Liver cirrhosis portal hypertension patients to reduce the number of blood cells are common in clinical, and often affect the prognosis. This paper discusses cirrhotic portal hypertension patients complicated by the r...Liver cirrhosis portal hypertension patients to reduce the number of blood cells are common in clinical, and often affect the prognosis. This paper discusses cirrhotic portal hypertension patients complicated by the reason of the decrease in the number of peripheral blood cells and what is the clinical significance of these reasons so as to provide theoretical support for the choice of treatment. Splenomegaly and hypersplenism caused should be the main reason for reducing the number of blood cells, but not all, other reasons are alcohol and virus inhibition of bone marrow, liver function impairment, autoimmune damage and loss of blood, etc. If it is a function of the spleen hyperfunction caused by blood cells decreases, blood should rise to normal after splenectomy, or consider other reason or there are other reasons at the same time.展开更多
Objective To investigate the clinical features and prognosis of prolonged cytopenia(PC)in patients with large B-cell lymphoma(LBCL)undergoing anti-CD19 chimeric antigen receptor T(CAR-T)cell therapy Methods A retrospe...Objective To investigate the clinical features and prognosis of prolonged cytopenia(PC)in patients with large B-cell lymphoma(LBCL)undergoing anti-CD19 chimeric antigen receptor T(CAR-T)cell therapy Methods A retrospective case series study was conducted on LBCL patients who received CAR-T cell therapy with a survival time of over one month at the Hematology Department of Peking Union Medical College Hospital from March 2019 to December 2023.Statistical analyses were performed on hematologic changes at 1,3,6,and 12 months post-CAR-T infusion,as well as on the progression-freesurvival(PFS)and post-treatment adverse events,including infections.Patientswere categorized into the PC and non-PC groups based on the occurrence of cytopenia at 90 days post-infusion.Differences between1groups were compared,and univariate logistic regression analysis was used to identify risk factors.Results The median age of 27 LBCL patients receiving CAR-T cell therapy was 58 years(range 27-69 years),with 18 males.Among the 27 LBCL patients who received CAR-T cell therapy,PC was observed in 19 patients(70.4%),with instances of neutropenia(48.1%,13 cases),anemia(37.0%,10 cases),and thrombocytopenia(22.2%,6 cases).Univariate logistic regression analysis revealed that prior chemotherapy sensitivity(0R=18.00,95%CI 1.56-207.45,P=0.020)and bone marrow suppression(OR=18.00,95%CI 1.38-235.69,P=0.028)were associated with PC.The median follow-up time was 13.5 months.The PC group exhibited a higher risk of infection within 3 months(9/19 vs.1/8)and a shorter mean PFS(19.3 months vs.24.4 months),although the difference was not statistically significant(both P>0.05).Conclusion PC is common following CAR-T cell therapy and is associated with an increased risk of infection and poorer prognosis.Prior treatment sensitivity and bone marrow suppression may serve as indicators of PC.展开更多
Objective To test NK cell quantities and function in patients with positive BMMNC-Coombs test(CBCPC)and cytopenia and to explore how NK cell participate in the progress of this disease.Methods The percentage of CD3-CD...Objective To test NK cell quantities and function in patients with positive BMMNC-Coombs test(CBCPC)and cytopenia and to explore how NK cell participate in the progress of this disease.Methods The percentage of CD3-CD56+NK cell in peripheral blood lymphocytes,the expression of activating receptor(NKG2D,NKp46,NKp44),inhibitory receptor(CD158a,CD158b),per-展开更多
A higher prevalence of immunological processes has recently been reported in patients with hepatitis C virus(HCV)infection,focusing the attention of physicians and researchers on the close association between HCV and ...A higher prevalence of immunological processes has recently been reported in patients with hepatitis C virus(HCV)infection,focusing the attention of physicians and researchers on the close association between HCV and immune disorders.HCV lymphotropism represents the most important step in the pathogenesis of virusrelated immunological diseases and experimental,virologic,and clinical evidence has demonstrated a trigger role for HCV both in systemic autoimmune diseases,such as rheumatoid arthritis,Sj?gren syndrome,hemolytic anemia and severe thrombocytopenia,and in organ-specific autoimmune diseases,such as autoimmune hepatitis,thyroid disorders and diabetes.This review will outline the principal aspects of such HCVinduced immunological alterations,focusing on the prevalence of these less characterized HCV extrahepatic manifestations.展开更多
文摘Liver cirrhosis portal hypertension patients to reduce the number of blood cells are common in clinical, and often affect the prognosis. This paper discusses cirrhotic portal hypertension patients complicated by the reason of the decrease in the number of peripheral blood cells and what is the clinical significance of these reasons so as to provide theoretical support for the choice of treatment. Splenomegaly and hypersplenism caused should be the main reason for reducing the number of blood cells, but not all, other reasons are alcohol and virus inhibition of bone marrow, liver function impairment, autoimmune damage and loss of blood, etc. If it is a function of the spleen hyperfunction caused by blood cells decreases, blood should rise to normal after splenectomy, or consider other reason or there are other reasons at the same time.
文摘Objective To investigate the clinical features and prognosis of prolonged cytopenia(PC)in patients with large B-cell lymphoma(LBCL)undergoing anti-CD19 chimeric antigen receptor T(CAR-T)cell therapy Methods A retrospective case series study was conducted on LBCL patients who received CAR-T cell therapy with a survival time of over one month at the Hematology Department of Peking Union Medical College Hospital from March 2019 to December 2023.Statistical analyses were performed on hematologic changes at 1,3,6,and 12 months post-CAR-T infusion,as well as on the progression-freesurvival(PFS)and post-treatment adverse events,including infections.Patientswere categorized into the PC and non-PC groups based on the occurrence of cytopenia at 90 days post-infusion.Differences between1groups were compared,and univariate logistic regression analysis was used to identify risk factors.Results The median age of 27 LBCL patients receiving CAR-T cell therapy was 58 years(range 27-69 years),with 18 males.Among the 27 LBCL patients who received CAR-T cell therapy,PC was observed in 19 patients(70.4%),with instances of neutropenia(48.1%,13 cases),anemia(37.0%,10 cases),and thrombocytopenia(22.2%,6 cases).Univariate logistic regression analysis revealed that prior chemotherapy sensitivity(0R=18.00,95%CI 1.56-207.45,P=0.020)and bone marrow suppression(OR=18.00,95%CI 1.38-235.69,P=0.028)were associated with PC.The median follow-up time was 13.5 months.The PC group exhibited a higher risk of infection within 3 months(9/19 vs.1/8)and a shorter mean PFS(19.3 months vs.24.4 months),although the difference was not statistically significant(both P>0.05).Conclusion PC is common following CAR-T cell therapy and is associated with an increased risk of infection and poorer prognosis.Prior treatment sensitivity and bone marrow suppression may serve as indicators of PC.
文摘Objective To test NK cell quantities and function in patients with positive BMMNC-Coombs test(CBCPC)and cytopenia and to explore how NK cell participate in the progress of this disease.Methods The percentage of CD3-CD56+NK cell in peripheral blood lymphocytes,the expression of activating receptor(NKG2D,NKp46,NKp44),inhibitory receptor(CD158a,CD158b),per-
文摘A higher prevalence of immunological processes has recently been reported in patients with hepatitis C virus(HCV)infection,focusing the attention of physicians and researchers on the close association between HCV and immune disorders.HCV lymphotropism represents the most important step in the pathogenesis of virusrelated immunological diseases and experimental,virologic,and clinical evidence has demonstrated a trigger role for HCV both in systemic autoimmune diseases,such as rheumatoid arthritis,Sj?gren syndrome,hemolytic anemia and severe thrombocytopenia,and in organ-specific autoimmune diseases,such as autoimmune hepatitis,thyroid disorders and diabetes.This review will outline the principal aspects of such HCVinduced immunological alterations,focusing on the prevalence of these less characterized HCV extrahepatic manifestations.
