In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control compa...In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control comparative study was performed for FMPF and traditional cerebrovascular risk factors on 110 cases of old ischemic cerebrovascular disease and 110 controls matched on age, sex and living condition. The results showed that cerebrovascular risk factors were more prevalent in case group than in control group. In the case group, FMPF was significantly higher than in control group. There was a significant positive correlation between hypertension and fibrin monomer polymerization velocity (FMPV), hypertension and fibrinogen (Fbg), alcohol consumption and Fbg, but no significant correlation between diabetic mellitus, smoking and FMPF was found. Among the parameters of blood lipids, there were significant positive correlations between total cholesterol (TC) and parameters of FMPF to varying degrees, triglycerides (TG) and FMPV, TG and Fbg. Our results also showed there were significant linear trends between TC and FMPV (P<0. 001), TC and Fbg (P=0. 0087), TG and FMPV/Amax (maximum absorbance)(P=0. 0143) respectively. Multiple logistic regression analysis revealed that FMPF in case group remained significantly higher than control group after adjustment of all risk factors that were significant in univariate analysis. It was concluded that there is a possible pathophysiological link between FMPF and cerebrovascular risk factors. An elevated FMPF is associated with ischemic cerebrovascular disease and an independent risk factor of this disease. In old people, detection of FMPF might be a useful screening to identify individuals at increased cerebrothrombotic risk.展开更多
Objective: To explore the effects of the somatosensory interaction technology combined with virtual reality technology on upper limbs function and activities of daily living (ADL) in cerebrovascular disease patients. ...Objective: To explore the effects of the somatosensory interaction technology combined with virtual reality technology on upper limbs function and activities of daily living (ADL) in cerebrovascular disease patients. Methods: Form January, 2019 to December, 2019, 80 cerebrovascular disease patients were recruited, and had been divided into control group (n = 40) and observation group (n = 40), randomly. The control groups received conventional rehabilitation treatment, for 40 minutes per day, while observation group received conventional rehabilitation treatment, for 20 minutes per day, and virtual reality technology treatment, 20 minutes per day, 5 days a week for 4 weeks. Wolf Motor Function Test (WMFT), Fugl-Meyer Assessment-Upper Extremities (FMA-UE) and modified Barthel index (MBI) were used to assess the motor function of the upper limbs and ADL before and after treatment. Results: Before treatment, the scores of WMFT, FMA-UE and MBI were no significant difference between two groups (P > 0.05). The scores improved in both groups after treatment (P < 0.01), and were higher in the observation group than in the control group (P < 0.05). Conclusion: The somatosensory interaction technology combined with virtual reality technology could facilitate to improve the upper limbs function and ADL in cerebrovascular disease patients.展开更多
目的探讨肌电生物反馈联合疏经推拿对脑出血后偏瘫患者运动功能、脑血管功能的影响。方法选择2021年10月—2023年10月80例脑出血后偏瘫患者,采用随机数表法分为观察组(41例)和对照组(39例)。对照组给予肌电生物反馈治疗,观察组给予肌电...目的探讨肌电生物反馈联合疏经推拿对脑出血后偏瘫患者运动功能、脑血管功能的影响。方法选择2021年10月—2023年10月80例脑出血后偏瘫患者,采用随机数表法分为观察组(41例)和对照组(39例)。对照组给予肌电生物反馈治疗,观察组给予肌电生物反馈联合疏经推拿。比较两组患者疗效、运动功能、脑血管功能、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、脑卒中专用生活质量量表(Stroke-Specific Quality of Life Scale,SS-QOL)评分及Barthel指数(Barthel index,BI)评分、生活质量。结果观察组患者临床总有效率92.68%(38/41),远高于对照组总有效率76.92%(30/39)(P<0.05);治疗后观察组上肢运动、下肢运动及总分明显高于对照组(P<0.05);治疗后观察组脑血管流速、脑血管流量高于对照组(P<0.05);血管外周阻力、动态阻力低于对照组(P<0.05);治疗后观察组NIHSS评分低于对照组(P<0.05);治疗后观察组SS-QOL评分、BI评分高于对照组(P<0.05);治疗后观察组Berg衡量表(Berg balance scale,BBS)评分、最快步行速度(maximum walking speed,MWS)高于对照组(P<0.05)。结论在脑出血后偏瘫患者中给予肌电生物反馈联合疏经推拿有较好的效果,可有效改善患者运动功能、脑血管功能。展开更多
In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested...In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.展开更多
Thirty-four patients with cerebral infarction and 18 patients with transient ischemic attack were examined by multi-slice spiral CT scan, CT perfusion imaging, and CT angiography within 6 hours after onset. By CT perf...Thirty-four patients with cerebral infarction and 18 patients with transient ischemic attack were examined by multi-slice spiral CT scan, CT perfusion imaging, and CT angiography within 6 hours after onset. By CT perfusion imaging, 29 cases in the cerebral infarction group and 10 cases in the transient ischemic attack group presented with abnormal blood flow perfusion, which corresponded to the clinical symptoms. By CT angiography, various degrees of vascular stenosis could be detected in 41 patients, including 33 in the cerebral infarction group and eight in the transient ischemic attack group. The incidence of intracranial artery stenosis was higher than that of extracranial artery stenosis. The intracranial artery stenosis was located predominantly in the middle cerebral artery and carotid artery siphon, while the extracranial artery stenosis occurred mainly in the bifurcation of the common carotid artery and the opening of the vertebral artery. There were 34 cases （83%） with convict vascular stenosis and perfusion abnormalities, and five cases （45%） with perfusion abnormalities but without convict vascular stenosis. The incidence of cerebral infarction in patients with National Institutes of Health Stroke Scale scores 〉 5 points during onset was significantly higher than that in patients with National Institutes of Health Stroke Scale scores 〈 5 points. These experimental findings indicate that the combined application of various CT imaging methods allows early diagnosis of acute ischemic cerebrovascular disease, which can comprehensively analyze the pathogenesis and severity of acute ischemic cerebrovascular disease at the morphological and functional levels.展开更多
目的探讨非痴呆型血管性认知功能障碍(vascular cognitive impairment no dementia,VCIND)与认知正常脑血管病变患者的脑血管形态学及血清指标差异。方法选取2023年6月至2024年9月于浙江省医疗健康集团衢州医院住院的VCIND患者100例纳...目的探讨非痴呆型血管性认知功能障碍(vascular cognitive impairment no dementia,VCIND)与认知正常脑血管病变患者的脑血管形态学及血清指标差异。方法选取2023年6月至2024年9月于浙江省医疗健康集团衢州医院住院的VCIND患者100例纳入试验组,选取同期住院的认知正常的脑血管病变患者100例纳入对照组,采用全脑血管造影及血清检查,比较两组患者的脑动脉延长扩张、脑血管狭窄、侧支循环建立、炎症因子、血脂代谢指标,并探究试验组不同责任血管病变与认知障碍严重程度的关系。结果试验组患者的脑动脉延长扩张率、血管狭窄率高于对照组,侧支循环建立率低于对照组(P<0.05);试验组患者的白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α、总胆固醇、低密度脂蛋白、载脂蛋白B及脂蛋白a水平均显著高于对照组,高密度脂蛋白水平低于对照组(P<0.05);试验组患者大脑前动脉血管病变20例,大脑中动脉血管病变22例,大脑后动脉血管病变26例,椎基底动脉血管病变32例,不同责任血管病变患者的简易精神状况检查量表评分、蒙特利尔认知评估量表评分、Hachinski缺血量表评分比较差异均无统计学意义(P>0.05)。结论脑动脉延长扩张、脑动脉狭窄、无侧支循环建立、炎症反应及血脂代谢异常的患者是发生VCIND的高危人群,此类患者需早期进行认知干预,预防VCIND发生。展开更多
目的 探讨半夏白术天麻汤合桃仁红花煎对风痰瘀阻证脑梗死患者神经功能保护作用。方法 选取安徽中医药大学第一附属医院涡阳分院涡阳中医院急诊科2019年1月至2024年9月收治的脑梗死患者92例,随机分为观察组和对照组,每组46例。对照组予...目的 探讨半夏白术天麻汤合桃仁红花煎对风痰瘀阻证脑梗死患者神经功能保护作用。方法 选取安徽中医药大学第一附属医院涡阳分院涡阳中医院急诊科2019年1月至2024年9月收治的脑梗死患者92例,随机分为观察组和对照组,每组46例。对照组予常规治疗方案,观察组联合半夏白术天麻汤合桃仁红花煎,两组均持续治疗4周。比较两组治疗后临床疗效、大脑中动脉血流速度(middle cerebral artery flow velocity,MCAFV)、搏动指数(pulsatility index,PI)、脑血管阻力(cerebral vascular resistance,CVR)、凝血功能指标、中医证候积分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、日常生活能力量表(activity of daily living scale,ADL)评分及不良反应发生率。结果 治疗后,观察组治疗总有效率高于对照组(89.13% vs.71.74%,P<0.05)。观察组MCAFV、CVR均高于对照组(P<0.05),PI低于对照组(P<0.05)。观察组凝血功能改善程度优于对照组(P<0.05)。观察组各中医证候积分、NIHSS评分均低于对照组(P<0.05),ADL评分高于对照组(P<0.05)。两组安全性情况差异无统计学意义(P>0.05)。结论 半夏白术天麻汤合桃仁红花煎对风痰瘀阻证脑梗死患者疗效明显,有助改善凝血功能、脑血管储备功能,对神经功能具有保护作用,并且不增加不良反应。展开更多
文摘In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control comparative study was performed for FMPF and traditional cerebrovascular risk factors on 110 cases of old ischemic cerebrovascular disease and 110 controls matched on age, sex and living condition. The results showed that cerebrovascular risk factors were more prevalent in case group than in control group. In the case group, FMPF was significantly higher than in control group. There was a significant positive correlation between hypertension and fibrin monomer polymerization velocity (FMPV), hypertension and fibrinogen (Fbg), alcohol consumption and Fbg, but no significant correlation between diabetic mellitus, smoking and FMPF was found. Among the parameters of blood lipids, there were significant positive correlations between total cholesterol (TC) and parameters of FMPF to varying degrees, triglycerides (TG) and FMPV, TG and Fbg. Our results also showed there were significant linear trends between TC and FMPV (P<0. 001), TC and Fbg (P=0. 0087), TG and FMPV/Amax (maximum absorbance)(P=0. 0143) respectively. Multiple logistic regression analysis revealed that FMPF in case group remained significantly higher than control group after adjustment of all risk factors that were significant in univariate analysis. It was concluded that there is a possible pathophysiological link between FMPF and cerebrovascular risk factors. An elevated FMPF is associated with ischemic cerebrovascular disease and an independent risk factor of this disease. In old people, detection of FMPF might be a useful screening to identify individuals at increased cerebrothrombotic risk.
文摘Objective: To explore the effects of the somatosensory interaction technology combined with virtual reality technology on upper limbs function and activities of daily living (ADL) in cerebrovascular disease patients. Methods: Form January, 2019 to December, 2019, 80 cerebrovascular disease patients were recruited, and had been divided into control group (n = 40) and observation group (n = 40), randomly. The control groups received conventional rehabilitation treatment, for 40 minutes per day, while observation group received conventional rehabilitation treatment, for 20 minutes per day, and virtual reality technology treatment, 20 minutes per day, 5 days a week for 4 weeks. Wolf Motor Function Test (WMFT), Fugl-Meyer Assessment-Upper Extremities (FMA-UE) and modified Barthel index (MBI) were used to assess the motor function of the upper limbs and ADL before and after treatment. Results: Before treatment, the scores of WMFT, FMA-UE and MBI were no significant difference between two groups (P > 0.05). The scores improved in both groups after treatment (P < 0.01), and were higher in the observation group than in the control group (P < 0.05). Conclusion: The somatosensory interaction technology combined with virtual reality technology could facilitate to improve the upper limbs function and ADL in cerebrovascular disease patients.
文摘目的探讨肌电生物反馈联合疏经推拿对脑出血后偏瘫患者运动功能、脑血管功能的影响。方法选择2021年10月—2023年10月80例脑出血后偏瘫患者,采用随机数表法分为观察组(41例)和对照组(39例)。对照组给予肌电生物反馈治疗,观察组给予肌电生物反馈联合疏经推拿。比较两组患者疗效、运动功能、脑血管功能、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、脑卒中专用生活质量量表(Stroke-Specific Quality of Life Scale,SS-QOL)评分及Barthel指数(Barthel index,BI)评分、生活质量。结果观察组患者临床总有效率92.68%(38/41),远高于对照组总有效率76.92%(30/39)(P<0.05);治疗后观察组上肢运动、下肢运动及总分明显高于对照组(P<0.05);治疗后观察组脑血管流速、脑血管流量高于对照组(P<0.05);血管外周阻力、动态阻力低于对照组(P<0.05);治疗后观察组NIHSS评分低于对照组(P<0.05);治疗后观察组SS-QOL评分、BI评分高于对照组(P<0.05);治疗后观察组Berg衡量表(Berg balance scale,BBS)评分、最快步行速度(maximum walking speed,MWS)高于对照组(P<0.05)。结论在脑出血后偏瘫患者中给予肌电生物反馈联合疏经推拿有较好的效果,可有效改善患者运动功能、脑血管功能。
基金the Incheon St. Mary’s Hospital of the Catholic University of Korea, through the Clinical Research Laboratory Foundation Program, Korea Health 21 R&D Project, No. A092058, and WCU Neurocytomics
文摘In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.
基金supported by the Youth Fund of the First Clinical College of Liaoning Medical University, No. 2010C20
文摘Thirty-four patients with cerebral infarction and 18 patients with transient ischemic attack were examined by multi-slice spiral CT scan, CT perfusion imaging, and CT angiography within 6 hours after onset. By CT perfusion imaging, 29 cases in the cerebral infarction group and 10 cases in the transient ischemic attack group presented with abnormal blood flow perfusion, which corresponded to the clinical symptoms. By CT angiography, various degrees of vascular stenosis could be detected in 41 patients, including 33 in the cerebral infarction group and eight in the transient ischemic attack group. The incidence of intracranial artery stenosis was higher than that of extracranial artery stenosis. The intracranial artery stenosis was located predominantly in the middle cerebral artery and carotid artery siphon, while the extracranial artery stenosis occurred mainly in the bifurcation of the common carotid artery and the opening of the vertebral artery. There were 34 cases （83%） with convict vascular stenosis and perfusion abnormalities, and five cases （45%） with perfusion abnormalities but without convict vascular stenosis. The incidence of cerebral infarction in patients with National Institutes of Health Stroke Scale scores 〉 5 points during onset was significantly higher than that in patients with National Institutes of Health Stroke Scale scores 〈 5 points. These experimental findings indicate that the combined application of various CT imaging methods allows early diagnosis of acute ischemic cerebrovascular disease, which can comprehensively analyze the pathogenesis and severity of acute ischemic cerebrovascular disease at the morphological and functional levels.
文摘目的探讨非痴呆型血管性认知功能障碍(vascular cognitive impairment no dementia,VCIND)与认知正常脑血管病变患者的脑血管形态学及血清指标差异。方法选取2023年6月至2024年9月于浙江省医疗健康集团衢州医院住院的VCIND患者100例纳入试验组,选取同期住院的认知正常的脑血管病变患者100例纳入对照组,采用全脑血管造影及血清检查,比较两组患者的脑动脉延长扩张、脑血管狭窄、侧支循环建立、炎症因子、血脂代谢指标,并探究试验组不同责任血管病变与认知障碍严重程度的关系。结果试验组患者的脑动脉延长扩张率、血管狭窄率高于对照组,侧支循环建立率低于对照组(P<0.05);试验组患者的白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α、总胆固醇、低密度脂蛋白、载脂蛋白B及脂蛋白a水平均显著高于对照组,高密度脂蛋白水平低于对照组(P<0.05);试验组患者大脑前动脉血管病变20例,大脑中动脉血管病变22例,大脑后动脉血管病变26例,椎基底动脉血管病变32例,不同责任血管病变患者的简易精神状况检查量表评分、蒙特利尔认知评估量表评分、Hachinski缺血量表评分比较差异均无统计学意义(P>0.05)。结论脑动脉延长扩张、脑动脉狭窄、无侧支循环建立、炎症反应及血脂代谢异常的患者是发生VCIND的高危人群,此类患者需早期进行认知干预,预防VCIND发生。
文摘目的 探讨半夏白术天麻汤合桃仁红花煎对风痰瘀阻证脑梗死患者神经功能保护作用。方法 选取安徽中医药大学第一附属医院涡阳分院涡阳中医院急诊科2019年1月至2024年9月收治的脑梗死患者92例,随机分为观察组和对照组,每组46例。对照组予常规治疗方案,观察组联合半夏白术天麻汤合桃仁红花煎,两组均持续治疗4周。比较两组治疗后临床疗效、大脑中动脉血流速度(middle cerebral artery flow velocity,MCAFV)、搏动指数(pulsatility index,PI)、脑血管阻力(cerebral vascular resistance,CVR)、凝血功能指标、中医证候积分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分、日常生活能力量表(activity of daily living scale,ADL)评分及不良反应发生率。结果 治疗后,观察组治疗总有效率高于对照组(89.13% vs.71.74%,P<0.05)。观察组MCAFV、CVR均高于对照组(P<0.05),PI低于对照组(P<0.05)。观察组凝血功能改善程度优于对照组(P<0.05)。观察组各中医证候积分、NIHSS评分均低于对照组(P<0.05),ADL评分高于对照组(P<0.05)。两组安全性情况差异无统计学意义(P>0.05)。结论 半夏白术天麻汤合桃仁红花煎对风痰瘀阻证脑梗死患者疗效明显,有助改善凝血功能、脑血管储备功能,对神经功能具有保护作用,并且不增加不良反应。
