Owing to their mechanism of action,antibiotics are prone to inducing drug resistance in the bacteria,viruses,and other pathogens.Therefore,there is an urgent need to develop a novel type of antimicrobial substance to ...Owing to their mechanism of action,antibiotics are prone to inducing drug resistance in the bacteria,viruses,and other pathogens.Therefore,there is an urgent need to develop a novel type of antimicrobial substance to safeguard human health.Antimicrobial peptides,members of the endogenous cathelicidin family in humans,possessing antibacterial,antiviral,and other related activities,represent promising potential alternatives to conventional antibiotics In terms of antibacterial properties.This review summarizes the relevant sources and secondary structure of LL-37 and elucidates that LL-37 not only exerts broad-spectrum antimicrobial effects through non-specific mechanisms such as disrupting pathogen cell membranes,which reduces the likelihood of resistance development,but also exhibits multiple biological activities,including immunomodulation,wound healing promotion,antitumor effects,and alleviation of osteoporosis.Currently,LL-37 shows broad application prospects in fields such as food preservation,pharmaceutical research and development,industrial biomaterial coatings,agricultural and crop disease resistance.However,LL-37 exhibits a dual role,capable of either inhibiting or promoting the proliferation of certain cancer cells depending on the context,which warrants further in-depth investigation using genetic engineering and other approaches.This article summarizes recent research progress on cathelicidin LL-37,outlines its mechanisms of action and application domains,aiming to provide a reference for future research advances on LL-37.展开更多
基金support provided by Tianjin University of Science and Technology 2023 College Students’Innovation and Entrepreneurship Training Program Project“Novel Antibiotic-The Role of Antimicrobial Peptide VIP in Poultry Farming”No.:202310057068.
文摘Owing to their mechanism of action,antibiotics are prone to inducing drug resistance in the bacteria,viruses,and other pathogens.Therefore,there is an urgent need to develop a novel type of antimicrobial substance to safeguard human health.Antimicrobial peptides,members of the endogenous cathelicidin family in humans,possessing antibacterial,antiviral,and other related activities,represent promising potential alternatives to conventional antibiotics In terms of antibacterial properties.This review summarizes the relevant sources and secondary structure of LL-37 and elucidates that LL-37 not only exerts broad-spectrum antimicrobial effects through non-specific mechanisms such as disrupting pathogen cell membranes,which reduces the likelihood of resistance development,but also exhibits multiple biological activities,including immunomodulation,wound healing promotion,antitumor effects,and alleviation of osteoporosis.Currently,LL-37 shows broad application prospects in fields such as food preservation,pharmaceutical research and development,industrial biomaterial coatings,agricultural and crop disease resistance.However,LL-37 exhibits a dual role,capable of either inhibiting or promoting the proliferation of certain cancer cells depending on the context,which warrants further in-depth investigation using genetic engineering and other approaches.This article summarizes recent research progress on cathelicidin LL-37,outlines its mechanisms of action and application domains,aiming to provide a reference for future research advances on LL-37.
