Objective:This study was aimed at investigating factors influencing the progression of native coronary atherosclerosis after percutaneous coronary intervention(PCI).Methods:A cohort of 462 patients was classified into...Objective:This study was aimed at investigating factors influencing the progression of native coronary atherosclerosis after percutaneous coronary intervention(PCI).Methods:A cohort of 462 patients was classified into progressive(n=73)or non-progressive(n=389)groups according to the presence of native coronary atherosclerosis progression on coronary angiography.Clinical data and angiography results were compared during follow-up,and the time to progression of native coronary atherosclerosis was recorded.Subsequently,multivariate Cox regression analysis was conducted.Results:In comparison to the non-progressive group,the progressive group had higher levels of glycosylated hemoglobin(HbA1c)and triglycerides(TG),and higher scores on the Synergy Between PCI with Taxus and Cardiac Surgery(SYNTAX)scale,but lower levels of high-density lipoprotein cholesterol.Moreover,the rates of hyperuricemia and acute coronary syndrome(ACS)were higher in the progressive group than the non-progressive group.Multivariate analysis identified ACS,HbA1c level≥6.5%,TG level≥5.6 mmol/L,and SYNTAX score≥23 as risk factors for the progression of native coronary atherosclerosis.Conclusion:ACS,elevated HbA1c and TG levels,and higher SYNTAX scores may be associated with the progression of native coronary atherosclerosis after PCI.展开更多
Antiplatelet therapy is the cornerstone for the management of patients with coronary artery disease. In the past two decades, the study on individualized antiplatelet therapy has never been more prosperous accompanied...Antiplatelet therapy is the cornerstone for the management of patients with coronary artery disease. In the past two decades, the study on individualized antiplatelet therapy has never been more prosperous accompanied with the rapid growth of percutaneous coronary interventions （PCIs）.展开更多
High-precision tissue incision in cardiovascular interventions remains hindered by thermal damage and mechanical trauma from conventional tools.Herein,we present a high-peak-power,all-fiber femtosecond laser system in...High-precision tissue incision in cardiovascular interventions remains hindered by thermal damage and mechanical trauma from conventional tools.Herein,we present a high-peak-power,all-fiber femtosecond laser system integrat-ing gain-managed nonlinear(GMN)amplification and hollow-core photonic bandgap fiber(HC-PBGF)compres-sion.The system delivers direct output pulses with durations of~50 fs and peak powers of>10 MW across a repetition rate range of 0.1-5.6 MHz.Notably,at the lowest repetition rate of 0.1 MHz,the system achieves pulse durations as short as 45 fs with a peak power reaching 14.4 MW,representing the highest peak power ever reported for a fully fiber-integrated femtosecond laser architecture.Experimental evaluations via myocardial incision and atrial septal puncture confirmed exceptional tissue-selective incision performance of the system,with no detectable thermal injury or carbonization observed following the procedure.These results overcome critical limitations of existing minimally invasive cardiac instruments,such as collateral thermal effects and inflexible optical configura-tions.By synergizing GMN spectral control with HC-PBGF dispersion engineering,this compact platform enables sub-100 fs pulse compression within<1 m fibers,resolving key barriers to clinical translation.The technology establishes a transformative pathway for cardiovascular catheter-based interventions,offering unprecedented precision for functional tissue preservation and postoperative recovery.展开更多
文摘Objective:This study was aimed at investigating factors influencing the progression of native coronary atherosclerosis after percutaneous coronary intervention(PCI).Methods:A cohort of 462 patients was classified into progressive(n=73)or non-progressive(n=389)groups according to the presence of native coronary atherosclerosis progression on coronary angiography.Clinical data and angiography results were compared during follow-up,and the time to progression of native coronary atherosclerosis was recorded.Subsequently,multivariate Cox regression analysis was conducted.Results:In comparison to the non-progressive group,the progressive group had higher levels of glycosylated hemoglobin(HbA1c)and triglycerides(TG),and higher scores on the Synergy Between PCI with Taxus and Cardiac Surgery(SYNTAX)scale,but lower levels of high-density lipoprotein cholesterol.Moreover,the rates of hyperuricemia and acute coronary syndrome(ACS)were higher in the progressive group than the non-progressive group.Multivariate analysis identified ACS,HbA1c level≥6.5%,TG level≥5.6 mmol/L,and SYNTAX score≥23 as risk factors for the progression of native coronary atherosclerosis.Conclusion:ACS,elevated HbA1c and TG levels,and higher SYNTAX scores may be associated with the progression of native coronary atherosclerosis after PCI.
文摘Antiplatelet therapy is the cornerstone for the management of patients with coronary artery disease. In the past two decades, the study on individualized antiplatelet therapy has never been more prosperous accompanied with the rapid growth of percutaneous coronary interventions （PCIs）.
基金National Natural Science Foundation of China(62035002)Natural Science Foundation of Beijing Municipality(1244050).
文摘High-precision tissue incision in cardiovascular interventions remains hindered by thermal damage and mechanical trauma from conventional tools.Herein,we present a high-peak-power,all-fiber femtosecond laser system integrat-ing gain-managed nonlinear(GMN)amplification and hollow-core photonic bandgap fiber(HC-PBGF)compres-sion.The system delivers direct output pulses with durations of~50 fs and peak powers of>10 MW across a repetition rate range of 0.1-5.6 MHz.Notably,at the lowest repetition rate of 0.1 MHz,the system achieves pulse durations as short as 45 fs with a peak power reaching 14.4 MW,representing the highest peak power ever reported for a fully fiber-integrated femtosecond laser architecture.Experimental evaluations via myocardial incision and atrial septal puncture confirmed exceptional tissue-selective incision performance of the system,with no detectable thermal injury or carbonization observed following the procedure.These results overcome critical limitations of existing minimally invasive cardiac instruments,such as collateral thermal effects and inflexible optical configura-tions.By synergizing GMN spectral control with HC-PBGF dispersion engineering,this compact platform enables sub-100 fs pulse compression within<1 m fibers,resolving key barriers to clinical translation.The technology establishes a transformative pathway for cardiovascular catheter-based interventions,offering unprecedented precision for functional tissue preservation and postoperative recovery.
