Fully synthetic vaccine,in which one or multi-molecular antigens are conjugated to a synthetic carrier with well-defined chemical structure,is a new direction to develop carbohydrate-based vaccine against cancer and p...Fully synthetic vaccine,in which one or multi-molecular antigens are conjugated to a synthetic carrier with well-defined chemical structure,is a new direction to develop carbohydrate-based vaccine against cancer and pathogens.Toll like receptor(TLR)agonists with the ability to stimulate immune response have been widely investigated and been applied as build-in adjuvants to construct fully synthetic vaccines.In particular,remarkable progress has been achieved in recent years in the development of vaccines constructed with the agonists of TLRI 2,TLR2/6 and TLR4 and tumor-associated carbohydrate antigens(TACAs).These di-,tri-or multi-component vaccine candidates showed attractive immunologi-cal properties.This review highlights recent advances in developing full synthetic carbohydrate antigen based vaccines,with an emphasis on the structure-activity relationships that provide a primary basis for future vaccine design and immunotherapy developing.展开更多
Carbohydrates are fundamental molecules involved in nearly all aspects of lives,such as being involved in formating the genetic and energy materials,supporting the structure of organisms,constituting invasion and host...Carbohydrates are fundamental molecules involved in nearly all aspects of lives,such as being involved in formating the genetic and energy materials,supporting the structure of organisms,constituting invasion and host defense systems,and forming antibiotics secondary metabolites.The naturally occurring carbohydrates and their derivatives have been extensively studied as therapeutic agents for the treatment of various diseases.During 2000 to 2021,totally 54 carbohydrate-based drugs which contain carbohydrate moities as the major structural units have been approved as drugs or diagnostic agents.Here we provide a comprehensive review on the chemical structures,activities,and clinical trial results of these carbohydrate-based drugs,which are categorized by their indications into antiviral drugs,antibacterial/antiparasitic drugs,anticancer drugs,antidiabetics drugs,cardiovascular drugs,nervous system drugs,and other agents.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21472070,21602084)the project for Jiangsu Scientific and Technological Innovation Team+4 种基金the fund for Jiangsu Distinguished Professorship Programthe project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe 111 Project(No.111-2-06)the Fundamental Research Funds for the Central Universities(No.JUSRP11729)the Open Foundation of Key Laboratory of Carbohydrate Chemistry&Biotechnology Ministry of Education(No.KLCCB-KF201608)
文摘Fully synthetic vaccine,in which one or multi-molecular antigens are conjugated to a synthetic carrier with well-defined chemical structure,is a new direction to develop carbohydrate-based vaccine against cancer and pathogens.Toll like receptor(TLR)agonists with the ability to stimulate immune response have been widely investigated and been applied as build-in adjuvants to construct fully synthetic vaccines.In particular,remarkable progress has been achieved in recent years in the development of vaccines constructed with the agonists of TLRI 2,TLR2/6 and TLR4 and tumor-associated carbohydrate antigens(TACAs).These di-,tri-or multi-component vaccine candidates showed attractive immunologi-cal properties.This review highlights recent advances in developing full synthetic carbohydrate antigen based vaccines,with an emphasis on the structure-activity relationships that provide a primary basis for future vaccine design and immunotherapy developing.
基金supported by the National Natural Science Foundation of China(82173662,22031011,and 21621002)Natural Science Foundation of Shanghai(20ZR1410400,China)+2 种基金the Shanghai Municipal Science and Technology Major Project,the State Key Basic Research Program of the China(2018YFC0310905)the Extraordinary 2025 Elite Project of Fudan University,the Open Funding of Key Laboratory of Diagnosis and Treatment of Severe Hepato-pancreatic Diseases of Zhejiang Province(2018E10008,China)the Open Funding of State Key Laboratory of Bio-organic and Natural Products Chemistry.
文摘Carbohydrates are fundamental molecules involved in nearly all aspects of lives,such as being involved in formating the genetic and energy materials,supporting the structure of organisms,constituting invasion and host defense systems,and forming antibiotics secondary metabolites.The naturally occurring carbohydrates and their derivatives have been extensively studied as therapeutic agents for the treatment of various diseases.During 2000 to 2021,totally 54 carbohydrate-based drugs which contain carbohydrate moities as the major structural units have been approved as drugs or diagnostic agents.Here we provide a comprehensive review on the chemical structures,activities,and clinical trial results of these carbohydrate-based drugs,which are categorized by their indications into antiviral drugs,antibacterial/antiparasitic drugs,anticancer drugs,antidiabetics drugs,cardiovascular drugs,nervous system drugs,and other agents.
