A novel solid solution Ce6MoO15 was achieved. Their structure and oxide ionic conductivity were studied.Based on Ce6MoO15, rare earth element substitution on cerium site shows that all resulting oxides enhance the con...A novel solid solution Ce6MoO15 was achieved. Their structure and oxide ionic conductivity were studied.Based on Ce6MoO15, rare earth element substitution on cerium site shows that all resulting oxides enhance the conductivity further, and have high oxide-ion conductivity, which may be a kind of promising material for SOFCs.展开更多
Photodynamic therapy is an"old"strategy for cancer therapy featuring clinical safety and rapid working,but suitable photosensitizers for colorectal cancer therapy remain lacking.This study synthesized a nove...Photodynamic therapy is an"old"strategy for cancer therapy featuring clinical safety and rapid working,but suitable photosensitizers for colorectal cancer therapy remain lacking.This study synthesized a novel photosensitizer termed Ce6-GFFY based on a self-assembling peptide GFFY and a photo-responsive molecule chlorin e6(Ce6).Ce6-GFFY forms macroparticles with a diameter of~160 nm and possesses a half-life of 10 h,as well as an ideal tumor-targeting ability in mouse models.Ce6-GFFY effectively penetrates cells and generates numerous reactive oxygen species upon 660 nm laser irradiation.The reactive oxygen species promotes the accumulation of cytotoxic T cells and decrease of myeloid-derived suppressor cells in the tumor microenvironment through immunogenic cell death,thus prohibiting the growth of both primary and metastatic tumors after once treatment.This study not only provides a strategy for photosensitizer development but also confirms a promising application of Ce6-GFFY for colorectal cancer therapy.展开更多
Hepatocellular carcinoma(HCC)has been known as the second common leading cancer worldwide,as it responds poorly to both chemotherapy and medication.Triptolide(TP),a diterpenoid triepoxide,is a promising treatment agen...Hepatocellular carcinoma(HCC)has been known as the second common leading cancer worldwide,as it responds poorly to both chemotherapy and medication.Triptolide(TP),a diterpenoid triepoxide,is a promising treatment agent for its effective anticancer effect on multiple cancers including HCC.However,its clinical application has been limited owing to its severe systemic toxicities,low solubility,and fast elimination in the body.Therefore,to overcome the above obstacles,photo-activatable liposomes(LP)integrated with both photosensitizer Ce6 and chemotherapeutic drug TP(TP/Ce6-LP)was designed in the pursuit of controlled drug release and synergetic photodynamic therapy in HCC therapy.The TP encapsulated in liposomes accumulated to the tumor site due to the enhanced permeability and retention(EPR)effect.Under laser irradiation,the photosensitizer Ce6 generated reactive oxygen species(ROS)and further oxidized the unsaturated phospholipids.In this way,the liposomes were destroyed to release TP.TP/Ce6-LP with NIR laser irradiation(TP/Ce6-LP+L)showed the best antitumor effect both in vitro and in vivo on a patient derived tumor xenograft of HCC(PDXHCC).TP/Ce6-LP significantly reduced the side effects of TP.Furthermore,TP/Ce6-LP+L induced apoptosis through a caspase-3/PARP signaling pathway.Overall,TP/Ce6-LP+L is a novel potential treatment option in halting HCC progression with attenuated toxicity.展开更多
Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient prognosis.Photodynamic therapy(PDT)has been widely applied as an antitumor modality,owing ...Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient prognosis.Photodynamic therapy(PDT)has been widely applied as an antitumor modality,owing to its minimal invasiveness,localized tumor damage,and high safety profile.However,its efficacy is limited by poor stability of photosensitizers,inadequate tumor accumulation,and a complex tumor microenvironment.To overcome these challenges,extensive endeavors have been made to explore the co-assembly of the widely used photosensitizer chlorin e6(Ce6)with various functional small molecules to enhance pharmacodynamic activity.This review provides a comprehensive overview of current studies on Ce6-based nanoparticles for effective PDT and precise delivery of functional molecules.The self-assembly mechanism will be discussed in detail,with a focus on potential strategies for combinational therapy with PDT.展开更多
In this study,a batch of φ12 mm Cs_(2)LiYCl_(6):Ce crystals codoped with different contents of Cu^(+)and Sc^(3+)was successfully grown using the Multi-ampule Bridgeman method.A new emission peaking at 418 nm is found...In this study,a batch of φ12 mm Cs_(2)LiYCl_(6):Ce crystals codoped with different contents of Cu^(+)and Sc^(3+)was successfully grown using the Multi-ampule Bridgeman method.A new emission peaking at 418 nm is found in the photoluminescence spectra of CLYC:Ce codoped with Cu^(+)ion.Codoping Cu^(+)or Sc^(3+)both increases the proportion of intrinsic self-trapped exciton(STE)luminescence,and extends the excitation band of Ce^(3+),especially in Cu^(+)codoped samples,where a new absorption peak at 248 nm can be identified.The light yield of Cu^(+)codoped samples remains largely unchanged,but the energy resolution shows a slight deterioration.Both light yield and energy resolution degrade after Sc^(3+)codoping,and the effect is much severe than that of Cu^(+)codoped samples.X-ray induced afterglow can be suppressed after Cu^(+)codoping and low content of Sc^(3+)codoping.The scintillation decay variation also depends on the codoping ions and their contents.展开更多
移动护士终端是基于医院信息系统HIS(Hospital Information System)的一个手持终端执行系统,主要用来协助护士对住院患者完成日常护理及病区管理等工作。设计采用ARM11系列的S3C6410嵌入式芯片、Windows CE6.0操作系统及RFID读卡器等技...移动护士终端是基于医院信息系统HIS(Hospital Information System)的一个手持终端执行系统,主要用来协助护士对住院患者完成日常护理及病区管理等工作。设计采用ARM11系列的S3C6410嵌入式芯片、Windows CE6.0操作系统及RFID读卡器等技术,具有成本低、体积小、便携式、操作简单、界面友好等特点。实际运行表明,系统运行稳定,能够代替医院传统的纸质医嘱,优化了工作流程,提高了护理工作的质量和效率,实现了HIS向病房的扩展与延伸。展开更多
文摘A novel solid solution Ce6MoO15 was achieved. Their structure and oxide ionic conductivity were studied.Based on Ce6MoO15, rare earth element substitution on cerium site shows that all resulting oxides enhance the conductivity further, and have high oxide-ion conductivity, which may be a kind of promising material for SOFCs.
基金supported by grants from the National Natural Science Foundation of China (No.82373174,82002466,82202907).
文摘Photodynamic therapy is an"old"strategy for cancer therapy featuring clinical safety and rapid working,but suitable photosensitizers for colorectal cancer therapy remain lacking.This study synthesized a novel photosensitizer termed Ce6-GFFY based on a self-assembling peptide GFFY and a photo-responsive molecule chlorin e6(Ce6).Ce6-GFFY forms macroparticles with a diameter of~160 nm and possesses a half-life of 10 h,as well as an ideal tumor-targeting ability in mouse models.Ce6-GFFY effectively penetrates cells and generates numerous reactive oxygen species upon 660 nm laser irradiation.The reactive oxygen species promotes the accumulation of cytotoxic T cells and decrease of myeloid-derived suppressor cells in the tumor microenvironment through immunogenic cell death,thus prohibiting the growth of both primary and metastatic tumors after once treatment.This study not only provides a strategy for photosensitizer development but also confirms a promising application of Ce6-GFFY for colorectal cancer therapy.
基金supported by China postdoctoral Science Foundation(No.2020M673026)the National Natural Science Foundation of China(Nos.81873248,81673903 and 81773642)+1 种基金Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University(Traditional Chinese Pharmacology,China),Zhejiang Chinese Medical University(No.ZYAOXZ2018014,China)State Key Laboratory of Molecular Engineering of Polymers(2019-06,Fudan University,China)
文摘Hepatocellular carcinoma(HCC)has been known as the second common leading cancer worldwide,as it responds poorly to both chemotherapy and medication.Triptolide(TP),a diterpenoid triepoxide,is a promising treatment agent for its effective anticancer effect on multiple cancers including HCC.However,its clinical application has been limited owing to its severe systemic toxicities,low solubility,and fast elimination in the body.Therefore,to overcome the above obstacles,photo-activatable liposomes(LP)integrated with both photosensitizer Ce6 and chemotherapeutic drug TP(TP/Ce6-LP)was designed in the pursuit of controlled drug release and synergetic photodynamic therapy in HCC therapy.The TP encapsulated in liposomes accumulated to the tumor site due to the enhanced permeability and retention(EPR)effect.Under laser irradiation,the photosensitizer Ce6 generated reactive oxygen species(ROS)and further oxidized the unsaturated phospholipids.In this way,the liposomes were destroyed to release TP.TP/Ce6-LP with NIR laser irradiation(TP/Ce6-LP+L)showed the best antitumor effect both in vitro and in vivo on a patient derived tumor xenograft of HCC(PDXHCC).TP/Ce6-LP significantly reduced the side effects of TP.Furthermore,TP/Ce6-LP+L induced apoptosis through a caspase-3/PARP signaling pathway.Overall,TP/Ce6-LP+L is a novel potential treatment option in halting HCC progression with attenuated toxicity.
基金National Natural Science Foundation of China,Grant/Award Number:82222903Li Ka Shing Faculty of Medicine(Start-up Fund)of The University of Hong Kong.
文摘Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient prognosis.Photodynamic therapy(PDT)has been widely applied as an antitumor modality,owing to its minimal invasiveness,localized tumor damage,and high safety profile.However,its efficacy is limited by poor stability of photosensitizers,inadequate tumor accumulation,and a complex tumor microenvironment.To overcome these challenges,extensive endeavors have been made to explore the co-assembly of the widely used photosensitizer chlorin e6(Ce6)with various functional small molecules to enhance pharmacodynamic activity.This review provides a comprehensive overview of current studies on Ce6-based nanoparticles for effective PDT and precise delivery of functional molecules.The self-assembly mechanism will be discussed in detail,with a focus on potential strategies for combinational therapy with PDT.
基金Project supported by the National Key Research and Development Program,China(2022YFB3503600)Manned Space Station Engineering Space Science and Applications Program(MSAP)(ZDBS-ZRKJZTLC011)+3 种基金National Natural Science Foundation of China,China(11975303,12211530561,12305211)Shanghai Municipal Natural Science Foundation,China(21TS1400100)CAS Cooperative Research Project(121631KYSB20210017)CAS Project for Young Scientist in Basic Research(YSBR-024)。
文摘In this study,a batch of φ12 mm Cs_(2)LiYCl_(6):Ce crystals codoped with different contents of Cu^(+)and Sc^(3+)was successfully grown using the Multi-ampule Bridgeman method.A new emission peaking at 418 nm is found in the photoluminescence spectra of CLYC:Ce codoped with Cu^(+)ion.Codoping Cu^(+)or Sc^(3+)both increases the proportion of intrinsic self-trapped exciton(STE)luminescence,and extends the excitation band of Ce^(3+),especially in Cu^(+)codoped samples,where a new absorption peak at 248 nm can be identified.The light yield of Cu^(+)codoped samples remains largely unchanged,but the energy resolution shows a slight deterioration.Both light yield and energy resolution degrade after Sc^(3+)codoping,and the effect is much severe than that of Cu^(+)codoped samples.X-ray induced afterglow can be suppressed after Cu^(+)codoping and low content of Sc^(3+)codoping.The scintillation decay variation also depends on the codoping ions and their contents.
文摘移动护士终端是基于医院信息系统HIS(Hospital Information System)的一个手持终端执行系统,主要用来协助护士对住院患者完成日常护理及病区管理等工作。设计采用ARM11系列的S3C6410嵌入式芯片、Windows CE6.0操作系统及RFID读卡器等技术,具有成本低、体积小、便携式、操作简单、界面友好等特点。实际运行表明,系统运行稳定,能够代替医院传统的纸质医嘱,优化了工作流程,提高了护理工作的质量和效率,实现了HIS向病房的扩展与延伸。
