This study investigates the formation feasibility of the integrated bottom car body components with dual die casting injection molding technology.During the production of a die-cast super-large one-piece body part wei...This study investigates the formation feasibility of the integrated bottom car body components with dual die casting injection molding technology.During the production of a die-cast super-large one-piece body part weighing over 10,000 t,a thorough comparison and investigation were conducted on the arising issues,using both single and double injection systems.Particular attention was given to meticulously discussing the die casting filling problems and microstructural defects that originated from the filling process.The research findings indicate that the implementation of a double injection system can significantly minimize cold shuts and reduce the solidification time.The effectiveness of this die casting technique was further confirmed by the production of high-quality castings using a scaled model that replicated real casting conditions at a 1:3 ratio,thereby maintaining a one-to-one correspondence in essential aspects.This successful study offers both theoretical insights and practical applications for the production of integrated bottom car bodies utilizing die casting in conjunction with a dual injection system.展开更多
A recently published study(Xin et al.,Prog Biochem Biophys,2026,53(2):431-441.DOI:10.3724/j.pibb.2025.0508)addresses the therapeutic challenges of pancreatic ductal adenocarcinoma(PDAC)by innovatively developing an or...A recently published study(Xin et al.,Prog Biochem Biophys,2026,53(2):431-441.DOI:10.3724/j.pibb.2025.0508)addresses the therapeutic challenges of pancreatic ductal adenocarcinoma(PDAC)by innovatively developing an orally administered nanogene delivery system.Designed to achieve in situ,efficient delivery of chimeric antigen receptor(CAR)genes to tumor sites,this approach offers a novel strategy for CAR-macrophage(CAR-M)based immunotherapy.Its key highlights are as follows.展开更多
Aerodynamic research on road cars was reviewed in this work under the thread of reducing drag,with the awareness that this may succeed in effectively decreasing the carbon footprint of transportation.First,a selection...Aerodynamic research on road cars was reviewed in this work under the thread of reducing drag,with the awareness that this may succeed in effectively decreasing the carbon footprint of transportation.First,a selection of studies was presented to focus on the most important aerodynamic features of the flow around realistic car body shapes.Then,the discussion was organized around three pillars related to passive flow control,active flow control and active aerodynamics.Both experimental and numerical investigations were included to provide a comprehensive overview.A clear distinction was made between simplified and realistic car models,as well as production vehicles(within the limits of restricted access information).Moreover,a short essay was dedicated to electric vehicles,for which aerodynamics matters,especially at highway speeds.Last,the impact of aerodynamic principles on the design of current and future vehicle fleet was assessed,honestly admitting that recent market trends must be reversed to turn decarbonization goals into reality and damp the effects of global warming.展开更多
The paradigm of cancer treatment has been reshaped by chimeric antigen receptor(CAR)αβT cell therapy,yet its full potential remains constrained by fundamental limitations.While conventional CARαβT cells have achie...The paradigm of cancer treatment has been reshaped by chimeric antigen receptor(CAR)αβT cell therapy,yet its full potential remains constrained by fundamental limitations.While conventional CARαβT cells have achieved notable success in hematological malignancies,their broader application is hindered by the high cost and delays of autologous manufacturing,as well as the critical risk of graft-vs-host disease(GvHD).In addition,their efficacy against solid tumors is often compromised by the immunosuppressive tumor microenvironment(TME).As a promising solution,γδT cells are being developed as an alternative CAR platform.Their intrinsic ability to recognize transformed cells in a major histocompatibility complex(MHC)-independent manner minimizes the risk of GvHD and supports the creation of safe,effective allogeneic therapies.Building on this unique biology,the therapeutic efficacy of CARγδT cells is being enhanced through advanced engineering strategies.Key innovations include“armoring”technologies,such as cytokine secretion,checkpoint blockade,and metabolic rewiring,to overcome local immunosuppression and improve persistence,as well as the use of induced pluripotent stem cells(iPSCs)to generate standardized products from a renewable and consistent source.This expanding technological toolbox is also enabling novel applications beyond oncology.For example,chimeric autoantibody receptor(CAAR)constructs built onγδT cells integrate both classical and emerging insights into CARγδT cell therapy,highlighting innovations that are driving the field toward safer,more versatile,and longer-lasting treatments for cancer and autoimmunity.In light of these advancements,this review provides an overview of the current understanding ofγδT cell biology and highlights emerging engineering strategies that enhance the efficacy and durability of CARγδT cells across oncologic and autoimmune contexts.展开更多
Lower limb injures are frequently observed in passenger car traffic accidents.Previous studies of the injuries focus on long bone fractures by using either cadaver component tests or simulations of the long bone kinem...Lower limb injures are frequently observed in passenger car traffic accidents.Previous studies of the injuries focus on long bone fractures by using either cadaver component tests or simulations of the long bone kinematics,which lack in-depth study on the fractures in stress analysis.This paper aims to investigate lower limb impact biomechanics in real-world car to pedestrian accidents and to predict fractures of long bones in term of stress parameter for femur,tibia,and fibula.For the above purposes,a 3D finite element(FE) model of human body lower limb(HBM-LL) is developed based on human anatomy.The model consists of the pelvis,femur,tibia,fibula,patella,foot bones,primary tendons,knee joint capsule,meniscus,and ligaments.The FE model is validated by comparing the results from a lateral impact between simulations and tests with cadaver lower limb specimens.Two real-world accidents are selected from an in-depth accident database with detailed information about the accident scene,car impact speed,damage to the car,and pedestrian injuries.Multi-body system(MBS) models are used to reconstruct the kinematics of the pedestrians in the two accidents and the impact conditions are calculated for initial impact velocity and orientations of the car and pedestrian during the collision.The FE model is used to perform injury reconstructions and predict the fractures by using physical parameters,such as von Mises stress of long bones.The calculated failure level of the long bones is correlated with the injury outcomes observed from the two accident cases.The reconstruction result shows that the HBM-LL FE model has acceptable biofidelity and can be applied to predict the risk of long bone fractures.This study provides an efficient methodology to investigate the long bone fracture suffered from vehicle traffic collisions.展开更多
The automatic control of clutch starting in car with a metal pushingbelt-planetary gear continuously variable transmission (CVT) is a complex problem. A suited controlstrategy is required to realize quick and smooth s...The automatic control of clutch starting in car with a metal pushingbelt-planetary gear continuously variable transmission (CVT) is a complex problem. A suited controlstrategy is required to realize quick and smooth start. A simulation state space equation isestablished on clutch staring control of a car with CVT by bond graph theory. According to the fuzzycontrol method with the expert system, a fuzzy control system of car starting process to weaken thejerk motion is introduced. The simulation results indicate that the jerk motion of clutch startingis below 10 m/s^3.展开更多
The most remarkable characteristic of a metal belt-planetary gearcontinuously variable transmission is a wider ratio range and a bigger torque capacity than aconventional metal pushing belt continuously variable trans...The most remarkable characteristic of a metal belt-planetary gearcontinuously variable transmission is a wider ratio range and a bigger torque capacity than aconventional metal pushing belt continuously variable transmission. A parallel hybrid car with thistransmission system not only can reduce fuel consumption and pollutant emission at a ECE city cycle,but also can keep the motor working in the most efficiency area and can be started by a lower powermotor by oneself. At the same time, the continuously variable transmission system can realize thesmooth switch between the motor and the engine.展开更多
The Cloud Aerosol- Radiation （CAR） ensemble modeling system has recently been built to better un- derstand cloud/aerosol/radiation processes and determine the uncertainties caused by different treatments of cloud/ae...The Cloud Aerosol- Radiation （CAR） ensemble modeling system has recently been built to better un- derstand cloud/aerosol/radiation processes and determine the uncertainties caused by different treatments of cloud/aerosol/radiation in climate models. The CAR system comprises a large scheme collection of cloud, aerosol, and radiation processes available in the literature, including those commonly used by the world＇s leading GCMs. In this study, detailed analyses of the overall accuracy and efficiency of the CAR system were performed. Despite the different observations used, the overall accuracies of the CAR ensemble means were found to be very good for both shortwave （SW） and longwave （LW） radiation calculations. Taking tile percentage errors for July 2004 compared to ISCCP （International Satellite Cloud Climatology Project） data over （60~N, 60~S） as an example, even among the 448 CAR members selected here, those errors of the CAR ensemble means were only about -0.67% （-0.6 W m-2） and -0.82% （-2.0 W m-2） for SW and LW upward fluxes at the top of atmosphere, and 0.06% （0.1 W m-2） and -2.12% （-7.8 W m 2） for SW and LW downward fluxes at the surface, respectively. Furthermore, model SW frequency distributions in July 2004 covered the observational ranges entirely, with ensemble means located in the middle of the ranges. Moreover, it was found that the accuracy of radiative transfer calculations can be significantly enhanced by＂ using certain combinations of cloud schemes for the cloud cover fraction, particle effective size, water path, and optical properties, along with better explicit treatments for unresolved cloud structures.展开更多
This paper presents the construction of a pneumatic active suspension system for a one-wheel car model using fuzzy reasoning and a disturbance observer. The one-wheel car model can be approximately described as a nonl...This paper presents the construction of a pneumatic active suspension system for a one-wheel car model using fuzzy reasoning and a disturbance observer. The one-wheel car model can be approximately described as a nonlinear two degrees of freedom system subject to excitation from a road profile. The active control is composed of fuzzy and disturbance controls, and the active control force is constructed by actuating a pneumatic actuator. A phase lead-lag compensator is inserted to counter the performance degradation due to the delay of the pneumatic actuator. The experimental result indicates that the proposed active suspension improves much the vibration suppression of the car model.展开更多
The continuous increase of human mobility combined with a relevant use of private vehicles contributes to increase the ill effects of vehicle externalities on the environment, e.g. high levels of air pollution, toxic ...The continuous increase of human mobility combined with a relevant use of private vehicles contributes to increase the ill effects of vehicle externalities on the environment, e.g. high levels of air pollution, toxic emissions, noise pollution, and on the quality of life, e.g. parking problem, traffic congestion, and increase in the number of crashes and accidents. Transport demand management plays a very critical role in achieving greenhouse gas emission reduction targets. This study demonstrates that car pooling (CP) is an effective strategy to reduce transport volumes, transportation costs and related hill externalities in agreement with EU programs of emissions reduction targets. This paper presents an original approach to solve the CP problem. It is based on hierarchical clustering models, which have been adopted by an original decision support system (DSS). The DSS helps mobility managers to generate the pools and to design feasible paths for shared vehicles. A significant case studies and obtained results by the application of the proposed models are illustrated. They demonstrate the effectiveness of the approach and the supporting decisions tool.展开更多
Torpedo cars,for the hot metal transportation by rail,play an indispensable role in China Steel Corporation (CSC)'s production.In order to meet the requirements of continual progress in hot metal production and sa...Torpedo cars,for the hot metal transportation by rail,play an indispensable role in China Steel Corporation (CSC)'s production.In order to meet the requirements of continual progress in hot metal production and safety management,the torpedo car tracking system suitable for our identification has been built up.This system not only combines the applications of of radio frequency identification(RFID) for accurately locating and radio modems to transmit the torpedo car position data,but also integrates the monitoring of railway switch machines and level crossings as well as the torpedo cars management system.Accordingly all torpedo car positions and operation data of railway equipments can be displayed in the control center for the reference of the effectively monitoring of torpedo cars and the dispatching of missions.展开更多
Perfect combination of structural size parameters of the hydroforming billets is essential to obtain even wall thicknesses of the car beam. Finite element （ FE ） analysis on hydroforming car beam was carried out, a...Perfect combination of structural size parameters of the hydroforming billets is essential to obtain even wall thicknesses of the car beam. Finite element （ FE ） analysis on hydroforming car beam was carried out, and the results were optimized according to multiple quality objectives by the grey system theory. With bending angle, bending radius and hight difference along the axis direction as variables, orthogonal FE analyses were conducted and the minimum and maximum wall thicknes ses of the billets with different sizes were obtained. Taking the minimum and maximum wall thick nesses as two references, the correlation coefficient between the data for reference and those for comparison by the grey system theory reduced multi objectives to a single quality objective, and the average correlation level of every billet facilitated the optimization of size parameters for hydroform ing car beam. The trial production showed that the optimization approach satisfied the need of hy droforming car beams.展开更多
Noise,vibration and harshness(NVH)problems in vehicle engineering are always challenging in both traditional vehicles and intelligent vehicles.Although high accuracy manufacturing,modern structural roads and advanced ...Noise,vibration and harshness(NVH)problems in vehicle engineering are always challenging in both traditional vehicles and intelligent vehicles.Although high accuracy manufacturing,modern structural roads and advanced suspension technology have already significantly reduced NVH problems and their impacts;off-road condition,obstacles and extreme operating condition could still trigger NVH problems unexpectedly.This paper proposes a vehicular electronic image stabilization(EIS)system to solve the vibration problem of the camera and ensure the environment perceptive function of vehicles.Firstly,feature point detection and matching based on an oriented FAST and rotated BRIEF(ORB)algorithm are implemented to match images in the process of EIS.Furthermore,a novel improved random sampling consensus algorithm(i-RANSAC)is proposed to eliminate mismatched feature points and increase the matching accuracy significantly.And an adaptive Kalman filter(AKF)is applied to improve the adaptability of the vehicular EIS.Finally,an experimental platform based on a gasoline model car was established to validate its performance.The experimental results show that the proposed EIS system can satisfy vehicular performance requirements even under off-road condition with obvious obstacles.展开更多
Combination of a bus system and cable car system can reduce the overall congestion of traffic in urban areas, where surrounding hills or mountains hold larger settlements or tourist and recreational infrastructure. Wi...Combination of a bus system and cable car system can reduce the overall congestion of traffic in urban areas, where surrounding hills or mountains hold larger settlements or tourist and recreational infrastructure. With this kind of integration number of individual car trips can be significantly reduced. In this paper, the authors present an analysis of the pilot project implementation, which was held in Maribor. The authors conducted a limited test trial of two means of transportation, combining them into a single operating transport offer for inhabitants and tourists. Combined transport option proved to be a good starting point for reduction of traffic and parking congestion during winter tourist season and beyond. Method used in the research, in order to gain actual potential of integrating two systems and improving public transport offer, was establishment and implementation of the pilot project in Maribor during January 2011. Data was gathered through interviews of two interest groups. The first covered the users who were brought to the foothills of Pohorje＇s ski center by bus. The second covered the cable car users that were traveling to the top of Pohorje. For a limited time period, a trial principle of a single ticket was established, which gave ski-pass holders free bus ride on bus line No. 6. With the aim of reducing CO2, test drives of hybrid bus and compressed natural gas bus were conducted alongside many promotional activities with which users were informed of importance of environmentally friendly mobility options.展开更多
With the rapid improvement of China’s economic level and the rapid development of e-commerce, the demand for logistics warehousing, which is one of the most important links in the logistics transportation system, has...With the rapid improvement of China’s economic level and the rapid development of e-commerce, the demand for logistics warehousing, which is one of the most important links in the logistics transportation system, has also greatly increased. The dispatching management system applied in the warehouse has a wide range of applications in the logistics storage system. Improving the operational efficiency of the dispatching management system can effectively improve the efficiency of the automated warehouse system and reduce the cost of logistics transportation. Therefore, this paper designs a set of dispatching systems with the tracking car as the control target and realizes the positioning and path planning functions of the tracking car in the system. At present, the tracking car can completely receive the commands sent by the system, accurately follow the established path. At the same time, the system software can also obtain the video images taken by the camera on the car and play them smoothly.展开更多
腺病毒(Adenovirus,Ad)是一类无包膜的双链DNA病毒,能广泛感染脊椎动物,导致从轻症到严重的感染。腺病毒通过其纤突蛋白与宿主细胞表面受体结合,柯萨奇-腺病毒受体(Coxsackievirus and adenovirus receptor,CAR)是主要的介导者。CAR是...腺病毒(Adenovirus,Ad)是一类无包膜的双链DNA病毒,能广泛感染脊椎动物,导致从轻症到严重的感染。腺病毒通过其纤突蛋白与宿主细胞表面受体结合,柯萨奇-腺病毒受体(Coxsackievirus and adenovirus receptor,CAR)是主要的介导者。CAR是一种高度保守的跨膜蛋白,在多种脊椎动物中发挥关键作用。文章聚焦于CAR的生物学功能和结构特征,探讨其在腺病毒感染机制中的核心作用;重点分析了CAR与人腺病毒、禽腺病毒及其他物种腺病毒的相互作用及功能差异,揭示腺病毒与宿主受体结合的多样性和复杂性。此外,文章讨论了CAR在基因治疗中的应用前景,特别是利用CAR介导的腺病毒载体递送抗癌基因和免疫调节基因的研究进展。同时,调控CAR表达水平及阻断其与病毒结合的策略被认为是优化腺病毒治疗的重要方向。文章通过总结现有研究成果,深化了对腺病毒感染机制的认识,并为基因治疗及相关疾病的治疗策略提供了重要的理论依据和实践参考。展开更多
基金supported by the National Natural Science Foundation of China(No.52175284)the National Key Research and Development Program of China(Grant No.2022YFB3404201).
文摘This study investigates the formation feasibility of the integrated bottom car body components with dual die casting injection molding technology.During the production of a die-cast super-large one-piece body part weighing over 10,000 t,a thorough comparison and investigation were conducted on the arising issues,using both single and double injection systems.Particular attention was given to meticulously discussing the die casting filling problems and microstructural defects that originated from the filling process.The research findings indicate that the implementation of a double injection system can significantly minimize cold shuts and reduce the solidification time.The effectiveness of this die casting technique was further confirmed by the production of high-quality castings using a scaled model that replicated real casting conditions at a 1:3 ratio,thereby maintaining a one-to-one correspondence in essential aspects.This successful study offers both theoretical insights and practical applications for the production of integrated bottom car bodies utilizing die casting in conjunction with a dual injection system.
文摘A recently published study(Xin et al.,Prog Biochem Biophys,2026,53(2):431-441.DOI:10.3724/j.pibb.2025.0508)addresses the therapeutic challenges of pancreatic ductal adenocarcinoma(PDAC)by innovatively developing an orally administered nanogene delivery system.Designed to achieve in situ,efficient delivery of chimeric antigen receptor(CAR)genes to tumor sites,this approach offers a novel strategy for CAR-macrophage(CAR-M)based immunotherapy.Its key highlights are as follows.
文摘Aerodynamic research on road cars was reviewed in this work under the thread of reducing drag,with the awareness that this may succeed in effectively decreasing the carbon footprint of transportation.First,a selection of studies was presented to focus on the most important aerodynamic features of the flow around realistic car body shapes.Then,the discussion was organized around three pillars related to passive flow control,active flow control and active aerodynamics.Both experimental and numerical investigations were included to provide a comprehensive overview.A clear distinction was made between simplified and realistic car models,as well as production vehicles(within the limits of restricted access information).Moreover,a short essay was dedicated to electric vehicles,for which aerodynamics matters,especially at highway speeds.Last,the impact of aerodynamic principles on the design of current and future vehicle fleet was assessed,honestly admitting that recent market trends must be reversed to turn decarbonization goals into reality and damp the effects of global warming.
基金supported by the National Research Foundation of Korea(NRF)through the Ministry of Education(2021R1I1A3059820)(to Jea-Hyun Baek).
文摘The paradigm of cancer treatment has been reshaped by chimeric antigen receptor(CAR)αβT cell therapy,yet its full potential remains constrained by fundamental limitations.While conventional CARαβT cells have achieved notable success in hematological malignancies,their broader application is hindered by the high cost and delays of autologous manufacturing,as well as the critical risk of graft-vs-host disease(GvHD).In addition,their efficacy against solid tumors is often compromised by the immunosuppressive tumor microenvironment(TME).As a promising solution,γδT cells are being developed as an alternative CAR platform.Their intrinsic ability to recognize transformed cells in a major histocompatibility complex(MHC)-independent manner minimizes the risk of GvHD and supports the creation of safe,effective allogeneic therapies.Building on this unique biology,the therapeutic efficacy of CARγδT cells is being enhanced through advanced engineering strategies.Key innovations include“armoring”technologies,such as cytokine secretion,checkpoint blockade,and metabolic rewiring,to overcome local immunosuppression and improve persistence,as well as the use of induced pluripotent stem cells(iPSCs)to generate standardized products from a renewable and consistent source.This expanding technological toolbox is also enabling novel applications beyond oncology.For example,chimeric autoantibody receptor(CAAR)constructs built onγδT cells integrate both classical and emerging insights into CARγδT cell therapy,highlighting innovations that are driving the field toward safer,more versatile,and longer-lasting treatments for cancer and autoimmunity.In light of these advancements,this review provides an overview of the current understanding ofγδT cell biology and highlights emerging engineering strategies that enhance the efficacy and durability of CARγδT cells across oncologic and autoimmune contexts.
基金supported by National Hi-tech Research and Development Program of China (863 Program,Grant No. 2006AA110101)"111 Program" of Ministry of Education and State Administration of Foreign Experts Affairs of China (Grant No. 111-2-11)+1 种基金General Motors Research and Development Center (Grant No. RD-209)Project of State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body,Hunan University,China (Grant No. 60870004)
文摘Lower limb injures are frequently observed in passenger car traffic accidents.Previous studies of the injuries focus on long bone fractures by using either cadaver component tests or simulations of the long bone kinematics,which lack in-depth study on the fractures in stress analysis.This paper aims to investigate lower limb impact biomechanics in real-world car to pedestrian accidents and to predict fractures of long bones in term of stress parameter for femur,tibia,and fibula.For the above purposes,a 3D finite element(FE) model of human body lower limb(HBM-LL) is developed based on human anatomy.The model consists of the pelvis,femur,tibia,fibula,patella,foot bones,primary tendons,knee joint capsule,meniscus,and ligaments.The FE model is validated by comparing the results from a lateral impact between simulations and tests with cadaver lower limb specimens.Two real-world accidents are selected from an in-depth accident database with detailed information about the accident scene,car impact speed,damage to the car,and pedestrian injuries.Multi-body system(MBS) models are used to reconstruct the kinematics of the pedestrians in the two accidents and the impact conditions are calculated for initial impact velocity and orientations of the car and pedestrian during the collision.The FE model is used to perform injury reconstructions and predict the fractures by using physical parameters,such as von Mises stress of long bones.The calculated failure level of the long bones is correlated with the injury outcomes observed from the two accident cases.The reconstruction result shows that the HBM-LL FE model has acceptable biofidelity and can be applied to predict the risk of long bone fractures.This study provides an efficient methodology to investigate the long bone fracture suffered from vehicle traffic collisions.
基金National Natural Science Founda-tion of China (No.59835160).
文摘The automatic control of clutch starting in car with a metal pushingbelt-planetary gear continuously variable transmission (CVT) is a complex problem. A suited controlstrategy is required to realize quick and smooth start. A simulation state space equation isestablished on clutch staring control of a car with CVT by bond graph theory. According to the fuzzycontrol method with the expert system, a fuzzy control system of car starting process to weaken thejerk motion is introduced. The simulation results indicate that the jerk motion of clutch startingis below 10 m/s^3.
基金This project is supported Fok Yingtung Education Foundation(No.81070)and National Natural Science Foundation of China(No.50005026).
文摘The most remarkable characteristic of a metal belt-planetary gearcontinuously variable transmission is a wider ratio range and a bigger torque capacity than aconventional metal pushing belt continuously variable transmission. A parallel hybrid car with thistransmission system not only can reduce fuel consumption and pollutant emission at a ECE city cycle,but also can keep the motor working in the most efficiency area and can be started by a lower powermotor by oneself. At the same time, the continuously variable transmission system can realize thesmooth switch between the motor and the engine.
基金supported by the National Basic Research Program of China (973 Program) (Grant No. 2010CB951901)the U.S. DOE office of Biological and Environmental Research (BER) (Grant No. DE-SC0001683)+2 种基金the National Natural Science Foundation of China (Grant Nos. 40605026 and 40830103)the "Strategic Priority Research Program-Climate Change: Carbon Budget and Relevant Issues" of the Chinese Academy of Sciences (Grant No. XDA05110101)the National Energy Research Scientific Computing Center, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231
文摘The Cloud Aerosol- Radiation （CAR） ensemble modeling system has recently been built to better un- derstand cloud/aerosol/radiation processes and determine the uncertainties caused by different treatments of cloud/aerosol/radiation in climate models. The CAR system comprises a large scheme collection of cloud, aerosol, and radiation processes available in the literature, including those commonly used by the world＇s leading GCMs. In this study, detailed analyses of the overall accuracy and efficiency of the CAR system were performed. Despite the different observations used, the overall accuracies of the CAR ensemble means were found to be very good for both shortwave （SW） and longwave （LW） radiation calculations. Taking tile percentage errors for July 2004 compared to ISCCP （International Satellite Cloud Climatology Project） data over （60~N, 60~S） as an example, even among the 448 CAR members selected here, those errors of the CAR ensemble means were only about -0.67% （-0.6 W m-2） and -0.82% （-2.0 W m-2） for SW and LW upward fluxes at the top of atmosphere, and 0.06% （0.1 W m-2） and -2.12% （-7.8 W m 2） for SW and LW downward fluxes at the surface, respectively. Furthermore, model SW frequency distributions in July 2004 covered the observational ranges entirely, with ensemble means located in the middle of the ranges. Moreover, it was found that the accuracy of radiative transfer calculations can be significantly enhanced by＂ using certain combinations of cloud schemes for the cloud cover fraction, particle effective size, water path, and optical properties, along with better explicit treatments for unresolved cloud structures.
文摘This paper presents the construction of a pneumatic active suspension system for a one-wheel car model using fuzzy reasoning and a disturbance observer. The one-wheel car model can be approximately described as a nonlinear two degrees of freedom system subject to excitation from a road profile. The active control is composed of fuzzy and disturbance controls, and the active control force is constructed by actuating a pneumatic actuator. A phase lead-lag compensator is inserted to counter the performance degradation due to the delay of the pneumatic actuator. The experimental result indicates that the proposed active suspension improves much the vibration suppression of the car model.
文摘The continuous increase of human mobility combined with a relevant use of private vehicles contributes to increase the ill effects of vehicle externalities on the environment, e.g. high levels of air pollution, toxic emissions, noise pollution, and on the quality of life, e.g. parking problem, traffic congestion, and increase in the number of crashes and accidents. Transport demand management plays a very critical role in achieving greenhouse gas emission reduction targets. This study demonstrates that car pooling (CP) is an effective strategy to reduce transport volumes, transportation costs and related hill externalities in agreement with EU programs of emissions reduction targets. This paper presents an original approach to solve the CP problem. It is based on hierarchical clustering models, which have been adopted by an original decision support system (DSS). The DSS helps mobility managers to generate the pools and to design feasible paths for shared vehicles. A significant case studies and obtained results by the application of the proposed models are illustrated. They demonstrate the effectiveness of the approach and the supporting decisions tool.
文摘Torpedo cars,for the hot metal transportation by rail,play an indispensable role in China Steel Corporation (CSC)'s production.In order to meet the requirements of continual progress in hot metal production and safety management,the torpedo car tracking system suitable for our identification has been built up.This system not only combines the applications of of radio frequency identification(RFID) for accurately locating and radio modems to transmit the torpedo car position data,but also integrates the monitoring of railway switch machines and level crossings as well as the torpedo cars management system.Accordingly all torpedo car positions and operation data of railway equipments can be displayed in the control center for the reference of the effectively monitoring of torpedo cars and the dispatching of missions.
基金Supported by the National Key Technology R&D Program of the 11th Five-Year Plan of China(2006BAF04B05)the Natural Science Foundation of Shanxi Province(2010021024-2)
文摘Perfect combination of structural size parameters of the hydroforming billets is essential to obtain even wall thicknesses of the car beam. Finite element （ FE ） analysis on hydroforming car beam was carried out, and the results were optimized according to multiple quality objectives by the grey system theory. With bending angle, bending radius and hight difference along the axis direction as variables, orthogonal FE analyses were conducted and the minimum and maximum wall thicknes ses of the billets with different sizes were obtained. Taking the minimum and maximum wall thick nesses as two references, the correlation coefficient between the data for reference and those for comparison by the grey system theory reduced multi objectives to a single quality objective, and the average correlation level of every billet facilitated the optimization of size parameters for hydroform ing car beam. The trial production showed that the optimization approach satisfied the need of hy droforming car beams.
基金National Natural Science Foundation of China(Grant Nos.52072072,52025121 and 51605087).
文摘Noise,vibration and harshness(NVH)problems in vehicle engineering are always challenging in both traditional vehicles and intelligent vehicles.Although high accuracy manufacturing,modern structural roads and advanced suspension technology have already significantly reduced NVH problems and their impacts;off-road condition,obstacles and extreme operating condition could still trigger NVH problems unexpectedly.This paper proposes a vehicular electronic image stabilization(EIS)system to solve the vibration problem of the camera and ensure the environment perceptive function of vehicles.Firstly,feature point detection and matching based on an oriented FAST and rotated BRIEF(ORB)algorithm are implemented to match images in the process of EIS.Furthermore,a novel improved random sampling consensus algorithm(i-RANSAC)is proposed to eliminate mismatched feature points and increase the matching accuracy significantly.And an adaptive Kalman filter(AKF)is applied to improve the adaptability of the vehicular EIS.Finally,an experimental platform based on a gasoline model car was established to validate its performance.The experimental results show that the proposed EIS system can satisfy vehicular performance requirements even under off-road condition with obvious obstacles.
文摘Combination of a bus system and cable car system can reduce the overall congestion of traffic in urban areas, where surrounding hills or mountains hold larger settlements or tourist and recreational infrastructure. With this kind of integration number of individual car trips can be significantly reduced. In this paper, the authors present an analysis of the pilot project implementation, which was held in Maribor. The authors conducted a limited test trial of two means of transportation, combining them into a single operating transport offer for inhabitants and tourists. Combined transport option proved to be a good starting point for reduction of traffic and parking congestion during winter tourist season and beyond. Method used in the research, in order to gain actual potential of integrating two systems and improving public transport offer, was establishment and implementation of the pilot project in Maribor during January 2011. Data was gathered through interviews of two interest groups. The first covered the users who were brought to the foothills of Pohorje＇s ski center by bus. The second covered the cable car users that were traveling to the top of Pohorje. For a limited time period, a trial principle of a single ticket was established, which gave ski-pass holders free bus ride on bus line No. 6. With the aim of reducing CO2, test drives of hybrid bus and compressed natural gas bus were conducted alongside many promotional activities with which users were informed of importance of environmentally friendly mobility options.
文摘With the rapid improvement of China’s economic level and the rapid development of e-commerce, the demand for logistics warehousing, which is one of the most important links in the logistics transportation system, has also greatly increased. The dispatching management system applied in the warehouse has a wide range of applications in the logistics storage system. Improving the operational efficiency of the dispatching management system can effectively improve the efficiency of the automated warehouse system and reduce the cost of logistics transportation. Therefore, this paper designs a set of dispatching systems with the tracking car as the control target and realizes the positioning and path planning functions of the tracking car in the system. At present, the tracking car can completely receive the commands sent by the system, accurately follow the established path. At the same time, the system software can also obtain the video images taken by the camera on the car and play them smoothly.
文摘腺病毒(Adenovirus,Ad)是一类无包膜的双链DNA病毒,能广泛感染脊椎动物,导致从轻症到严重的感染。腺病毒通过其纤突蛋白与宿主细胞表面受体结合,柯萨奇-腺病毒受体(Coxsackievirus and adenovirus receptor,CAR)是主要的介导者。CAR是一种高度保守的跨膜蛋白,在多种脊椎动物中发挥关键作用。文章聚焦于CAR的生物学功能和结构特征,探讨其在腺病毒感染机制中的核心作用;重点分析了CAR与人腺病毒、禽腺病毒及其他物种腺病毒的相互作用及功能差异,揭示腺病毒与宿主受体结合的多样性和复杂性。此外,文章讨论了CAR在基因治疗中的应用前景,特别是利用CAR介导的腺病毒载体递送抗癌基因和免疫调节基因的研究进展。同时,调控CAR表达水平及阻断其与病毒结合的策略被认为是优化腺病毒治疗的重要方向。文章通过总结现有研究成果,深化了对腺病毒感染机制的认识,并为基因治疗及相关疾病的治疗策略提供了重要的理论依据和实践参考。
