For at least the past five decades,structural synthesis has been used as a main means of finding better mechanisms with some predefined function.In structural synthesis,isomorphism identification is still a problem un...For at least the past five decades,structural synthesis has been used as a main means of finding better mechanisms with some predefined function.In structural synthesis,isomorphism identification is still a problem unsolved well,and to solve this problem is very significant to the design of new mechanisms.According to the given degree of freedom（DOF） and link connection property of planar closed chain mechanisms,vertex assortment is obtained.For solving the isomorphism problem,a method of the adding sub-chains is proposed with the detailed steps and algorithms in the synthesizing process.Employing this method,the identification code and formation code of every topological structure are achieved,therefore many isomorphic structures could be eliminated in time during structural synthesis by comparing those codes among different topological graphs,resulting in the improvement of synthesizing efficiency and accuracy,and the approach for eliminating rigid sub-chains in and after the synthesizing process is also presented.Some examples are given,including how to add sub-chains,how to detect simple rigid sub-chains and how to obtain identification codes and formulation codes et al.Using the adding sub-chain method,the relative information of some common topological graphs is given in the form of table.The comparison result is coincident with many literatures,so the correctness of the adding sub-chain method is convinced.This method will greatly improve the synthesizing efficiency and accuracy,and has a good potential for application.展开更多
With the rapid development of economy and the intensification of market competition, project management involves various aspects of social development. The limitations of traditional project scheduling management meth...With the rapid development of economy and the intensification of market competition, project management involves various aspects of social development. The limitations of traditional project scheduling management methods are becoming more and more obvious. It is extremely urgent to create and apply new management technologies. According to the constraint theory, critical chain method is a method of controlling a project, which can greatly shorten the completion period of the project and reduce the cost of the enterprise. Firstly, the shortcomings of traditional project scheduling management methods are analyzed, and the importance of adopting key chain technology is pointed out. Secondly, the content of the basic chain method is summarized. Finally, the problems existing in the application of critical chain method are analyzed.展开更多
Electrification of heavy duty vehicles(HDVs)is critical to realization of the target of carbon neutralization in the future.For most HDVs,the influence of road slope on vehicle power usually cannot be ignored due to s...Electrification of heavy duty vehicles(HDVs)is critical to realization of the target of carbon neutralization in the future.For most HDVs,the influence of road slope on vehicle power usually cannot be ignored due to significant road slope variation during long driving mileages.In order to design the powertrain system for electrified HDVs effectively,it is necessary to construct representative driving cycles with road slope information.There are two difficulties for this task.(1)Road slope measuring devices are usually costly.A cheaper yet effective method for measuring road slope needs to be developed.(2)A 3D(three dimension)Markov chain method is usually utilized for constructing cycles with velocity and road slope.This method is complex and time consuming,and needs to be improved.In this paper,a 2D(two dimension)Markov chain method for addressing these issues is proposed.A road slope observation is designed based on normal GPS(Global Positioning System)signals and a high order Butterworth filter.The effectiveness of the method is validated.Driving velocity and road slope are collected and observed for the area between Beijing and Zhangjiakou in northern China.Representative cycles with road slope are constructed using a 2D Markov chain method and a matching algorithm based on average speed.With the introduced technology,three representative driving cycles with road slope for urban,suburban and highway routes are designed.Statistic results on vehicle power show that,the representative driving cycles are effective with relative errors less than 4%compared to the real driving conditions.These driving cycles will be utilized in designing electric HDVs,such as hydrogen fuel cell vehicles in the future.展开更多
Elastic impedance inversion with high efficiency and high stability has become one of the main directions of seismic pre-stack inversion. The nonlinear elastic impedance inversion method based on a fast Markov chain M...Elastic impedance inversion with high efficiency and high stability has become one of the main directions of seismic pre-stack inversion. The nonlinear elastic impedance inversion method based on a fast Markov chain Monte Carlo （MCMC） method is proposed in this paper, combining conventional MCMC method based on global optimization with a preconditioned conjugate gradient （PCG） algorithm based on local optimization, so this method does not depend strongly on the initial model. It converges to the global optimum quickly and efficiently on the condition that effi- ciency and stability of inversion are both taken into consid- eration at the same time. The test data verify the feasibility and robustness of the method, and based on this method, we extract the effective pore-fluid bulk modulus, which is applied to reservoir fluid identification and detection, and consequently, a better result has been achieved.展开更多
This paper addresses the issues of channel estimation in a Multiple-Input/Multiple-Output (MIMO) system. Markov Chain Monte Carlo (MCMC) method is employed to jointly estimate the Channel State Information (CSI) and t...This paper addresses the issues of channel estimation in a Multiple-Input/Multiple-Output (MIMO) system. Markov Chain Monte Carlo (MCMC) method is employed to jointly estimate the Channel State Information (CSI) and the transmitted signals. The deduced algorithms can work well under circumstances of low Signal-to-Noise Ratio (SNR). Simulation results are presented to demonstrate their effectiveness.展开更多
Based on the two-level supply chain composed of suppliers and retailers, we assume that market demand is subject to an ARIMA(1, 1, 1). The supplier uses the minimum mean square error method (MMSE), the simple moving a...Based on the two-level supply chain composed of suppliers and retailers, we assume that market demand is subject to an ARIMA(1, 1, 1). The supplier uses the minimum mean square error method (MMSE), the simple moving average method (SMA) and the weighted moving average method (WMA) respectively to forecast the market demand. According to the statistical properties of stationary time series, we calculate the mean square error between supplier forecast demand and market demand. Through the simulation, we compare the forecasting effects of the three methods and analyse the influence of the lead-time L and the moving average parameter N on prediction. The results show that the forecasting effect of the MMSE method is the best, of the WMA method is the second, and of the SMA method is the last. The results also show that reducing the lead-time and increasing the moving average parameter improve the prediction accuracy and reduce the supplier inventory level.展开更多
A simple, efficient, automatic and universal method to fulfill displacementanalysis of a great deal of mechanisms regenerated by Yan's mechanism creative theory has beendeveloped. For a regenerated mechanism, at f...A simple, efficient, automatic and universal method to fulfill displacementanalysis of a great deal of mechanisms regenerated by Yan's mechanism creative theory has beendeveloped. For a regenerated mechanism, at first, the method identifies its type and structure andchanges it into a rigid structure by fixing the ground link and the input link. And then this rigidstructure is decomposed into a set of basic kinematic chains (BKCs). By matching the type of BKC,the displacement analysis equations can be set up, and all possible configurations, in whichpositions of all movable links are considered, can be given out.展开更多
We discuss the incomplete semi-iterative method (ISIM) for an approximate solution of a linear fixed point equations x=Tx+c with a bounded linear operator T acting on a complex Banach space X such that its resolvent h...We discuss the incomplete semi-iterative method (ISIM) for an approximate solution of a linear fixed point equations x=Tx+c with a bounded linear operator T acting on a complex Banach space X such that its resolvent has a pole of order k at the point 1. Sufficient conditions for the convergence of ISIM to a solution of x=Tx+c, where c belongs to the range space of R(I-T) k, are established. We show that the ISIM has an attractive feature that it is usually convergent even when the spectral radius of the operator T is greater than 1 and Ind 1T≥1. Applications in finite Markov chain is considered and illustrative examples are reported, showing the convergence rate of the ISIM is very high.展开更多
INTRODUCTIONAcute narcotizing pancreatitis usually takes a severe clinical course and is associated with multiple organ dysfunction .With the further understanding of pathophysiological events of acute pancreatisis an...INTRODUCTIONAcute narcotizing pancreatitis usually takes a severe clinical course and is associated with multiple organ dysfunction .With the further understanding of pathophysiological events of acute pancreatisis and the therapeutic measuses taken by the clinicians ,the patients can pass through the critical carry stages ,and then the septic complication caused by rtanslocated bacteria, mostly gram-negative microbes from the intestines ensues[1].展开更多
Prolog is one of the most important candidates to build expert systems and AI-related programs and has potential applications in embedded systems. However, Prolog is not suitable to develop many kinds of components, s...Prolog is one of the most important candidates to build expert systems and AI-related programs and has potential applications in embedded systems. However, Prolog is not suitable to develop many kinds of components, such as data acquisition and task scheduling, which are also crucial. To make the best use of the advantages and bypass the disadvantages, it is attractive to integrate Prolog with programs developed by other languages. In this paper, an IPC-based method is used to integrate backward chaining inference implemented by Prolog into applications or embedded systems. A Prolog design pattern is derived from the method for reuse, whose principle and definition are provided in detail. Additionally, the design pattern is applied to a target system, which is free software, to verify its feasibility. The detailed implementation of the application is given to clarify the design pattern. The design pattern can be further applied to wide range applications and embedded systems and the method described in this paper can also be adopted for other logic programming languages.展开更多
Using the defining matrices of A1 in classical algebras An, Bn, Cn and Dn, deduce the embedding indices of the physical A1 algebra in classical algebras, The Ginocchio so(8) model is as an example.
Coevolution can be seen as the interdependency between evolutionary histories. In the context of protein evolution, functional correlation proteins are ever-present coordinated evolutionary characters without disrupti...Coevolution can be seen as the interdependency between evolutionary histories. In the context of protein evolution, functional correlation proteins are ever-present coordinated evolutionary characters without disruption of organismal integrity. As to complex system, there are two forms of protein-protein interactions in vivo, which refer to inter-complex interaction and intra-complex interaction. In this paper, we studied the difference of coevolution characters between inter-complex interaction and intra-complex interaction using ＂Mirror tree＂ method on the respiratory chain （RC） proteins. We divided the correlation coefficients of every pairwise RC proteins into two groups corresponding to the binary protein--protein interaction in intra-complex and the binary protein--protein interaction in inter-complex, respectively. A dramatical discrepancy is detected between the coevolution characters of the two sets of protein interactions （Wilcoxon test, p-value = 4.4 × 10 6）. Our finding reveals some critical information on coevolutionary study and assists the mechanical investigation of protein-protein interaction. Furthermore, the results also provide some unique clue for supramolecular organization of protein complexes in the mitochondrial inner membrane. More detailed binding sites map and genome information of nuclear encoded RC proteins will be extraordinary valuable for the further mitochondria dynamics study.展开更多
Avian influenza （AI）, caused by the influenza A virus, has been a global concern for public health. AI outbreaks not only impact the poultry production, but also give rise to a risk in food safety caused by viral co...Avian influenza （AI）, caused by the influenza A virus, has been a global concern for public health. AI outbreaks not only impact the poultry production, but also give rise to a risk in food safety caused by viral contamination of poultry products in the food supply chain. Distinctions in AI outbreak between strains H5N1 and H7N9 indicate that early detection of the AI virus in poultry is crucial for the effective warning and control of AI to ensure food safety. Therefore, the establishment of a poultry surveillance system for food safety by early detection is urgent and critical. In this article, methods to detect AI virus, including current methods recommended by the World Health Organization （WHO） and the World Organisation for Animal Health （Office International des Epizooties, OIE） and novel techniques not commonly used or commercialized are reviewed and evaluated for feasibility of use in the poultry surveillance system. Conventional methods usually applied for the purpose of AI diagnosis face some practical challenges to establishing a comprehensive poultry surveillance program in the poultry supply chain. Diverse development of new technologies can meet the specific requirements of AI virus detection in various stages or scenarios throughout the poultry supply chain where onsite, rapid and ultrasensitive methods are emphasized. Systematic approaches or integrated methods ought to be employed according to the application scenarios at every stage of the poultry supply chain to prevent AI outbreaks.展开更多
Short two-dimensional compact chains adsorbed on the attractive surface at different temperatures were investigated by using the enumeration calculation method. First we investigate the chain size and shape of adsorbe...Short two-dimensional compact chains adsorbed on the attractive surface at different temperatures were investigated by using the enumeration calculation method. First we investigate the chain size and shape of adsorbed chains, such as characteristic ratios of mean-square radii of gyration 〈S^2〉x/N and 〈S^2〉y/N, shape factor 〈δ〉, and the orientation of chain bonds 〈cos^2 θ〉 to illuminate how the size and shape of adsorbed compact chains change with increasing temperatures. There are some special behaviors for the chain size and shape at low temperature, especially for strong attraction interaction. In the meantime, adsorbed compact chains have different behaviors from general adsorbed polymer chains. Some thermodynamics properties are also discussed here. Heat capacity changes non-monotonously, first increases and then reduces. The transition temperature Tc is nearly 1.0, 1.4, 2.0 and 4.2 （in the unit of To） for the case of ε = 0, -1, -2 and -4 （in the unit of kTo）, respectively. Average energy per bond increases while average Helmholtz free energy per bond decreases with increasing temperatures. From these two thermodynamics parameters we can also get another transition temperature Tc＇, and it is close to 0.7, 1.1, 1.5 and 3.4 for ε= 0, -1, -2, and -4, respectively. Therefore, Tc is greater than Tc＇ under the same condition. These investigations may provide some insights into the thermodynamics behaviors of adsorbed protein-like chains.展开更多
The systematic analysis of the hierarchical relationship among the factors affecting the sustainable supply chain implementation of water diversion projects has theoretical value and practical significance for the sus...The systematic analysis of the hierarchical relationship among the factors affecting the sustainable supply chain implementation of water diversion projects has theoretical value and practical significance for the sustainable development of large-scale water diversion projects. Through the investigation of relevant literature, books, web pages, materials, and discussions with relevant experts and scholars, a total of 23 factors influencing the sustainable supply chain implementation of water diversion projects were identified. Then using ISM (Interpretative Structural Modeling Method) to analyze the causality of each factor, a multi-level hierarchical structure model was obtained. The results showed that: 1) The surface-level influencing factors of the sustaina<span>ble supply chain implementation of the water diversion project mainly i</span>ncluded 8 factors such as water-saving awareness and water-saving intensity in the diversion area, water quality, water pollution and other disasters, effective incentive mechanisms, etc., and surface-level influencing factors were directly related to the sustainable supply chain implementation of water diversio<span>n projects. 2) The indirect influencing factors of the sustainable supply chai</span>n of water diversion projects included 12 factors such as the water quality and quantity guarantee rate of the supply chain, the government’s enforcement of laws and regulations, water distribution, ecological compensation, and compensatio<span>n mechanisms for residents in the water source area. Indirect influencing</span> factor scan acts directly on the direct influencing factors, and int<span>ervening in the factors that can be controlled by humans is one of the important ways to improve the sustainable operation of water diversion proj</span><span>e</span><span>cts. 3) T</span><span>he fundamental influencing factors for the sustainable supply chain implementation of water diversion projects included three f</span>actors: Resettlement policy, government financial support, and sound laws and regulations. Deep influencing factors had multi-channel influence and controllability, and intervening in them was the main means to improve the sustainable operation of water diversion projects.展开更多
Feedback supply chain is a key structure in the supply chain system, and the development of feedback supply chain for biogas biomass energy is one of the important ways of the rural ecological civilization constructio...Feedback supply chain is a key structure in the supply chain system, and the development of feedback supply chain for biogas biomass energy is one of the important ways of the rural ecological civilization construction. Presently, the efficiency problem of biogas supply chain in rural China has been restricting the development of biogas biomass energy business. This article, on the basis of combination of regulation parameters, describes the dynamic changes in the system, using differential equations integrated with simulation to reveal the rules of regulation parameters to investigate the efficiency problem in the biogas supply chain. First of all, on the basis of the actual situation, the flow level and flow rate system structure model and simulation equation set are established for the biogas energy feedback supply chain from a scale livestock farm to peasant households; On the basis of the differentiability of the simulation equation a third order inhomogeneous differential equation with constant coefficients containing regulative parameters is established for the quantity of biogas stored in the feedback supply chain. A theorem and its corollaries are established for the operating efficiency of supply chain to reveal the change law of the quantity of biogas, the quantity of biogas consumed daily by peasant households and its standard-reaching rate as well as other variables.展开更多
An algorithm of continuous stage space MCMC method for solving algebra equation f(x) =0 is given.It is available for the case that the sign of f(x) changes frequently or the derivative f′(x) does not exist in th...An algorithm of continuous stage space MCMC method for solving algebra equation f(x) =0 is given.It is available for the case that the sign of f(x) changes frequently or the derivative f′(x) does not exist in the neighborhood o f the root,while the Newton method is hard to work.Let n be the number of random variables created by computer in our algorithm.Then after m=O(n) transactions from the initial value x 0,x * can be got such that |f(x *)|<e -cm |f(x 0)| by choosing suitable positive constant c. An illustration is also given with the discussion of convergence by adjusting the parameters in the algorithm.展开更多
基金supported by National Natural Science Foundation of China (Grant No. 51075079)National Hi-tech Research and Development Program of China(863 Program,Grant No. 2008AA04Z202)
文摘For at least the past five decades,structural synthesis has been used as a main means of finding better mechanisms with some predefined function.In structural synthesis,isomorphism identification is still a problem unsolved well,and to solve this problem is very significant to the design of new mechanisms.According to the given degree of freedom（DOF） and link connection property of planar closed chain mechanisms,vertex assortment is obtained.For solving the isomorphism problem,a method of the adding sub-chains is proposed with the detailed steps and algorithms in the synthesizing process.Employing this method,the identification code and formation code of every topological structure are achieved,therefore many isomorphic structures could be eliminated in time during structural synthesis by comparing those codes among different topological graphs,resulting in the improvement of synthesizing efficiency and accuracy,and the approach for eliminating rigid sub-chains in and after the synthesizing process is also presented.Some examples are given,including how to add sub-chains,how to detect simple rigid sub-chains and how to obtain identification codes and formulation codes et al.Using the adding sub-chain method,the relative information of some common topological graphs is given in the form of table.The comparison result is coincident with many literatures,so the correctness of the adding sub-chain method is convinced.This method will greatly improve the synthesizing efficiency and accuracy,and has a good potential for application.
文摘With the rapid development of economy and the intensification of market competition, project management involves various aspects of social development. The limitations of traditional project scheduling management methods are becoming more and more obvious. It is extremely urgent to create and apply new management technologies. According to the constraint theory, critical chain method is a method of controlling a project, which can greatly shorten the completion period of the project and reduce the cost of the enterprise. Firstly, the shortcomings of traditional project scheduling management methods are analyzed, and the importance of adopting key chain technology is pointed out. Secondly, the content of the basic chain method is summarized. Finally, the problems existing in the application of critical chain method are analyzed.
基金This work was supported by Toyota Motor Corporation(TMC)in the Tsinghua-Toyota Joint Research Center for Hydrogen Energy and Fuel Cell Technology of Vehicles(TTFC-2019-0)National Natural Science Foundation of China(Nos.52022050 and 52002210).
文摘Electrification of heavy duty vehicles(HDVs)is critical to realization of the target of carbon neutralization in the future.For most HDVs,the influence of road slope on vehicle power usually cannot be ignored due to significant road slope variation during long driving mileages.In order to design the powertrain system for electrified HDVs effectively,it is necessary to construct representative driving cycles with road slope information.There are two difficulties for this task.(1)Road slope measuring devices are usually costly.A cheaper yet effective method for measuring road slope needs to be developed.(2)A 3D(three dimension)Markov chain method is usually utilized for constructing cycles with velocity and road slope.This method is complex and time consuming,and needs to be improved.In this paper,a 2D(two dimension)Markov chain method for addressing these issues is proposed.A road slope observation is designed based on normal GPS(Global Positioning System)signals and a high order Butterworth filter.The effectiveness of the method is validated.Driving velocity and road slope are collected and observed for the area between Beijing and Zhangjiakou in northern China.Representative cycles with road slope are constructed using a 2D Markov chain method and a matching algorithm based on average speed.With the introduced technology,three representative driving cycles with road slope for urban,suburban and highway routes are designed.Statistic results on vehicle power show that,the representative driving cycles are effective with relative errors less than 4%compared to the real driving conditions.These driving cycles will be utilized in designing electric HDVs,such as hydrogen fuel cell vehicles in the future.
基金the sponsorship of the National Basic Research Program of China (973 Program,2013CB228604,2014CB239201)the National Oil and Gas Major Projects of China (2011ZX05014-001-010HZ,2011ZX05014-001-006-XY570) for their funding of this research
文摘Elastic impedance inversion with high efficiency and high stability has become one of the main directions of seismic pre-stack inversion. The nonlinear elastic impedance inversion method based on a fast Markov chain Monte Carlo （MCMC） method is proposed in this paper, combining conventional MCMC method based on global optimization with a preconditioned conjugate gradient （PCG） algorithm based on local optimization, so this method does not depend strongly on the initial model. It converges to the global optimum quickly and efficiently on the condition that effi- ciency and stability of inversion are both taken into consid- eration at the same time. The test data verify the feasibility and robustness of the method, and based on this method, we extract the effective pore-fluid bulk modulus, which is applied to reservoir fluid identification and detection, and consequently, a better result has been achieved.
文摘This paper addresses the issues of channel estimation in a Multiple-Input/Multiple-Output (MIMO) system. Markov Chain Monte Carlo (MCMC) method is employed to jointly estimate the Channel State Information (CSI) and the transmitted signals. The deduced algorithms can work well under circumstances of low Signal-to-Noise Ratio (SNR). Simulation results are presented to demonstrate their effectiveness.
文摘Based on the two-level supply chain composed of suppliers and retailers, we assume that market demand is subject to an ARIMA(1, 1, 1). The supplier uses the minimum mean square error method (MMSE), the simple moving average method (SMA) and the weighted moving average method (WMA) respectively to forecast the market demand. According to the statistical properties of stationary time series, we calculate the mean square error between supplier forecast demand and market demand. Through the simulation, we compare the forecasting effects of the three methods and analyse the influence of the lead-time L and the moving average parameter N on prediction. The results show that the forecasting effect of the MMSE method is the best, of the WMA method is the second, and of the SMA method is the last. The results also show that reducing the lead-time and increasing the moving average parameter improve the prediction accuracy and reduce the supplier inventory level.
基金This project is supported by Teaching Research Award Program for Outstanding Young Teachers of MOE (No.1999076)by Shanghai Sustentation Foundation, China.
文摘A simple, efficient, automatic and universal method to fulfill displacementanalysis of a great deal of mechanisms regenerated by Yan's mechanism creative theory has beendeveloped. For a regenerated mechanism, at first, the method identifies its type and structure andchanges it into a rigid structure by fixing the ground link and the input link. And then this rigidstructure is decomposed into a set of basic kinematic chains (BKCs). By matching the type of BKC,the displacement analysis equations can be set up, and all possible configurations, in whichpositions of all movable links are considered, can be given out.
基金Project1 990 1 0 0 6 supported by National Natural Science Foundation of China,Doctoral Foundation of China,Chi-na Scholarship council and Laboratory of Computational Physics in Beijing of Chinathe second author is also supportedby the State Major Key
文摘We discuss the incomplete semi-iterative method (ISIM) for an approximate solution of a linear fixed point equations x=Tx+c with a bounded linear operator T acting on a complex Banach space X such that its resolvent has a pole of order k at the point 1. Sufficient conditions for the convergence of ISIM to a solution of x=Tx+c, where c belongs to the range space of R(I-T) k, are established. We show that the ISIM has an attractive feature that it is usually convergent even when the spectral radius of the operator T is greater than 1 and Ind 1T≥1. Applications in finite Markov chain is considered and illustrative examples are reported, showing the convergence rate of the ISIM is very high.
文摘INTRODUCTIONAcute narcotizing pancreatitis usually takes a severe clinical course and is associated with multiple organ dysfunction .With the further understanding of pathophysiological events of acute pancreatisis and the therapeutic measuses taken by the clinicians ,the patients can pass through the critical carry stages ,and then the septic complication caused by rtanslocated bacteria, mostly gram-negative microbes from the intestines ensues[1].
基金supported by the National Natural Science Foundation of China (No.61304111)National Basic Research Program of China (No. 2014CB744904)Fundamental Research Funds for the Central Universities of China (Nos. YWF-14-KKX-001 and YWF-13-JQCJ)
文摘Prolog is one of the most important candidates to build expert systems and AI-related programs and has potential applications in embedded systems. However, Prolog is not suitable to develop many kinds of components, such as data acquisition and task scheduling, which are also crucial. To make the best use of the advantages and bypass the disadvantages, it is attractive to integrate Prolog with programs developed by other languages. In this paper, an IPC-based method is used to integrate backward chaining inference implemented by Prolog into applications or embedded systems. A Prolog design pattern is derived from the method for reuse, whose principle and definition are provided in detail. Additionally, the design pattern is applied to a target system, which is free software, to verify its feasibility. The detailed implementation of the application is given to clarify the design pattern. The design pattern can be further applied to wide range applications and embedded systems and the method described in this paper can also be adopted for other logic programming languages.
文摘Using the defining matrices of A1 in classical algebras An, Bn, Cn and Dn, deduce the embedding indices of the physical A1 algebra in classical algebras, The Ginocchio so(8) model is as an example.
基金supported by the grants from the National Science Foundation of China(No.31071163)the National Basic Research Program(973 Program)(No.2010CB126604)the Ministry of Science and Technology of the People's Republic of China
文摘Coevolution can be seen as the interdependency between evolutionary histories. In the context of protein evolution, functional correlation proteins are ever-present coordinated evolutionary characters without disruption of organismal integrity. As to complex system, there are two forms of protein-protein interactions in vivo, which refer to inter-complex interaction and intra-complex interaction. In this paper, we studied the difference of coevolution characters between inter-complex interaction and intra-complex interaction using ＂Mirror tree＂ method on the respiratory chain （RC） proteins. We divided the correlation coefficients of every pairwise RC proteins into two groups corresponding to the binary protein--protein interaction in intra-complex and the binary protein--protein interaction in inter-complex, respectively. A dramatical discrepancy is detected between the coevolution characters of the two sets of protein interactions （Wilcoxon test, p-value = 4.4 × 10 6）. Our finding reveals some critical information on coevolutionary study and assists the mechanical investigation of protein-protein interaction. Furthermore, the results also provide some unique clue for supramolecular organization of protein complexes in the mitochondrial inner membrane. More detailed binding sites map and genome information of nuclear encoded RC proteins will be extraordinary valuable for the further mitochondria dynamics study.
基金supported by the National Natural Science Foundation of China (21405008)the Shenzhen Municipal Government Subsidies for Postdoctoral Research+1 种基金the Special Fund for Sino-US Joint Research Center for Food Safety in Northwest A&F University, China (A200021501)the Start-up Funds for Talents in Northwest A&F University, China (Z111021403)
文摘Avian influenza （AI）, caused by the influenza A virus, has been a global concern for public health. AI outbreaks not only impact the poultry production, but also give rise to a risk in food safety caused by viral contamination of poultry products in the food supply chain. Distinctions in AI outbreak between strains H5N1 and H7N9 indicate that early detection of the AI virus in poultry is crucial for the effective warning and control of AI to ensure food safety. Therefore, the establishment of a poultry surveillance system for food safety by early detection is urgent and critical. In this article, methods to detect AI virus, including current methods recommended by the World Health Organization （WHO） and the World Organisation for Animal Health （Office International des Epizooties, OIE） and novel techniques not commonly used or commercialized are reviewed and evaluated for feasibility of use in the poultry surveillance system. Conventional methods usually applied for the purpose of AI diagnosis face some practical challenges to establishing a comprehensive poultry surveillance program in the poultry supply chain. Diverse development of new technologies can meet the specific requirements of AI virus detection in various stages or scenarios throughout the poultry supply chain where onsite, rapid and ultrasensitive methods are emphasized. Systematic approaches or integrated methods ought to be employed according to the application scenarios at every stage of the poultry supply chain to prevent AI outbreaks.
基金This work was supported by the National Natural Science Foundation of China (Nos. 20174036, 20274040, 20574052)the Program for New Century Excellent Talents in University (NCET)the Natural Science Foundation of Zhejiang Province(No. R404047)
文摘Short two-dimensional compact chains adsorbed on the attractive surface at different temperatures were investigated by using the enumeration calculation method. First we investigate the chain size and shape of adsorbed chains, such as characteristic ratios of mean-square radii of gyration 〈S^2〉x/N and 〈S^2〉y/N, shape factor 〈δ〉, and the orientation of chain bonds 〈cos^2 θ〉 to illuminate how the size and shape of adsorbed compact chains change with increasing temperatures. There are some special behaviors for the chain size and shape at low temperature, especially for strong attraction interaction. In the meantime, adsorbed compact chains have different behaviors from general adsorbed polymer chains. Some thermodynamics properties are also discussed here. Heat capacity changes non-monotonously, first increases and then reduces. The transition temperature Tc is nearly 1.0, 1.4, 2.0 and 4.2 （in the unit of To） for the case of ε = 0, -1, -2 and -4 （in the unit of kTo）, respectively. Average energy per bond increases while average Helmholtz free energy per bond decreases with increasing temperatures. From these two thermodynamics parameters we can also get another transition temperature Tc＇, and it is close to 0.7, 1.1, 1.5 and 3.4 for ε= 0, -1, -2, and -4, respectively. Therefore, Tc is greater than Tc＇ under the same condition. These investigations may provide some insights into the thermodynamics behaviors of adsorbed protein-like chains.
文摘The systematic analysis of the hierarchical relationship among the factors affecting the sustainable supply chain implementation of water diversion projects has theoretical value and practical significance for the sustainable development of large-scale water diversion projects. Through the investigation of relevant literature, books, web pages, materials, and discussions with relevant experts and scholars, a total of 23 factors influencing the sustainable supply chain implementation of water diversion projects were identified. Then using ISM (Interpretative Structural Modeling Method) to analyze the causality of each factor, a multi-level hierarchical structure model was obtained. The results showed that: 1) The surface-level influencing factors of the sustaina<span>ble supply chain implementation of the water diversion project mainly i</span>ncluded 8 factors such as water-saving awareness and water-saving intensity in the diversion area, water quality, water pollution and other disasters, effective incentive mechanisms, etc., and surface-level influencing factors were directly related to the sustainable supply chain implementation of water diversio<span>n projects. 2) The indirect influencing factors of the sustainable supply chai</span>n of water diversion projects included 12 factors such as the water quality and quantity guarantee rate of the supply chain, the government’s enforcement of laws and regulations, water distribution, ecological compensation, and compensatio<span>n mechanisms for residents in the water source area. Indirect influencing</span> factor scan acts directly on the direct influencing factors, and int<span>ervening in the factors that can be controlled by humans is one of the important ways to improve the sustainable operation of water diversion proj</span><span>e</span><span>cts. 3) T</span><span>he fundamental influencing factors for the sustainable supply chain implementation of water diversion projects included three f</span>actors: Resettlement policy, government financial support, and sound laws and regulations. Deep influencing factors had multi-channel influence and controllability, and intervening in them was the main means to improve the sustainable operation of water diversion projects.
基金supported by the National Natural Science Funds(71261018,71171208,71473285)
文摘Feedback supply chain is a key structure in the supply chain system, and the development of feedback supply chain for biogas biomass energy is one of the important ways of the rural ecological civilization construction. Presently, the efficiency problem of biogas supply chain in rural China has been restricting the development of biogas biomass energy business. This article, on the basis of combination of regulation parameters, describes the dynamic changes in the system, using differential equations integrated with simulation to reveal the rules of regulation parameters to investigate the efficiency problem in the biogas supply chain. First of all, on the basis of the actual situation, the flow level and flow rate system structure model and simulation equation set are established for the biogas energy feedback supply chain from a scale livestock farm to peasant households; On the basis of the differentiability of the simulation equation a third order inhomogeneous differential equation with constant coefficients containing regulative parameters is established for the quantity of biogas stored in the feedback supply chain. A theorem and its corollaries are established for the operating efficiency of supply chain to reveal the change law of the quantity of biogas, the quantity of biogas consumed daily by peasant households and its standard-reaching rate as well as other variables.
基金Supported by the National Natural Science Foundation of China(70 1 71 0 0 8)
文摘An algorithm of continuous stage space MCMC method for solving algebra equation f(x) =0 is given.It is available for the case that the sign of f(x) changes frequently or the derivative f′(x) does not exist in the neighborhood o f the root,while the Newton method is hard to work.Let n be the number of random variables created by computer in our algorithm.Then after m=O(n) transactions from the initial value x 0,x * can be got such that |f(x *)|<e -cm |f(x 0)| by choosing suitable positive constant c. An illustration is also given with the discussion of convergence by adjusting the parameters in the algorithm.
