BACKGROUND Debate exists regarding the use of thermal ablation(TA)to treat papillary thyroid carcinoma(PTC).Some studies have recommended TA as a new,efcient and safe technology for PTC.In this article,we report one ...BACKGROUND Debate exists regarding the use of thermal ablation(TA)to treat papillary thyroid carcinoma(PTC).Some studies have recommended TA as a new,efcient and safe technology for PTC.In this article,we report one case of a residual tumor and central lymph node metastasis(CLNM)after TA for PTC.CASE SUMMARY A 63-year-old female underwent bilateral ultrasound(US)-guided radiofrequency ablation for PTC.Three months later,she was diagnosed as thyroid cancer with suspected CLNM by US and contrast-enhanced computed tomography.The subsequent fine-needle aspiration(FNA)biopsies were negative.Due to her strong personal preference,she underwent total thyroidectomy and central lymph node dissection.Local tissue adhesion and a difficult dissection were noted during the operation.The pathology of the frozen sections during the operation was still negative.The final pathology results of paraffin-embedded sections revealed residual tumor cells at the edge of the PTC and CLNM.CONCLUSION TA may lead to a residual tumor in patients with PTC.Follow-up using US and FNA biopsy may not be adequate to evaluate the residual tumor.TA should be carefully considered in PTC treatment.展开更多
Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-r...Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,展开更多
Background: Central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) allows correct pathologic staging of lymph nodes and planning of postoperative management. The purpose of this study was to determ...Background: Central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) allows correct pathologic staging of lymph nodes and planning of postoperative management. The purpose of this study was to determine the number of the lymph nodes in the CLND and the relationship to presence of chronic lymphocytic thyroiditis (CLT) and thymic tissue (TT). Methods: Total thyroidectomy and CLND materials from 153 patients with PTC were included in this study. Two histopathologic features (presence of CLT and TT) were evaluated for their value in adequacy of CLND. Results: Histopathologic examination revealed CLT and TT in CLND materials in 70 (46%) and 63 (41%) patients, respectively. Total number of lymph nodes in CLND materials was significantly higher in CLT (+) and TT (+) groups (p Conclusions: Our study demonstrates that presence of CLT in thyroid gland has been associated with higher number of central lymph nodes mainly due to increased number of benign hyperplastic lymph nodes. It may be possible to conclude that upper limit of lymph nodes for satisfactory CLND would be higher to correctly evaluate central lymph node status in existing staging systems if specimens have CLT. Results of this study also show that the presence of TT in surgical materials may represent the adequacy of CLND.展开更多
Myelinated axons of the peripheral and central nervous system（PNS＆CNS）are divided into molecularly distinct excitable domains,including the axon initial segment（AIS）and nodes of Ranvier.The AIS is composed of a d...Myelinated axons of the peripheral and central nervous system（PNS＆CNS）are divided into molecularly distinct excitable domains,including the axon initial segment（AIS）and nodes of Ranvier.The AIS is composed of a dense network of cytoskeletal proteins,cell adhesion molecules,and voltage gated ion channels and is located at the proximal most region of the axon（Koleand Stuart, 2012）.展开更多
【目的】地球表层系统科学数据有向加权关联网络的关键节点识别对科学数据精准推荐与知识发现具有重要意义,但现有方法存在评估片面、特征利用不足及权重分配科学性欠缺等挑战。【方法】本文提出一种基于主客观融合权重的逼近理想解排序...【目的】地球表层系统科学数据有向加权关联网络的关键节点识别对科学数据精准推荐与知识发现具有重要意义,但现有方法存在评估片面、特征利用不足及权重分配科学性欠缺等挑战。【方法】本文提出一种基于主客观融合权重的逼近理想解排序法(Technique for Order Preference by Similarity to an Ideal Solution, TOPSIS)的关键节点识别方法。首先,提出节点相似中心性指标,通过融合关联度与强度平衡局部拓扑与全局影响力;然后,构建整合网络拓扑、数据关联及节点相似性的多指标评价体系,全面刻画节点重要性;接着,提出双层权重优化策略,结合层次分析法(Analytic Hierarchy Process, AHP)和指标相关性定权法(Criteria Importance Through Intercriteria Correlation, CRITIC)方法,融合主客观权重,提升评估科学性;最后,结合TOPSIS评估方法进行节点重要性的综合评估。【结果】实验基于团队构建的不同规模的地表系统科学数据有向加权关联网络,结合加权易感-感染-恢复(SIR)模型进行实验验证,结果表明:与传统网络加权中心性以及基于主观或客观权重的TOPSIS等方法相比,本文方法在肯德尔相关系数值和TOP-K命中率方面表现更优,且在网络中展现强鲁棒性。【结论】该方法为地表系统科学数据网络分析提供了新方法,可支撑智能推荐、资源优化及系统脆弱性分析等实际应用,助力地球系统科学研究的深度发展。展开更多
The brittleness analysis and important nodes detection have been a hot spot in the complex networks.How to get the overall feature of the whole network and how to find out some important nodes are requisites to solve ...The brittleness analysis and important nodes detection have been a hot spot in the complex networks.How to get the overall feature of the whole network and how to find out some important nodes are requisites to solve these problems. In this paper, we adopt the trace of the adjacency matrix and the centrality of the complex networks to give a quantitative and qualitative analysis of networks being studied. Results show that the k-shell plays a more important role than the degree centrality and the betweenness in finding important nodes, and it can also be used to give direction on the immunization and maintenance of complex networks.展开更多
The identification of the influential nodes in a network is of great significance for understanding the features of the network and controlling the complexity of networks in society and in biology. In this paper, we ...The identification of the influential nodes in a network is of great significance for understanding the features of the network and controlling the complexity of networks in society and in biology. In this paper, we propose a novel centrality measure for a node by considering the importance of edges and compare the performance of this method with existing seven topological-based ranking methods on the Susceptible-Infected-Recovered （SIR） model. The simulation results for four different types of real networks show that the proposed method is robust and exhibits excellent performance in identifying the most influential nodes when spreading starting from both single origin and multipleorigins simultaneously.展开更多
基金the Shanghai Municipal Administrator of Traditional Chinese Medicine,No.2018ZY03005.
文摘BACKGROUND Debate exists regarding the use of thermal ablation(TA)to treat papillary thyroid carcinoma(PTC).Some studies have recommended TA as a new,efcient and safe technology for PTC.In this article,we report one case of a residual tumor and central lymph node metastasis(CLNM)after TA for PTC.CASE SUMMARY A 63-year-old female underwent bilateral ultrasound(US)-guided radiofrequency ablation for PTC.Three months later,she was diagnosed as thyroid cancer with suspected CLNM by US and contrast-enhanced computed tomography.The subsequent fine-needle aspiration(FNA)biopsies were negative.Due to her strong personal preference,she underwent total thyroidectomy and central lymph node dissection.Local tissue adhesion and a difficult dissection were noted during the operation.The pathology of the frozen sections during the operation was still negative.The final pathology results of paraffin-embedded sections revealed residual tumor cells at the edge of the PTC and CLNM.CONCLUSION TA may lead to a residual tumor in patients with PTC.Follow-up using US and FNA biopsy may not be adequate to evaluate the residual tumor.TA should be carefully considered in PTC treatment.
文摘Lung cancer is the most common cancer worldwide. In the United States, it causes more cancer-related deaths than the next four causes （breast cancer, prostate cancer, colon cancer, and pancreatic cancer） of cancer-related mortality combined （1）. About 30% of people have already progressed to stage III lung cancer and 40% to stage IV at the time they are diagnosed （2）. Although chest X-ray and sputum cytology, when applied in health check-ups, can identify some relatively small tumors, they are not able to lower the overall mortality （3）. More recently,
文摘Background: Central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) allows correct pathologic staging of lymph nodes and planning of postoperative management. The purpose of this study was to determine the number of the lymph nodes in the CLND and the relationship to presence of chronic lymphocytic thyroiditis (CLT) and thymic tissue (TT). Methods: Total thyroidectomy and CLND materials from 153 patients with PTC were included in this study. Two histopathologic features (presence of CLT and TT) were evaluated for their value in adequacy of CLND. Results: Histopathologic examination revealed CLT and TT in CLND materials in 70 (46%) and 63 (41%) patients, respectively. Total number of lymph nodes in CLND materials was significantly higher in CLT (+) and TT (+) groups (p Conclusions: Our study demonstrates that presence of CLT in thyroid gland has been associated with higher number of central lymph nodes mainly due to increased number of benign hyperplastic lymph nodes. It may be possible to conclude that upper limit of lymph nodes for satisfactory CLND would be higher to correctly evaluate central lymph node status in existing staging systems if specimens have CLT. Results of this study also show that the presence of TT in surgical materials may represent the adequacy of CLND.
基金supported by National Institutes of Health Grants NS069688 and NS044916, TIRR Foundationthe Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
文摘Myelinated axons of the peripheral and central nervous system（PNS＆CNS）are divided into molecularly distinct excitable domains,including the axon initial segment（AIS）and nodes of Ranvier.The AIS is composed of a dense network of cytoskeletal proteins,cell adhesion molecules,and voltage gated ion channels and is located at the proximal most region of the axon（Koleand Stuart, 2012）.
文摘【目的】地球表层系统科学数据有向加权关联网络的关键节点识别对科学数据精准推荐与知识发现具有重要意义,但现有方法存在评估片面、特征利用不足及权重分配科学性欠缺等挑战。【方法】本文提出一种基于主客观融合权重的逼近理想解排序法(Technique for Order Preference by Similarity to an Ideal Solution, TOPSIS)的关键节点识别方法。首先,提出节点相似中心性指标,通过融合关联度与强度平衡局部拓扑与全局影响力;然后,构建整合网络拓扑、数据关联及节点相似性的多指标评价体系,全面刻画节点重要性;接着,提出双层权重优化策略,结合层次分析法(Analytic Hierarchy Process, AHP)和指标相关性定权法(Criteria Importance Through Intercriteria Correlation, CRITIC)方法,融合主客观权重,提升评估科学性;最后,结合TOPSIS评估方法进行节点重要性的综合评估。【结果】实验基于团队构建的不同规模的地表系统科学数据有向加权关联网络,结合加权易感-感染-恢复(SIR)模型进行实验验证,结果表明:与传统网络加权中心性以及基于主观或客观权重的TOPSIS等方法相比,本文方法在肯德尔相关系数值和TOP-K命中率方面表现更优,且在网络中展现强鲁棒性。【结论】该方法为地表系统科学数据网络分析提供了新方法,可支撑智能推荐、资源优化及系统脆弱性分析等实际应用,助力地球系统科学研究的深度发展。
文摘The brittleness analysis and important nodes detection have been a hot spot in the complex networks.How to get the overall feature of the whole network and how to find out some important nodes are requisites to solve these problems. In this paper, we adopt the trace of the adjacency matrix and the centrality of the complex networks to give a quantitative and qualitative analysis of networks being studied. Results show that the k-shell plays a more important role than the degree centrality and the betweenness in finding important nodes, and it can also be used to give direction on the immunization and maintenance of complex networks.
基金Supported by the Research Foundation of Hubei Province Department of Education(Q20151505)the East China Jiaotong University Doctor Scientific Research Start Fund Project(26441021)
文摘The identification of the influential nodes in a network is of great significance for understanding the features of the network and controlling the complexity of networks in society and in biology. In this paper, we propose a novel centrality measure for a node by considering the importance of edges and compare the performance of this method with existing seven topological-based ranking methods on the Susceptible-Infected-Recovered （SIR） model. The simulation results for four different types of real networks show that the proposed method is robust and exhibits excellent performance in identifying the most influential nodes when spreading starting from both single origin and multipleorigins simultaneously.
