Heart function and plasma atrial natriuretic peptide (ANP).plasma renin actiity(PRA) andangiotensionⅡ(Ang Ⅱ) were examined with echocardiography and radioimmunoassay in patients with dilated cardiomyopathy(DCM),
Over the last two decades, the rise in the prevalence rates of overweight and obesity explains the emergence of nonalcoholic fatty liver disease(NAFLD) as the leading cause of chronic liver disease worldwide. As descr...Over the last two decades, the rise in the prevalence rates of overweight and obesity explains the emergence of nonalcoholic fatty liver disease(NAFLD) as the leading cause of chronic liver disease worldwide. As described in adults, children and adolescents with fatty liver display insulin resistance, glucose intolerance, and dyslipidemia. Thus NAFLD has emerged as the hepatic component of the metabolic syndrome(MetS) and a strong cardiovascular risk factor even at a very early age. Several studies, including pediatric populations, have reported independent associations between NAFLD and markers of subclinical atherosclerosis including impaired flow-mediated vasodilation, increased carotid artery intima-media thickness, and arterial stiffness, after adjusting for cardiovascular risk factors and MetS. Also, it has been shown that NAFLD is associated with cardiac alterations, including abnormal left ventricular structure and impaired diastolic function. The duration of these subclinical abnormalities may be important, because treatment to reverse the process is most likely to be effective earlier in the disease. In the present review, we examine the current evidence on the association between NAFLD and atherosclerosis as well as between NAFLD and cardiac dysfunction in the pediatric population, and discuss briefly the possible biological mechanisms linking NAFLD and cardiovascular changes. We also address the approach to treatment for this increasingly prevalent disease, which is likely to have an important future global impact on the burden of ill health, to prevent not only end-stage liver disease but also cardiovascular disease.展开更多
Heart failure(HF)represents a multifaceted clinical syndrome featured by cardiac structural or functional abnormalities secondary to diverse etiologies.Neurohormonal activation,including sympathetic nervous system(SNS...Heart failure(HF)represents a multifaceted clinical syndrome featured by cardiac structural or functional abnormalities secondary to diverse etiologies.Neurohormonal activation,including sympathetic nervous system(SNS)and the renin-angiotensin-aldosterone system(RAAS),is one of the most important mechanisms underlying the pathogenesis of HF.Since the 1990s,a growing number of experimental and clinical studies have shown that immunoinflammation makes an important contribution to the pathogenesis of HF.Recently,the immunoinflammation mechanisms of HF have been highlighted by clinical studies showing that interleukin(IL)-1β antagonists can prevent HF in patients with coronary heart disease(CHD)and acute ST-segment elevation myocardial infarction(STEMI).展开更多
文摘Heart function and plasma atrial natriuretic peptide (ANP).plasma renin actiity(PRA) andangiotensionⅡ(Ang Ⅱ) were examined with echocardiography and radioimmunoassay in patients with dilated cardiomyopathy(DCM),
文摘Over the last two decades, the rise in the prevalence rates of overweight and obesity explains the emergence of nonalcoholic fatty liver disease(NAFLD) as the leading cause of chronic liver disease worldwide. As described in adults, children and adolescents with fatty liver display insulin resistance, glucose intolerance, and dyslipidemia. Thus NAFLD has emerged as the hepatic component of the metabolic syndrome(MetS) and a strong cardiovascular risk factor even at a very early age. Several studies, including pediatric populations, have reported independent associations between NAFLD and markers of subclinical atherosclerosis including impaired flow-mediated vasodilation, increased carotid artery intima-media thickness, and arterial stiffness, after adjusting for cardiovascular risk factors and MetS. Also, it has been shown that NAFLD is associated with cardiac alterations, including abnormal left ventricular structure and impaired diastolic function. The duration of these subclinical abnormalities may be important, because treatment to reverse the process is most likely to be effective earlier in the disease. In the present review, we examine the current evidence on the association between NAFLD and atherosclerosis as well as between NAFLD and cardiac dysfunction in the pediatric population, and discuss briefly the possible biological mechanisms linking NAFLD and cardiovascular changes. We also address the approach to treatment for this increasingly prevalent disease, which is likely to have an important future global impact on the burden of ill health, to prevent not only end-stage liver disease but also cardiovascular disease.
基金The Noncommunicable Chronic Diseases—National Science and Technology Major Project(Nos.2025ZD0548400 and 2023ZD0504600)the National Key Research and Development Program(No.2022YFC2503501)+1 种基金Hubei Technology Innovation Project(No.2024BCB046)Key Research and Development Program of Wuhan(No.2024020702030092).
文摘Heart failure(HF)represents a multifaceted clinical syndrome featured by cardiac structural or functional abnormalities secondary to diverse etiologies.Neurohormonal activation,including sympathetic nervous system(SNS)and the renin-angiotensin-aldosterone system(RAAS),is one of the most important mechanisms underlying the pathogenesis of HF.Since the 1990s,a growing number of experimental and clinical studies have shown that immunoinflammation makes an important contribution to the pathogenesis of HF.Recently,the immunoinflammation mechanisms of HF have been highlighted by clinical studies showing that interleukin(IL)-1β antagonists can prevent HF in patients with coronary heart disease(CHD)and acute ST-segment elevation myocardial infarction(STEMI).
