This study investigates the variability in cancer diagnosis across different tissues and organs, with a focus on the role of diagnostic methods such as Hematoxylin and Eosin (H&E) staining and immunohistochemistry...This study investigates the variability in cancer diagnosis across different tissues and organs, with a focus on the role of diagnostic methods such as Hematoxylin and Eosin (H&E) staining and immunohistochemistry (IHC). The predominance of female breast cancer (30%) aligns with global trends, underscoring the need for robust diagnostic protocols, particularly in developing regions. Other prevalent cancers, including skin, stomach, and cervix uteri, reflect a mix of environmental, genetic, and infectious factors. The underrepresentation of gallbladder and thyroid cancers (<1%) suggests potential underdiagnosis or lower prevalence. Age distribution data indicate peak cancer incidence in individuals aged 31 - 45 years, with gender-specific cancers like breast and cervical cancer predominantly affecting females (63.4%). The analysis also highlights significant diagnostic gaps, as 61.2% of cases did not undergo IHC testing due to resource constraints, leading to potential biases in cancer prevalence and diagnostic accuracy. The study emphasizes the complementary role of IHC in confirming ambiguous H&E findings, with strong alignment observed when both methods were used. However, the absence of IHC in many cases limits the robustness of conclusions, suggesting the need for increased access to IHC testing. The findings advocate for integrating IHC into routine diagnostics, expanding diagnostic capabilities, and improving sample sizes to ensure more reliable and comprehensive cancer data.展开更多
The global average life expectancy is projected to rise to 80 years by 2040[1].Since cancer is closely linked to aging,its prevalence is expected to grow as the population ages.Advancements in cancer diagnosis and tre...The global average life expectancy is projected to rise to 80 years by 2040[1].Since cancer is closely linked to aging,its prevalence is expected to grow as the population ages.Advancements in cancer diagnosis and treatment have led to an increasing number of cancer survivors.In a 2021 consensus statement,the International Society for Geriatric Oncology updated its top priorities for improving care for older cancer patients[2,3].According to the Global Burden of Disease(GBD)study,there were over four million deaths from gastrointestinal(GI)cancer in 2021[4].The aging population,advancements in cancer management,and shifting risk factors are undoubtedly influencing the prevalence of GI cancers in older adults[5].While aging has increasingly captured the attention of policymakers and stakeholders,epidemiological data on GI cancers in older adults remains limited.Older patients are also underrepresented in GI-specific clinical trials.This study aimed to estimate the global burden of GI cancers in older adults using the most recent GBD 2021[6].展开更多
Mycotoxins are secondary metabolites of filamentous fungi that colonize a wide range of crops, including cereals and oilseeds, both in the field and after </span><span style="font-variant-ligatures:...Mycotoxins are secondary metabolites of filamentous fungi that colonize a wide range of crops, including cereals and oilseeds, both in the field and after </span><span style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">harvest, especially during storage. Several studies carried out on the</span><span lang="EN-US" style="font-size:10.0pt;font-family:"color:black;"><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">occurrence of mycotoxins in crops and their derived products such as maize, peanuts, rice and attieke (cassava product), reported substantial levels of Aflatoxins (AFs), Fumonisins (FBs), Ochratoxin A (OTA) and Zearalenone (ZEA). The aim of the present study was to analyze findings available on Aflatoxins, Ochratoxin A and Fusarium toxins occurrence in maize, peanuts, rice and attieke in order to assess the exposure level and cancers risk in </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">the </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">Ivorian population. References and publications related to OTA in C<span "=""><span "="">ôte d’Ivoire were searched and selected. Medline/PubMed, Elsevier Bibliographic Databases, BioInfoBank Library, DOAJ (Directory of Open Acess Journal), Australian Journal of Basic and Applied Sciences and </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">https://medwelljournals.com/home.php</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">were used as databases. Data available showed Estimated Daily Intake (EDI) of AFs</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> and</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> OTA </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">were</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">above </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">of </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">their </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">Tolerable Daily Intake (TDI) </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">as </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">recommended by the Joint</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> FAO/WHO Experts Committee on Food Additives th</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">r</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">ough rice, maize, peanut and attieke consumption in</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> C<span "="">ôte d’Ivoire. In addition, there is a veritable incidence of cancers with the abundant and frequent consumption of foods maize, rice, peanuts and attieke. However, maize and rice seemed </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">to be </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">sources of FBs展开更多
文摘This study investigates the variability in cancer diagnosis across different tissues and organs, with a focus on the role of diagnostic methods such as Hematoxylin and Eosin (H&E) staining and immunohistochemistry (IHC). The predominance of female breast cancer (30%) aligns with global trends, underscoring the need for robust diagnostic protocols, particularly in developing regions. Other prevalent cancers, including skin, stomach, and cervix uteri, reflect a mix of environmental, genetic, and infectious factors. The underrepresentation of gallbladder and thyroid cancers (<1%) suggests potential underdiagnosis or lower prevalence. Age distribution data indicate peak cancer incidence in individuals aged 31 - 45 years, with gender-specific cancers like breast and cervical cancer predominantly affecting females (63.4%). The analysis also highlights significant diagnostic gaps, as 61.2% of cases did not undergo IHC testing due to resource constraints, leading to potential biases in cancer prevalence and diagnostic accuracy. The study emphasizes the complementary role of IHC in confirming ambiguous H&E findings, with strong alignment observed when both methods were used. However, the absence of IHC in many cases limits the robustness of conclusions, suggesting the need for increased access to IHC testing. The findings advocate for integrating IHC into routine diagnostics, expanding diagnostic capabilities, and improving sample sizes to ensure more reliable and comprehensive cancer data.
文摘The global average life expectancy is projected to rise to 80 years by 2040[1].Since cancer is closely linked to aging,its prevalence is expected to grow as the population ages.Advancements in cancer diagnosis and treatment have led to an increasing number of cancer survivors.In a 2021 consensus statement,the International Society for Geriatric Oncology updated its top priorities for improving care for older cancer patients[2,3].According to the Global Burden of Disease(GBD)study,there were over four million deaths from gastrointestinal(GI)cancer in 2021[4].The aging population,advancements in cancer management,and shifting risk factors are undoubtedly influencing the prevalence of GI cancers in older adults[5].While aging has increasingly captured the attention of policymakers and stakeholders,epidemiological data on GI cancers in older adults remains limited.Older patients are also underrepresented in GI-specific clinical trials.This study aimed to estimate the global burden of GI cancers in older adults using the most recent GBD 2021[6].
文摘Mycotoxins are secondary metabolites of filamentous fungi that colonize a wide range of crops, including cereals and oilseeds, both in the field and after </span><span style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">harvest, especially during storage. Several studies carried out on the</span><span lang="EN-US" style="font-size:10.0pt;font-family:"color:black;"><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">occurrence of mycotoxins in crops and their derived products such as maize, peanuts, rice and attieke (cassava product), reported substantial levels of Aflatoxins (AFs), Fumonisins (FBs), Ochratoxin A (OTA) and Zearalenone (ZEA). The aim of the present study was to analyze findings available on Aflatoxins, Ochratoxin A and Fusarium toxins occurrence in maize, peanuts, rice and attieke in order to assess the exposure level and cancers risk in </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">the </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">Ivorian population. References and publications related to OTA in C<span "=""><span "="">ôte d’Ivoire were searched and selected. Medline/PubMed, Elsevier Bibliographic Databases, BioInfoBank Library, DOAJ (Directory of Open Acess Journal), Australian Journal of Basic and Applied Sciences and </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">https://medwelljournals.com/home.php</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">were used as databases. Data available showed Estimated Daily Intake (EDI) of AFs</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> and</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> OTA </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">were</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">above </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">of </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">their </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">Tolerable Daily Intake (TDI) </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">as </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">recommended by the Joint</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> FAO/WHO Experts Committee on Food Additives th</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">r</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">ough rice, maize, peanut and attieke consumption in</span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;"> C<span "="">ôte d’Ivoire. In addition, there is a veritable incidence of cancers with the abundant and frequent consumption of foods maize, rice, peanuts and attieke. However, maize and rice seemed </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">to be </span><span "="" style="font-variant-ligatures:normal;font-variant-caps:normal;orphans:2;text-align:start;widows:2;-webkit-text-stroke-width:0px;text-decoration-thickness:initial;text-decoration-style:initial;text-decoration-color:initial;word-spacing:0px;">sources of FBs
