Let n≥1 be an integer.In this article,we study the notions of Cartan-Eilenberg FP_(n)injective and Cartan-Eilenberg FP_(n)-flat complexes.We also investigate duality pairs relative to the Cartan-Eilenberg FP_(n)-inje...Let n≥1 be an integer.In this article,we study the notions of Cartan-Eilenberg FP_(n)injective and Cartan-Eilenberg FP_(n)-flat complexes.We also investigate duality pairs relative to the Cartan-Eilenberg FP_(n)-injective and Cartan-Eilenberg FP_(n)-flat complexes.As applications,we obtain that any complex admits Cartan-Eilenberg FP_(n)-injective(resp.,Cartan-Eilenberg FP_(n)-flat)cover and preenvelope and we characterize left n-coherent rings using these two classes of complexes.展开更多
Dermatitis is a combination of various skin disease agents such as bacteria,fungi,ectoparasites,viruses and metabolic diseases with various clinical symptoms or signs.Dermatitis can cause an imbalance between ROS and ...Dermatitis is a combination of various skin disease agents such as bacteria,fungi,ectoparasites,viruses and metabolic diseases with various clinical symptoms or signs.Dermatitis can cause an imbalance between ROS and antioxidants.Exogenous antioxidants are needed to help balance antioxidant and ROS levels in the body by providing trigona honey.This study aims to determine the MDA and SOD levels of dogs with complex dermatitis after administration of trigona honey.This study used 12 dogs with complex dermatitis,with a moderate severity score.Dogs 4-6 months old.Samples were divided into control group(P0)without honey,fresh honey group(P1)5 mL/head/day and capsule honey group(P2)0.1 mg/head/day.Honey was given for 4 weeks in the treatment group.Examination of MDA and SOD levels was carried out using the ELISA kit.The results showed that the Trigona honey treatment had a significant effect(P<0.05)in reducing MDA levels and increasing SOD levels in dogs with complex dermatitis.Duncan's test results showed that SOD levels increased significantly at week 4,while week 2 and week 0 did not increase significantly.Trigona honey has anti-inflammatory,antibacterial,antiaging,antiulcer effects,helps in wound healing dermatitis and is an antioxidant.So that trigona honey can reduce plasma MDA levels and increase plasma SOD levels in dogs with complex dermatitis.展开更多
Complex survey designs often involve unequal selection probabilities of clus-ters or units within clusters. When estimating models for complex survey data, scaled weights are incorporated into the likelihood, producin...Complex survey designs often involve unequal selection probabilities of clus-ters or units within clusters. When estimating models for complex survey data, scaled weights are incorporated into the likelihood, producing a pseudo likeli-hood. In a 3-level weighted analysis for a binary outcome, we implemented two methods for scaling the sampling weights in the National Health Survey of Pa-kistan (NHSP). For NHSP with health care utilization as a binary outcome we found age, gender, household (HH) goods, urban/rural status, community de-velopment index, province and marital status as significant predictors of health care utilization (p-value < 0.05). The variance of the random intercepts using scaling method 1 is estimated as 0.0961 (standard error 0.0339) for PSU level, and 0.2726 (standard error 0.0995) for household level respectively. Both esti-mates are significantly different from zero (p-value < 0.05) and indicate consid-erable heterogeneity in health care utilization with respect to households and PSUs. The results of the NHSP data analysis showed that all three analyses, weighted (two scaling methods) and un-weighted, converged to almost identical results with few exceptions. This may have occurred because of the large num-ber of 3rd and 2nd level clusters and relatively small ICC. We performed a sim-ulation study to assess the effect of varying prevalence and intra-class correla-tion coefficients (ICCs) on bias of fixed effect parameters and variance components of a multilevel pseudo maximum likelihood (weighted) analysis. The simulation results showed that the performance of the scaled weighted estimators is satisfactory for both scaling methods. Incorporating simulation into the analysis of complex multilevel surveys allows the integrity of the results to be tested and is recommended as good practice.展开更多
According to news reports on severe earthquakes since 2008,a total of 51 cases with magnitudes of 6.0 or above were analyzed,and 14 frequently occurring secondary disasters were identified.A disaster chain model was d...According to news reports on severe earthquakes since 2008,a total of 51 cases with magnitudes of 6.0 or above were analyzed,and 14 frequently occurring secondary disasters were identified.A disaster chain model was developed using principles from complex network theory.The vulnerability and risk level of each edge in this model were calculated,and high-risk edges and disaster chains were identified.The analysis reveals that the edge“floods→building collapses”has the highest vulnerability.Implementing measures to mitigate this edge is crucial for delaying the spread of secondary disasters.The highest risk is associated with the edge“building collapses→casualties,”and increased risks are also identified for chains such as“earthquake→building collapses→casualties,”“earthquake→landslides and debris flows→dammed lakes,”and“dammed lakes→floods→building collapses.”Following an earthquake,the prompt implementation of measures is crucial to effectively disrupt these chains and minimize the damage from secondary disasters.展开更多
Objective There is a large population of patients classified as complex higher-risk and indicated patients(CHIPs)in China with a poor prognosis.The treatment of these patients is complex and challenging,especially whe...Objective There is a large population of patients classified as complex higher-risk and indicated patients(CHIPs)in China with a poor prognosis.The treatment of these patients is complex and challenging,especially when acute cardiac events occur,such as acute coronary syndrome(ACS)or heart failure.Pharmacotherapy and some mechanical circulatory support(MCS)therapeutic devices can provide stable hemodynamic support for CHIPs-percutaneous coronary intervention(PCI).LDL-C is an important pathogenic factor in atherosclerosis,and the target of blood lipid control.Recent studies have revealed that lipoprotein(a)[Lp(a)],which is formed when a covalent bond between apolipoprotein(a)and apolipoprotein B-100 is made,produces an LDL-like particle.This particle is an independent risk factor for the development of atherosclerosis,and is closely correlated to stent thrombosis and restenosis.Furthermore,this requires active intervention.PCSK9 inhibitors have been used in lipid-lowering treatment,and preventing atherosclerosis.The present study explores the efficacy of PCSK9 inhibitors in CHIPs-ACS,and the association between the change in Lp(a)and survival after 2 years of follow-up.Methods The present real-world,prospective control study enrolled 321 CHIPs-ACS who underwent emergency PCI from August 2019 to November 2020,and these patients were followed up for 2 years.These patients were divided into two groups:PCSK9 group(n=161)given the combined PCSK9 inhibitor(140 mg of evolocumab every 2 weeks)and statins-based therapy,and SOC group(n=160)treated with statin-based lipid-lowering therapy alone.Then,the change in lipid index was measured,and the cardiovascular(CV)event recurrence rate was evaluated after one month and 2 years.Afterwards,the contribution of serum lipid parameters,especially the Lp(a)alteration,in patients with earlier initiation of the PCSK9 inhibitor to the CV outcome was analyzed.Results The LDL-C level was significantly reduced in both groups:52.3%in the PCSK9 group and 32.3%(P<0.001)in the SOC group.It is noteworthy that the Lp(a)level decreased by 13.2%in the PCSK9 group,but increased by 30.3%in the SOC group(P<0.001).Furthermore,the number of CV events was not significantly different between the PCSK9 and SOC groups after the 2-year follow-up period.In the PCSK9 group,the Lp(a)reduction was associated with the baseline Lp(a)levels of the patients(r2=−0.315,P<0.001).Moreover,the decrease in Lp(a)contributed to the decline in CV events in patients who received ACS CHIPs-PCI,and the decrease in Lp(a)level was independent of the LDL-C level reduction.Conclusion The early initiation of PCSK9 inhibitors can significantly reduce the LDL-C and Lp(a)levels in ACS CHIPs-PCI.However,further studies are needed to confirm whether PCSK9 inhibitors can reduce the incidence of CV disease in CHIPs.展开更多
To increase accuracy of navigation parameters,a perspective measuring complex with intellectual components is developed.Conception of synthesis optimal structure of the measuring complex is realized basing on a select...To increase accuracy of navigation parameters,a perspective measuring complex with intellectual components is developed.Conception of synthesis optimal structure of the measuring complex is realized basing on a selective method using principles of the functional systems.Selection of measured information is finished by original numeric criterion of observation level of state vector components.Prediction is realized by algorithm of self-organization that makes synthesis of the optimal complication.Therefore mechanism of self-regulation is realized and accuracy of the selective navigation complex is increased.展开更多
Studying the topology of infrastructure communication networks(e.g., the Internet) has become a means to understand and develop complex systems. Therefore, investigating the evolution of Internet network topology migh...Studying the topology of infrastructure communication networks(e.g., the Internet) has become a means to understand and develop complex systems. Therefore, investigating the evolution of Internet network topology might elucidate disciplines governing the dynamic process of complex systems. It may also contribute to a more intelligent communication network framework based on its autonomous behavior. In this paper, the Internet Autonomous Systems(ASes) topology from 1998 to 2013 was studied by deconstructing and analysing topological entities on three different scales(i.e., nodes,edges and 3 network components: single-edge component M1, binary component M2 and triangle component M3). The results indicate that: a) 95% of the Internet edges are internal edges(as opposed to external and boundary edges); b) the Internet network consists mainly of internal components, particularly M2 internal components; c) in most cases, a node initially connects with multiple nodes to form an M2 component to take part in the network; d) the Internet network evolves to lower entropy. Furthermore, we find that, as a complex system, the evolution of the Internet exhibits a behavioral series,which is similar to the biological phenomena concerned with the study on metabolism and replication. To the best of our knowledge, this is the first study of the evolution of the Internet network through analysis of dynamic features of its nodes,edges and components, and therefore our study represents an innovative approach to the subject.展开更多
Multi-disciplinary virtual prototypes of complex products are increasingly and widely used in modern advanced manufactur- ing. How to effectively address the problems of unified modeling, composition and reuse based o...Multi-disciplinary virtual prototypes of complex products are increasingly and widely used in modern advanced manufactur- ing. How to effectively address the problems of unified modeling, composition and reuse based on the multi-disciplinary heteroge- neous models has brought great challenges to the modeling and simulation （M＆S） science and technology. This paper presents a top-level modeling theory based on the meta modeling framework （M2F） of the COllaborative SIMulation （COSlM） theory of virtual prototyping to solve the problems. Firstly the fundamental prin- ciples of the top-level modeling theory are decribed to expound the premise, assumptions, basic conventions and special require- ments in the description of complex heterogeneous systems. Next the formalized definitions for each factor in top level modeling are proposed and the hierarchical nature of them is illustrated. After demonstrating that they are self-closing, this paper divides the top- level modeling into two views, static structural graph and dynamic behavioral graph. Finally, a case study is discussed to demon- strate the feasibility of the theory.展开更多
基金Supported by the National Natural Science Foundation of China(Grant No.12061061)the Science and Technology Project of Gansu Province(Grant No.22JR5RA153).
文摘Let n≥1 be an integer.In this article,we study the notions of Cartan-Eilenberg FP_(n)injective and Cartan-Eilenberg FP_(n)-flat complexes.We also investigate duality pairs relative to the Cartan-Eilenberg FP_(n)-injective and Cartan-Eilenberg FP_(n)-flat complexes.As applications,we obtain that any complex admits Cartan-Eilenberg FP_(n)-injective(resp.,Cartan-Eilenberg FP_(n)-flat)cover and preenvelope and we characterize left n-coherent rings using these two classes of complexes.
文摘Dermatitis is a combination of various skin disease agents such as bacteria,fungi,ectoparasites,viruses and metabolic diseases with various clinical symptoms or signs.Dermatitis can cause an imbalance between ROS and antioxidants.Exogenous antioxidants are needed to help balance antioxidant and ROS levels in the body by providing trigona honey.This study aims to determine the MDA and SOD levels of dogs with complex dermatitis after administration of trigona honey.This study used 12 dogs with complex dermatitis,with a moderate severity score.Dogs 4-6 months old.Samples were divided into control group(P0)without honey,fresh honey group(P1)5 mL/head/day and capsule honey group(P2)0.1 mg/head/day.Honey was given for 4 weeks in the treatment group.Examination of MDA and SOD levels was carried out using the ELISA kit.The results showed that the Trigona honey treatment had a significant effect(P<0.05)in reducing MDA levels and increasing SOD levels in dogs with complex dermatitis.Duncan's test results showed that SOD levels increased significantly at week 4,while week 2 and week 0 did not increase significantly.Trigona honey has anti-inflammatory,antibacterial,antiaging,antiulcer effects,helps in wound healing dermatitis and is an antioxidant.So that trigona honey can reduce plasma MDA levels and increase plasma SOD levels in dogs with complex dermatitis.
文摘Complex survey designs often involve unequal selection probabilities of clus-ters or units within clusters. When estimating models for complex survey data, scaled weights are incorporated into the likelihood, producing a pseudo likeli-hood. In a 3-level weighted analysis for a binary outcome, we implemented two methods for scaling the sampling weights in the National Health Survey of Pa-kistan (NHSP). For NHSP with health care utilization as a binary outcome we found age, gender, household (HH) goods, urban/rural status, community de-velopment index, province and marital status as significant predictors of health care utilization (p-value < 0.05). The variance of the random intercepts using scaling method 1 is estimated as 0.0961 (standard error 0.0339) for PSU level, and 0.2726 (standard error 0.0995) for household level respectively. Both esti-mates are significantly different from zero (p-value < 0.05) and indicate consid-erable heterogeneity in health care utilization with respect to households and PSUs. The results of the NHSP data analysis showed that all three analyses, weighted (two scaling methods) and un-weighted, converged to almost identical results with few exceptions. This may have occurred because of the large num-ber of 3rd and 2nd level clusters and relatively small ICC. We performed a sim-ulation study to assess the effect of varying prevalence and intra-class correla-tion coefficients (ICCs) on bias of fixed effect parameters and variance components of a multilevel pseudo maximum likelihood (weighted) analysis. The simulation results showed that the performance of the scaled weighted estimators is satisfactory for both scaling methods. Incorporating simulation into the analysis of complex multilevel surveys allows the integrity of the results to be tested and is recommended as good practice.
基金National Key Research and Development Program of China(No.2022YFC3803000).
文摘According to news reports on severe earthquakes since 2008,a total of 51 cases with magnitudes of 6.0 or above were analyzed,and 14 frequently occurring secondary disasters were identified.A disaster chain model was developed using principles from complex network theory.The vulnerability and risk level of each edge in this model were calculated,and high-risk edges and disaster chains were identified.The analysis reveals that the edge“floods→building collapses”has the highest vulnerability.Implementing measures to mitigate this edge is crucial for delaying the spread of secondary disasters.The highest risk is associated with the edge“building collapses→casualties,”and increased risks are also identified for chains such as“earthquake→building collapses→casualties,”“earthquake→landslides and debris flows→dammed lakes,”and“dammed lakes→floods→building collapses.”Following an earthquake,the prompt implementation of measures is crucial to effectively disrupt these chains and minimize the damage from secondary disasters.
基金the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(No.ZNLH-201907)the Hubei Province Health and Family Planning Scientific Research Project(No.WJ2019Q041)the Chinese Academy of Medical Science Innovation Fund for Medical Sciences(No.2021-I2M-1-009).
文摘Objective There is a large population of patients classified as complex higher-risk and indicated patients(CHIPs)in China with a poor prognosis.The treatment of these patients is complex and challenging,especially when acute cardiac events occur,such as acute coronary syndrome(ACS)or heart failure.Pharmacotherapy and some mechanical circulatory support(MCS)therapeutic devices can provide stable hemodynamic support for CHIPs-percutaneous coronary intervention(PCI).LDL-C is an important pathogenic factor in atherosclerosis,and the target of blood lipid control.Recent studies have revealed that lipoprotein(a)[Lp(a)],which is formed when a covalent bond between apolipoprotein(a)and apolipoprotein B-100 is made,produces an LDL-like particle.This particle is an independent risk factor for the development of atherosclerosis,and is closely correlated to stent thrombosis and restenosis.Furthermore,this requires active intervention.PCSK9 inhibitors have been used in lipid-lowering treatment,and preventing atherosclerosis.The present study explores the efficacy of PCSK9 inhibitors in CHIPs-ACS,and the association between the change in Lp(a)and survival after 2 years of follow-up.Methods The present real-world,prospective control study enrolled 321 CHIPs-ACS who underwent emergency PCI from August 2019 to November 2020,and these patients were followed up for 2 years.These patients were divided into two groups:PCSK9 group(n=161)given the combined PCSK9 inhibitor(140 mg of evolocumab every 2 weeks)and statins-based therapy,and SOC group(n=160)treated with statin-based lipid-lowering therapy alone.Then,the change in lipid index was measured,and the cardiovascular(CV)event recurrence rate was evaluated after one month and 2 years.Afterwards,the contribution of serum lipid parameters,especially the Lp(a)alteration,in patients with earlier initiation of the PCSK9 inhibitor to the CV outcome was analyzed.Results The LDL-C level was significantly reduced in both groups:52.3%in the PCSK9 group and 32.3%(P<0.001)in the SOC group.It is noteworthy that the Lp(a)level decreased by 13.2%in the PCSK9 group,but increased by 30.3%in the SOC group(P<0.001).Furthermore,the number of CV events was not significantly different between the PCSK9 and SOC groups after the 2-year follow-up period.In the PCSK9 group,the Lp(a)reduction was associated with the baseline Lp(a)levels of the patients(r2=−0.315,P<0.001).Moreover,the decrease in Lp(a)contributed to the decline in CV events in patients who received ACS CHIPs-PCI,and the decrease in Lp(a)level was independent of the LDL-C level reduction.Conclusion The early initiation of PCSK9 inhibitors can significantly reduce the LDL-C and Lp(a)levels in ACS CHIPs-PCI.However,further studies are needed to confirm whether PCSK9 inhibitors can reduce the incidence of CV disease in CHIPs.
文摘To increase accuracy of navigation parameters,a perspective measuring complex with intellectual components is developed.Conception of synthesis optimal structure of the measuring complex is realized basing on a selective method using principles of the functional systems.Selection of measured information is finished by original numeric criterion of observation level of state vector components.Prediction is realized by algorithm of self-organization that makes synthesis of the optimal complication.Therefore mechanism of self-regulation is realized and accuracy of the selective navigation complex is increased.
基金Project supported by the National Natural Science Foundation of China(Grant No.61671142)
文摘Studying the topology of infrastructure communication networks(e.g., the Internet) has become a means to understand and develop complex systems. Therefore, investigating the evolution of Internet network topology might elucidate disciplines governing the dynamic process of complex systems. It may also contribute to a more intelligent communication network framework based on its autonomous behavior. In this paper, the Internet Autonomous Systems(ASes) topology from 1998 to 2013 was studied by deconstructing and analysing topological entities on three different scales(i.e., nodes,edges and 3 network components: single-edge component M1, binary component M2 and triangle component M3). The results indicate that: a) 95% of the Internet edges are internal edges(as opposed to external and boundary edges); b) the Internet network consists mainly of internal components, particularly M2 internal components; c) in most cases, a node initially connects with multiple nodes to form an M2 component to take part in the network; d) the Internet network evolves to lower entropy. Furthermore, we find that, as a complex system, the evolution of the Internet exhibits a behavioral series,which is similar to the biological phenomena concerned with the study on metabolism and replication. To the best of our knowledge, this is the first study of the evolution of the Internet network through analysis of dynamic features of its nodes,edges and components, and therefore our study represents an innovative approach to the subject.
基金supported by the National High Technology Research and Development Program (863 Program) (2011AA040502).
文摘Multi-disciplinary virtual prototypes of complex products are increasingly and widely used in modern advanced manufactur- ing. How to effectively address the problems of unified modeling, composition and reuse based on the multi-disciplinary heteroge- neous models has brought great challenges to the modeling and simulation （M＆S） science and technology. This paper presents a top-level modeling theory based on the meta modeling framework （M2F） of the COllaborative SIMulation （COSlM） theory of virtual prototyping to solve the problems. Firstly the fundamental prin- ciples of the top-level modeling theory are decribed to expound the premise, assumptions, basic conventions and special require- ments in the description of complex heterogeneous systems. Next the formalized definitions for each factor in top level modeling are proposed and the hierarchical nature of them is illustrated. After demonstrating that they are self-closing, this paper divides the top- level modeling into two views, static structural graph and dynamic behavioral graph. Finally, a case study is discussed to demon- strate the feasibility of the theory.
