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Current status and recent changes of glaciers in Tajikistan
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作者 XU Chunhai LI Zhongqin +6 位作者 HE Zhonghua WANG Feiteng MU Jianxin CHEN Yaning Sheralizoda NAZRIALO Farhod NASRULLOEV Aminjon GULAHMADZODA 《Regional Sustainability》 2026年第1期75-90,共16页
Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monito... Tajikistan contains the majority of Central Asia’s glaciers,which cover about 6.00%of the national territory;their rapid shrinkage poses a significant threat to regional water resource security.However,glacier monitoring in Tajikistan was interrupted after 1991,creating a substantial gap in understanding the current state and temporal evolution of these glaciers.Based on glacier inventory data,in situ measurements,and published literature,this study examined the present status and recent variations of glaciers in Tajikistan through data integration and validation,literature collation and comparative analysis,and the application of Geographic Information System(GIS)spatial analysis techniques.As of 2023,Tajikistan possesses a total of 11,528 glaciers,encompassing an area of 7624.48(±305.58)km2.Small glaciers dominate in number,whereas large glaciers account for the majority of the total area.Over the past two decades,the glacier count has decreased by 2014,and the total area has decreased by 628.98 km2,corresponding to an average annual reduction rate of 0.33%.Regional shrinkage rates range from 4.10%to 22.28%.Glaciers have undergone accelerated mass loss during the past 20 a;only those on the northeastern Pamir Plateau exhibit a weak positive mass balance.Observations of typical monitored glaciers also reveal intensified melting and retreat,consistent with regional trends.In light of the recent acceleration of glacier shrinkage in Tajikistan,focused measures should be implemented to strengthen glacier monitoring,enhance public awareness of glacier preservation,and promote the sustainable development and utilization of glacier tourism.These findings bridge the knowledge gap regarding the spatiotemporal dynamics of Tajikistan’s glaciers over recent decades and provide essential data support for regional water resource management. 展开更多
关键词 Glacier inventory Glacier change Glacier mass balance Climate change TAJIKISTAN
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MewCDNet: A Wavelet-Based Multi-Scale Interaction Network for Efficient Remote Sensing Building Change Detection
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作者 Jia Liu Hao Chen +5 位作者 Hang Gu Yushan Pan Haoran Chen Erlin Tian Min Huang Zuhe Li 《Computers, Materials & Continua》 2026年第1期687-710,共24页
Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectra... Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectral similarity between buildings and backgrounds,sensor variations,and insufficient computational efficiency.To address these challenges,this paper proposes a novel Multi-scale Efficient Wavelet-based Change Detection Network(MewCDNet),which integrates the advantages of Convolutional Neural Networks and Transformers,balances computational costs,and achieves high-performance building change detection.The network employs EfficientNet-B4 as the backbone for hierarchical feature extraction,integrates multi-level feature maps through a multi-scale fusion strategy,and incorporates two key modules:Cross-temporal Difference Detection(CTDD)and Cross-scale Wavelet Refinement(CSWR).CTDD adopts a dual-branch architecture that combines pixel-wise differencing with semanticaware Euclidean distance weighting to enhance the distinction between true changes and background noise.CSWR integrates Haar-based Discrete Wavelet Transform with multi-head cross-attention mechanisms,enabling cross-scale feature fusion while significantly improving edge localization and suppressing spurious changes.Extensive experiments on four benchmark datasets demonstrate MewCDNet’s superiority over comparison methods:achieving F1 scores of 91.54%on LEVIR,93.70%on WHUCD,and 64.96%on S2Looking for building change detection.Furthermore,MewCDNet exhibits optimal performance on the multi-class⋅SYSU dataset(F1:82.71%),highlighting its exceptional generalization capability. 展开更多
关键词 Remote sensing change detection deep learning wavelet transform MULTI-SCALE
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Trajectory and influencing factors of changes in anxiety and depression in elderly patients after lumbar interbody fusion
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作者 Xiao-Feng Liu Yan-Hua Wu +4 位作者 Guang-Xi Huang Bin Yu Hui-Juan Xu Meng-Hua Qiu Lin Kang 《World Journal of Psychiatry》 2026年第1期312-321,共10页
BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery... BACKGROUND Lumbar interbody fusion(LIF)is the primary treatment for lumbar degenerative diseases.Elderly patients are prone to anxiety and depression after undergoing surgery,which affects their postoperative recovery speed and quality of life.Effective prevention of anxiety and depression in elderly patients has become an urgent problem.AIM To investigate the trajectory of anxiety and depression levels in elderly patients after LIF,and the influencing factors.METHODS Random sampling was used to select 239 elderly patients who underwent LIF from January 2020 to December 2024 in Shenzhen Pingle Orthopedic Hospital.General information and surgery-related indices were recorded,and participants completed measures of psychological status,lumbar spine dysfunction,and quality of life.A latent class growth model was used to analyze the post-LIF trajectory of anxiety and depression levels,and unordered multi-categorical logistic regression was used to analyze the influencing factors.RESULTS Three trajectories of change in anxiety level were identified:Increasing anxiety(n=26,10.88%),decreasing anxiety(n=27,11.30%),and stable anxiety(n=186,77.82%).Likewise,three trajectories of change in depression level were identified:Increasing depression(n=30,12.55%),decreasing depression(n=26,10.88%),and stable depression(n=183,76.57%).Regression analysis showed that having no partner,female sex,elevated Oswestry dysfunction index(ODI)scores,and reduced 36-Item Short Form Health Survey scores all contributed to increased anxiety levels,whereas female sex,postoperative opioid use,and elevated ODI scores all contributed to increased depression levels.CONCLUSION During clinical observation,combining factors to predict anxiety and depression in post-LIF elderly patients enables timely intervention,quickens recovery,and enhances quality of life. 展开更多
关键词 Lumbar interbody fusion Elderly patients ANXIETY DEPRESSION Trajectory of change Influencing factors
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Water resources and sustainable management in Tajikistan under global change
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作者 CHEN Yaning FANG Gonghuan +5 位作者 LI Zhi ZHANG Xueqi LI Weihong Nekruz GULAHMADOV Farhod NASRULLOEV Aminjon GULAKHMADOV 《Regional Sustainability》 2026年第1期1-10,共10页
As a major source of freshwater in Central Asia,Tajikistan is endowed with abundant glaciers and water resources.However,the country faces multiple challenges,including accelerated glacier retreat,complex inter-govern... As a major source of freshwater in Central Asia,Tajikistan is endowed with abundant glaciers and water resources.However,the country faces multiple challenges,including accelerated glacier retreat,complex inter-government water resource management,and inefficient water use.Existing research has predominantly focused on individual hydrological processes,such as glacier retreat,snow cover change,or transboundary water issues,but it has yet to fully capture the overall complexity of water system.Tajikistan’s water system functions as an integrated whole from mountain runoff to downstream supply,but a comprehensive study of its water resource has yet to be conducted.To address this research gap,this study systematically examined the status,challenges,and sustainable management strategies of Tajikistan’s water resources based on a literature review,remote sensing data analysis,and case studies.Despite Tajikistan’s relative abundance of water resources,global warming is accelerating glacier melting and altering the hydrological cycles,which have resulted in unstable runoff patterns and heightened risks of extreme events.In Tajikistan,outdated infrastructure and poor management are primary causes of low water-use efficiency in the agricultural sector,which accounts for 85.00%of the total water withdrawals.At the governance level,Tajikistan faces challenges in balancing the water-energy-food nexus and transboundary water resource issues.To address these issues,this study proposes core paths for Tajikistan to achieve sustainable water resource management,such as accelerating technological innovation,promoting water-saving agricultural technologies,improving water resource utilization efficiency,and establishing a community participation-based comprehensive management framework.Additionally,strengthening cross-border cooperation and improving real-time monitoring systems have been identified as critical steps to advance sustainable water resource utilization and evidence-based decision-making in Tajikistan and across Central Asia. 展开更多
关键词 Climate change Glacial retreat Cross-border cooperation Water resource management TAJIKISTAN Central Asia
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Impact of green energy development on climate change mitigation
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作者 Kobiljon Khushvakht KHUSHVAKHTZODA Ilkhom Burkhonovich MAKHSUMOV +1 位作者 Muzaffar Boynazarovich KHOLNAZAROV Irina Mikhailovna KIRPICHNIKOVA 《Regional Sustainability》 2026年第1期11-22,共12页
This study examined the role of green energy development in mitigating climate change and fostering sustainable development in Central Asia including Kazakhstan,Uzbekistan,Kyrgyzstan,Tajikistan,and Turkmenistan.The re... This study examined the role of green energy development in mitigating climate change and fostering sustainable development in Central Asia including Kazakhstan,Uzbekistan,Kyrgyzstan,Tajikistan,and Turkmenistan.The region has substantial untapped potential in solar energy,wind energy,hydropower energy,as well as biomass and bioenergy,positioning it strategically for renewable energy deployment.The result demonstrated that integrating renewable energy can reduce greenhouse gas emissions,improve air quality,enhance energy security,and support rural development.Case studies from Kazakhstan,Uzbekistan,Kyrgyzstan,and Tajikistan showed measurable environmental and economic benefits.However,the large-scale use of renewable energy still faces numerous barriers,including outdated infrastructure,fragmented regulatory frameworks,limited investment,and shortages of technical expertise.Overcoming these obstacles requires institutional reform,stronger regional cooperation,and increasing engagement from international financial institutions and private investors.Modernizing grids,deploying storage systems,and investing in education,research,and innovation are critical for building human capacity in renewable energy sector.Accelerating the renewable energy transition is essential for Central Asia to meet climate goals,enhance environmental resilience,and ensure long-term socioeconomic development through innovation,investment,and regional collaboration. 展开更多
关键词 Renewable energy Climate change mitigation Green energy transition Sustainable development Energy security
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Surface flux–induced salinity change and its effects on ocean stratification in response to global warming
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作者 Hai Zhi Tianyi Ma +2 位作者 Rong-Hua Zhang Xiaokun Wang Minmin Wu 《Atmospheric and Oceanic Science Letters》 2026年第1期59-65,共7页
Global warming induced by increased CO_(2) has caused marked changes in the ocean.Previous estimates of ocean salinity change in response to global warming have considerable ambiguity,largely attributable to the diver... Global warming induced by increased CO_(2) has caused marked changes in the ocean.Previous estimates of ocean salinity change in response to global warming have considerable ambiguity,largely attributable to the diverse sensitivities of surface fluxes.This study utilizes data from the Flux-Anomaly-Forced Model Intercomparison Project to investigate how ocean salinity responds to perturbations of surface fluxes.The findings indicate the emergence of a sea surface salinity(SSS)dipole pattern predominantly in the North Atlantic and Pacific fresh pools,driven by surface flux perturbations.This results in an intensification of the“salty gets saltier and fresh gets fresher”SSS pattern across the global ocean.The spatial pattern amplification(PA)of SSS under global warming is estimated to be approximately 11.5%,with surface water flux perturbations being the most significant contributor to salinity PA,accounting for 8.1% of the change after 70 years in experiments since pre-industrial control(piControl).Notably,the zonal-depth distribution of salinity in the upper ocean exhibits lighter seawater above the denser water,with bowed isopycnals in the upper 400 m.This stable stratification inhibits vertical mixing of salinity and temperature.In response to the flux perturbations,there is a strong positive feedback due to consequent freshening.It is hypothesized that under global warming,an SSS amplification of 7.2%/℃ and a mixed-layer depth amplification of 12.5%/℃ will occur in the global ocean.It suggests that the salinity effect can exert a more stable ocean to hinder the downward transfer of heat,which provides positive feedback to future global warming. 展开更多
关键词 Sea surface salinity change Pattern amplification Upper-ocean stratification Flux-anomaly-forced model intercomparison project
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Hydrological change trends of the Surkhob and Khingov river basins in the Vakhsh River of Tajikistan under climate change
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作者 Nasrulloev FARHOD CHEN Yaning +3 位作者 Sheralizoda NAZRIALO Gulahmadov NEKRUZ Shobairi SEYED OMID REZA Murodov MURODKHUJA 《Regional Sustainability》 2026年第1期144-155,共12页
The hydrological system in Central Asia is highly sensitive to global climate change,significantly affecting water supply and energy production.In Tajikistan,the Vakhsh River—one of the main tributaries of the Amu Da... The hydrological system in Central Asia is highly sensitive to global climate change,significantly affecting water supply and energy production.In Tajikistan,the Vakhsh River—one of the main tributaries of the Amu Darya—plays a key role in the region’s hydropower and irrigation.However,research on long-term hydrological changes in its two top large basins—the Surkhob and Khingov river basins—remains limited.Therefore,this study analyzed long-term climate and hydrological changes in the Vakhsh River,including its main tributaries—the Surkhob and Khingov rivers—which are vital for the water resource management in Tajikistan and even in Central Asia.Using long-term hydrometeorological observations,the change trends of temperature(1933–2020),precipitation(1970–2020),and runoff(1940–2018)were examined to assess the impact of climate change on the regional water resources.The analysis revealed the occurrence of significant warming and a spatially uneven increase in precipitation.The temperature changes across three climatic periods(1933–1960,1960–1990,and 1990–2020)indicated that there was a transition from baseline level to accelerated warming.The precipitation showed a 2.99 mm/a increase in the Khingov River Basin and a 2.80 mm/a increase in the Surkhob River Basin during 1970–2020.Moreover,there was a gradual shift toward wetter conditions in recent decades.Despite the relatively stable annual mean runoff,seasonal redistribution occurred,with increased runoff in spring and reduced runoff in summer,due to the compensation of glacier melting.Moreover,this study forecasted runoff change during 2019–2040 using the exponential triple smoothing(ETS)method and revealed the occurrence of alternating wet and dry phases,emphasizing the sensitivity of the Vakhsh River Basin’s hydrological system to climate change and the necessity of adaptive water resource management in mountainous regions of Central Asia.Therefore,this study can provide evidence-based insights that are critical for future water resources planning,climate-resilient hydropower development,and regional adaptation strategies in climate-vulnerable basins in Central Asia. 展开更多
关键词 Climate change Exponential triple smoothing(ETS)method Sustainable water resources management Vakhsh River Basin Central Asia
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Spatiotemporal heterogeneity of runoff in Tajikistan and its driving mechanisms under climate change
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作者 LI Chunlan YU Yang +8 位作者 SUN Lingxiao HE Jing LU Yuanbo GUO Zengkun FANG Gonghuan Alexandr ULMAN Vitaliy SALNIKOV Ireneusz MALIK Małgorzata WISTUBA 《Regional Sustainability》 2026年第1期91-109,共19页
Based on monthly runoff and climate datasets spanning 2000–2024,this study employed the Theil–Sen’s slope estimation,Mann–Kendall(M–K)trend test,as well as Pearson correlation and Spearman rank correlation analys... Based on monthly runoff and climate datasets spanning 2000–2024,this study employed the Theil–Sen’s slope estimation,Mann–Kendall(M–K)trend test,as well as Pearson correlation and Spearman rank correlation analyses to systematically examine the spatiotemporal patterns of runoff and its climatic driving mechanisms across Tajikistan,providing a scientific basis for sustainable water resource utilization and management in the study area.Results indicated that during 2000–2024,the annual runoff in Tajikistan exhibited statistically non-significant long-term trend(P=0.76),while displaying pronounced seasonal variability and strong spatial heterogeneity.Spring and summer average runoff primarily exhibited slight declining tendencies,while winter average runoff exhibited pronounced reduction in localized regions,such as the Syr Darya Basin,the Vakhsh River Basin,and the lower reaches of the Zeravshan River Basin.Precipitation emerged as the dominant positive driver of runoff,exhibiting moderate to strong positive correlations across over 78.00%of the country,whereas potential evapotranspiration consistently functioned as a negative driver.Rising temperatures exerted a dual competitive effect on runoff:in high-elevation,glacier-covered regions,rising temperatures temporarily increased runoff by accelerating glacier melt;however,at the national scale,the negative impact of rising temperature on runoff has played a slightly dominant role to a certain extent by enhancing evapotranspiration.Collectively,these results indicated that the present stability of runoff in Tajikistan is strongly dependent on the short-term compensatory effects of glacier melt and the risk of future runoff decline is likely to intensify as glacier reserves continue to diminish.This study provides a critical scientific evidence to inform sustainable water resource management in Tajikistan and underscores the need for glacier conservation and integrated water resource management strategies. 展开更多
关键词 Runoff variation Climate change Theil-Sen’s slope estimation Mann-Kendall(M-K)trend test Water resource management TAJIKISTAN
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血清IL-6联合MoCA评分、CHANGE风险评分对急性脑卒中后认知障碍的多维度预测模型研究
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作者 郭莞莹 舒可 +2 位作者 王若怡 亚金蓉 杨鹤云 《现代生物医学进展》 2025年第18期2981-2987,共7页
目的:探讨血清白细胞介素-6(interleukin-6,IL-6)联合蒙特利尔认知评估量表(Montreal Cognitive Assessment,Mo CA)评分、CHANGE风险评分在急性脑卒中后认知障碍(post-stroke cognitive impairment,PSCI)的预测价值,为高风险患者早期识... 目的:探讨血清白细胞介素-6(interleukin-6,IL-6)联合蒙特利尔认知评估量表(Montreal Cognitive Assessment,Mo CA)评分、CHANGE风险评分在急性脑卒中后认知障碍(post-stroke cognitive impairment,PSCI)的预测价值,为高风险患者早期识别及干预提供依据。方法:回顾性分析2022年10月至2024年9月我院收治的200例急性脑卒中患者的一般资料,根据急性脑卒中后3个月是否发生PSCI分为PSCI组(49例)和非PSCI组(151例)。对比两组的一般资料,采用多因素Logistic回归分析PSCI影响因素,并使用受试者工作特征(receiver operating characteristic,ROC)曲线评估血清IL-6、MoCA评分及CHANGE风险评分对PSCI发生的预测效能。结果:两组年龄、受教育程度比较差异有统计学意义(P<0.05)。PSCI组血清IL-6水平及CHANGE风险评分高于非PSCI组,MoCA评分低于非PSCI组(P<0.05)。多因素Logistic回归显示IL-6水平升高(OR=1.851,P=0.001)、CHANGE风险评分升高(OR=1.076,P=0.016)是PSCI发生的独立危险因素,MoCA评分升高(OR=0.806,P=0.001)是保护因素(P<0.05)。IL-6水平、MoCA评分及CHANGE风险评分均对预测PSCI发生有较高的效能,三者单独预测PSCI发生的曲线下面积(area under the curve,AUC)分别为0.783、0.825、0.857,三者联合检测AUC为0.912,显著高于各指标单独检测。结论:血清IL-6升高、MoCA评分降低及CHANGE风险评分升高是PSCI的危险因素,三者联合检测模型对PSCI发生的预测效能最高,可为临床早期干预提供科学依据。 展开更多
关键词 急性脑卒中 卒中后认知障碍 白细胞介素-6 蒙特利尔认知评估量表 change风险评分
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定志小丸对血管性痴呆小鼠PINK1/PARKIN/MEF2D线粒体自噬通路的影响 被引量:1
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作者 邓敏贞 王宇 +5 位作者 宁振求 胡达峰 王凯 王成毅 孙景波 程骁 《中药新药与临床药理》 北大核心 2025年第3期328-337,共10页
目的研究定志小丸对血管性痴呆(VD)小鼠PTEN诱导假定激酶1(PINK1)/E3泛素连接酶PARK2(PARKIN)/肌细胞增强因子2D(MEF2D)线粒体自噬通路的影响。方法采用双侧颈总动脉夹闭再灌注方法复制VD小鼠模型。将ICR小鼠随机分为假手术组、模型组... 目的研究定志小丸对血管性痴呆(VD)小鼠PTEN诱导假定激酶1(PINK1)/E3泛素连接酶PARK2(PARKIN)/肌细胞增强因子2D(MEF2D)线粒体自噬通路的影响。方法采用双侧颈总动脉夹闭再灌注方法复制VD小鼠模型。将ICR小鼠随机分为假手术组、模型组、盐酸多奈哌齐组(1 mg·kg^(-1),灌胃给药)、PINK1抑制剂组(20 mg·kg^(-1)环孢菌素A,腹腔注射给药)及定志小丸低、中、高剂量组(0.71、1.43、2.56 g·kg^(-1),灌胃给药),每组6只,每天1次,连续给药4周。采用Morris水迷宫实验检测小鼠学习记忆能力;ELISA法检测海马组织乙酰胆碱酯酶(AchE)、活性氧(ROS)、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、谷胱甘肽过氧化物酶4(GPX4)、紧密连接蛋白1(ZO-1)水平及血清神经元特异性烯醇化酶(NSE)、基质金属蛋白酶9(MMP9)、中枢神经特异性蛋白(S100β)水平;qRT-PCR及Western Blot法检测海马组织中PINK1、PARKIN、MEF2D、Bcl-2同源结构域蛋白(Beclin-1)、微管相关蛋白1轻链3β(LC3B)、螯合体1(p62)mRNA及蛋白表达水平;HE及尼氏染色法观察海马组织病理变化。结果与假手术组比较,模型组小鼠的逃逸潜伏期显著延长(P<0.01),穿越平台次数显著减少(P<0.01);海马组织AchE、ROS、IL-1β、TNF-α水平显著升高(P<0.01),GPX4、ZO-1水平显著降低(P<0.01);血清NSE、MMP9、S100β水平显著升高(P<0.01);海马组织中PINK1、PARKIN、Beclin-1、LC3B mRNA及蛋白表达显著上调(P<0.01),MEF2D、p62 mRNA及蛋白表达显著下调(P<0.01);海马CA1区神经元排列疏松,细胞核呈三角形或不规则形状,或出现溶解现象,细胞出现较为明显的变性;海马CA1区的尼氏体数量和层数明显减少,排列较为紊乱,甚至出现空泡结构。与模型组比较,各给药组小鼠的逃逸潜伏期显著缩短(P<0.01),穿越平台次数显著增加(P<0.01);海马组织AchE、ROS、IL-1β、TNF-α水平显著降低(P<0.01),GPX4、ZO-1水平显著升高(P<0.01);血清NSE、MMP9、S100β水平显著降低(P<0.01);海马组织中PINK1、PARKIN、Beclin-1、LC3B mRNA表达显著下调(P<0.01),MEF2D、p62 mRNA表达显著上调(P<0.01);小鼠海马CA1区神经元排列更为紧密,核固缩现象有所缓解,发生变性的细胞数量减少;海马CA1区的尼氏体数量均有所增加,细胞层数损失减少,排列相对紧密有序。与模型组比较,定志小丸各剂量组及PINK1抑制剂组小鼠海马组织中PINK1、PARKIN蛋白表达显著下调(P<0.05,P<0.01);定志小丸各剂量组的Beclin-1蛋白表达显著下调(P<0.01),p62蛋白表达显著上调(P<0.05,P<0.01);定志小丸中、高剂量组及PINK1抑制剂组的MEF2D蛋白表达显著上调(P<0.01);定志小丸中、高剂量组的LC3B蛋白表达显著下调(P<0.01)。结论定志小丸对VD小鼠具有海马神经元保护作用,能降低氧化应激和炎症反应,其机制可能与调控PINK1/PARKIN/MEF2D线粒体自噬通路相关。 展开更多
关键词 定志小丸 血管性痴呆 PINK1/PARKIN/mef2D通路 线粒体自噬 氧化应激 炎症反应 小鼠
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MEF2C在骨组织发育与代谢中的多效性作用
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作者 肖豪杰 黄睿奇 +3 位作者 林圣傑 李金旸 衣雪洁 高海宁 《生理学报》 北大核心 2025年第2期374-384,共11页
人体内骨的发育过程以及成年后骨量的维持受多种生物因子调控。肌细胞增强因子2C(myocyte enhancer factor 2C,MEF2C)作为诸多调控骨组织发育和平衡因子中的一员,已被证明在骨发育以及骨代谢过程中发挥关键作用。然而关于该因子对骨组... 人体内骨的发育过程以及成年后骨量的维持受多种生物因子调控。肌细胞增强因子2C(myocyte enhancer factor 2C,MEF2C)作为诸多调控骨组织发育和平衡因子中的一员,已被证明在骨发育以及骨代谢过程中发挥关键作用。然而关于该因子对骨组织的影响鲜少有系统性的整理与总结。为更好地了解MEF2C对骨组织产生的效应,本文系统梳理了MEF2C在骨发育以及骨代谢中的作用。在骨发育过程中,MEF2C促进神经嵴细胞(neural crest cells,NC)发育为颅面软骨,且直接促进软骨肥大。对于骨代谢,在不同类型的骨细胞中,MEF2C展现出差异化的调控模式,对骨形成过程既有促进也有其他潜在的调控作用,但对破骨细胞目前只确定了其促进作用。鉴于MEF2C对骨组织的复杂效应,本文也讨论了MEF2C对部分骨病的影响,为骨组织的生理学研究及骨性疾病的预防提供理论参考。 展开更多
关键词 mef2C 软骨 成骨细胞 破骨细胞 骨病
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关岭牛MEF2A启动子甲基化负向调控mRNA转录
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作者 孙金魁 许厚强 《华北农学报》 北大核心 2025年第4期203-209,共7页
肌肉生成依赖于各种细胞内外的信号和因子的相互调控,通过组织和细胞水平探究肌细胞增强因子2A(MEF2A)表达量与其启动子甲基化的调控关系,为关岭牛的遗传发育提供理论参考。以关岭牛为试验对象,首先对关岭牛组织MEF2A表达量与其启动子... 肌肉生成依赖于各种细胞内外的信号和因子的相互调控,通过组织和细胞水平探究肌细胞增强因子2A(MEF2A)表达量与其启动子甲基化的调控关系,为关岭牛的遗传发育提供理论参考。以关岭牛为试验对象,首先对关岭牛组织MEF2A表达量与其启动子甲基化水平联合分析。其次,将MEF2A基因的干扰和超表达载体转染至关岭牛原代成肌细胞内,分析MEF2A表达量变化对其启动子甲基化水平的影响。结果表明,关岭牛犊牛各组织MEF2A表达量高于成年牛,而犊牛组织MEF2A甲基化率低于成年牛,DNMT1表达量趋势与之一致。此外,MEF2A表达量升高导致其甲基化率降低,降低MEF2A表达量则导致其甲基化率升高。从组织和细胞两方面证实关岭牛MEF2A基因表达水平与其甲基化率呈负相关,为遗传标记辅助牛的遗传改良提供了理论依据。 展开更多
关键词 关岭牛 mef2A 启动子 DNA甲基化 成肌细胞
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CD19/CD22 CAR-T细胞治疗MEF2D基因重排难治/复发儿童B细胞急性淋巴细胞白血病临床分析
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作者 石文华 苏萌 +6 位作者 张婧 安康 钱娟 蔡娇阳 沈树红 李本尚 汤燕静 《中国小儿血液与肿瘤杂志》 2025年第6期402-407,共6页
目的分析CD19/CD22嵌合抗原受体T(CAR-T)细胞治疗MEF2D基因重排(MEF2D-r)的难治/复发儿童B细胞急性淋巴细胞白血病(R/R B-ALL)的安全性及有效性。方法回顾性分析2020年9月—2023年12月在上海交通大学医学院附属上海儿童医学中心接受CD19... 目的分析CD19/CD22嵌合抗原受体T(CAR-T)细胞治疗MEF2D基因重排(MEF2D-r)的难治/复发儿童B细胞急性淋巴细胞白血病(R/R B-ALL)的安全性及有效性。方法回顾性分析2020年9月—2023年12月在上海交通大学医学院附属上海儿童医学中心接受CD19/CD22 CAR-T细胞治疗的MEF2D-rR/R B-ALL患儿的临床资料。结果共纳入15例MEF2D-rR/R B-ALL患儿,CAR-T细胞输注中位年龄为6.7(2.4~13.8)岁,14例(93%)患儿在CD19/CD22 CAR-T细胞治疗后发生细胞因子释放综合征(CRS);1例患儿出现3级免疫效应细胞相关神经毒性综合征(ICANS)。15例MEF2D-r患儿在CD19/CD22 CAR-T细胞治疗后14天内缓解率为100%;中位随访时间25.9(3.2~56.6)个月,1年、2年OS率分别为80%(95%CI:48%~93%)、58.6%(95%CI:38.3%~78.9%);1年、2年EFS率分别为53.3%(95%CI:26.3%~74.3%)、40%(95%CI:16.5%~62.7%)。4例患儿在CD19/CD22 CAR-T细胞治疗后桥接造血干细胞移植(HSCT)治疗,2年OS率、EFS率均为75.0%(95%CI:12.8%~96%);未桥接HSCT的2年OS率、EFS率为51.9%(95%CI:19.8%~76.7%)、27.2%(95%CI:6.6%~53.8%)。结论MEF2D-r儿童R/R B-ALL在经CD19/CD22 CAR-T细胞治疗可获得有效缓解,桥接HSCT可提高患儿长期生存。 展开更多
关键词 嵌合抗原受体T细胞 儿童 复发/难治 B细胞急性淋巴细胞白血病 mef2D基因重排
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Impact of climate change on Kupang River flow and hydrological extremes in Greater Pekalongan,Indonesia 被引量:2
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作者 Fernaldi Gradiyanto Priyo Nugroho Parmantoro Suharyanto 《Water Science and Engineering》 2025年第1期69-77,共9页
Located downstream the Kupang Catchment in Indonesia,Pekalongan faces significant land subsidence issues,leading to severe coastal flooding.This study aimed to assess the impact of climate change on future flow regime... Located downstream the Kupang Catchment in Indonesia,Pekalongan faces significant land subsidence issues,leading to severe coastal flooding.This study aimed to assess the impact of climate change on future flow regimes and hydrological extremes to inform long-term water resources management strategies for the Kupang Catchment.Utilizing precipitation and air temperature data from general circulation models in the Coupled Model Intercomparison Project 6(CMIP6)and employing bias correction techniques,the Soil and Water Assessment Tool(SWAT)hydrological model was employed to analyze climate-induced changes in hydrological fluxes,specifically streamflow.Results indicated a consistent increase in monthly streamflow during the wet season,with a substantial rise of 22.8%,alongside a slight decrease of 18.0%during the dry season.Moreover,both the frequency and severity of extremely low and high flows were projected to intensify by approximately 50%and 70%,respectively,for a 20-year return period,suggesting heightened flood and drought risks in the future.The observed declining trend in low flow,by up to 11%,indicated the potential for long-term groundwater depletion exacerbating the threat of land subsidence and coastal flooding,especially in areas with inadequate surface water management policies and infrastructure. 展开更多
关键词 Climate change CMIP6 Hydrological extremes SWAT Pekalongan
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The Impacts of Climate Change on the Environment and Human Health in China:A Call for more Ambitious Action 被引量:1
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作者 Shilu Tong Yu Wang +11 位作者 Yonglong Lu Cunde Xiao Qiyong Liu Qi Zhao Cunrui Huang Jiayu Xu Ning Kang Tong Zhu Dahe Qin Ying Xu Buda Su Xiaoming Shi 《Biomedical and Environmental Sciences》 2025年第2期127-143,共17页
As global greenhouse gases continue rising,the urgency of more ambitious action is clearer than ever before.China is the world’s biggest emitter of greenhouse gases and one of the countries affected most by climate c... As global greenhouse gases continue rising,the urgency of more ambitious action is clearer than ever before.China is the world’s biggest emitter of greenhouse gases and one of the countries affected most by climate change.The evidence about the impacts of climate change on the environment and human health may encourage China to take more decisive action to mitigate greenhouse gas emissions and adapt to climate impacts. 展开更多
关键词 change GREENHOUSE CLIMATE
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Carbon-based porous materials for performance-enhanced composite phase change materials in thermal energy storage:Materials,fabrication and applications 被引量:5
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作者 Lei Hu Li Zhang +4 位作者 Wei Cui Qinyou An Ting Ma Qiuwang Wang Liqiang Mai 《Journal of Materials Science & Technology》 2025年第7期204-226,共23页
Latent heat thermal energy storage(TES)effectively reduces the mismatch between energy supply and demand of renewable energy sources by the utilization of phase change materials(PCMs).However,the low thermal conductiv... Latent heat thermal energy storage(TES)effectively reduces the mismatch between energy supply and demand of renewable energy sources by the utilization of phase change materials(PCMs).However,the low thermal conductivity and poor shape stability are the main drawbacks in realizing the large-scale application of PCMs.Promisingly,developing composite PCM(CPCM)based on porous supporting mate-rial provides a desirable solution to obtain performance-enhanced PCMs with improved effective thermal conductivity and shape stability.Among all the porous matrixes as supports for PCM,three-dimensional carbon-based porous supporting material has attracted considerable attention ascribing to its high ther-mal conductivity,desirable loading capacity of PCMs,and excellent chemical compatibility with various PCMs.Therefore,this work systemically reviews the CPCMs with three-dimensional carbon-based porous supporting materials.First,a concise rule for the fabrication of CPCMs is illustrated in detail.Next,the experimental and computational research of carbon nanotube-based support,graphene-based support,graphite-based support and amorphous carbon-based support are reviewed.Then,the applications of the shape-stabilized CPCMs including thermal management and thermal conversion are illustrated.Last but not least,the challenges and prospects of the CPCMs are discussed.To conclude,introducing carbon-based porous materials can solve the liquid leakage issue and essentially improve the thermal conductivity of PCMs.However,there is still a long way to further develop a desirable CPCM with higher latent heat capacity,higher thermal conductivity,and more excellent shape stability. 展开更多
关键词 Thermal energy storage Phase change material Supporting material Carbon-based material Thermal conductivity Shape-stabilized composite
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MEF2D在神经系统疾病中的研究进展
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作者 焦腾飞 热娜·阿不都萨拉木(综述) 韩登峰(审校) 《中风与神经疾病杂志》 2025年第3期279-283,共5页
神经系统疾病是影响全球人类疾病负担的一个重要原因,但是有关神经系统疾病的发生发展机制的研究尚不完全清楚,但大多数的研究发现与人体基因的变异表达有关。MEF2D作为MEF2家族基因中的一个重要基因,在生理和病理过程中都发挥着重要作... 神经系统疾病是影响全球人类疾病负担的一个重要原因,但是有关神经系统疾病的发生发展机制的研究尚不完全清楚,但大多数的研究发现与人体基因的变异表达有关。MEF2D作为MEF2家族基因中的一个重要基因,在生理和病理过程中都发挥着重要作用。相关研究发现MEF2D可以参与神经元的存活,并能调节神经元对刺激的反应,可以参与神经系统疾病的致病过程。本综述主要总结了MEF2D在常见神经系统疾病中的进展研究。 展开更多
关键词 mef2D 神经系统疾病 研究进展
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Spatiotemporal analysis of AGB and BGB in China:Responses to climate change under SSP scenarios 被引量:2
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作者 Chuanmei Zhu Yupu Li +7 位作者 Jianli Ding Jiexin Rao Yihang Xiang Xiangyu Ge Jinjie Wang Jingzhe Wang Xiangyue Chen Zipeng Zhang 《Geoscience Frontiers》 2025年第3期359-375,共17页
Aboveground biomass(AGB)and belowground biomass(BGB)are key components of carbon storage,yet their responses to future climate changes remain poorly understood,particularly in China.Understanding these dynamics is ess... Aboveground biomass(AGB)and belowground biomass(BGB)are key components of carbon storage,yet their responses to future climate changes remain poorly understood,particularly in China.Understanding these dynamics is essential for global carbon cycle modeling and ecosystem management.This study integrates field observations,machine learning,and multi-source remote sensing data to reconstruct the distributions of AGB and BGB in China from 2000 to 2020.Then CMIP6 was used to predict the distribution of China under three SSP scenarios(SSP1-1.9,SSP2-4.5,SSP5-8.5)from 2020 to 2100 to fill the existing knowledge gap.The predictive accuracy for AGB(R^(2)=0.85)was significantly higher than for BGB(R^(2)=0.48),likely due to the greater complexity of modeling belowground dynamics.NDVI(Normalized Difference Vegetation Index)and soil organic carbon density(SOC)were identified as the primary drivers of AGB and BGB changes.During 2000-2020,AGB in China remained stable at approximately 10.69 Pg C,while BGB was around 5.06 Pg C.Forest ecosystems contributed 88.52% of AGB and 43.83% of BGB.AGB showed a relatively slow annual increase,while BGB demonstrated a significant annual growth rate of approximately 37 Tg C yr^(−1).Under the low-emission scenario,both AGB and BGB show fluctuations and steady growth,particularly in South China and the northwestern part of Northeast China.Under the moderate-emission scenario,AGB and BGB show significant declines and increases,respectively.In the high-emission scenario,both AGB and BGB decline significantly,particularly in the southwestern and central regions.These results provide valuable insights into ecosystem carbon dynamics under climate change,emphasizing the relatively low responsiveness of AGB and BGB to climatic variability,and offering guidance for sustainable land use and management strategies. 展开更多
关键词 Aboveground biomass Belowground biomass ECOSYSTEM Shared socioeconomic pathways Climate change
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Exploring the spatiotemporal heterogeneity of vegetation changes in subtropical humid karst region under CO_(2)fertilization 被引量:1
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作者 CHEN Meng ZHOU Qiuwen +1 位作者 PENG Dawei YAN Weihong 《Journal of Geographical Sciences》 2025年第1期65-87,共23页
Terrestrial ecosystems heavily depend on vegetation,which responds to carbon dioxide(CO_(2))fertilization in hot and humid regions.The subtropical humid karst region is a hot and humid region;whether and to what exten... Terrestrial ecosystems heavily depend on vegetation,which responds to carbon dioxide(CO_(2))fertilization in hot and humid regions.The subtropical humid karst region is a hot and humid region;whether and to what extent CO_(2)fertilization affects vegetation changes in such regions remains unclear.In this study,we investigated the degree to which CO_(2)fertilization influences vegetation changes,along with their spatial and temporal differences,in the subtropical humid karst region using time-lag effect analysis,a random forest model,and multiple regression analysis.Results showed that CO_(2)fertilization plays an important role in vegetation changes,exhibiting clear spatial variations across different geomorphological zones,with its degree of influence ranging mainly between 11%and 25%.The highest contribution of CO_(2)fertilization was observed in the karst basin and non-karstic region,whereas the lowest contribution was found in the karst plateau region.Previous studies have primarily attributed vegetation changes in subtropical humid karst region to ecological engineering,leading to an overestimation of its contribution to these changes.The findings of this study enhance the understanding of the mechanism of vegetation changes in humid karst region and provide theoretical and practical insights for ecological and environmental protection in these regions. 展开更多
关键词 KARST vegetation changes NDVI driving factors carbon dioxide FERTILIZATION
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Interactions Among Food Systems,Climate Change,and Air Pollution:A Review 被引量:1
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作者 Chaopeng Hong Rui Zhong +7 位作者 Mengyao Xu Peidong He Huibin Mo Yue Qin Danna Shi Xinlei Chen Kebin He Qiang Zhang 《Engineering》 2025年第1期215-233,共19页
Food systems are deeply affected by climate change and air pollution,while being key contributors to these environmental challenges.Understanding the complex interactions among food systems,climate change,and air poll... Food systems are deeply affected by climate change and air pollution,while being key contributors to these environmental challenges.Understanding the complex interactions among food systems,climate change,and air pollution is crucial for mitigating climate change,improving air quality,and promoting the sustainable development of food systems.However,the literature lacks a comprehensive review of these interactions,particularly in the current phase of rapid development in the field.To address this gap,this study systematically reviews recent research on the impacts of climate change and air pollution on food systems,as well as the greenhouse gas and air pollutant emissions from agri-food systems and their contribution to global climate change and air pollution.In addition,this study summarizes various strategies for mitigation and adaptation,including adjustments in agricultural practices and food supply chains.Profound changes in food systems are urgently needed to enhance adaptability and reduce emissions.This review offers a critical overview of current research on the interactions among food systems,climate change,and air pollution and highlights future research directions to support the transition to sustainable food systems. 展开更多
关键词 Food systems Climate change Air pollution INTERACTIONS Systematic review
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