest in the development of ion channel-targeting drugs and the identification of new therapeutic targets for that can increase the cure rate of nervous system diseases and reduce the occurrence of adverse reactions in other systems.
基金supported by the Fund of the National Key Laboratory of Plasma Physics(Grant No.6142A04230204)the National Natural Science Foundation of China(Project No.12075046).
文摘We propose a photon-photon collider based on synchrotron gamma sources driven by relativistic electron beams in hollow plasma channels.The collimated(with a divergence angle of~1 mrad)and ultrabrilliant(>10^(28)photons s^(-1)·mrad^(-2)·mm^(-2)per 0.1% bandwidth at 0.6 MeV)photon beams are generated by strong electromagnetic fields induced by current filamentation instability,and up to~10^(6) Breit-Wheeler(BW)pairs can be created per shot.Notably,the usage of hollow plasma channels not only enhances synchrotron radiation,but also allows flexible control of the produced photon beams,ensuring the alignment of the two colliding beams and maximizing the two-photon BW process.This setup has the advantage of a clean background by eliminating the yield from the nonlinear BW process,and the signal-to-noise ratio is higher than 10^(2).
基金supported by DST-FIST(Government of India)(Grant No.SR/FIST/MS-1/2017/13)and Seed Money Project(Grant No.DoRDC/733).
文摘This study numerically examines the heat and mass transfer characteristics of two ternary nanofluids via converging and diverg-ing channels.Furthermore,the study aims to assess two ternary nanofluids combinations to determine which configuration can provide better heat and mass transfer and lower entropy production,while ensuring cost efficiency.This work bridges the gap be-tween academic research and industrial feasibility by incorporating cost analysis,entropy generation,and thermal efficiency.To compare the velocity,temperature,and concentration profiles,we examine two ternary nanofluids,i.e.,TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O and TiO_(2)+SiO_(2)+Cu/H_(2)O,while considering the shape of nanoparticles.The velocity slip and Soret/Dufour effects are taken into consideration.Furthermore,regression analysis for Nusselt and Sherwood numbers of the model is carried out.The Runge-Kutta fourth-order method with shooting technique is employed to acquire the numerical solution of the governed system of ordinary differential equations.The flow pattern attributes of ternary nanofluids are meticulously examined and simulated with the fluc-tuation of flow-dominating parameters.Additionally,the influence of these parameters is demonstrated in the flow,temperature,and concentration fields.For variation in Eckert and Dufour numbers,TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O has a higher temperature than TiO_(2)+SiO_(2)+Cu/H_(2)O.The results obtained indicate that the ternary nanofluid TiO_(2)+SiO_(2)+Al_(2)O_(3)/H_(2)O has a higher heat transfer rate,lesser entropy generation,greater mass transfer rate,and lower cost than that of TiO_(2)+SiO_(2)+Cu/H_(2)O ternary nanofluid.
文摘Taihu Snow (838262) is a home textile manufacturing company listed on the Beijing Stock Exchange in 2022.It is a bedding manufacturer focusing on silk products.The company was esta blished on May 18,2006,Centered around the"Taihu Snow"brand,its products cover suite products (such as pillowcases,quilt covers,sheets),quilt cores,silk scarves and otheremerging retail products.
基金Supported by Calygene Biotechnology Inc.,No.XT[2016]008@。
文摘Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder.Despite the availability of numerous pharmacotherapies,a range of adverse reactions,including hypoglycemia,gastrointestinal discomfort,and lactic acidosis,limits their patient applicability and long-term application.Therefore,it is necessary to screen novel therapeutic drugs for T2DM treatment that have high efficacy but few adverse effects.AMP-activated protein kinase(AMPK)stands out as one of the most powerful targets for T2DM treatment.It can be activated through energysensing or calcium signaling.Medications that activate AMPK through the energy-sensing mechanism exhibit remarkable potency,but they are accompanied by lactic acidosis,carrying an alarmingly high mortality rate.Interestingly,medications that activate AMPK through calcium signaling,such as gliclazide,seldom induce lactic acidosis.However,the efficacy of gliclazide is much lower than metformin.Therefore,it is necessary to explore targets that activate AMPK via calcium signaling to avoid lactic acidosis while maintaining high potency.Ion channels are the main controller of intracellular calcium flow.Specific agonists and inhibitors targeting ion channels have been reported to activate AMPK.In this review,we will summarize the structure and function of calcium-permeable ion channels and discuss the potential of targeting these calcium channels for T2DM treatment.
基金supported by the National Natural Science Foundation of China(82301052)China Postdoctoral Science Foundation(2023M732151)+3 种基金Shanxi Provincial Science and Technology Department(202303021212131)Health Commission of Shanxi Province(2022XM14)Shanxi Provincial Education Department(2022L165)Shanxi Medical University(XD2232)。
文摘The huge carrier transfer resistance caused by large-sized"nitrogen pot"severely limits the photocatalytic performance of carbon nitride(CN).This study aims to explore the selection principle of metal ion bridges for constructing dual carrier-transfer channels to delivery carriers to respectively active sites using photodegradation of phenol as the model reaction.Density functional theory(DFT)calculation was used to optimize the structure model of nitrogen vacancies(Nv,provide active sites for reduction of O_(2) and oxidation of phenol)and metal ions(Fe^(3+),Co^(2+),Ni^(2+)or Cu^(2+))co-modified CN,and screen metal ion bridges based on the three parameters including bonding state of metal ion and"nitrogen pot",electrostatic potential(ESP)distribution around the active sites,and three-electron bond length.Both calculation results and activity data show that Fe^(3+),Co^(2+)and Ni^(2+)can construct dual carrier-transfer channels to promote the degradation of phenol while Cu^(2+)cannot Ny and Fe^(3+)co-modified CN(Fe/N_(v)-CN)showed the best catalytic performance among various catalysts and was used as the model catalyst for the detailed characterization to verify the calculation results.This work provides not only the novel strategy for constructing dual carrier-transfer channels in CN,but also the crucial basis for computer simulation as a prediction tool of catalyst structure design rationality.
基金supported by Geological Disaster Patterns and Mitigation Strategies Under River-Reservoir Hydrodynamics in the Three Gorges Reservoir Fluctuation Zone(5000002024CC20004)the National Key Research and Development Program of China(2023YFC3007205)+1 种基金the National Natural Science Foundation of China(No.42271013)the West Light Foundation of the Chinese Academy of Sciences.
文摘The distribution of the sediment material storage quantity along the debris flow channels(SMSQ_DFC)can provide a foundation for runoffgenerated debris flow prediction or susceptibility assessment.Current models for estimating SMSQ_DFC do not consider the capacity of the channel cross-section to accommodate sediment materials.This accommodation condition serves as a limiting factor in determining whether the expected surplus of sediment materials can ultimately be stored.To address this issue,a mass-conservative index was used to represent the balance of deposit materials at any cross-section,considering the influx from upstream,outflux to downstream,and accommodation capacity.Based on this index,a new model for estimating SMSQ_DFC was developed and subsequently evaluated.The evaluation results show that the model meets the accuracy requirements with average error rates of 14.06%for self-validation and 14.81%for generalization ability validation.To assess its practical applications,the model was applied to the Yeniu Gully in Wenchuan County,Sichuan Province,an area with detailed field survey data.The results show that the model exhibits a commendable performance.Compared to traditional theoretical and semi-theoretical statistical models,our model is easier to use(input parameters can be obtained using Geographic Information Systems(GIS)).The modeling parameters chosen in this study have more theoretical significance than those used in existing purely statistical models,offering more effective technical support for estimating SMSQ_DFC.
基金National Key R&D Program of China,Grant/Award Number:2023YFB2503900National Natural Science Foundation of China,Grant/Award Number:12172143Shenzhen Science and Technology Program,Grant/Award Numbers:JCYJ20220818100418040,JCYJ20220530160816038。
文摘Constructing silicon(Si)-based composite electrodes that possess high energy density,long cycle life,and fast charging capability simultaneously is critical for the development of high performance lithium-ion batteries for mitigating range anxiety and slow charging issues in new energy vehicles.Herein,a thick silicon/carbon composite electrode with vertically aligned channels in the thickness direction(VC-SC)is constructed by employing a bubble formation method.Both experimental characterizations and theoretical simulations confirm that the obtained vertical channel structure can effectively address the problem of sluggish ion transport caused by high tortuosity in conventional thick electrodes,conspicuously enhance reaction kinetics,reduce polarization and side reactions,mitigate stress,increase the utilization of active materials,and promote cycling stability of the thick electrode.Consequently,when paired with LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622),the VC-SC||NCM622 pouch type full cell(~6.0 mAh cm^(-2))exhibits significantly improved rate performance and capacity retention compared with the SC||NCM622 full cell with the conventional silicon/carbon composite electrode without channels(SC)as the anode.The assembled VC-SC||NCM622 pouch full cell with a high energy density of 490.3 Wh kg^(-1)also reveals a remarkable fast charging capability at a high current density of 2.0 mA cm^(-2),with a capacity retention of 72.0%after 500 cycles.
基金supported in part by the Natural Science Foundation of Xinjiang Uygur Autonomous Region under Grant 2022D01B184the National Natural Science Foundation of China under Grant 62301117,62131005.
文摘Covert communication guarantees the security of wireless communications via hiding the existence of the transmission.This paper focuses on the first and second order asymptotics of covert communication in the AWGN channels.The covertness is measured by the total variation distance between the channel output distributions induced with and without the transmission.We provide the exact expressions of the maximum amount of information that can be transmitted with the maximum error probability and the total variation less than any small numbers.The energy detection and the random coding are employed to prove our results.We further compare our results with those under relative entropy.The results show how many additional amounts of information can be transmitted covertly when changing the covertness constraint to total variation.
基金supported by the European Union’s Horizon 2022 Research and Innovation Programme under Marie Skłodowska-Curie Grant No.10110799.
文摘In this paper,we investigate the performance of physical layer security(PLS)over reconfigurable intelligent surfaces(RIS)-aided wireless communication systems,where all fading channels are modeled with Fisher-Snedecor F distribution.Specifically,we consider a RIS with N reflecting elements between the transmitter and the legitimate receiver to develop a smart environment and also meliorate secure communications.In this regard,we derive the closed-form expressions for the secrecy outage probability(SOP)and average secrecy capacity(ASC).We also analyze the asymptotic behaviour of the SOP and ASC by exploiting the residue approach.Monte-Carlo(MC)simulation results are provided throughout to validate the correctness of the developed analytical results,showing that considering RIS in wireless communication systems has constructive effects on the secrecy performance.
基金supported by the National Natural Science Foundation of China(Grant Nos.61505261,62101597,61605248,and 61675235)the National Key Research and Development Program of China(Grant No.2020YFA0309702)the Natural Science Foundation of Henan Province(Grant Nos.202300410534 and 202300410534)。
文摘The robustness of reference-frame-independent measurement-device-independent quantum key distribution(RFIMDI-QKD)against detection system vulnerabilities and its tolerance to reference frame drifts make it an ideal choice for hybrid channels.However,the impact of atmospheric turbulence on transmittance fluctuations remains a significant challenge for enhancing the performance of RFI-MDI-QKD.In this paper,we apply prefixed-threshold real-time selection and advantage distillation techniques to RFI-MDI-QKD in a hybrid channels scenario.Then,we analytically derive formulas for secret key rate in hybrid channels.Simulation results show that our modified scheme has apparent advances in both maximum tolerant loss and secure key rate compared to the fiber-only channel.Specifically,the result demonstrates that the maximum transmission distance can be improved by 15 km and 28 km when N=10^(12)and 10^(11).Our work not only provides a more robust key distribution protocol but also establishes a solid theoretical foundation for enhancing the performance of RFI-MDI-QKD in hybrid channels.
基金supported by the National Key R&D Program of China under Grant No.2023YFB2904802National Natural Science Foundation of China under Grant Nos.62301022,62221001,62431003,and 62101507+1 种基金Young Elite Scientists Sponsorship Program by CAST under Grant No.2022QNRC001Program for Science&Technology R&D Plan Joint Fund of Henan Province under Grant No.225200810112。
文摘Reliable channel data helps characterize the limitations and performance boundaries of communication technologies accurately.However,channel measurement is highly costly and time-consuming,and taking actual measurement as the only channel data source may reduce efficiency because of the constraints of high testing difficulty and limited data volume.Although existing standard channel models can generate channel data,their authenticity and diversity cannot be guaranteed.To address this,we use deep learning methods to learn the attributes of limited measured data and propose a generative model based on generative adversarial networks to rapidly synthesize data.A software simulation platform is also established to verify that the proposed model can generate data that are statistically similar to the measured data while maintaining necessary randomness.The proposed algorithm and platform can be applied to channel data enhancement and serve channel modeling and algorithm evaluation applications with urgent needs for data.
基金support from the Chinese Academy of Sciences and University of Science and Technology of China,National Key Research and Development Program of China(No.2021YFA1500402)National Natural Science Foundation of China(Nos.21571167,51502282 and 22075266)Fundamental Research Funds for the Central Universities(Nos.WK2060190053 and WK2060190100)。
文摘Efficient selective adsorption and separation using porous frameworks are critical in many industrial processes,where adsorption energy and dynamic diffusion rate are predominant factors governing selectivity.They are highly susceptible to framework charge,which plays a significant role in selective adsorption.Currently,ionic porous frameworks can be divided into two types.One of them is composed of a charged backbone and counter ions.The framework with zwitterionic channels is another type.It is composed of regular and alternating arrangements of cationic and anionic building units.Herein,we report a hydrogen-bonded ionic framework(HIF)of{(CN_(3)H_(6))_(2)[Ti(μ_(2)-O)(SO_(4))_(2)]}_nwith 1D channel exhibits unique adsorption selectivity for Ar against N_(2)and CO_(2).Density functional theory(DFT)results suggest that CO_(2)cannot be adsorbed by HIF at the experimental temperature due to a positive adsorption free energy.In addition,due to a relatively large diffusion barrier at 77 K,N_(2)molecules hardly diffuse in HIF channels,while Ar has a negligible diffusion barrier.The unique net positively-charged space in the channel is the key to the unusual phenomena,based on DFT simulations and structural analysis.The findings in this work proposes the new adsorption mechanism and provides unique perspective for special separation applications,such as isotope and noble gasses separations.
基金funded by the Key Project from the Hebei Provincial Department of Science and Technology,China(Grant No.:21372601D)the Foundation Postdoctoral Mobile Station of Basic Medical Sciences,Hebei Medical University,China(Grant No.:20123120019)+4 种基金the Natural Science Foundation of Hebei Province,China(Grant No.:H2021206352)the Science and Technology Research Project of Colleges and Universities in Hebei Province,China(Grant No.:QN2023197)Hebei Medical University,Science and Technology,China(Grant No.:CYQD2023014)Hebei Provincial Department of Human Resources and Social Security,China(Grant No.:B2023003034)the Consultative Foundation from Hebei Province,China(Grant No.:2020TXZH01).
文摘This research study focuses on addressing the limitations of current neuropathic pain(NP)treatments by developing a novel dual-target modulator,E0199,targeting both Na_(V)1.7,Na_(V)1.8,and Na_(V)1.9 and K_(V)7 channels,a crucial regulator in controlling NP symptoms.The objective of the study was to synthesize a compound capable of modulating these channels to alleviate NP.Through an experimental design involving both in vitro and in vivo methods,E0199 was tested for its efficacy on ion channels and its therapeutic potential in a chronic constriction injury(CCI)mouse model.The results demonstrated that E0199 significantly inhibited Na_(V)1.7,Na_(V)1.8,and Na_(V)1.9 channels with a particularly low half maximal inhibitory concentration(IC50)for Na_(V)1.9 by promoting sodium channel inactivation,and also effectively increased K_(V)7.2/7.3,K_(V)7.2,and K_(V)7.5 channels,excluding K_(V)7.1 by promoting potassium channel activation.This dual action significantly reduced the excitability of dorsal root ganglion neurons and alleviated pain hypersensitivity in mice at low doses,indicating a potent analgesic effect without affecting heart and skeletal muscle ion channels critically.The safety of E0199 was supported by neurobehavioral evaluations.Conclusively,E0199 represents a ground-breaking approach in NP treatment,showcasing the potential of dual-target small-molecule compounds in providing a more effective and safe therapeutic option for NP.This study introduces a promising direction for the future development of NP therapeutics.
基金supported by the National Key R&D Program of China(No.2023YFB2904803)the Beijing Natural Science Foundation(L243002),the National Natural Science Foundation of China(No.62341128)+2 种基金the Guangdong Major Project of Basic and Applied Basic Research(No.2023B0303000001)the National Natural Science Foundation of China(No.62201086)Beijing University of Posts and Telecommunications-China Mobile Research Institute Joint Innovation Center.
文摘Extremely large-scale multiple-input multiple-output(XL-MIMO)is regarded as a promis-ing technology for next-generation communication systems.However,this will expand the near-field(NF)range,rendering more users more likely to be located in the NF region.In this paper,we aim to answer two questions:What are the new characteristics of the NF channel?Is it necessary to develop new transciver techniques to maintain system performance within the NF region?To this end,we first review current NF channel models and analyze the differences between the existing 3GPP TR 38.901 channel model and the NF channel model,including the spherical wavefront and spatially non-stationarity.Then,we provide ex-amples on how these differences affect the XL-MIMO system performance in terms of beamforming gain and achievable rate.Simulation results demonstrate that,when using far-field(FF)technique under the NF channel,the maximum normalized beam gain loss is less than 3 dB for most users in the NF region de-fined by Rayleigh distance.Moreover,the achievable rate loss of beam training is less than 3%compared to that realized by NF technique.Finally,we demonstrate the necessity of employing NF transceiver techniques based on simulation results.
基金funded by the National Nature Science Foundation of China,grant number 52406024.
文摘Power batteries serve as key components of new energy vehicles and are distinguished by their large capacity,long lifespan,high energy density,and stable operation.The strict temperature demands of power battery packs necessitate the development of highly efficient thermal management systems.In this study,a converging-diverging liquid cooling channel featuring a wave shaped structure was designed and analyzed for 18,650-type lithium-ion batteries.To investigate the design methodology for flow channel structure,a thermal model for the heat generation rate of the 18,650-type battery was developed.A comparative analysis of four geometrical configurations of convergingdiverging channels.It identified the flat-bottomed channel achieves a maximum reduction of 20.6%in peak internal temperature compared to the other designs.Subsequently,the effects of the arc depth,cell spacing,and Reynolds number on the heat dissipation of the flat-bottomed flow channel were comprehensively investigated.The results demonstrated that increasing the Reynolds number,maximizing the arc depth of the converging-diverging structure,and reducing cell spacing considerably improved the cooling heat dissipation efficiency.Based on the particle swarm optimization algorithm,the optimal parameter combination of the battery pack was obtained at a discharge rate of 2C,comprising an arc depth of 8.5 mm,cell spacing of 1 mm,and Reynolds number of 700.The study provides valuable guidance and references for the practical design and implementation of thermal management systems in new energy vehicles.
文摘The study of stretching surfaces has garnered significant attention due to its importance in a wide range of industrial and engineering functions,including the drawing of wires and plastic films,shrink film production,polymer sheet extrusion,the manufacturing of glass fibers,and the manufacturing of polyester heat-shrink tubing.This research incorporates a Darcy-Forchheimer porous medium to account for the effects of porosity.The governing equations are transformed into a boundary value problem and solved semi-analytically using the Taylor wavelet method.The effects of various parameters are depicted through graphical analyses.The results show that for both converging and diverging stretching surfaces,an increase in the porosity parameter causes a decrease in the velocity field.Additionally,higher Reynolds numbers enhance inertial effects,leading to more pronounced velocity fluctuations.Stretching causes a consistent drop in velocity toward the center and an increase close to the walls in both types of channels,indicating that the volume percentage of nanoparticles influences the heat distribution.Notably,stretching induces a marked temperature drop at the channel's center.
基金supported by National Natural Science Foundation of China(NSFC No.62020106001)。
文摘This paper investigates the uplink spectral efficiency of distributed cell-free(CF)massive multiple-input multiple-output(mMIMO)networks with correlated Rayleigh fading channels based on three different channel estimation schemes.Specifically,each access point(AP)first uses embedded pilots to estimate the channels of all users based on minimum mean-squared error(MMSE)estimation.Given the high computational cost of MMSE estimation,the low-complexity element-wise MMSE(EW-MMSE)channel estimator and the least-squares(LS)channel estimator without prior statistical information are also analyzed.To reduce non-coherent and coherent interference during uplink payload data transmission,simple centralized decoding(SCD)and large-scale fading decoding(LSFD)are examined.Then,the closedform expressions for uplink spectral efficiency(SE)using MMSE,EW-MMSE,and LS estimators are developed for maximum ratio(MR)combining under LSFD,where each AP may have any number of antennas.The sum SE maximization problem with uplink power control is formulated.Since the maximization problem is non-convex and challenging,a block coordinate descent approach based on the weighted MMSE method is used to get the optimal local solution.Numerical studies demonstrate that LSFD and efficient uplink power control can considerably increase SE in distributed CF m MIMO networks.
基金supported by National Natural Science Foundation of China(No.62471054).
文摘The construction of polar codes in corre-lated block fading channels is still an open issue to be solved.In this paper,to explicitly reveal the impact of correlation on error performance of polar coded diver-sity communication systems,an integrated framework has been established to analyze the theoretical error performance of polar codes in correlated block fading channels.First,the upper bound on error probabil-ity of polarized channels is derived based on split po-lar spectrum,which is fully determined by covariance channel matrix as well as the block-wise weight distri-bution of the corresponding polar subcode.Further,to facilitate practical implementations,we design a con-struction metric named polarized correlation weight(PCW)to generate polar codes in correlated block fad-ing channels.Finally,simulation results on block error rate indicate that the proposed metric can exhibit both diversity gain and coding gain compared to the con-ventional methods under successive cancellation de-coding.
