Paracetamol induces oxidative damage of liver and hepatotoxicity continues to be among the main threats of public health. The present study evaluated the antioxidant and hepatoprotective activities of P. chaba roots. ...Paracetamol induces oxidative damage of liver and hepatotoxicity continues to be among the main threats of public health. The present study evaluated the antioxidant and hepatoprotective activities of P. chaba roots. Hepatoprotective effects were demonstrated by significant alteration of serum biomarker enzymes and antioxidant enzymes. Co-administration of P. chaba extract to paracetamol-induced rats resulted in a partial recovery in the serum biochemical parameters (SGOT, SGPT, ALP and Bilirubin). However, ethanolic extract of Piper chaba at lower dose (200 mg/kg b.w.) was more effective than the higher dose 400 mg/kg b.w. in reducing serum dysfunction biomarker enzymes. The histopathological studies of liver tissues also showed better hepatoprotective activity of Piper chaba roots at the lower dose (200 mg/kg b.w.). Paracetamol induced hepatotoxicity in rats resulted in increase of antioxidant enzyme activities such as catalase, super oxide dismutase. The scavenging activity of P. chaba extract was moderate when compared with standard catechin and the IC50 values of P. chaba and standard catechin were 1.563 ± 0.70 and 3.125 ± 0.676, respectively in DPPH radical scavenging assay. The total antioxidant potential of P. chaba was concentration dependent and revealed promising antioxidant activity as compared to the reference standard catechin. At a concentration of 100 μg/mL the absorbance of P. chaba extract and catechin were 0.430 and 0.746 respectively. The research result indicated that P. chaba extract has protective effects on paracetamol induced oxidative stress and liver damage.展开更多
Typhoon Chaba was the most intense typhoon to strike western Guangdong since Typhoon Mujigae in 2015.According to the National Disaster Reduction Center of China,in the morning of July 7,2022,over 1.5 million people i...Typhoon Chaba was the most intense typhoon to strike western Guangdong since Typhoon Mujigae in 2015.According to the National Disaster Reduction Center of China,in the morning of July 7,2022,over 1.5 million people in Guangdong,Guangxi,and Hainan were affected by Typhoon Chaba.The typhoon also caused the“Fukui 001”ship to be in distress in the waters near Yangjiang,Guangdong,on July 2,resulting in big casualties.Studies have indicated that wind field forecast for Typhoon Chaba was not accurate.To better simulate typhoon events and assess their impacts,we proposed the use of a model wind field(Fujita-Takahashi)integrated with the Copernicus Marine and Environmental Monitoring Service(CMEMS)data to reconstruct effectively the overall wind field of Typhoon Chaba.The simulation result aligns well with the observations,particularly at the Dashu Island Station,showing consistent trends in wind speed changes.However,certain limitations were noted.The model shows that the attenuation of wind speed is slower when typhoon neared land than that observed,indicating that the model has a high simulation accuracy for the ocean wind field,but may have deviations near coastal areas.The result is accurate for open sea but deviated for near land due to the land friction effect.Therefore,we recommend to adjust the model to improve the accuracy for near coasts.展开更多
文摘Paracetamol induces oxidative damage of liver and hepatotoxicity continues to be among the main threats of public health. The present study evaluated the antioxidant and hepatoprotective activities of P. chaba roots. Hepatoprotective effects were demonstrated by significant alteration of serum biomarker enzymes and antioxidant enzymes. Co-administration of P. chaba extract to paracetamol-induced rats resulted in a partial recovery in the serum biochemical parameters (SGOT, SGPT, ALP and Bilirubin). However, ethanolic extract of Piper chaba at lower dose (200 mg/kg b.w.) was more effective than the higher dose 400 mg/kg b.w. in reducing serum dysfunction biomarker enzymes. The histopathological studies of liver tissues also showed better hepatoprotective activity of Piper chaba roots at the lower dose (200 mg/kg b.w.). Paracetamol induced hepatotoxicity in rats resulted in increase of antioxidant enzyme activities such as catalase, super oxide dismutase. The scavenging activity of P. chaba extract was moderate when compared with standard catechin and the IC50 values of P. chaba and standard catechin were 1.563 ± 0.70 and 3.125 ± 0.676, respectively in DPPH radical scavenging assay. The total antioxidant potential of P. chaba was concentration dependent and revealed promising antioxidant activity as compared to the reference standard catechin. At a concentration of 100 μg/mL the absorbance of P. chaba extract and catechin were 0.430 and 0.746 respectively. The research result indicated that P. chaba extract has protective effects on paracetamol induced oxidative stress and liver damage.
基金Supported by the National Key Research and Development Program of China(Nos.2021YFC3101801,2023YFC3008200)the National Natural Science Foundation of China(Nos.42476219,41976200)+6 种基金the National Foreign Experts Program(No.S20240134)the Innovative Team Plan of the Department of Education of Guangdong Province(No.2023KCXTD015)the Tropical Ocean Environment in Western Coastal Waters Observation and Research Station of Guangdong Province(No.2024B1212040008)the Independent Research Project of the Southern Ocean Laboratory(No.SML2022SP301)the Shandong Innovation and Development Research Institute Think Tank Projectthe Guangdong Ocean University Scientific Research Program(No.060302032106)the Start-up Fund for Ph D Researchers(No.060302032104)。
文摘Typhoon Chaba was the most intense typhoon to strike western Guangdong since Typhoon Mujigae in 2015.According to the National Disaster Reduction Center of China,in the morning of July 7,2022,over 1.5 million people in Guangdong,Guangxi,and Hainan were affected by Typhoon Chaba.The typhoon also caused the“Fukui 001”ship to be in distress in the waters near Yangjiang,Guangdong,on July 2,resulting in big casualties.Studies have indicated that wind field forecast for Typhoon Chaba was not accurate.To better simulate typhoon events and assess their impacts,we proposed the use of a model wind field(Fujita-Takahashi)integrated with the Copernicus Marine and Environmental Monitoring Service(CMEMS)data to reconstruct effectively the overall wind field of Typhoon Chaba.The simulation result aligns well with the observations,particularly at the Dashu Island Station,showing consistent trends in wind speed changes.However,certain limitations were noted.The model shows that the attenuation of wind speed is slower when typhoon neared land than that observed,indicating that the model has a high simulation accuracy for the ocean wind field,but may have deviations near coastal areas.The result is accurate for open sea but deviated for near land due to the land friction effect.Therefore,we recommend to adjust the model to improve the accuracy for near coasts.
