Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be d...Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be detected in bodily fluids.A PubMed search using the terms“ctHPV”or“circulating tumor DNA”and“cervical cancer”,limited to the past ten years,identified 104 articles,complemented by hand-searching for literature addressing medico-legal implications.Studies were evaluated for relevance and methodological quality.Detection and characterization of circulating tumor HPV DNA(ctHPV DNA)have emerged as promising tools for assessing prognosis and disease recurrence in cervical cancer.Detection techniques include polymerase chain reaction(PCR),digital droplet PCR(ddPCR),and next-generation sequencing(NGS).This review summarizes current knowledge on ctHPV DNA in cervical cancer and explores its clinical and medico-legal implications,including management of discordant results,diagnostic errors,liability,and data protection compliance.展开更多
In May 2018,the Director-General of the World Health Organization(WHO)called for global action to eliminate cervical cancer~1.This call marked the beginning of an ambitious international effort to scale up 3 key strat...In May 2018,the Director-General of the World Health Organization(WHO)called for global action to eliminate cervical cancer~1.This call marked the beginning of an ambitious international effort to scale up 3 key strategies:human papillomavirus(HPV)vaccination,cervical cancer screening,and treatment of precancerous lesions and cancer.Subsequently,the WHO and its partners developed a global strategy to accelerate the reduction of cervical cancer incidence,with an ultimate goal of achieving elimination within the next century.This Global Strategy represents a formal international commitment and is anchored in the 90-70-90 targets to be achieved by 2030.In parallel,several countries have also set national commitments,such as Sweden's pledge to achieve elimination by 2027 and Australia's target of achieving elimination by 2035.展开更多
As the 30th anniversary of the landmark Beijing Fourth World Conference on Women approaches,the forthcoming 2025 World Women's Summit in Beijing offers a timely platform to reaffirm commitments to women's well...As the 30th anniversary of the landmark Beijing Fourth World Conference on Women approaches,the forthcoming 2025 World Women's Summit in Beijing offers a timely platform to reaffirm commitments to women's well-being worldwide.In alignment with this milestone,Cancer Biology&Medicine is proud to present this special issue dedicated to accelerating the global elimination of cervical cancer.展开更多
Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical ca...Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.展开更多
This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical cancer.While radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in...This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical cancer.While radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’lives.Currently,most treatments are supportive,with no specific treatment options available in Western medicine.Non-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical cancer.Despite these potential benefits,challenges such as limited evidence and restricted application areas persist.While non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.展开更多
BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment modalitie...BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment modalities.The case report presents a unique case of a large cervical cancer achieving complete response(CR)with concurrent chemoradiotherapy(CCRT),highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy(RT)in optimizing patient outcomes.CASE SUMMARY We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive,moderately differentiated cervical squamous cell carcinoma.The tumor measured 14 cm×12 cm×8 cm,the largest size reported in the literature to achieve CR with CCRT.Despite this monumental feat,the patient remained disease-free and is currently on follow-up for 2 years;however,she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis,underscoring the continuing impact of cervical cancer on quality of life.CONCLUSION In this case report,we highlight the effectiveness of CCRT in achieving CR,even in cases of bulky cervical cancer,with adaptive RT offering a customized strategy to improve patient outcomes.We also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.展开更多
Objective:Cervical cancer is a growing concern in China,especially among women who reside in rural areas and older women.Understanding age-and region-specific trends in cervical cancer is vital for informing policy an...Objective:Cervical cancer is a growing concern in China,especially among women who reside in rural areas and older women.Understanding age-and region-specific trends in cervical cancer is vital for informing policy and assessing progress toward WHO elimination targets.Methods:The 2000±2020 data from 22 long-standing registries contributing to the China national cancer registry was analyzed to estimate age-standardized incidence and mortality rates(ASIR and ASMR,respectively).Joinpoint regression yielded an average annual percentage change(AAPC)stratified by age group(<35,35±64,65±74,and≥75 y)and by urban-rural area.The comparative analysis included GLOBOCAN Overtime data from selected Asia-Pacific countries.Results:The ASIR tripled in China between 2000 and 2020 before stabilizing(AAPC=6.5%),while the ASMR rose steadily(AAPC=3.9%).The urban incidence declined after 2009 among women<35 y,while rural trends were broadly stable.The ASIR and ASMR increased in urban areas among women 35±64 y of age,while rural areas had a rising ASIR and a stable ASMR,suggesting potential screening effects.In contrast,women≥65 y of age had a steadily increasing incidence and mortality in rural and urban areas.Australia and Republic of Korea had consistent declines in the ASIRs and ASMRs compared to other Asia-Pacific countries,whereas Japan exhibited rising trends.The Philippines experienced a surge in mortality rates,despite incidence rates remaining stable or declining.Conclusions:The cervical cancer burden in China has begun to plateau but large disparities persist by age and geography.To achieve elimination of cervical cancer,it is imperative to implement tailored strategies that prioritize the urgent expansion of HPV vaccination programs,the deployment of high-efficacy screening methods,and the universal access to treatment throughout the nation.展开更多
Objective:To investigate the therapeutic adjuvant potential of fucoidan in cervical cancer and to evaluate its efficacy in combination with immunotherapy.Methods:Fucoidan extracted from Fucus vesiculosus was dissolved...Objective:To investigate the therapeutic adjuvant potential of fucoidan in cervical cancer and to evaluate its efficacy in combination with immunotherapy.Methods:Fucoidan extracted from Fucus vesiculosus was dissolved in phosphate buffered saline and used to treat TC-1 cervical cancer cells in vitro as well as tumor-bearing C57BL/6 mice in vivo.Mice were divided into four groups:the vehicle control group,the mRNA therapy-alone group,the fucoidan-only group,and the combination group.MAPK signaling proteins(p-ERK,T-ERK,p-p38)were analyzed by Western blotting assays.T cell surface markers and intracellular cytokines in splenocytes were assessed by flow cytometry,and plasma cytokine levels were measured by ELISA.Results:Fucoidan decreased the p-ERK/T-ERK ratio and p-p38.Fucoidan combined with mRNA therapy did not significantly affect CD4^(+)T-cell activation but reduced CD8^(+)T-cell activation compared with mRNA therapy alone.MCP-1 and IFN-γwere significantly reduced in the combination therapy group compared with mRNA therapy alone,while IL-6,TNF-α,perforin,and granzyme B did not show significant changes between the two groups.Conclusions:These findings suggest that fucoidan could inhibit excessive T cell activation and cytokine production by suppressing MAPK p-p38 protein expression.展开更多
To many people,especially women at the Mzuzu Central Hospital(MCH)in the Northern Region of Malawi,Du Shumin is a familiar and respected name.This is because of her expertise in cervical cancer treatment and the many ...To many people,especially women at the Mzuzu Central Hospital(MCH)in the Northern Region of Malawi,Du Shumin is a familiar and respected name.This is because of her expertise in cervical cancer treatment and the many women,some of whom never dreamed of living a normal life again,that Du has helped.展开更多
In the article“LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis”(Oncology Research,2024,Vol 32,No.7,pp.1221-1229.doi:10.32604/or.2024.047454),there were some errors in the content.In ...In the article“LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis”(Oncology Research,2024,Vol 32,No.7,pp.1221-1229.doi:10.32604/or.2024.047454),there were some errors in the content.In order to ensure the scientific and rigorous nature of our academic publications,we deleted the incorrect content that is not related to this study,supplemented the details of the method.展开更多
Introduction Progress toward the global elimination of cervical cancer as a public health concern remains slow and highly uneven across countries.High-income nations such as Australia and FinlandDboth of which have ac...Introduction Progress toward the global elimination of cervical cancer as a public health concern remains slow and highly uneven across countries.High-income nations such as Australia and FinlandDboth of which have achieved high human papillomavirus(HPV)vaccination coverage and implemented quality-assured cervical cancer screening programs-have successfully decreased the incidence rates to below 8 cases per 100,000 women~1.These countries are on track to reach the elimination threshold of fewer than 4 cases per 100,000 women within the next few years,as defined by the World Health Organization(WHO).展开更多
BACKGROUND Currently,there is limited research examining the relationship between anxiety,depression,coping styles,and illness uncertainty in patients with cervical cancer(CC)undergoing radiotherapy.Addressing this ga...BACKGROUND Currently,there is limited research examining the relationship between anxiety,depression,coping styles,and illness uncertainty in patients with cervical cancer(CC)undergoing radiotherapy.Addressing this gap could provide valuable insights and more reliable evidence for clinical practice targeting this patient population.AIM To analyze the anxiety,depression,and coping styles of patients with CC undergoing radiotherapy and explore their correlations with illness uncertainty.METHODS A total of 200 patients with CC undergoing radiotherapy at The First Affiliated Hospital of Soochow University between June 2018 and June 2022 were enrolled.Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale(HADS),comprising subscales for anxiety(HADS-A)and depression(HADS-D).Coping styles were evaluated using the Jalowiec Coping Scale(JCS-60),comprising dimensions such as confrontive,evasive,optimistic,fatalistic,emotive,palliative,supportive,and self-reliant.Illness uncertainty was measured using the Mishel Uncertainty in Illness Scale(MUIS),encompassing ambiguity,complexity,information deficit,and unpredictability.Correlations among anxiety,depression,coping styles,and illness uncertainty were analyzed.RESULTS During radiotherapy,the mean scores were 7.12±3.39 for HADS-A,6.68±3.49 for HADS-D,1.52±0.23 for JCS-60,and 93.40±7.44 for MUIS.Anxiety(HADS-A≥8)was present in 39.5%of patients,depression(HADS-D≥8)in 41.0%,and both in 14.0%.Anxiety was significantly positively correlated with ambiguity,unpredictability,and total MUIS score(P<0.05).Depression was significantly positively correlated with ambiguity,information deficit,unpredictability,and total MUIS score(P<0.05).Most patients adopted an optimistic coping style,whereas the emotive style was least utilized.Evasive,fatalistic,and emotive coping styles were significantly positively correlated with illness uncertainty,whereas the self-reliant style was significantly negatively correlated with unpredictability(P<0.05).CONCLUSION Anxiety,depression,and coping styles in patients with CC undergoing radiotherapy correlate significantly with their level of illness uncertainty.Medical staff should address patients’psychological status and coping strategies by providing targeted information to reduce negative emotions,foster adaptive coping styles,and decrease illness uncertainty.展开更多
Objective:To investigate the effects of arecoline on HPV-positive cervical cells and unveil its underlying mechanism in cervical carcinogenesis.Methods:The cytotoxicity of arecoline was determined and the effect of su...Objective:To investigate the effects of arecoline on HPV-positive cervical cells and unveil its underlying mechanism in cervical carcinogenesis.Methods:The cytotoxicity of arecoline was determined and the effect of subtoxic concentrations of arecoline on the expression of viral oncoproteins and transcriptional factors was examined in CaSki and SiHa cells.HPV16 promoter activity was evaluated in a plasmid containing HPV16 long control region(pGL3-HPV16LCR)-transfected cells.Cell proliferation,cell migration,and number of colonies were assessed by MTT,wound healing assay,and colony-forming assay,respectively.Results:Arecoline at 0.01μg/mL significantly upregulated HPV16 E6 and E7 oncoproteins in both CaSki and SiHa cells.It also upregulated the expression level of c-Fos and c-Jun mRNAs,and c-Myc protein in CaSki and SiHa cells.In addition,arecoline at subtoxic concentrations(0.0025 and 0.01μg/mL)significantly induced HPV16 promoter activity in pGL3-16LCR-transfected cells.It also promoted SiHa and CaSki cell proliferation,migration,and colony formation.Conclusions:Arecoline at subtoxic concentrations promotes the proliferation,migration,and colony formation of CaSki and SiHa cells via upregulation of c-Fos,c-Jun,c-Myc,and HPV16 E6 and E7 expressions.展开更多
BACKGROUND Cervical cancer is a prevalent form of cancer affecting women worldwide and it is the second most common cancer among women in Indonesia,accounting for 8.5%of all cancer-related deaths.Cervical cancer progr...BACKGROUND Cervical cancer is a prevalent form of cancer affecting women worldwide and it is the second most common cancer among women in Indonesia,accounting for 8.5%of all cancer-related deaths.Cervical cancer progression can be evaluated through laboratory tests to detect anaemia,an increased platelet count,and elevated inflammatory markers,therefore,effective laboratory examination is crucial for early detection and treatment of cervical cancer.AIM To evaluate the association between laboratory findings(haematology,haematology index,and inflammatory index)and the clinical stage of cervical cancer.METHODS This cross-sectional study analyzed adult cervical cancer patients’data from medical records and laboratory results including sociodemographic status,histopathological finding,clinical stage,and complete haematology examination.Numerical data was analyzed by the one-way ANOVA(normal data distribution),while the Kruskal-Wallis test was used for non-parametric data(abnormal distribution),followed by appropriate post-hoc analysis.The categorical data was analyzed by the Chi-square or Fisher Exact tests.The significance level was established at a P value<0.05.RESULTS This study involved the data of 208 adult cervical cancer patients and found no association between age,marital history,parity history,hormonal contraceptive use and cervical cancer stages.There were significant differences in the clinical laboratory test results based on the clinical stage of cervical cancer,including haemoglobin levels(P<0.001),leucocytes(P<0.001),neutrophils(P<0.001),monocytes(P=0.002),lymphocytes(P=0.006),platelets(P<0.001),neutrophil-lymphocyte ratio/NLR(P<0.001),lymphocyte-monocyte ratio/LMR(P<0.001),and plateletlymphocyte ratio/PLR(P<0.001).There were also significant differences in the systemic inflammatory index(SII)and systematic inflammatory response index(SIRI)between stage III+IV cervical cancer and stage II(SII P<0.001;SIRI P=0.001)and stage I(SII P<0.001;SIRI P=0.016),associated with the shifts in previously mentioned complete haematological values with cancer advancement.CONCLUSION The haematological parameters,inflammatory haematological ratios,and inflammatory indices exhibited significant differences between cervical cancer stages,therefore these tests can be utilized to evaluate cervical cancer progression.展开更多
The published article titled“MicroRNA-92a Promotes Cell Proliferation in Cervical Cancer via Inhibiting p21 Expression and Promoting Cell Cycle Progression”has been retracted from Oncology Research,Vol.25,No.1,2017,...The published article titled“MicroRNA-92a Promotes Cell Proliferation in Cervical Cancer via Inhibiting p21 Expression and Promoting Cell Cycle Progression”has been retracted from Oncology Research,Vol.25,No.1,2017,pp.137–145.展开更多
BACKGROUND Cervical cancer,a prevalent gynecological malignancy,exhibits recurrence rates of 30%-50%post-treatment,with recurrent cases facing a dire 10%-20%long-term survival rate,severely impacting patients’mental ...BACKGROUND Cervical cancer,a prevalent gynecological malignancy,exhibits recurrence rates of 30%-50%post-treatment,with recurrent cases facing a dire 10%-20%long-term survival rate,severely impacting patients’mental health and quality of life.Fear of cancer recurrence(FCR)emerges as a critical psychological challenge,often leading to anxiety,social avoidance,and even suicidal tendencies.Despite its high prevalence,structured,evidence-based interventions for FCR in cervical cancer remain scarce,with most studies focusing on general psychological support rather than targeted strategies.The fear of progression theory provides a theoretical framework,highlighting cognitive-emotional conflicts arising from perceived threats of disease recurrence.Addressing this gap,this study developed a specialized,phased psychological intervention program grounded in fear of progression theory,aiming to reduce FCR and enhance resilience in cervical cancer survivors through multi-disciplinary strategies.AIM To establish a psychological intervention program to support the fear of cervical cancer recurrence and to alleviate the psychological pressure of patients after cervical cancer surgery.METHODS Thirteen experts were selected to conduct two rounds of correspondence through literature review and group discussions to amend the psychological intervention draft and form the basis for the psychological intervention.The selected experts also performed two rounds of correspondence to revise the psychological intervention draft and outline the first draft,and pre-experiments were conducted for further improvement of the psychological intervention program.Experiments were performed in 80 patients with cervical cancer to further improve the psychological intervention program of relapse fear support.RESULTS The expert authority coefficient of the first and second rounds was higher than 0.8,indicating high authority.The coordination coefficient>0.8 indicated high consistency with high significance(all P<0.05).The FCR Inventory,Kessler Psychological Distress Scale,Psychological Distress Thermometer,and General Hospital Anxiety and Depression Scale scores at 3 and 6 months in the study group were lower than those of the control group,and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and Perceived Social Support Scale scores were higher than those of the control group(P<0.05).CONCLUSION The psychological intervention program of relapse fear support which considers the individual differences between patients and expert opinions,has a good scientific and practical basis,and can be used to enhance the quality of life of patients.展开更多
BACKGROUND Cervical cancer is a significant health concern among females in perimenopause,with a high prevalence of depression in this population.The rationale for this study was to explore the risk factors associated...BACKGROUND Cervical cancer is a significant health concern among females in perimenopause,with a high prevalence of depression in this population.The rationale for this study was to explore the risk factors associated with depression in patients in perimenopause with cervical cancer.We hypothesized that socioeconomic status,disease characteristics,and quality of life factors contributed to the development of depression in these patients.AIM To investigate the risk factors associated with depression in patients in perimenopause with cervical cancer.METHODS A retrospective study was conducted on 254 patients in perimenopause with cervical cancer admitted to a single center.Patients were divided into a nondepression group(n=152)and a depression group(n=102)based on whether depression occurred after treatment.Data collection included demographic,clinical,and psychosocial factors.The Hamilton Depression Rating Scale was used to assess depression.Logistic regression analysis was performed to identify risk factors.RESULTS Patients with depression more often had low income(<4000 China yuan:66.7%vs 6.6%,P<0.001),initial disease onset(70.6%vs 57.2%,P=0.001),low social support(70.6%vs 55.3%,P=0.014),pathological stages III-IV(70.6%vs 41.5%,P<0.001),high pain level(65.7%vs 34.2%,P<0.001),and poor sleep quality(67.6%vs 32.2%,P<0.001).Logistic regression identified low income[odds ratio(OR)=32.606,P<0.001],initial disease onset(OR=4.282,P=0.001),pathological stages III-IV(OR=4.123,P=0.0005),high pain level(OR=1.181,P=0.0000434),and poor sleep quality(OR=3.094,P=0.0041)as key risk factors.CONCLUSION Low income,initial onset,low support,advanced stages,high pain,and poor sleep quality increased depression risk in patients in perimenopause with cervical cancer.Studies investigating interventions for this population are needed.展开更多
BACKGROUND Anxiety and depression are highly prevalent among patients with cervical cancer(CC).However,few studies have systematically analyzed the psychological effects of tumor stage,treatment methods,and related fa...BACKGROUND Anxiety and depression are highly prevalent among patients with cervical cancer(CC).However,few studies have systematically analyzed the psychological effects of tumor stage,treatment methods,and related factors on these patients,or developed predictive models for these outcomes.AIM To identify factors influencing anxiety and depression in patients with CC and construct predictive models.METHODS We retrospectively analyzed data from 119 patients with CC treated at the Gynecology Department of Suzhou Ninth People’s Hospital between January 2017 and May 2025.Clinical data,psychological hope levels at diagnosis,and Self-Rating Anxiety Scale and Self-Rating Depression Scale scores during treatment were collected.Influencing factors were identified,and predictive models were developed.The model performance was evaluated using receiver operating characteristic(ROC)curves and the Hosmer-Lemeshow goodness-of-fit test.RESULTS During treatment,64.71%of the patients experienced anxiety and 52.10%experienced depression.Significant differences in family income,tumor stage,treatment modality,and hope level were observed between patients with and without anxiety/depression(P<0.05).Multivariate analysis showed that a family monthly income<5000 yuan,stage III-IV tumor,comprehensive treatment,and low hope level were independent risk factors(P<0.05).The predictive formula for anxiety was as follows:Logit(P)=0.795×monthly income+0.594×tumor stage+1.095×treatment method+1.184×hope level−9.176;for depression:Logit(P)=0.432×monthly income+0.518×tumor stage+0.727×treatment method+1.095×hope level−8.541.The area under the ROC curves were 0.865 for anxiety and 0.837 for depression.Goodness-of-fit test confirmed no overfitting(P>0.05).CONCLUSION Family income,tumor stage,treatment method,and hope level are key determinants of anxiety and depression in patients with CC.Predictive models incorporating these factors can effectively assess risk of anxiety and depression during treatment.展开更多
Objective:Cervical cancer remains a global health challenge with substantial disparities between countries.High-quality colposcopy is essential for cervical cancer prevention,yet training opportunities remain inadequa...Objective:Cervical cancer remains a global health challenge with substantial disparities between countries.High-quality colposcopy is essential for cervical cancer prevention,yet training opportunities remain inadequate worldwide.We developed the Intelligent Digital Education Tool for Colposcopy(iDECO)to address training gaps and evaluated the effect across diverse international settings.Methods:Six pre-post interventional training programmes were conducted in China,Mexico,and Mongolia from December 2024 to May 2025.A total of 369 trainees from 87 centers participated in a 3-week online training programme using iDECO,a bilingual webbased platform featuring authentic colposcopy cases,gamified learning pathways,and personalized analytics.The primary outcomes included colposcopy competence in general assessment,colposcopic findings,diagnostic accuracy,and management decisions.The secondary outcomes focused on participant feedback and satisfaction.Results:Of 369 participants who completed pretests,333(90.24%)completed post-training assessments.Significant improvements were observed across all competency domains.Diagnostic accuracy increased with an odds ratio(OR)of 1.72(95%CI:1.60±1.86)with the greatest gains in high-grade lesion identification[OR=2.27(95%CI:1.94±2.64)].Squamocolumnar junction visibility and transformation zone type assessments improved with ORs of 1.41(95%CI:1.31±1.51)and 1.87(95%CI:1.73±2.01),respectively.Biopsy decision-making accuracy also showed significant improvement[OR=2.09(95%CI:1.91±2.29)].International participants showed lower baseline performance but achieved the greatest improvements.Greater than 85%of participants rated the training highly satisfactory and 83.56%preferred intelligent training over traditional methods.Conclusions:iDECO-based training significantly improved colposcopy competence across diverse international settings with high user satisfaction.These findings support the potential for worldwide implementation of intelligent digital training tools to address colposcopy training gaps and contribute to the elimination of cervical cancer.展开更多
[Objectives]To explore the effectiveness of exercise therapy for lower limb lymphedema after cervical cancer surgery,and to inform future research and clinical practice in developing evidence-based nursing interventio...[Objectives]To explore the effectiveness of exercise therapy for lower limb lymphedema after cervical cancer surgery,and to inform future research and clinical practice in developing evidence-based nursing interventions.[Methods]Using the JBI scoping review guidelines as a methodological framework,relevant studies were retrieved from PubMed,Embase,Web of Science,Cochrane Library,CINAHL,CNKI,Wanfang Data,and Chinese Biomedical Literature Database from their inception to December 2024.[Results]The findings of included 18 studies showed that exercise therapy,mainly including progressive resistance training,aerobic exercise,aquatic exercise,and mixed exercise modalities,could effectively alleviate lower limb lymphedema symptoms in patients after cervical cancer surgery and improve quality of life.Progressive resistance training has been proven to be a safe and feasible preventive intervention;aerobic exercise and aquatic exercise have certain relieving effects on established lymphedema;mixed exercise interventions can improve patients functional activity capacity.[Conclusions]Exercise therapy is a feasible,safe,and effective intervention for lower limb lymphedema after cervical cancer surgery.Future high-quality randomized controlled trials are required to validate the effectiveness of different exercise modalities and to develop individualized exercise prescriptions that enhance patient adherence and reduce complications.展开更多
文摘Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be detected in bodily fluids.A PubMed search using the terms“ctHPV”or“circulating tumor DNA”and“cervical cancer”,limited to the past ten years,identified 104 articles,complemented by hand-searching for literature addressing medico-legal implications.Studies were evaluated for relevance and methodological quality.Detection and characterization of circulating tumor HPV DNA(ctHPV DNA)have emerged as promising tools for assessing prognosis and disease recurrence in cervical cancer.Detection techniques include polymerase chain reaction(PCR),digital droplet PCR(ddPCR),and next-generation sequencing(NGS).This review summarizes current knowledge on ctHPV DNA in cervical cancer and explores its clinical and medico-legal implications,including management of discordant results,diagnostic errors,liability,and data protection compliance.
基金supported by the CAMS Innovation Fund for Medical Sciences(No.2023-I2M-3-019)National Natural Science Foundation of China(No.82404366)。
文摘In May 2018,the Director-General of the World Health Organization(WHO)called for global action to eliminate cervical cancer~1.This call marked the beginning of an ambitious international effort to scale up 3 key strategies:human papillomavirus(HPV)vaccination,cervical cancer screening,and treatment of precancerous lesions and cancer.Subsequently,the WHO and its partners developed a global strategy to accelerate the reduction of cervical cancer incidence,with an ultimate goal of achieving elimination within the next century.This Global Strategy represents a formal international commitment and is anchored in the 90-70-90 targets to be achieved by 2030.In parallel,several countries have also set national commitments,such as Sweden's pledge to achieve elimination by 2027 and Australia's target of achieving elimination by 2035.
文摘As the 30th anniversary of the landmark Beijing Fourth World Conference on Women approaches,the forthcoming 2025 World Women's Summit in Beijing offers a timely platform to reaffirm commitments to women's well-being worldwide.In alignment with this milestone,Cancer Biology&Medicine is proud to present this special issue dedicated to accelerating the global elimination of cervical cancer.
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)National Natural Science Foundation of China(grant numbers:82172894,82073028,82204121)China Postdoctoral Science Foundation(grant number:2023M742617).
文摘Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.
文摘This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical cancer.While radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’lives.Currently,most treatments are supportive,with no specific treatment options available in Western medicine.Non-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical cancer.Despite these potential benefits,challenges such as limited evidence and restricted application areas persist.While non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.
文摘BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment modalities.The case report presents a unique case of a large cervical cancer achieving complete response(CR)with concurrent chemoradiotherapy(CCRT),highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy(RT)in optimizing patient outcomes.CASE SUMMARY We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive,moderately differentiated cervical squamous cell carcinoma.The tumor measured 14 cm×12 cm×8 cm,the largest size reported in the literature to achieve CR with CCRT.Despite this monumental feat,the patient remained disease-free and is currently on follow-up for 2 years;however,she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis,underscoring the continuing impact of cervical cancer on quality of life.CONCLUSION In this case report,we highlight the effectiveness of CCRT in achieving CR,even in cases of bulky cervical cancer,with adaptive RT offering a customized strategy to improve patient outcomes.We also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.
基金supported by a grant from the National Key Research and Development Program of China(No.2022YFC2409901)the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-011)。
文摘Objective:Cervical cancer is a growing concern in China,especially among women who reside in rural areas and older women.Understanding age-and region-specific trends in cervical cancer is vital for informing policy and assessing progress toward WHO elimination targets.Methods:The 2000±2020 data from 22 long-standing registries contributing to the China national cancer registry was analyzed to estimate age-standardized incidence and mortality rates(ASIR and ASMR,respectively).Joinpoint regression yielded an average annual percentage change(AAPC)stratified by age group(<35,35±64,65±74,and≥75 y)and by urban-rural area.The comparative analysis included GLOBOCAN Overtime data from selected Asia-Pacific countries.Results:The ASIR tripled in China between 2000 and 2020 before stabilizing(AAPC=6.5%),while the ASMR rose steadily(AAPC=3.9%).The urban incidence declined after 2009 among women<35 y,while rural trends were broadly stable.The ASIR and ASMR increased in urban areas among women 35±64 y of age,while rural areas had a rising ASIR and a stable ASMR,suggesting potential screening effects.In contrast,women≥65 y of age had a steadily increasing incidence and mortality in rural and urban areas.Australia and Republic of Korea had consistent declines in the ASIRs and ASMRs compared to other Asia-Pacific countries,whereas Japan exhibited rising trends.The Philippines experienced a surge in mortality rates,despite incidence rates remaining stable or declining.Conclusions:The cervical cancer burden in China has begun to plateau but large disparities persist by age and geography.To achieve elimination of cervical cancer,it is imperative to implement tailored strategies that prioritize the urgent expansion of HPV vaccination programs,the deployment of high-efficacy screening methods,and the universal access to treatment throughout the nation.
文摘Objective:To investigate the therapeutic adjuvant potential of fucoidan in cervical cancer and to evaluate its efficacy in combination with immunotherapy.Methods:Fucoidan extracted from Fucus vesiculosus was dissolved in phosphate buffered saline and used to treat TC-1 cervical cancer cells in vitro as well as tumor-bearing C57BL/6 mice in vivo.Mice were divided into four groups:the vehicle control group,the mRNA therapy-alone group,the fucoidan-only group,and the combination group.MAPK signaling proteins(p-ERK,T-ERK,p-p38)were analyzed by Western blotting assays.T cell surface markers and intracellular cytokines in splenocytes were assessed by flow cytometry,and plasma cytokine levels were measured by ELISA.Results:Fucoidan decreased the p-ERK/T-ERK ratio and p-p38.Fucoidan combined with mRNA therapy did not significantly affect CD4^(+)T-cell activation but reduced CD8^(+)T-cell activation compared with mRNA therapy alone.MCP-1 and IFN-γwere significantly reduced in the combination therapy group compared with mRNA therapy alone,while IL-6,TNF-α,perforin,and granzyme B did not show significant changes between the two groups.Conclusions:These findings suggest that fucoidan could inhibit excessive T cell activation and cytokine production by suppressing MAPK p-p38 protein expression.
文摘To many people,especially women at the Mzuzu Central Hospital(MCH)in the Northern Region of Malawi,Du Shumin is a familiar and respected name.This is because of her expertise in cervical cancer treatment and the many women,some of whom never dreamed of living a normal life again,that Du has helped.
文摘In the article“LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis”(Oncology Research,2024,Vol 32,No.7,pp.1221-1229.doi:10.32604/or.2024.047454),there were some errors in the content.In order to ensure the scientific and rigorous nature of our academic publications,we deleted the incorrect content that is not related to this study,supplemented the details of the method.
文摘Introduction Progress toward the global elimination of cervical cancer as a public health concern remains slow and highly uneven across countries.High-income nations such as Australia and FinlandDboth of which have achieved high human papillomavirus(HPV)vaccination coverage and implemented quality-assured cervical cancer screening programs-have successfully decreased the incidence rates to below 8 cases per 100,000 women~1.These countries are on track to reach the elimination threshold of fewer than 4 cases per 100,000 women within the next few years,as defined by the World Health Organization(WHO).
基金Supported by National Natural Science Foundation of China,No.81602792The Natural Science Foundation of the Jiangsu Higher Education Institutions of China,No.23KJB310023+5 种基金Jiangsu Provincial Medical Key Discipline,No.ZDXK202235The Maternal and Child Health Research Project of Jiangsu Province,No.F202210The Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University,No.GZK1202101Suzhou Science and Technology Development Plan Project,No.KJXW2020008BOXI Natural Science Cultivation Foundation of China of The First Affiliated Hospital of Soochow University,No.BXQN202107Clinical Diagnosis and Treatment Technology Innovation Project Youth Characteristic Technology Project of The First Affiliated Hospital of Soochow University,No.2100201.
文摘BACKGROUND Currently,there is limited research examining the relationship between anxiety,depression,coping styles,and illness uncertainty in patients with cervical cancer(CC)undergoing radiotherapy.Addressing this gap could provide valuable insights and more reliable evidence for clinical practice targeting this patient population.AIM To analyze the anxiety,depression,and coping styles of patients with CC undergoing radiotherapy and explore their correlations with illness uncertainty.METHODS A total of 200 patients with CC undergoing radiotherapy at The First Affiliated Hospital of Soochow University between June 2018 and June 2022 were enrolled.Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale(HADS),comprising subscales for anxiety(HADS-A)and depression(HADS-D).Coping styles were evaluated using the Jalowiec Coping Scale(JCS-60),comprising dimensions such as confrontive,evasive,optimistic,fatalistic,emotive,palliative,supportive,and self-reliant.Illness uncertainty was measured using the Mishel Uncertainty in Illness Scale(MUIS),encompassing ambiguity,complexity,information deficit,and unpredictability.Correlations among anxiety,depression,coping styles,and illness uncertainty were analyzed.RESULTS During radiotherapy,the mean scores were 7.12±3.39 for HADS-A,6.68±3.49 for HADS-D,1.52±0.23 for JCS-60,and 93.40±7.44 for MUIS.Anxiety(HADS-A≥8)was present in 39.5%of patients,depression(HADS-D≥8)in 41.0%,and both in 14.0%.Anxiety was significantly positively correlated with ambiguity,unpredictability,and total MUIS score(P<0.05).Depression was significantly positively correlated with ambiguity,information deficit,unpredictability,and total MUIS score(P<0.05).Most patients adopted an optimistic coping style,whereas the emotive style was least utilized.Evasive,fatalistic,and emotive coping styles were significantly positively correlated with illness uncertainty,whereas the self-reliant style was significantly negatively correlated with unpredictability(P<0.05).CONCLUSION Anxiety,depression,and coping styles in patients with CC undergoing radiotherapy correlate significantly with their level of illness uncertainty.Medical staff should address patients’psychological status and coping strategies by providing targeted information to reduce negative emotions,foster adaptive coping styles,and decrease illness uncertainty.
文摘Objective:To investigate the effects of arecoline on HPV-positive cervical cells and unveil its underlying mechanism in cervical carcinogenesis.Methods:The cytotoxicity of arecoline was determined and the effect of subtoxic concentrations of arecoline on the expression of viral oncoproteins and transcriptional factors was examined in CaSki and SiHa cells.HPV16 promoter activity was evaluated in a plasmid containing HPV16 long control region(pGL3-HPV16LCR)-transfected cells.Cell proliferation,cell migration,and number of colonies were assessed by MTT,wound healing assay,and colony-forming assay,respectively.Results:Arecoline at 0.01μg/mL significantly upregulated HPV16 E6 and E7 oncoproteins in both CaSki and SiHa cells.It also upregulated the expression level of c-Fos and c-Jun mRNAs,and c-Myc protein in CaSki and SiHa cells.In addition,arecoline at subtoxic concentrations(0.0025 and 0.01μg/mL)significantly induced HPV16 promoter activity in pGL3-16LCR-transfected cells.It also promoted SiHa and CaSki cell proliferation,migration,and colony formation.Conclusions:Arecoline at subtoxic concentrations promotes the proliferation,migration,and colony formation of CaSki and SiHa cells via upregulation of c-Fos,c-Jun,c-Myc,and HPV16 E6 and E7 expressions.
文摘BACKGROUND Cervical cancer is a prevalent form of cancer affecting women worldwide and it is the second most common cancer among women in Indonesia,accounting for 8.5%of all cancer-related deaths.Cervical cancer progression can be evaluated through laboratory tests to detect anaemia,an increased platelet count,and elevated inflammatory markers,therefore,effective laboratory examination is crucial for early detection and treatment of cervical cancer.AIM To evaluate the association between laboratory findings(haematology,haematology index,and inflammatory index)and the clinical stage of cervical cancer.METHODS This cross-sectional study analyzed adult cervical cancer patients’data from medical records and laboratory results including sociodemographic status,histopathological finding,clinical stage,and complete haematology examination.Numerical data was analyzed by the one-way ANOVA(normal data distribution),while the Kruskal-Wallis test was used for non-parametric data(abnormal distribution),followed by appropriate post-hoc analysis.The categorical data was analyzed by the Chi-square or Fisher Exact tests.The significance level was established at a P value<0.05.RESULTS This study involved the data of 208 adult cervical cancer patients and found no association between age,marital history,parity history,hormonal contraceptive use and cervical cancer stages.There were significant differences in the clinical laboratory test results based on the clinical stage of cervical cancer,including haemoglobin levels(P<0.001),leucocytes(P<0.001),neutrophils(P<0.001),monocytes(P=0.002),lymphocytes(P=0.006),platelets(P<0.001),neutrophil-lymphocyte ratio/NLR(P<0.001),lymphocyte-monocyte ratio/LMR(P<0.001),and plateletlymphocyte ratio/PLR(P<0.001).There were also significant differences in the systemic inflammatory index(SII)and systematic inflammatory response index(SIRI)between stage III+IV cervical cancer and stage II(SII P<0.001;SIRI P=0.001)and stage I(SII P<0.001;SIRI P=0.016),associated with the shifts in previously mentioned complete haematological values with cancer advancement.CONCLUSION The haematological parameters,inflammatory haematological ratios,and inflammatory indices exhibited significant differences between cervical cancer stages,therefore these tests can be utilized to evaluate cervical cancer progression.
文摘The published article titled“MicroRNA-92a Promotes Cell Proliferation in Cervical Cancer via Inhibiting p21 Expression and Promoting Cell Cycle Progression”has been retracted from Oncology Research,Vol.25,No.1,2017,pp.137–145.
文摘BACKGROUND Cervical cancer,a prevalent gynecological malignancy,exhibits recurrence rates of 30%-50%post-treatment,with recurrent cases facing a dire 10%-20%long-term survival rate,severely impacting patients’mental health and quality of life.Fear of cancer recurrence(FCR)emerges as a critical psychological challenge,often leading to anxiety,social avoidance,and even suicidal tendencies.Despite its high prevalence,structured,evidence-based interventions for FCR in cervical cancer remain scarce,with most studies focusing on general psychological support rather than targeted strategies.The fear of progression theory provides a theoretical framework,highlighting cognitive-emotional conflicts arising from perceived threats of disease recurrence.Addressing this gap,this study developed a specialized,phased psychological intervention program grounded in fear of progression theory,aiming to reduce FCR and enhance resilience in cervical cancer survivors through multi-disciplinary strategies.AIM To establish a psychological intervention program to support the fear of cervical cancer recurrence and to alleviate the psychological pressure of patients after cervical cancer surgery.METHODS Thirteen experts were selected to conduct two rounds of correspondence through literature review and group discussions to amend the psychological intervention draft and form the basis for the psychological intervention.The selected experts also performed two rounds of correspondence to revise the psychological intervention draft and outline the first draft,and pre-experiments were conducted for further improvement of the psychological intervention program.Experiments were performed in 80 patients with cervical cancer to further improve the psychological intervention program of relapse fear support.RESULTS The expert authority coefficient of the first and second rounds was higher than 0.8,indicating high authority.The coordination coefficient>0.8 indicated high consistency with high significance(all P<0.05).The FCR Inventory,Kessler Psychological Distress Scale,Psychological Distress Thermometer,and General Hospital Anxiety and Depression Scale scores at 3 and 6 months in the study group were lower than those of the control group,and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and Perceived Social Support Scale scores were higher than those of the control group(P<0.05).CONCLUSION The psychological intervention program of relapse fear support which considers the individual differences between patients and expert opinions,has a good scientific and practical basis,and can be used to enhance the quality of life of patients.
基金Natural Science Key Research Project of Bengbu Medical University,No.2021byzd098.
文摘BACKGROUND Cervical cancer is a significant health concern among females in perimenopause,with a high prevalence of depression in this population.The rationale for this study was to explore the risk factors associated with depression in patients in perimenopause with cervical cancer.We hypothesized that socioeconomic status,disease characteristics,and quality of life factors contributed to the development of depression in these patients.AIM To investigate the risk factors associated with depression in patients in perimenopause with cervical cancer.METHODS A retrospective study was conducted on 254 patients in perimenopause with cervical cancer admitted to a single center.Patients were divided into a nondepression group(n=152)and a depression group(n=102)based on whether depression occurred after treatment.Data collection included demographic,clinical,and psychosocial factors.The Hamilton Depression Rating Scale was used to assess depression.Logistic regression analysis was performed to identify risk factors.RESULTS Patients with depression more often had low income(<4000 China yuan:66.7%vs 6.6%,P<0.001),initial disease onset(70.6%vs 57.2%,P=0.001),low social support(70.6%vs 55.3%,P=0.014),pathological stages III-IV(70.6%vs 41.5%,P<0.001),high pain level(65.7%vs 34.2%,P<0.001),and poor sleep quality(67.6%vs 32.2%,P<0.001).Logistic regression identified low income[odds ratio(OR)=32.606,P<0.001],initial disease onset(OR=4.282,P=0.001),pathological stages III-IV(OR=4.123,P=0.0005),high pain level(OR=1.181,P=0.0000434),and poor sleep quality(OR=3.094,P=0.0041)as key risk factors.CONCLUSION Low income,initial onset,low support,advanced stages,high pain,and poor sleep quality increased depression risk in patients in perimenopause with cervical cancer.Studies investigating interventions for this population are needed.
基金Supported by 2024 Hospital-Level Research Start-up Fund,No.YK202426Suzhou Wujiang District"Science and Education for Health"Project,No.WWK202201Development Fund Project of the Affiliated Hospital of Xuzhou Medical University,No.XYFY202423.
文摘BACKGROUND Anxiety and depression are highly prevalent among patients with cervical cancer(CC).However,few studies have systematically analyzed the psychological effects of tumor stage,treatment methods,and related factors on these patients,or developed predictive models for these outcomes.AIM To identify factors influencing anxiety and depression in patients with CC and construct predictive models.METHODS We retrospectively analyzed data from 119 patients with CC treated at the Gynecology Department of Suzhou Ninth People’s Hospital between January 2017 and May 2025.Clinical data,psychological hope levels at diagnosis,and Self-Rating Anxiety Scale and Self-Rating Depression Scale scores during treatment were collected.Influencing factors were identified,and predictive models were developed.The model performance was evaluated using receiver operating characteristic(ROC)curves and the Hosmer-Lemeshow goodness-of-fit test.RESULTS During treatment,64.71%of the patients experienced anxiety and 52.10%experienced depression.Significant differences in family income,tumor stage,treatment modality,and hope level were observed between patients with and without anxiety/depression(P<0.05).Multivariate analysis showed that a family monthly income<5000 yuan,stage III-IV tumor,comprehensive treatment,and low hope level were independent risk factors(P<0.05).The predictive formula for anxiety was as follows:Logit(P)=0.795×monthly income+0.594×tumor stage+1.095×treatment method+1.184×hope level−9.176;for depression:Logit(P)=0.432×monthly income+0.518×tumor stage+0.727×treatment method+1.095×hope level−8.541.The area under the ROC curves were 0.865 for anxiety and 0.837 for depression.Goodness-of-fit test confirmed no overfitting(P>0.05).CONCLUSION Family income,tumor stage,treatment method,and hope level are key determinants of anxiety and depression in patients with CC.Predictive models incorporating these factors can effectively assess risk of anxiety and depression during treatment.
基金supported by CAMS Innovation Fund for Medical Sciences(CIFMS 2021-I2M-1-004)Tencent Sustainable Social Value Inclusive Health Lab and through the ChongQing Tencent Sustainable Development Foundation"Comprehensive Prevention and Control Demonstration Project for Eliminating Cervical Cancer and Breast Cancer in Low Health Resource Areas of China"(Project No.SD20240904145730)+1 种基金Tencent Sustainable Social Value Inclusive Health Lab(Project No.SSVPJ202307060001)Sanming Project of Medicine in Shenzhen(Project No.SZSM202211032)。
文摘Objective:Cervical cancer remains a global health challenge with substantial disparities between countries.High-quality colposcopy is essential for cervical cancer prevention,yet training opportunities remain inadequate worldwide.We developed the Intelligent Digital Education Tool for Colposcopy(iDECO)to address training gaps and evaluated the effect across diverse international settings.Methods:Six pre-post interventional training programmes were conducted in China,Mexico,and Mongolia from December 2024 to May 2025.A total of 369 trainees from 87 centers participated in a 3-week online training programme using iDECO,a bilingual webbased platform featuring authentic colposcopy cases,gamified learning pathways,and personalized analytics.The primary outcomes included colposcopy competence in general assessment,colposcopic findings,diagnostic accuracy,and management decisions.The secondary outcomes focused on participant feedback and satisfaction.Results:Of 369 participants who completed pretests,333(90.24%)completed post-training assessments.Significant improvements were observed across all competency domains.Diagnostic accuracy increased with an odds ratio(OR)of 1.72(95%CI:1.60±1.86)with the greatest gains in high-grade lesion identification[OR=2.27(95%CI:1.94±2.64)].Squamocolumnar junction visibility and transformation zone type assessments improved with ORs of 1.41(95%CI:1.31±1.51)and 1.87(95%CI:1.73±2.01),respectively.Biopsy decision-making accuracy also showed significant improvement[OR=2.09(95%CI:1.91±2.29)].International participants showed lower baseline performance but achieved the greatest improvements.Greater than 85%of participants rated the training highly satisfactory and 83.56%preferred intelligent training over traditional methods.Conclusions:iDECO-based training significantly improved colposcopy competence across diverse international settings with high user satisfaction.These findings support the potential for worldwide implementation of intelligent digital training tools to address colposcopy training gaps and contribute to the elimination of cervical cancer.
文摘[Objectives]To explore the effectiveness of exercise therapy for lower limb lymphedema after cervical cancer surgery,and to inform future research and clinical practice in developing evidence-based nursing interventions.[Methods]Using the JBI scoping review guidelines as a methodological framework,relevant studies were retrieved from PubMed,Embase,Web of Science,Cochrane Library,CINAHL,CNKI,Wanfang Data,and Chinese Biomedical Literature Database from their inception to December 2024.[Results]The findings of included 18 studies showed that exercise therapy,mainly including progressive resistance training,aerobic exercise,aquatic exercise,and mixed exercise modalities,could effectively alleviate lower limb lymphedema symptoms in patients after cervical cancer surgery and improve quality of life.Progressive resistance training has been proven to be a safe and feasible preventive intervention;aerobic exercise and aquatic exercise have certain relieving effects on established lymphedema;mixed exercise interventions can improve patients functional activity capacity.[Conclusions]Exercise therapy is a feasible,safe,and effective intervention for lower limb lymphedema after cervical cancer surgery.Future high-quality randomized controlled trials are required to validate the effectiveness of different exercise modalities and to develop individualized exercise prescriptions that enhance patient adherence and reduce complications.
