AIM: To investigate oxaliplatin-induced severe anaphylactic reactions (SAR) in metastatic colorectal cancer in a retrospective case series analysis and to conduct a systemic literature review. METHODS: During a 6-year...AIM: To investigate oxaliplatin-induced severe anaphylactic reactions (SAR) in metastatic colorectal cancer in a retrospective case series analysis and to conduct a systemic literature review. METHODS: During a 6-year period from 2006 to 2011 at Kaohsiung Veterans General Hospital, a total of 412 patients exposed to oxaliplatin-related chemotherapy were retrospectively reviewed. Relevant Englishlanguage studies regarding life-threatening SAR following oxaliplatin were also reviewed in MEDLINE and PubMed search. RESULTS: Eight patients (1.9%, 8 of 412 cases) were identified. Seven patients were successful resuscitated without any sequelae and one patient expired. We changed the chemotherapy regimen in five patients and rechallenged oxaliplatin use in patient 3. Twenty-three relevant English-language studies with 66 patients were reported. Patients received a median of 10 cycles of oxaliplatin (range, 2 to 29). Most common symptoms were respiratory distress (60%), fever (55%), and hypotension (54%). Three fatal events were reported (4.5%). Eleven patients (16%) of the 66 cases were rechallenged by oxaliplatin. CONCLUSION: SAR must be considered in patients receiving oxaliplatin-related chemotherapy, especially in heavily pretreated patients. Further studies on the mechanism, predictors, preventive methods and management of oxaliplatin-related SAR are recommended.展开更多
1.Introduction Liver cancer is the sixth leading cause of cancer and the third leading cause of cancer-related deaths globally(GLOBOCAN).Hepatocellular carcinoma(HCC)represents about 90%of primary liver cancers and co...1.Introduction Liver cancer is the sixth leading cause of cancer and the third leading cause of cancer-related deaths globally(GLOBOCAN).Hepatocellular carcinoma(HCC)represents about 90%of primary liver cancers and constitutes a major global health problem.^([1])The number of new cases in China accounted for 46.6%of the global liver cancer cases,and 47.1%of the global liver cancer deaths occurred in China.^([2])展开更多
According to data from the International Agency for Research on Cancer(IARC),nearly 20 million new cancer cases were diagnosed in 2022,with the number of cancer-related deaths reaching 9.7 million.Research indicates t...According to data from the International Agency for Research on Cancer(IARC),nearly 20 million new cancer cases were diagnosed in 2022,with the number of cancer-related deaths reaching 9.7 million.Research indicates that the lifetime risk of developing cancer is as high as 20%,and the number of cancer deaths among men is significantly greater than that among women(Bray et al.,2024).Cancer has become a major burden on society.展开更多
Malignant tumors remain a significant cause of death worldwide.In 2022,nearly 20 million new cancer cases were reported globally,with approximately 9.7 million resulting in death.By 2050,the number of new cancer cases...Malignant tumors remain a significant cause of death worldwide.In 2022,nearly 20 million new cancer cases were reported globally,with approximately 9.7 million resulting in death.By 2050,the number of new cancer cases is predicted to reach 35 million,underscoring the growing urgency of this global challenge[1].展开更多
Background：Studies on the association between spicy food intake and cancer risk have reported inconsistent results.We quantitatively assessed this association by conducting a meta-analysis based on evidence from case...Background：Studies on the association between spicy food intake and cancer risk have reported inconsistent results.We quantitatively assessed this association by conducting a meta-analysis based on evidence from case-control studies.Methods：PubMed,EMBASE,and the Cochrane Library were searched for eligible publications.Combined odds ratios （ORs） with their 95% confidence interval （CI） were calculated using a random-or fixed-effects model.The methodological quality of the included articles was assessed using the Newcastle-Ottawa scale （NOS）.All data were analyzed using STATA 1 1.0 software （version 11.0;StataCorp.,College Station,TX,USA）.Subgroup analyses were also performed with stratification by region,sex,number of cases,cancer subtype,source of the control group,and NOS score.Results：A total 39 studies from 28 articles fulfilled the inclusion criteria for the meta-analysis （7884 patients with cancer and 10,142 controls）.Comparison of the highest versus lowest exposure category in each study revealed a significant OR of 1.76 （95% CI =1.35-2.29） in spite of significant heterogeneity （P 〈 0.00l）.In the subgroup analyses,this positive correlation was still found for gastric cancer,different regions,different numbers of cases,different sources of the control group,and high-quality articles （NOS score of≥ 7）.However,no statistically significant association was observed for women,esophageal cancer,gallbladder cancer,or low-quality articles （NOS score of〈7）.No evidence of publication bias was found.Conclusions：Evidence from case-control studies suggested that a higher level of spicy food intake may be associated with an increased incidence of cancer despite significant heterogeneity.More studies are warranted to clarify our understanding of the association between high spicy food intake and the risk of cancer.展开更多
Gallbladder cancer(GBC)is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developingCurrently,GBC has a low early diagnosis rate and an extr...Gallbladder cancer(GBC)is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developingCurrently,GBC has a low early diagnosis rate and an extremely poor prognosis,leading to major problems for treatment of GBC.Liver invasion and metastasis one of the main causes of its poor prognosis,with its average overall survival of 6 months.展开更多
文摘AIM: To investigate oxaliplatin-induced severe anaphylactic reactions (SAR) in metastatic colorectal cancer in a retrospective case series analysis and to conduct a systemic literature review. METHODS: During a 6-year period from 2006 to 2011 at Kaohsiung Veterans General Hospital, a total of 412 patients exposed to oxaliplatin-related chemotherapy were retrospectively reviewed. Relevant Englishlanguage studies regarding life-threatening SAR following oxaliplatin were also reviewed in MEDLINE and PubMed search. RESULTS: Eight patients (1.9%, 8 of 412 cases) were identified. Seven patients were successful resuscitated without any sequelae and one patient expired. We changed the chemotherapy regimen in five patients and rechallenged oxaliplatin use in patient 3. Twenty-three relevant English-language studies with 66 patients were reported. Patients received a median of 10 cycles of oxaliplatin (range, 2 to 29). Most common symptoms were respiratory distress (60%), fever (55%), and hypotension (54%). Three fatal events were reported (4.5%). Eleven patients (16%) of the 66 cases were rechallenged by oxaliplatin. CONCLUSION: SAR must be considered in patients receiving oxaliplatin-related chemotherapy, especially in heavily pretreated patients. Further studies on the mechanism, predictors, preventive methods and management of oxaliplatin-related SAR are recommended.
基金Supported by a grant from the Talent Exchange Service Center of National Health Commission(RCLX2315049)。
文摘1.Introduction Liver cancer is the sixth leading cause of cancer and the third leading cause of cancer-related deaths globally(GLOBOCAN).Hepatocellular carcinoma(HCC)represents about 90%of primary liver cancers and constitutes a major global health problem.^([1])The number of new cases in China accounted for 46.6%of the global liver cancer cases,and 47.1%of the global liver cancer deaths occurred in China.^([2])
文摘According to data from the International Agency for Research on Cancer(IARC),nearly 20 million new cancer cases were diagnosed in 2022,with the number of cancer-related deaths reaching 9.7 million.Research indicates that the lifetime risk of developing cancer is as high as 20%,and the number of cancer deaths among men is significantly greater than that among women(Bray et al.,2024).Cancer has become a major burden on society.
基金partially supported by the National Key R&D Programof China(2024YFA1306400,2021YFF1200404,and 2021YFA1201200)the National Center of Technology Innovation for Biopharmaceuticals(NCTIB2022HS02010)+2 种基金Shanghai Artificial Intelligence Lab(P22KN00272)the National Independent Innovation Demonstration Zone Shanghai Zhangjiang Major Projects(ZjzX2020014)the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(SN-ZJU-SIAS-003).
文摘Malignant tumors remain a significant cause of death worldwide.In 2022,nearly 20 million new cancer cases were reported globally,with approximately 9.7 million resulting in death.By 2050,the number of new cancer cases is predicted to reach 35 million,underscoring the growing urgency of this global challenge[1].
文摘Background：Studies on the association between spicy food intake and cancer risk have reported inconsistent results.We quantitatively assessed this association by conducting a meta-analysis based on evidence from case-control studies.Methods：PubMed,EMBASE,and the Cochrane Library were searched for eligible publications.Combined odds ratios （ORs） with their 95% confidence interval （CI） were calculated using a random-or fixed-effects model.The methodological quality of the included articles was assessed using the Newcastle-Ottawa scale （NOS）.All data were analyzed using STATA 1 1.0 software （version 11.0;StataCorp.,College Station,TX,USA）.Subgroup analyses were also performed with stratification by region,sex,number of cases,cancer subtype,source of the control group,and NOS score.Results：A total 39 studies from 28 articles fulfilled the inclusion criteria for the meta-analysis （7884 patients with cancer and 10,142 controls）.Comparison of the highest versus lowest exposure category in each study revealed a significant OR of 1.76 （95% CI =1.35-2.29） in spite of significant heterogeneity （P 〈 0.00l）.In the subgroup analyses,this positive correlation was still found for gastric cancer,different regions,different numbers of cases,different sources of the control group,and high-quality articles （NOS score of≥ 7）.However,no statistically significant association was observed for women,esophageal cancer,gallbladder cancer,or low-quality articles （NOS score of〈7）.No evidence of publication bias was found.Conclusions：Evidence from case-control studies suggested that a higher level of spicy food intake may be associated with an increased incidence of cancer despite significant heterogeneity.More studies are warranted to clarify our understanding of the association between high spicy food intake and the risk of cancer.
文摘Gallbladder cancer(GBC)is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developingCurrently,GBC has a low early diagnosis rate and an extremely poor prognosis,leading to major problems for treatment of GBC.Liver invasion and metastasis one of the main causes of its poor prognosis,with its average overall survival of 6 months.
